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Diagnosis of choroid plexus papilloma: Current perspectives and future directions

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Cancer Pathogenesis and Therapy 2024年第3期2卷 173-179页

作者： esma'il Akade Fereshteh Aslani Kimia Verdi Mohammad Bahadoram Gholam Abbas Kaydani Department of Medical Virology School of MedicineAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Department of Laboratory Sciences School of Allied Medical SciencesAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Department of Physiology School of MedicineAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Department of Neurology School of MedicineAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran

Choroid plexus papilloma(CPP)is a rare,slow-growing,and typically benign brain tumor that predominantly affects *** is characterized by well-defined circular or lobulated masses in the ventricles,leading to symptoms related to increased intracranial pressure and *** diagnosis relies on a combination of clinical presentation,imaging findings,and histological *** World Health Organization(WHO)classification categorizes choroid plexus tumors into CPP(Grade Ⅰ),atypical CPP(aCPP,Grade Ⅱ),and choroid plexus carcinoma(CPC,Grade Ⅲ).This article reviewed current diagnostics modalities and explored the emergence of new diagnostic methods for *** on molecular markers and genetic alterations associated with CPP is ongoing,and some potential markers have been *** results offered insights into potential therapeutic targets and personalized treatment approaches for *** in radiomics and liquid biopsy hold promise for improving diagnostic accuracy and monitoring treatment outcomes for choroid plexus *** can provide quantitative data from imaging studies,whereas liquid biopsy can analyze tumor-derived genetic material and molecular markers from body fluids,such as cerebrospinal fluid(CSF)and *** rapidly evolving fields of molecular and genetic research and novel diagnostic methods require continuous updates and advancements before their application in clinical *** hope that these advancements will lead to earlier and more precise diagnoses,better treatment options,and improved outcomes in patients with CPP and other brain tumors.

关键词： Cerebral ventricle neoplasms Biomarkers Neuroimaging Translational research Histopathological features

Performance comparison of training algorithms for the estimation of B?hme abrasion resistance using neural networks

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Journal of Mountain Science 2023年第12期20卷 3732-3742页

作者： Ali Can OZDEMIR esma KAHRAMAN Department of Mining Engineering Çukurova UniversityAdana 01250Türkiye

Natural stones used as floor and wall coverings are exposed to many different abrasive forces,so it is essential to choose suitable materials for wear resistance in terms of the life of the *** abrasion resistance of natural stones can be determined in the laboratory by applying the B?hme abrasion resistance(BAR)***,the direct analysis of BAR in the laboratory has disadvantages such as wasting time and energy,experimental errors,and health *** eliminate these disadvantages,the estimation of BAR using artificial neural networks(ANN)was *** natural stone samples were collected from Türkiye,and uniaxial compressive strength(UCS),flexural strength(FS),water absorption rate(WA),unit volume weight(UW),effective porosity(n),and BAR tests were carried *** outputs of these tests were gathered and a data set,consisting of a total of 105 data,was randomly divided into two groups:testing and *** the current study,the success of three different training algorithms of Levenberg-Marquardt(LM),Bayesian regularization(BR),and scaled conjugate gradient(SCG)were compared for BAR prediction of natural *** criteria such as coefficient of determination(R~2),mean square error(MSE),mean square error(RMSE),and mean absolute percentage error(MAPE),which are widely used and adopted in the literature,were used to determine predictive *** findings of the study indicated that ANN is a valid method for estimating the BAR ***,the LM algorithm(R~2=0.9999,MSE=0.0001,RMSE=0.0110,and MAPE=0.0487)in training and the BR algorithm(R~2=0.9896,MSE=0.0589,RMSE=0.2427,and MAPE=1.2327)in testing showed the best prediction *** has been observed that the proposed method is quite practical to *** the artificial neural networks method will provide an advantage in similar laborintensive experimental studies.

关键词： Böhme abrasion resistance Neural networks Levenberg-Marquardt Bayesian regularization Scaled conjugate gradient

SPT based determination of undrained shear strength:Regression models and machine learning

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Frontiers of Structural and Civil Engineering 2020年第1期14卷 185-198页

作者： Walid Khalid MBARAK esma Nur CINICIOGLU Ozer CINICIOGLU Department of Civil Engigeering Bogazici UniversityIstanbul 34342Turkey School of Business Quantitative Methods DivisionIstanbul UniversityIstanbul 34320Turkey

The purpose of this study is the accurate prediction of undrained shear strength using Standard Penetration Test results and soil consistency indices,such as water content and Atterberg *** this study,along with the conventional methods of simple and multiple linear regression models,three machine learning algorithms,random forest,gradient boosting and stacked models,are developed for prediction of undrained shear *** models are employed on a relatively large data set from different projects around Turkey covering 230 *** an improvement over the available studies in literature,this study utilizes correct statistical analyses techniques on a relatively large database,such as using a train/test split on the data set to avoid overfitting of the developed ***,the validity and consistency of the prediction results are ensured with the correct use of statistical measures like p-value and cross-validation which were missing in previous *** compare the performances of the models developed in this study with the prior ones existing in literature,all models were applied on the test data set and their performances are evaluated in terms of the resulting root mean squared error(RMSE)values and coefficient of determination(R^2).Accordingly,the models developed in this study demonstrate superior prediction capabilities compared to all of the prior ***,to facilitate the use of machine learning algorithms for prediction purposes,entire source code prepared for this study and the collected data set are provided as supplements of this study.

关键词： undrained shear strength linear regression random forest gradient boosting machine learning standard penetration test

Adsorptive stripping voltammetric methods for determination of aripiprazole

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Journal of Pharmaceutical Analysis 2012年第3期2卷 193-199页

作者： Derya Asangil brahim Hüdai Tasdemir esma KIlI Ankara University Faculty of ScienceDepartment of Chemistry06100 AnkaraTurkey Amasya University Faculty of Arts and ScienceDepartment of Chemistry05100 AmasyaTurkey

Anodic behavior of aripiprazole(ARP) was studied using electrochemical *** transfer,diffusion and surface coverage coefcients of adsorbed molecules and the number of electrons transferred in electrode mechanisms were calculated for quasi-reversible and adsorp-tion-controlled electrochemical oxidation of ARP at 1.15 V versus Ag/AgCl at pH 4.0 in Britton-Robinson buffer(BR) on glassy carbon *** methods for direct determination of ARP in pharmaceutical dosage forms and biological samples were *** range is found as from 11.4 μM(5.11 mg/L) to 157 μM(70.41 mg/L) without stripping mode and it is found as from 0.221 μM(0.10 mg/L) to 13.6 μM(6.10 mg/L) with stripping *** of detection(LOD) was found to be 0.11 μM(0.05 mg/L) in stripping *** were successfully applied to assay the drug in tablets,human serum and human urine with good recoveries between 95.0% and 104.6% with relative standard deviation less than 10%.

关键词： Adsorptive stripping voltammetry Aripiprazole Electrochemical behavior Human serum and urine Pharmaceuticals

Novel insights regarding the role of noncoding RNAs in diabetes

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World Journal of Diabetes 2023年第7期14卷 958-976页

作者： Mirjana T Macvanin Zoran Gluvic Vladan Bajic esma R Isenovic Department of Radiobiology and Molecular Genetics Vinča Institute of Nuclear Sciences-National Institute of the Republic of SerbiaUniversity of BelgradeBelgrade 11000Serbia Department of Endocrinology and Diabetes Clinic for Internal MedicineZemun Clinical HospitalSchool of MedicineUniversity of BelgradeBelgrade 11000Serbia

Diabetes mellitus(DM)is a group of metabolic disorders defined by hyperglycemia induced by insulin resistance,inadequate insulin secretion,or excessive glucagon *** 2021,the global prevalence of diabetes is anticipated to be 10.7%(537 million people).Noncoding RNAs(ncRNAs)appear to have an important role in the initiation and progression of DM,according to a growing body of *** two major groups of ncRNAs implicated in diabetic disorders are miRNAs and long noncoding *** are singlestranded,short(17–25 nucleotides),ncRNAs that influence gene expression at the post-transcriptional *** DM has reached epidemic proportions worldwide,it appears that novel diagnostic and therapeutic strategies are required to identify and treat complications associated with these diseases *** are gaining attention as biomarkers for DM diagnosis and potential treatment due to their function in maintaining physiological homeostasis via gene expression *** this review,we address the issue of the gradually expanding global prevalence of DM by presenting a complete and upto-date synopsis of various regulatory miRNAs involved in these *** hope this review will spark discussion about ncRNAs as prognostic biomarkers and therapeutic tools for *** examine and synthesize recent research that used novel,high-throughput technologies to uncover ncRNAs involved in DM,necessitating a systematic approach to examining and summarizing their roles and possible diagnostic and therapeutic uses.

关键词： Noncoding RNA miRNA Diabetes Circulating miRNA biomarkers Therapeutic target CRISPR/Cas9 system

Conducting polymer tattoo electrodes in clinical electro-and magneto-encephalography

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npj Flexible Electronics 2020年第1期4卷 36-44页

作者： Laura M.Ferrari Usein Ismailov Jean-Michel Badier Francesco Greco esma Ismailova Center for MicroBiorobotics Istituto Italiano di Tecnologia56025 PontederaItaly The BioRobotics Institute Scuola Superiore Sant’Anna56025 PontederaItaly Department of Bioelectronics Ecole Nationale Supérieure des Mines de Saint EtienneCMP-EMSEMOC1354 GardanneFrance Aix Marseille Univ INSERMINSInst Neurosci SystMarseilleFrance Institute of Solid State Physics NAWI GrazGraz University of Technology8010 GrazAustria Department of Life Science and Medical Bioscience Waseda University169-8480 TokyoJapan

Temporary tattoo electrodes are the most recent development in the field of cutaneous *** have successfully demonstrated their performances in the monitoring of various electrophysiological signals on the *** epidermal electronic devices offer a conformal and imperceptible contact with the wearer while enabling good quality recordings over *** of brain activity in clinical practice face multiple limitations,where such electrodes can provide realistic technological solutions and increase diagnostics *** we present the performance of inkjet-printed conducting polymer tattoo electrodes in clinical electroencephalography and their compatibility with *** working mechanism of these dry sensors is investigated through the modeling of the skin/electrode impedance for better understanding of the biosignals transduction at this ***,a custom-made skin phantom platform demonstrates the feasibility of high-density recordings,which are essential in localizing neuropathological *** evaluations provide valuable input for the successful application of these ultrathin electronic tattoos sensors in multimodal brain monitoring and diagnosis.

关键词： polymer recording conformal

Microbial profile and antibiotic sensitivity pattern in bile cultures from endoscopic retrograde cholangiography patients

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World Journal of Gastroenterology 2012年第27期18卷 3585-3589页

作者： Muhsin Kaya Remzi Bestas Fatma Bacalan Ferhat Bacaksz esma Gülsun Arslan Mehmet Ali Kaplan Department of Gastroenterology School of MedicineDicle UniversityDiyarbakr 21280Turkey Department of Clinical Microbiology School of MedicineDicle UniversityDiyarbakr 21280Turkey Department of Internal Medicine School of MedicineDicle UniversityDiyarbakr 21280Turkey

AIM： To identify the frequency of bacterial growth, the most commonly grown bacteria and their antibiotic susceptibility, and risk factors for bacterial colonization in bile collected from patients with different biliary dis- eases. METHODS： This prospective study was conducted be- tween April 2010 and August 2011. Patients with vari- ous biliary disorders were included. Bile was aspirated by placing a single-use, 5F, standard sphincterotome catheter into the bile duct before the injection of con- trast agent during endoscopic retrograde cholangio- pancreaticography （ERCP）. Bile specimens were trans- ported to the microbiology laboratory in blood culture bottles within an anaerobic transport system. Bacteria were cultured and identified according to the standard protocol used in our clinical microbiology laboratory. The susceptibilities of the organisms recovered were identified using antimicrobial disks, chosen according tothe initial gram stain of the positive cultures RESULTS： Ninety-one patients （27% male, mean age 53.7 4- 17.5 years, range： 17-86 years） were included in the study. The main indication for ERCP was benign biliary disease in 79 patients and malignant disease in 12 patients. The bile culture was positive for bacterial growth in 46 out of 91 （50.5%） patients. The most frequently encountered organisms were Gram-negative bacteria including Escherich/a coli （28.2%）, Pseudo- monas （17.3%） and Stenotrophomonas rnaltophilia （15.2%）. There were no significant differences between patients with malignant and benign disease （58% vs 49%, P = 0.474）, patients with acute cholangitis and without acute cholangitis （52.9% vs 50%, P = 0.827）, patients who were empirically administered antibiotics before intervention and not administered （51.4% vs 60.7%, P = 0.384）, with regard to the bacteriobilia. We observed a large covering spectrum or low resistance to meropenem, amikacin and imipenem. CONCLUSION： We did not find a significant risk fac- tor for bacteriobilia in

关键词： Cholangitis Endoscopic retrograde cholan-giopancreaticography Bacteriobilia Bile culture

In vitro assessment of antioxidant,neuroprotective,anti-urease and anti-tyrosinase capacities of Tamarix africana leaves extracts

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Journal of Traditional Chinese Medicine 2023年第2期43卷 252-264页

作者： esma Anissa Trad Khodja Abd El Hamid Khabtane Rabah Arhab Djamila Benouchenne Mohamed Sabri Bensaad Chawki Bensouici Ramazan Erenler Biotechnology WaterEnvironment and Health LaboratoryFaculty of Natural and Life SciencesUniversity Abbes LaghrourKhenchela 40000Algeria Laboratory of Natural Substances Biomolecules and Biotechnological ApplicationsFaculty of Natural and Life SciencesUniversity Larbi Ben M HidiOum El-Bouaghi 04000Algeria Genetics Biochemistry and Plant Biotechnology LaboratoryFaculty of Natural and Life SciencesUniversity Constantine 1Constantine 25000Algeria Pharmaceutical Sciences Research Center Constantine 25000Algeria Laboratory of Cellular and Molecular Physio-Toxicology-Pathology and Biomolecules(LPTPCMB) Faculty of Natural and Life SciencesUniversity Batna 2Batna 05000Algeria Laboratory of Biotechnology of Bioactive Molecules and Cellular Physiopathology(LBMBPC) Faculty of Natural and Life Sciences University Batna 2Batna 05000Algeria Biotechnology Research Center Ali Mendjli UV 03 Constantine 25000Algeria Department of Chemistry Faculty of Science and LiteratureUniversity TokatGaziosmanpasaTokat 60250Turkey

OBJECTIVE:To characterize the chemical profile of methanolic crude extract and its fractions(Ethyl acetate,n-butanol and aqueous)using liquid chromatographymass spectrometry(LC-MS)analysis,to evaluate their biological and pharmacological properties:antioxidant(1,1-diphenyl-2-pycrylhydrazyl(DPPH),2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic)(ABTS·+),galvinoxyle free radical scavenging,reducing power,phenanthroline andβcarotene-linoleic acid bleaching assays),enzymes inhibitory ability against several enzymes[acetylcholinesterase(AChE),buthyrylcholinesterase(BChE),urease and tyrosinase].METHODS:Secondary metabolites were extracted from Tamarix africana air-dried powdered leaves by maceration,the crude extract was fractionated using different solvents with different polarities(Ethyl acetate,n-butanol and aqueous).The amount of polyphenols,flavonoids and tannins(hydrolysable and condensed)were determined using colorimetric assays.A variety of in vitro biochemical tests were carried out to assess antioxidant and oxygen radical scavenging properties using DPPH,ABTS,galvinoxyle free radical scavenging,reducing power,phenanthroline andβcarotene-linoleic acid bleaching *** effect was examined against acetylcholinesterase and buthyrylcholinesterase *** anti-urease and antityrosinase activities were performed against urease and tyrosinase enzymes *** extract’s components were identified using LC-MS and compared to reference ***:The results indicated that Tamarix africana extracts presented a powerful antioxidant activity in all assays and exhibited a potent inhibitory effect against AChE and BChE as well as urease and tyrosinase ***-MS analysis identified amount of eight phenolic compounds were revealed in this analysis;Apigenin,Diosmin,Quercetin,Quercetine-3-glycoside,Apigenin 7-O glycoside,Rutin,Neohesperidin and Wogonin in methanolic extract and its different fractions of Tamarix africana from ***

关键词： antioxidants anti-tyrosinase anti-urease liquid chromatography-mass spectrometry neuroprotection phenolic content Tamarix africana

Non-alcoholic fatty liver disease:a multidisciplinary clinical practice approach—the institutional adaptation to existing Clinical Practice Guidelines

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Emergency and Critical Care Medicine 2022年第1期2卷 12-22页

作者： Zoran Gluvic Ratko Tomasevic Ksenija Bojovic Milan Obradovic esma R.Isenovic University Clinical-Hospital Centre Zemun-Belgrade Clinic of Internal MedicineSchool of MedicineUniversity of BelgradeBelgradeSerbia Clinical Centre of Serbia Clinic of Infectious and Tropical DiseasesSchool of MedicineUniversity of BelgradeBelgradeSerbia Department of Radiobiology and Molecular Genetics “VINČA”Institute of Nuclear Sciences-National Institute of thеRepublic of SerbiaUniversity of BelgradeBelgradeSerbia

Non-alcoholic fatty liver disease(NAFLD)is among the most frequently encountered chronic liver diseases in everyday clinical *** is considered the hepatic manifestation of metabolic ***,liver biopsy is still the gold standard for NAFLD confirmation and assessing NAFLD’s possible progression to non-alcoholic steatohepatitis,fibrosis,cirrhosis,and hepatocellular *** of the high prevalence of NAFLD and potential associated risks of invasive diagnostic procedures,it is of great interest to recruit the patients for liver ***,as the presence of liver fibrosis determines the further clinical course,liver biopsy is expectedly reserved for those with increased fibrosis *** quality of liver biopsy recruitment and patient monitoring could be significantly improved by using non-invasive tools to assess liver fibrosis presence and interactive collaboration between general practitioners,gastroenterologists,and *** a result,the quality of liver biopsy recruitment and patients monitoring could be significantly ***,we proposed clinical practice guidelines that could be implemented for everyday clinical practice in NAFLD patients.

关键词： Diagnostics of NAFLD Fatty liver index Fibrosis score-4 Management of NAFLD Non-alcoholic fatty liver disease