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Geochemistry of magnetite in beach sands, stream sediments,and in situ magnetites in surrounding rocks at north Taiwan island

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Acta Geochimica 2022年第3期41卷 434-452页

作者： eslam mohammed ali mitwally Bing-Sheng Yu Institute of Mineral Resources Engineering National Taipei University of TechnologyTaipeiTaiwanRepublic of China Geology Department Faculty of ScienceAl Azhar UniversityAsyuˆtEgypt

The geochemistry of magnetite provides constraints on the source(s) of the magnetite and other ore minerals. In this study, we constructed a magnetite distribution map, compared the chemical composition of magnetite present in hard rocks with that present in sand beach and stream deposits to determine magnetite’s provenance,investigated relationships among different trace elements,examined variations in the concentrations of trace elements present in magnetite, and identified the type of studied magnetite. Laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS) and inductively coupled plasma mass spectrometry/inductively coupled plasma atomic emission spectroscopy was used to analyze samples available in small and large amounts, respectively. The average magnetite compositions of beach and river samples were substantially similar to those of andesite rocks,revealing that the magnetite samples may have originated from surrounding andesite rocks;this finding is consistent with the chemical composition of the samples analyzed using LA-ICP-MS. Some of the andesite rocks found in the study area were the primary source of magnetite aggregations in the beach sands and stream sands near or slightly away from these rocks. High Ti–V magnetites lie within the fields of Fe–Ti–V bearing magnetite and titanomagnetite(ulv?spinel). These titanomagnetites may be undergoing transformation to spinel minerals such as galaxite,gahnite, magnesiochromite, and chromite, which are characterized by the high concentrations of Al, Ti, Mg, Cr,Ni, Mn, and Zn. The positive correlation between Fe and Ti, Cr and Ni, and also the negative correlation between Fe and Mg, Mn and Zn can be attributed to various magnetite phases present in the study area. V, Co, Mo, Nb, Ga, Sn,and Ta exhibited a positive correlation with Fe and a negative correlation with Al. The positive correlation between Fe and these elements indicates the enrichment of these elements in the magnetite series. We observ

关键词： Magnetite chemistry LA-ICP-MS Element incorporation Multi variation diagram Distribution map North Taiwan

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Decoding molecular mechanisms:brain aging and Alzheimer's disease

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Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay ali Syed Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

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Metabolic associated fatty liver disease and cancer risk: causal role or epiphenomenon?

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 774-776页

作者： ali Bayoumi mohammed Shatat mohammed eslam Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneyWestmeadNSWAustralia Department of Internal Medicine Faculty of MedicineMinya University HospitalMinyaEgypt

The majority of global deaths are attributed to one of the noncommunicable diseases(NCDs),and cancer is projected to be the leading cause of death worldwide in the 21st century(1).There were 18.1 million incident cancer cases worldwide in 2018,43.8 million are living with cancer and 9.6 million deaths from *** in 6 deaths is due to cancer and these numbers are projected to rise to 13 million by 2030,more than that from tuberculosis,malaria and HIV/AIDS *** addition,the total annual global cost of cancer was estimated at around US$1.16 trillion,representing a significant burden on health care systems and families(1).

关键词： cancer diseases tuberculosis

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Biomarkers of Metabolic(Dysfunction)-associated Fatty Liver Disease:An Update

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 134-139页

作者： Jawaher Alharthi mohammed eslam Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyNSWAustralia Department of Biotechnology Faculty of ScienceTaif UniversityTaifSaudi Arabi

The prevalence of metabolic(dysfunction)-associated fatty liver disease(MAFLD)is rapidly increasing and affects up to two billion individuals globally,and this has also resulted in increased risks for cirrhosis,hepatocellular carcinoma,and liver *** addition,it has also been linked to extrahepatic consequences,such as cardiovascular disease,diabetes,and various types of ***,only a small proportion of patients with MAFLD develop these ***,the identification of high-risk patients is *** fibrosis is the major determinant in developing these ***,liver biopsy is still considered the gold standard for the assessment of patients with *** of its invasive nature,among many other limitations,the search for noninvasive biomarkers for MAFLD remains an area of intensive *** this review,we provide an update on the current and future biomarkers of MAFLD,including a discussion of the associated genetics,epigenetics,microbiota,and *** also touch on the next wave of multiomic-based biomarkers.

关键词： Biomarkers Metabolic(dysfunction)-associated fatty liver disease Scores

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Metabolic associated fatty liver disease(MAFLD):a milestone in the history of fatty liver disease

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 696-698页

作者： Jawaher Alharthi mohammed eslam Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyAustralia

With the widespread increase in energy intake and physical inactivity,the prevalence of metabolic health is ***,metabolic associated fatty liver disease(MAFLD)[formerly known as non-alcoholic fatty liver disease(NAFLD)]has risen in prevalence and present a significant challenge to global health causing considerable morbidity and mortality,particularly when fibrosis is present(1).

关键词： liver NAFLD MAF

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A joint InSAR-GNSS workfow for correction and selection of interferograms to estimate high-resolution interseismic deformations

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Satellite Navigation 2023年第1期4卷 183-195,I0006页

作者： Hongzhi Liu Lei Xie Guoqiang Zhao eslam ali Wenbin Xu School of Geoscience and Info-Physics Central South UniversityChangsha 410083China Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of Education Changsha 410083China Public Works Department Geomatics DivisionFaculty of EngineeringCairo UniversityGiza Governorate 12613Egypt

Knowledge of the spatial distribution of interseismic deformations is essential to better understand earthquake *** existing methods for improving the reliability of the obtained deformations often rely on visual inspection and prior model corrections that are time-consuming,labor-intensive,and do not consider the spatial distribution of interseismic *** Synthetic Aperture Radar(InSAR)data provides wide-scale coverage for interseismic deformation monitoring over a wide ***,the interseismic signal featured as millimeter-scale and long-wave deformations is often contaminated with *** the present study,a new workfow to correct the interferometric phase and quantitatively select interferograms is proposed to improve the accuracy of interseismic deformation ***,the Generic Atmospheric Correction Online Service(GACOS),Intermittent Code for Atmospheric Noise Depression through Iterative Stacking(I-CANDIS),and plate model are combined to correct the atmospheric screen and long-wave ramp ***,the Pearson’s Correlation Coefcient(PCC)between the interferometric phase and the Global Navigation Satellite System(GNSS)constrained interseismic model as well as the STandard Deviation(STD)of the interferometric phase are introduced as criteria to optimize the selection of ***,the intermittent stacking method is used to generate an average velocity map.A comprehensive test using Sentinel-1 images covering the Haiyuan Fault Zone validate the efectiveness of our workfow in measuring interseismic *** demonstrates that the proposed joint InSAR-GNSS workfow can be extended to study the subtle interseismic deformations of major fault systems in Tibet and worldwide.

关键词： Interferometric synthetic aperture radar GNSS Joint workfow Interseismic deformation Haiyuan fault zone

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Macrophages in metabolic associated fatty liver disease

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World Journal of Gastroenterology 2020年第16期26卷 1861-1878页

作者： Jawaher Alharthi Olivier Latchoumanin Jacob George mohammed eslam Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydney 2145NSWAustralia

Metabolic associated fatty liver disease(MAFLD),formerly named non-alcoholic fatty liver disease is the most common liver disorder in many *** inflammatory subtype termed steatohepatitis is a driver of disease progression to cirrhosis,hepatocellular carcinoma,liver transplantation,and death,but also to extrahepatic complications including cardiovascular disease,diabetes and chronic kidney *** plasticity of macrophages in response to various environmental cues and the fact that they can orchestrate cross talk between different cellular players during disease development and progression render them an ideal target for drug *** report reviews recent advances in our understanding of macrophage biology during the entire spectrum of MAFLD including steatosis,inflammation,fibrosis,and hepatocellular carcinoma,as well as for the extra-hepatic manifestations of *** discuss the underlying molecular mechanisms of macrophage activation and polarization as well as cross talk with other cell types such as hepatocytes,hepatic stellate cells,and adipose *** conclude with a discussion on the potential translational implications and challenges for macrophage based therapeutics for MAFLD.

关键词： Metabolic associated fatty liver disease Macrophages Inflammation Fibrosis Hepatic stellate cells

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Interaction of IFNL3 with insulin resistance,steatosis and lipid metabolism in chronic hepatitis C virus infection

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World Journal of Gastroenterology 2013年第41期19卷 7055-7061页

作者： mohammed eslam David R Booth Jacob George Golo Ahlenstiel Storr Liver Unit Westmead Millennium Institute and Westmead HospitalUniversity of SydneySydneyNSW 2145Australia Institute for Immunology and Allergy Research Westmead Millennium InstituteUniversity of SydneySydneyNSW 2145Australia

Metabolic changes are inextricably linked to chronic hepatitis C(CHC).Recently polymorphisms in the IFNL3(IL28B)region have been shown to be strongly associated with spontaneous and treatment induced recovery from hepatitis C virus(HCV)***,circumstantial evidence suggests a link between IFNL3single nucleotide polymorphisms and lipid metabolism,steatosis and insulin resistance in *** emerging picture suggests that the responder genotypes of IFNL3polymorphisms are associated with a higher serum lipid profile,and less frequent steatosis and insulin *** review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression.

关键词： IFNL3 Chronic hepatitis C Insulin resistance Lipids

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The role of B cells in metabolic(dysfunction)-associated fatty liver disease

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 875-877页

作者： Ziyan Pan Wah-Kheong Chan mohammed eslam Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyAustralia Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia

Metabolic(dysfunction)-associated fatty liver disease(MAFLD;formerly known as non-alcoholic fatty liver disease)is the most common liver disorder,affecting around one-third of the population worldwide(1).MAFLD is a heterogeneous disease with a spectrum of liver pathologies that spans from hepatic lipid accumulation(steatosis)to chronic inflammation(steatohepatitis),which can progress to cirrhosis and hepatocellular *** is impacted by a myriad of factors,including metabolic health,biological and chronological age,genetics and epigenetics(2-4).However,only a proportion(5-40%)of patients develop liver inflammation or steatohepatitis(5).This transition is a cardinal feature of progressive liver disease,which is the precursor to the development of the hepatic and extra-hepatic outcomes.

关键词： inflammation hepatic liver

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Generating Pairs for the Fischer Group Fi_(23)

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Algebra Colloquium 2020年第4期27卷 713-730页

作者： Faryad ali mohammed Al-Kadhi Department of Mathematics and Statistics College of Science Imam Mohammad Ibn Saud Islamic University(IMSIU)P.O.Box 90950Riyadh 11623Saudi Arabia

A group G is said to be(l,m,n)-generated if it is a quotient of the triangle groupT(l,m,n)=(x,y,z|x^(l)=y^(m)=z^(n)=xyz=1).Moori posed in 1993 the question of finding all the triples(l,m,n)such that non-abelian finite simple groups are(l,m,n)-*** partially answer this question for the Fischer sporadic simple group *** particular,we investigate all(2,q,r)-generations for the Fischer sporadic simple group Fi23,where q and r are distinct prime divisors of|Fi_(23)|.

关键词： generating pair Fischer group Fi_(23) sporadic group generating triple

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