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TBBPA rather than its main derivatives enhanced growth of.endometrial cancer via p53 ubiquitination

Journal of.Environmental Sciences 2024年第3期137卷 82-95页

作者： Hongyan Yu Jingxu Zhang Jing Liu Ruonan Pan Yu Wang Xiaoting Jin Rif.t Zubair ahmed Yuxin Zheng Department of.Occupational Health and Environmental Health School of Public HealthQingdao UniversityQingdao 266071China State Key Laboratory of.Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of.Genetics University of KarachiKarachi 75270Pakistan

Tetrabromobisphenol A(TBBPA)and its derivatives widely exist in various environments and *** the available data indicate that TBBPA exposure is highly associated with the increased incidence of.endometrial cancer(EC),the ef.ects of.TBBPA and its main derivatives on EC prolif.ration and the involved crucial mechanism remain *** present study aimed to investigate the ef.ects of.TBBPA and its derivatives under environmental concentrations on the prolif.ration of.EC,and the crucial mechanism on the progression of.EC caused by bromine f.me retardants *** this research,TBBPA and two of.the most common TBBPA derivatives including TBBPA bis(2-hydroxyethyl ether)(TBBPABHEE)and TBBPA bis(dibromopropyl ether)(TBBPA-BDBPE)were screened f.r their capacities in induced EC prolif.ration and explored the related mechanism by in vitro cell culture model and in vivo mice *** environmental concentrations,TBBPA promoted the prolif.ration of.EC,the main derivatives of.TBBPA(TBBPA-BHEE and TBBPA-BDBPE)did not present the similar f.cilitation *** ubiquitination degradation of.p53 was crucial in TBBPA induced EC prolif.ration,which resulted in the increase of.downstream cell cycle and decrease of.*** f.rther molecular docking result suggested the high af.inity between TBBPA and ubiquitinated *** f.nding revealed the ef.ects of.TBBPA and its derivatives on EC prolif.ration,thus providing novel insights into the underlying mechanisms of.TBBPA-caused EC.

关键词： Tetrabromobisphenol A(TBBPA) Endometrial cancer(EC) Derivatives Ubiquitin proteases p53

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Heating-Cooling Monitoring and Power Consumption f.recasting Using LSTM f.r Energy-Ef.icient Smart Management of.Buildings: A Computational Intelligence Solution f.r Smart Homes

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Tsinghua Science and Technology 2024年第1期29卷 143-157页

作者： Omid Akbarzadeh Sahand Hamzehei Hani Attar Ayman Amer Nazanin f.sihihour Mohammad R.Khosravi ahmed A.Solyman Department of.Electronics and Telecommunications Politecnico di TorinoTurin 10129Italy Department of.Energy Engineering Zarqa UniversityZarqa 13110Jordan Shandong Provincial University Laboratory f.r Protected Horticulture Weifang University of Science and TechnologyWeifang 262799China Department of.Electrical and Electronics Engineering Faculty of Engineering and ArchitectureNisantası UniversityIstanbul 25370The Republic of Turkiye

Energy management in smart homes is one of.the most critical problems f.r the Quality of.Lif.(QoL)and preserving energy *** of.the relevant issues in this subject is environmental contamination,which threatens the world's *** computing-enabled Artif.cial Intelligence(Al)algorithms can provide impactf.l solutions to this *** research proposes using one of.the Recurrent Neural Network(RNN)algorithms known as Long Short-Term Memory(LSTM)to comprehend how it is f.asible to perf.rm the cloud/f.g/edge-enabled prediction of.the building's *** parameters of.power electricity,power heating,power cooling,and total power in an of.ice/home in cold-climate cities are considered as our f.atures in the *** on the collected data,we evaluate the LSTM approach f.r f.recasting parameters f.r the next year to predict energy consumption and online monitoring of.the model's perf.rmance under various *** implementing the Al predictive algorithm,several existing tools are *** results have been generated through simulations,and we f.nd them promisingf.rf.tureapplications.

关键词： design-builder Besos smart cities smart building neural network Long Short-Term Memory(LSTM)

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A Hybrid and Lightweight Device-to-Server Authentication Technique f.r the Internet of.Things

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Computers, Materials & Continua 2024年第3期78卷 3805-3823页

作者： Shaha Al-Otaibi Rahim Khan Hashim Ali Af.ab ahmed Khan Amir Saeed Jehad Ali Department of.Inf.rmation Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of.Computer Science Abdul Wali Khan University MardanMardan23200Pakistan Department of.Computer Science and IT UET PeshawarJalozai Campus PeshawarPeshawar24240Pakistan Department of.AI Convergence Network Ajou UniversitySuwon16499South Korea

The Internet of.Things(IoT)is a smart networking inf.astructure of.physical devices,i.e.,things,that are embedded with sensors,actuators,sof.ware,and other technologies,to connect and share data with the respective server *** IoTs are cornerstones in dif.erent application domains,the device’s authenticity,i.e.,of.server(s)and ordinary devices,is the most crucial issue and must be resolved on a priority ***,various f.eld-proven methodologies were presented to streamline the verif.cation process of.the communicating devices;however,location-aware authentication has not been reported as per our knowledge,which is a crucial metric,especially in scenarios where devices are *** paper presents a lightweight and location-aware device-to-server authentication technique where the device’s membership with the nearest server is subjected to its location inf.rmation along with other ***,Media Access Control(MAC)address and Advance Encryption Scheme(AES)along with a secret shared key,i.e.,λ_(i) of.128 bits,have been utilized by Trusted Authority(TA)to generate MaskIDs,which are used instead of.the original ID,f.r every device,i.e.,server and member,and are shared in the of.line ***,TA shares a list of.authentic devices,i.e.,server S_(j) and members C_(i),with every device in the IoT f.r the onward verif.cation process,which is required to be executed bef.re the initialization of.the actual communication ***,every device should be located such that it lies within the coverage area of.a server,and this location inf.rmation is used in the authentication process.A thorough analytical analysis was carried out to check the susceptibility of.the proposed and existing authentication approaches against well-known intruder attacks,i.e.,man-in-the-middle,masquerading,device,and server impersonations,etc.,especially in the IoT ***,proposed authentication and existing state-of.the-art approaches have been s

关键词： Internet of.things authenticity security location communication

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Dielectric Resonator Magnetoelectric Dipole Arrays with Low Cross Polarization,Backward Radiation,and Mutual Coupling f.r MIMO Base Station Applications

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China Communications 2024年第6期21卷 290-304页

作者： Song Simin Da Yiran Qian Bingyi Huang Xiaoyu Chen Xiaoming Li Yingsong ahmed A.Kishk School of.Inf.rmation and Communications Engineering Xi’an Jiaotong UniversityXi’an 710049China Key Laboratory of.Intelligent Computing and Signal Processing Ministry of.Education Anhui UniversityHefei 230039China Department of.Electrical and Computer Engineering Concordia UniversityMontrealQC H3G 1M8Canada

Dielectric resonator magnetoelectric dipole(DRMED)arrays with enhanced isolation,reduced cross-polarization,and backward radiation are proposed f.r base station(BS)*** proposed antenna comprises an elevated dielectric resonator antenna(DRA)on a small metal plate above a sizeable common ground *** DRA is designed in its T Eδ11 mode,acting like a magnetic *** surf.ce current excited by the dif.erential probes f.owing on the small ground plane is equivalent to an electric *** these two equivalent dipoles are orthogonal,they have the magnetoelectric dipole characteristics with reduced backward ***,the small ground planes can be treated as decoupling structures to provide a neutralization path to cancel the original coupling path.A linearly-polarized 4-element prototype array was verif.ed experimentally in previous ***,a dual-polarized DRMED antenna is presented to construct a 2-element and 4×4 array f.r BS *** investigate its MIMO perf.rmance,sophisticated multi-cell scenario simulations are carried *** using the proposed dualpolarized DRMED array,the cellular system capacityis improved by 118.6%compared to a conventional DRA *** signif.cant MIMO system improvement is mainly due to the reduced backward radiation and,theref.re,reduced inter-cell *** align well with the simulations.

关键词： backward radiation dielectric resonator antennas(DRAs) isolation magnetoelectric-dipole(ME-dipole)antennas

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Intravesical instillation of.platelet-rich plasma f.r treatment of.interstitial cystitis/bladder pain syndrome:A pilot study

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Current Urology 2024年第1期18卷 49-54页

作者： ahmed S.El Hef.awy Mohamed Attya ahmed Hasan Esam El Sawy Mohamed Abdel-Razik Nasr El-Tabey Mansoura Urology and Nephrology Center Faculty of MedicineMansoura UniversityMansouraEgypt

Objective:The aim of.this study was to evaluate the f.asibility of.intravesical instillation of.platelet-rich plasma(PRP)to treat interstitial cystitis/bladder pain syndrome(IC/BPS).Materials and methods:Twenty PRP samples were tested in vitro f.r stability af.er exposure to urine samples with dif.erent pH.A pilot study involving 21 f.male patients with IC/BPS was conducted,and 6 weekly doses of.autologous PRP(50 mL)were *** were f.llowed up at the 2nd,4th,8th,and 12th weeks af.er terminating *** primary endpoint was the visual analog scale(VAS)f.r pain,and the secondary endpoints included the IC symptom index,IC problem index of.the O'Leary-Sant questionnaire and global response assessment,urine culture,and *** was def.ned as a reduction in VAS by 30%or more compared with basal level,and adverse events were ***:The mean±SD of.VAS was signif.cantly reduced compared with basal level(4.4±2.6 vs.8.8±1.1,respectively,p=0.001).Meanwhile,80%of.cases were considered successf.l,with a 50.1%reduction in the mean score compared with the basal *** mean±SD of.IC symptom index and IC problem index signif.cantly improved compared with the basal *** response assessment was markedly,moderately,and slightly improved in 2(10%),10(50%),and 5(25%)patients,respectively,and showed no change in 3(15%).Three patients had positive urine cultures at f.llow-up,but 1 withdrew af.er 2 sessions because of.a lack of.***:Repeated intravesical instillation of.PRP could be considered an ef.ective and saf. approach f.r treating IC/BPS.

关键词： Bladder pain syndrome Interstitial cystitis Platelet-rich plasma

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Gut microbiota predicts the diagnosis of.ulcerative colitis in Saudi children

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World Journal of.Clinical Pediatrics 2024年第1期13卷 118-124页

作者： Mohammad El Mouzan ahmed Al Sarkhy Asaad Assiri Department of.Pediatrics Gastroenterology UnitKing Saud UniversityRiyadh 11461Saudi Arabia

BACKGROUND Ulcerative colitis(UC)is an immune-mediated chronic inf.ammatory condition with a worldwide *** the etiology of.this disease is still unknown,the understanding of.the role of.the microbiota is becoming increasingly *** To investigate the predictive power of.the gut microbiota f.r the diagnosis of.UC in a cohort of.newly diagnosed treatment-naïve Saudi children with *** The study population included 20 children with a conf.rmed diagnosis of.UC and 20 healthy *** DNA was extracted and sequenced,and shotgun metagenomic analysis was perf.rmed f.r bacteria and *** and bioinf.rmatics demonstrated signif.cant dysbiosis in the f.rm of.reduced alpha diversity,beta diversity,and signif.cant dif.erence of.abundance of.taxa between children with UC and control *** receiver operating characteristic curve,a probability curve,was used to determine the dif.erence between the UC and control *** area under the curve(AUC)represents the degree of.separability between the UC group and the control *** AUC was calculated f.r all identif.ed bacterial species and f.r bacterial species identif.ed by the random f.rest classif.cation algorithm as important potential biomarkers of.UC.A similar method of.AUC calculation f.r all bacteriophages and important species was *** The median age and range were 14(0.5-21)and 12.9(6.8-16.3)years f.r children with UC and controls,respectively,and 40%and 35%were male f.r children with UC and controls,*** AUC f.r all identif.ed bacterial species was 89.5%.However,when using the bacterial species identif.ed as important by random f.rest classif.cation algorithm analysis, the accuracy increased to 97.6%. Similarly, the AUC f.r all theidentif.ed bacteriophages was 87.4%, but this value increased to 94.5% when the important bacteriophagebiomarkers were *** very high to excellent AUCs of.f.cal bacterial and viral species sugge

关键词： Ulcerative colitis Microbiota Area under the curve Children Saudi Arabia

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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacif.c Journal of.Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa Abd El-Salam El-Sayed Mohamed Z.Sayed-ahmed Shaimaa ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo Igarashi Mohamed Abdo Rizk National Research Center f.r Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of.Biochemistry and Chemistry of.Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of.Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of.Nursing Jouf UniversitySakaka 72388Saudi Arabia f.culty of.Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of.Internal Medicine and Inf.ctious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of.pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinf.rmatic analysis was perf.rmed using atom pair *** in vitro combination test was perf.rmed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic ef.icacy of.pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of.Babesia microti in mice using a f.uorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of.pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth signif.cantly compared with those observed af.er treatment with 25 mg/kg diminazene aceturate alone f.om day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of.inf.cted ***:An oral dose of.pyronaridine tetraphosphate combined with a subcutaneous dose of.diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm f.r the treatment of.babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

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Kaoline-based catalyst f.r a high stability desulf.rization of.sour heavy naphtha in a three-phase oscillatory baf.led reactor

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Particuology 2024年第1期84卷 249-260页

作者： Hassan M.Hmood Saba A.Gheni Saf.a M.R.ahmed Mudheher M.Ali Hamid Yonis Saleh Mohammed H.Mohammed Awad E.Mohammed Marwan A.Mahomood Hiba R.Mohammed ahmed A.Hassan Adam Harvey North Ref.neries Company Ministry of OilIraq Chemical Engineering Department Tikrit UniversityIraq Ministry of.Oil Iraq AL-Hawija Technical Institute Northern Technical UniversityMoselIraq School of.Engineering Newcastle UniversityUK

To meet the rapidly increasing demand f.r energy and the dramatic depletion of.conventional crude oil,it is imperative to utilize sour *** no coke being produced,oxidative desulf.rization(ODS)of.naphtha lowers its sulf.r content and average molecular *** this article,we outline a method f.r heavy naphtha non-extractive ODS using a very stable *** technique involves the use of.a solid catalyst with oxygen gas as the *** necessitated relatively high mixing intensities;hence a three-phase Oscillatory Baf.led Reactor(OBR)was *** catalyst was based on the zeolite ZSM-5,prepared f.om natural kaolin by a series of.delamination and activation steps and impregnated with f..A TiO2 nanolayer was applied,using the sol-gel method,to prevent rapid *** reactor perf.rmance was evaluated to minimize the sulf.r content in the naphtha *** to the protective coating,the sulf.r conversion stabilized at 90%.The results of.this work establish the use of.natural clay-based catalysts in a continuous,three-phase ODS,particularly with regard to proving long-term *** also showed that modest ODS can be achieved using an environmentally f.iendly oxidant,at mild operating conditions,whilst maintaining stability.

关键词： Natural kaoline Desulf.rization Three-phase Oscillatory baf.led reactor

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RPL-Based IoT Networks under Decreased Rank Attack:Perf.rmance Analysis in Static and Mobile Environments

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Computers, Materials & Continua 2024年第1期78卷 227-247页

作者： Amal Hkiri Mouna Karmani Omar Ben Bahri ahmed Mohammed Murayr f.waz Hassan Alasmari Mohsen Machhout Physic Department Electronics and Micro-Electronics LaboratoryFaculty of Sciences of MonastirMonastir5000Tunisia Department of.Science and Technology College of RanyahTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

The RPL(IPv6 Routing Protocol f.r Low-Power and Lossy Networks)protocol is essential f.r ef.icient communi-cation within the Internet of.Things(IoT)*** its signif.cance,RPL’s susceptibility to attacks remains a *** paper presents a comprehensive simulation-based analysis of.the RPL protocol’s vulnerability to the decreased rank attack in both static andmobilenetwork *** employ the Random Direction Mobility Model(RDM)f.r mobile scenarios within the Cooja *** systematic evaluation f.cuses on critical perf.rmance metrics,including Packet Delivery Ratio(PDR),Average End to End Delay(AE2ED),throughput,Expected Transmission Count(ETX),and Average Power Consumption(APC).Our f.ndings illuminate the disruptive impact of.this attack on the routing hierarchy,resulting in decreased PDR and throughput,increased AE2ED,ETX,and *** results underscore the urgent need f.r robust security measures to protect RPL-based IoT ***,our study emphasizes the exacerbated impact of.the attack in mobile scenarios,highlighting the evolving security requirements of.IoT networks.

关键词： RPL decreased rank attacks mobility random direction model

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The Lambert-G f.mily:Properties,Inf.rence,and Applications

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 513-536页

作者： Jamal N.Al Abbasi ahmed Z.Af.f. Badr Alnssyan Mustaf. S.Shama Accounting Department Ashur UniversityBaghdad10011Iraq Department of.Statistics Mathematics and InsuranceBenha UniversityBenha13511Egypt Department of.Management Inf.rmation Systems and Production Management College of Business and EconomicsQassim UniversityBuraydah51452Saudi Arabia Department of.Basic Sciences Common First Year(CFY)King Saud UniversityRiyadh11362Saudi Arabia Department of.Mathematics and Statistics Osim Higher Institute of Administrative ScienceOsim12961Egypt

This study proposes a new f.exible f.mily of.distributions called the Lambert-G *** Lambert f.mily is very f.exible and exhibits desirable *** three-parameter special sub-models provide all signif.cantmonotonic and non-monotonic f.ilure rates.A special sub-model of.the Lambert f.mily called the Lambert-Lomax(LL)distribution is *** expressions f.r the LL statistical properties are *** of.the LL distribution are addressed mathematically based on its hazard *** estimation of.the LL parameters is discussed using six estimation *** perf.rmance of.this estimation method is explored through simulation *** usef.lness and f.exibility of.the LL distribution are demonstrated empirically using two real-lif. data *** LL model better f.ts the exponentiated Lomax,inverse power Lomax,Lomax-Rayleigh,power Lomax,and Lomax distributions.

关键词： Lambert f.nction Lomax distribution maximum likelihood hazard f.nction statistical model simulation

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