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Histo-morphometric vicissitudes in diet-controlled diabetic placenta:A quantitative stereological model

Gynecology and Obstetrics Clinical Medicine 2023年第2期3卷 112-118页

作者： Rabia Arshad erum amir Asra Khan Pahore Tazeen Mustansar Department of Pharmacology Altamash Institute of Dental MedicineKarachiPakistan Pathology Department Karachi Medical and Dental CollegeKarachiPakistan Pathology Department DMCDow University of Health SciencesKarachiPakistan

Background:An affordable approach accepted worldwide to successfully treat mild maternal hyperglycemia in gestational diabetes(GDM),is diet-controlled *** no elaborate research was available,this study was crafted to investigate morphometric stereological details and to determine the mean placental oxygen diffusion capacity for patients who were kept on diet therapy for mild gestational ***:A clinical trial(NCT04907708)was conducted from January 2018 to February 2019.A total of 70 women completed the study,out of which 35 served as healthy controls as Group A and 35 were diagnosed as mild gestational diabetics according to WHO criteria(Group B).These patients were kept on a restricted calorie diet with light exercise during gestation and were followed regularly during *** after delivery,conserved placentas underwent complete gross,microscopic,and stereological investigations with the point and intersection-counting ***:Significant differences were observed for placental width and syncytial knots(p<0.010 and 0.025 respectively)between the groups on gross and light *** of the parameters were non-significant,though numerically more in the GDM *** stereological details,mean placental volume,mean placental components volumes(villi,inter-villous space,fetal capillary,and fetal connective tissue),mean villi and mean fetal capillary diameter,mean villi and capillary surface density and mean morphometric diffusing capacity of placenta showed non-significant results between the ***:Minimal changes were observed in gross,microscopy,and morphometric stereological details in the placentae of GDM patients managed with nutritional therapy during gestation compared with the healthy controls.

关键词： Placenta Gestational diabetes mellitus Diet-controlled Stereology Morphometry

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