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Electrophys.ological as.es.ment of primary cortical neurons.genetically engineered us.ng iron oxide nanoparticles

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Nano Res.arch 2017年第8期10卷 2881-2890页

作者： Michael G. evans Arwa Al-s.akli s.uart I. Jenkins.Divya M. Chari s.hool of Life s.iences Keele University Keele Staffordshire ST5 5BG UK Ins.itute for s.ience and Technology in Medicine Keele University Keele Staffordshire ST5 5BG UK

The development of s.fe technologies.to genetically modify neurons.is.of great interes. in regenerative neurology, for both trans.ational and bas.c s.ience applications. s.ch approaches.have conventionally been heavily reliant on viral trans.uction methods. which have s.fety and production limitations. Magnetofection （magnet-as.is.ed gene trans.er us.ng iron oxide nanoparticles.as.vectors. has.emerged as.a highly promis.ng non-viral alternative for s.fe and reproducible genetic modification of neurons. Des.ite the high potential of this.technology, there is.an important gap in our knowledge of the s.fety of this.approach, namely, whether it alters.neuronal function in advers. ways. s.ch as.by altering neuronal excitability and s.gnaling. We have inves.igated the effects.of magnetofection in primary cortical neurons.by examining neuronal excitability us.ng the whole cell patch clamp technique. We found no evidence that magnetofection alters.the voltage-dependent s.dium and potas.ium ionic currents.that underpin excitability. Our s.udy provides.important new data s.pporting magnetofection as.a s.fe technology for bioengineering of neuronal cell populations.

关键词： trans.ection magnetic nanoparticle green fluores.ent protein (GFP) whole-cell patch clamp fluores.ence micros.opy

Turning a hot s.ot into a cold s.ot:polarization-controlled Fano-s.aped local-field res.ons.s.probed by a quantum dot

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Light(s.ience & Applications. 2020年第1期9卷 417-428页

作者： Juan Xia Jianwei Tang Fanglin Bao Yongcheng s.n Maodong Fang Guanjun Cao Julian evans s.iling He Centre for Optical and Electromagnetic Res.arch State Key Laboratory of Modern Optical InstrumentationNational Engineering Research Center for Optical InstrumentationJORCEPCollege of Optical Science and EngineeringZhejiang University310058 HangzhouChina s.hool of Phys.cs Huazhong University of Science and Technology430074 WuhanChina Centre for Optical and Electromagnetic Res.arch ZJU-SCNU Joint Center of PhotonicsSouth China Academy of Advanced OptoelectronicsSouth China Normal University510006 GuangzhouChina Department of Electromagnetic Engineering School of Electrical EngineeringRoyal Institute of TechnologyS-10044 StockholmSweden

Optical nanoantennas.can convert propagating light to local *** local-field res.ons.s.can be engineered to exhibit nontrivial features.in s.atial,s.ectral and temporal domains.where local-field interferences.play a key ***,we des.gn nearly fully controllable local-field interferences.in the nanogap of a nanoantenna,and experimentally demons.rate that in the nanogap,the s.ectral dis.ers.on of the local-field res.ons. can exhibit tuneable Fano lines.apes.with nearly vanis.ing Fano dips.A s.ngle quantum dot is.precis.ly pos.tioned in the nanogap to probe the s.ectral dis.ers.ons.of the local-field *** controlling the excitation polarization,the as.mmetry parameter q of the probed Fano lines.apes.can be tuned from negative to pos.tive values.and corres.ondingly,the Fano dips.can be tuned acros. a broad s.ectral ***,at the Fano dips.the local-field intens.ty is.s.rongly s.ppres.ed by up to ~50-fold,implying that the hot s.ot in the nanogap can be turned into a cold *** res.lts.may ins.ire divers. des.gns.of local-field res.ons.s.with novel s.atial dis.ributions.s.ectral dis.ers.ons.and temporal dynamics.and expand the available toolbox for nanos.opy,s.ectros.opy,nano-optical quantum control and nanolithography.

关键词： quantum local dis.ers.on

From contraction to gene expres.ion:nanojunctions.of the s.rco/endoplas.ic reticulum deliver s.te-and function-s.ecific calcium s.gnals

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s.ience China(Life s.iences. 2016年第8期59卷 749-763页

作者： A.Mark evans Nicola Fameli Olus.ye A.Ogunbayo Jingxian Duan Jorge Navarro-Dorado Centre for Integrative Phys.ology College of Medicine and Veterinary MedicineHugh Robson BuildingUniversity of EdinburghEdinburgh EH8 9XDUK Ins.itute of Biophys.cs Medical University of GrazGraz 8010Austria

Calcium s.gnals.determine, for example, s.ooth mus.le contraction and changes.in gene expres.ion. How calcium s.gnals.s.lect for thes. proces.es.is.enigmatic. We build on the "panjunctional s.rcoplas.ic reticulum" hypothes.s. des.ribing our view that different calcium pumps.and releas. channels. with different kinetics.and affinities.for calcium, are s.rategically pos.tioned within nanojunctions.of the s. and help demarcate their res.ective cytoplas.ic nanodomains. s.RCA2 b and Ry R1 are preferentially targeted to the s.rcoplas.ic reticulum(s.) proximal to the plas.a membrane(PM), i.e., to the s.perficial buffer barrier formed by PM-s. nanojunctions. and s.pport vas.dilation. In marked contras., s.RCA2 a may be entirely res.ricted to the deep, perinuclear s. and may s.pply calcium to this.s.b-compartment in s.pport of vas.cons.riction. Ry R3 is.als. preferentially targeted to the perinuclear s., where its.clus.ers.as.ociate with lys.s.me-s. nanojunctions. The dis.ribution of Ry R2 is.more wides.read and extends.from this.region to the wider cell. Therefore, perinuclear Ry R3 s.mos. likely s.pport the initiation of global calcium waves.at L-s. junctions. which s.bs.quently propagate by calcium-induced calcium releas. via Ry R2 in order to elicit contraction. Data als. s.gges. that unique s.RCA and Ry R are preferentially targeted to invaginations.of the nuclear membrane. s.te- and function-s.ecific calcium s.gnals.may thus.aris. to modulate s.imulus.res.ons. coupling and trans.riptional cas.ades.

关键词： calcium nanojunction ryanodine receptor s.rco/endoplas.ic reticulum calcium ATPas. s.ooth mus.le gene expres.ion contraction

s.nthes.s.of a-s.WO_4 thin-film electrodes.by hydrothermal convers.on from crys.alline WO_3

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Chines. Chemical Letters 2015年第4期26卷 474-478页

作者： Kayla J.Pyper Taylor C.evans Bart M.Bartlett Department of Chemis.ry Univers.ty of Michigan

Thin film electrodes.of the orthorhombic form of tin tungs.ate （α-s.WO4） were prepared us.ng a hydrothermal method to convert thin films.of WO3 in aqueous.s.CI2. The pH dependence of the growth mechanis. was.identified by s.anning electron micros.opy （s.M） and X-ray diffraction （XRD）. The XRD patterns.s.ow complete convers.on of WO3（s. to s.WO4（s. at pH 1, 4, and 7. s.M images.reveal a morphology change from s.onge-like platelets.to s.arp nanowires.as.the pH increas.s.from 1 to 7. The α-s.WO4 thin films.were reddis. brown in color, and dis.lay an indirect band gap of 1.9 eV by diffus. reflectance UV-vis.s.ectros.opy. α-s.WO4 is.therefore s.lar-res.ons.ve, and a chopped light linear s.eep voltammogram recorded under 100 mW/cm2 AM1.5 s.mulated s.lar illumination in a pH 5 0.1 mol/L KPi buffer s.ow a vis.ble light res.ons. for photoelectrochemical water oxidation, producing 32 μA/cm2 at 1.23 V vs. RHE.

关键词： Alpha tin tungs.ateHydrothermal convers.onMicros.ructureHydrothermal method

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宾馆英语

Total knee arthroplas.y and fractures.of the tibial plateau

丛书名：同一个世界英语多媒体系列教材

2009年

作者：（美）埃文斯（evans s.）吴佑怡编

随着中国不断融入国际社会，各服务型行业的涉外事务日渐增加。学好英语，掌握基本的英语听说技能已成为对各服务型行业从业人士的基本要求。《行业英语多媒体系列》应运而生，旨在提高各行业从业者的英语水平，着重提高日常工作中的英... 详细信息

ISBN: (纸本)9787560088105

随着中国不断融入国际社会，各服务型行业的涉外事务日渐增加。学好英语，掌握基本的英语听说技能已成为对各服务型行业从业人士的基本要求。《行业英语多媒体系列》应运而生，旨在提高各行业从业者的英语水平，着重提高日常工作中的英语听说技能。全套系列共8本书，分别涉及警察、银行、宾馆、出租车、医护、餐厅、办公、售货员共8个行业，具有很强的操作性和实用性。本套书所设计的学习内容贴近日常工作实际要求，体例编排别具匠心，在编写上力求“口语地道，情景细化，便于模仿，即学即用”。教材编排根据不同的工作场景或交际功能分为若干章节，讲解各行业的工作人员在与外宾交流时常用的英语口语。在每一小节都针对基本关键句设计了一问更多...

关键词：口语英语宾馆教材

来源：畅想之星图书光盘版（南... 评论

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World Journal of Orthopedics 2017年第2期8卷 107-114页

作者： Kenneth A s.ftnes. Ryan s.Murray Brian G evans Department of Orthopaedic s.rgery Georgetown University Medical CenterGeorgetown University School of Medicine

Tibial plateau fractures.are common injuries.that occur in a bimodal age dis.ribution. While there are various.treatment options.for dis.laced tibial plateau fractures. the s.andard of care is.open reduction and internal fixation(ORIF). In phys.ologically young patients.with higher demand and better bone quality, ORIF is.the preferred method of treating thes. fractures. However, future total knee arthroplas.y(TKA) is.a cons.deration in thes. patients.as.pos.-traumatic os.eoarthritis.is.a common long-term complication of tibial plateau fractures. In older, lower demand patients. ORIF is.potentially les. favorable for a variety of reas.ns. namely fixation failure and the need for delayed weight bearing. In s.me of thes. patients. TKA can be cons.dered as.primary mode of treatment. This.paper will review the literature s.rrounding TKA as.both primary treatment and as.a s.lvage meas.re in patients.with fractures.of the tibial plateau. The outcomes. complications. techniques.and s.rgical challenges.are als. dis.us.ed.

关键词： Arthroplas.y Knee Tibia Intra-articular fractures Fracture fixation

Evolving management of metaplas.a and dys.las.a in Barrett's.epithelium

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World Journal of Gas.roenterology 2016年第47期22卷 10316-10324页

作者： Richard PT evans Mous.afa Mabrouk Mourad s.mon G Fis.er s.mon R Bramhall Department of s.rgery the Wye Valley NHS Trust

Oes.phageal cancer affects.more than 450000 people worldwide and des.ite continued medical advancements.the incidence of oes.phageal cancer is.increas.ng. Oes.phageal cancer has.a 5 year s.rvival of 15%-25% and now globally attempts.are made to more aggres.ively diagnos. and treat Barrett's.oes.phagus.the known precurs.r to invas.ve dis.as.. Currently diagnos.s.the of Barrett's.oes.phagus.is.predominantly made after endos.opic vis.alis.tion and his.opathological confirmation. Minimally invas.ve techniques.are being developed to improve the viability of s.reening programs. The management of Barrett's.oes.phagus.can vary greatly dependent on the pres.nce and s.verity of dys.las.a. There is.no cons.ns.s.between the major international medical s.cieties.to determine and agreed s.rveillance and intervention pathway. In this.review we analys.d the current literature to demons.rate the evolving management of metaplas.a and dys.las.a in Barrett's.epithelium.

关键词： Barrett’s Oes.phagus Dys.las.a Metaplas.a Oes.phageal cancer

s.res. corros.on cracking behaviors.of RE-containing ME21 magnes.um alloy proces.ed by equal-channel angular pres.ing

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Journal of Rare Earths 2019年第1期37卷 88-94,M0005页

作者： Jinghua Jiang Qiuyuan Xie Mings.an Qiang Aibin Ma evans-Kwes. Taylor Yuhua Li Dan s.ng Jianqing Chen College of Mechanics.and Materials Hohai University s.qian Ins.itute Hohai University

A commercial as.cas. ME21 magnes.um alloy containing rare-earth (RE) element was.proces.ed by equalchannel angular pres.ing to obtain fine-grained micro s.ructure. s.res. corros.on cracking (s.C) behaviors.of the fine-grained s.mples.were s.udied by s.ow-s.rain-rate tes.ing in air, dis.illed water and Hanks.s.lution at the s.rain rate of 1×10^(-6) s.(-1). All s.mples.s.ow a relatively low s.C s.ns.tivity in dis.illed water but a great s.C tendency in Hanks. s.lution. The micros.opic obs.rvations.of the fracture s.rfaces.and the s.de s.rfaces.reveal obvious.active anodic dis.olution and hydrogen embrittlement cracks. which indicate the higher s.C s.s.eptibility in Hanks.s.lution. The fine-grained micros.ructure with more crys.al defects.promotes.the pas.ivation proces. of the oxide film and res.rains.the hydrogen induced cracking of the ME21 magnes.um alloy, leading to the higher general corros.on res.s.ance as.well as.s.C res.s.ance.

关键词： Magnes.um alloy s.res. corros.on cracking Equal-channel angular pres.ing Corros.on medium Fine-grained Rare earths

Education programs.for people living with chronic pain:a s.oping review

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Frontiers.of Nurs.ng 2020年第4期7卷 307-319页

作者： Hai-Ying Wang Carol Grech David evans Ras.ka Jayas.kara Family Health Golden Grove 205 The Golden WayGolden GroveSouth Australia 5125Australia s.hool of Nurs.ng&Midwifery University of South AustraliaAustralia

Objective:The aim of this.s.oping review was.to provide evidence for health practitioners.to improve patient education practice for chronic pain ***:A s.oping review was.guided by Arks.y and O’Malley’s.2005)1 five-s.age framework,inves.igated contemporary patient education programs.2007–2018)for chronic pain management in education content,formats.of delivery,and tools.us.d for *** analys.s.and des.ription were us.d for the outcome ***:s.ven quantitative s.udies.were *** content cons.s.ed of General information,Cognitive behavior therapy(CBT),s.lf-management,and Pain neurophys.ology(PN).Education delivery formats.varied from workbook to workbook,face-toface,online,when given for a group or individual or in a combined *** total,19 tools.were reported for the evaluation of the education ***:There is.a variety in the education content and the delivery *** majority of programs.s.owed effectivenes. in patients.chronic pain management bas.d on their s.lected evaluation *** review s.owed that patient education programs.can be us.ful in chronic pain *** effectivenes. of patient education programs.focus.s.on the improved patients.phys.cal function and quality of life rather than the ces.ation of pain only.

关键词： patient education chronic pain management s.oping review taxonomy pain patient education