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Outcomes following operative vs. non-operative management of blunt traumatic pancreatic injuries: a retrospective multi-institutional study

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Burns & Trauma 2016年第4期4卷 316-322页

作者： poppy Addison Toni Iurcotta Leo I.Amodu Geoffrey Crandall Meredith Akerman Daniel Galvin Annemarie Glazer Nathan Christopherson Jose prince Matthew Bank Christopher Sorrentino Joaquin Cagliani Jeffrey Nicastro Gene Coppa ernesto p.molmenti Horacio L.Rodriguez Rilo Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA pancreas Disease Center Northwell HealthManhassetNYUSA Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA Department of Biostatistics Feinstein Institute for Medical ResearchManhassetNYUSA pancreas Disease Center Northwell HealthManhassetNYUSA Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA pancreas Disease Center Northwell HealthManhassetNYUSA Northwell Health 900 Northern BoulevardSuite 150Great NeckNY 11020USA

Background:Traumatic pancreatic injuries are rare,and guidelines specifying management are controversial and difficult to apply in the acute clinical *** to sparse data on these injuries,we carried out a retrospective review to determine outcomes following surgical or non-surgical management of traumatic pancreatic *** hypothesize a higher morbidity and mortality rate in patients treated surgically when compared to patients treated ***:We performed a retrospective review of data from four trauma centers in New York from 1990–2014,comparing patients who had blunt traumatic pancreatic injuries who were managed operatively to those managed *** compared continuous variables using the Mann-Whitney U test and categorical variables using the chi-square and Fisher’s exact *** analysis was performed to determine the possible confounding factors associated with mortality in both treatment ***:Twenty nine patients were managed operatively and 32 *** was a significant difference between the operative and non-operative groups in median age(37.0 vs.16.2 years,p=0.016),grade of pancreatic injury(grade I;30.8 vs.85.2%,p value for all comparisonsp=0.002),blood transfusion(55.2 vs.15.6%,p=0.0012),other abdominal injuries(79.3 vs.38.7%,p=0.0014),pelvic fractures(17.2 vs.0.00%,p=0.020),intensive care unit(ICU)admission(86.2 vs.50.0%,p=0.003),median length of stay(LOS)(16.0 vs.4.0 days,pp=0.010).Conclusions:patients with traumatic pancreatic injuries treated operatively were more severely injured and suffered greater complications than those treated *** greater morbidity and mortality associated with these patients warrants further study to determine optimal triage strategies and which subset of patients is likely to benefit from surgery.

关键词： Injury Management Non-operative Operative pancreas Trauma

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Assessing the Environmental Impact of Extensive Beef production in Grazing Lands of Argentina

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phyton-International Journal of Experimental Botany 2024年第8期93卷 1943-1962页

作者： ernesto Viglizzo Florencia Ricard Instituto de Ciencias de la Tierra y Ambientales de La pampa Consejo Nacional de Investigaciones Científicas y TécnicasSanta Rosa6300La PampaArgentina Universidad Austral Rosario2000Santa FeArgentina Secretaría de Ambiente y Cambio Climático del Gobierno de La pampa Santa Rosa6300La PampaArgentina Facultad de Ciencias Exactas y Naturales Universidad Nacional de La PampaSanta Rosa6300La PampaArgentina

Because of environmental constraints,beef cattle was for more than a century the only viable farming option in the extensive semiarid and subhumid lands of Argentina and the main source of nutrients for humans as ***,a growing concern and criticism have risen today about its possible negative impact on the climate and the *** worries tend to affect current public opinions,national policies,and international *** on 40 beef cattle farms scattered across different semiarid and subhumid regions of Argentina,here we evaluated the impact of extensive cattle production on carbon,water,and nutrient ***-Cycle Assessment(LCA)and Land-Based Assessment(LBA)were the two approaches we used here to compare the environmental impact of beef *** the environmental footprint(EF)resulting from LCA expresses the impact per unit of food,the environmental balance(EB),derived from LBA,aims at quantifying the impact per unit of *** such,the EB considers both negative and positive impacts on the farm as an integrated *** standardized procedures,we evaluated EF and EB up to the farm gate,leaving aside delocalized post-farm impacts such as those of processing,packaging,and transportation that occur beyond the farm *** agreement with previous evidence,our results show that the EF tends to decrease as per-head production *** coefficients and statistical significance were the following for carbon(R=−0.574;pppphosphorus(p)pollution(R=−0.802;pper-hectare beef production *** were the following for carbon emissions(CE:R=0.955;pption(WC:R=0.822;ppphosphorus excretion(pE:R=0.945;ppact in intensive beef

关键词： Beef production extensive cattle raising grazing conditions environmental impact assessment

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Efficient removal of the recalcitrant metamizole contaminant from drinking water by using a CaLaCoO_(9) perovskite supported on recycled polyethylene

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Journal of Environmental Sciences 2024年第2期136卷 56-67页

作者： ernesto Valadez-Renteria Christian perez-Carrasco Dulce Yolotzin Medina-Velazquez Vicente Rodriguez-Gonzalez Jorge Oliva CONACYT-División de Materiales Avanzados Instituto Potosino de Investigación Científica y Tecnológica A.C.San Luis PotosíSLP 78216México División de Ciencias Básicas e Ingeniería Universidad Autónoma Metropolitana AzcapotzalcoCol.Reynosa-TamaulipasC.P.MéxicoDF 02200México

Metamizole(MZ)is a widely used anti-inflammatory *** to its common use,this contaminant is found in sewage and *** order to reduce the contamination produced by the MZ,we fabricated in this work a photocatalytic composite using recycled polyethylene(RpE)and the CaLaCoO_(9)(LCCO)*** nanoparticles had a microplate-like morphology and sizes of 1.4–5.5μm according to the analysis of *** photocatalytic properties of the LCCO powders were evaluated under ultraviolet-visible(UV-Vis)irradiation and found a removal efficiency of 96%.When the RpE+LCCO composite was employed for the photocatalytic degradation of MZ,a maximum degradation of 92.5%was *** influence of the pH on the photocatalytic activity was also studied and found that an initial pH=3 produced a total degradation of MZ after 240 min of UV-Vis ***,three reuse cycles were carried out for the pure LCCO powders and for the RpE+LCCO composites and found that the maximum loss of degradation was 5%.Furthermore,scavenger experiments demonstrated that the super oxide and hydroxyl radicals are formed during the photocatalytic reaction and were responsible for the degradation of ***,the X-ray photoelectron-spectroscopy and Raman analysis demonstrated the formation of defects(oxygen vacancies),those ones delayed the electron-hole recombination,which in turn,enhanced the degradation of the ***,the studies performed in this work proved that composites made with recycled plastics and LCCO perovskites are a low-cost and feasible alternative for the cleaning of water sources polluted with pharmaceutical compounds.

关键词： photocatalysis Metamizole pharmaceutical contaminant UV-Vis irradiation perovskite

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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： ernesto Doncel-pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

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Designing for well-Being: Using facial micro-expression analysis and EEG biosensor to evaluate human responses to 2D biophilically-driven geometries

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Frontiers of Architectural Research 2024年第2期13卷 219-234页

作者： Andrea Macruz ernesto Bueno Gustavo Sol Jaime Vega Ricardo palmieri Bing Zhao College of Architecture and Urban planning Tongji UniversityShanghaiChina Universidade presbiteriana Mackenzie Sao PauloBrazil Centro Universitario Belas Artes Sao PauloBrazil Universidade Anhembi Morumbi Sao PauloBrazil Universidade Federal do ABC Santo AndreBrazil

This research explores the capacity of emerging technologies to enhance well-being. It involves the generation of 2D biophilically-driven geometries to represent human-response-oriented built environments and conducts inter and intra-individual analyses to assess human responses using a range of technologies within the realms of facial micro-expression analysis and EEG biosensor use. The outcomes of this analysis allow for the grading of these geometries in terms of emotional valences, meditation levels, and subjective preferences. These graded geometries can subsequently be employed in specific architectural contexts, such as interior decor, wallpapers, furniture surfaces, or other architectural and interior components. It is an interdisciplinary effort that underscores the importance of incorporating emerging technological means with human-response-oriented design approaches to foster built environments that promote well-being.

关键词： Biophilic design Geometrical algorithmicmodeling Facial micro-expressionanalysis EEG biosensor Neuroscience

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Use of bio-based products towards more sustainable road paving binders: A state-of-the-art review

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Journal of Road Engineering 2024年第2期4卷 151-162页

作者： Alessio Musco Giulia Tarsi piergiorgio Tataranni ernesto Salzano Cesare Sangiorgi Department of Civil ChemicalEnvironmental and Materials Engineering(DICAM)Alma Mater Studiorum-University of BolognaBologna 40131Italy

Many industrial sectors exploit fossil sources to develop useful and necessary materials for our needs,such as bituminous paving ***,a key component of asphalt mixtures,is derived from oil refining and its properties are influenced by the crude oil source and refining process,resulting in a significant carbon *** growing awareness of resource depletion and environmental concerns,pavement researchers are exploring sustainable alternatives to reduce dependence on fossil *** includes a rising trend in using renewable materials like biomasses to produce bio-based binders as substitutes for bitumen,aiming for a more sustainable ***,including vegetal and animal wastes,and waste cooking oils,as substitutes for crude oil in the production of *** thermochemical conversion(TCC),such as pyrolysis,biomasses can be converted into bio-char and bio-oils,which can replace fossil-based components in *** have utilized these bio-products to reduce the dependency on fossil fuels in ***,there are no set minimum requirements for bio-components in bio-based *** the percentage of replaced bitumen increases,various types of binders are produced,including modified bitumen,extended bitumen,and alternative binders,where the fossil replacement is *** rheological tests on bio-binders,reveal that those containing biochar exhibit increased viscosity,stiffness,rutting resistance,and sometimes antioxidant ***,bio-binders with bio-oils as bitumen substitutes show poorer performance at high temperatures but improved behavior at low *** results suggest that bio-binders could provide versatile solutions for various climatic and loading conditions in road ***,the development of pavement mixtures based on bio-binders has not been studied in depth and requires further attention to unlock its full *** sustainability considerations,includin

关键词： Biomass Chemical process Bitumen replacement Bio-binder paving material

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Wood anatomical acclimation in the endemic genus polylepis in peruvian Andean forests

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Journal of Mountain Science 2024年第9期21卷 2986-3000页

作者： Anthony GUERRA Fressia N.AMES-MARTÍNEZ ernesto C.RODRÍGUEZ-RAMÍREZ postgraduate programme in Agronomy/plant physiology Department of Biology-Institute of Natural Sciences Federal University of LavrasLavras 37203-202Minas Gerais 30000-31999Brazil Laboratory of Biotechnology and Molecular Biology Continental UniversitySan Antonio UrbanizationHuancayo 12000Peru Ecology and Biodiversity Research programme ANDINUS AssociationMiguel Grau Street 370Huancayo 12000Peru Dendrochronology Laboratory Continental UniversitySan Carlos Avenue 1980Huancayo 12000Peru

polylepis(Queñua)is a dominant woody plant genus in Andean puna forests that occurs in a wide range of montane habitats and is ecologically diverse in endemism,which may be particularly threatened by climate *** anatomical traits are essential for understanding how plants adjust their ecophysiological requirements and maximize their resilience,resistance,and recovery to extreme *** the effects of extreme climatic conditions in high altitude ecosystems have been studied extensively,our knowledge is relatively limited to quantitative differences in the main xylem *** address this gap,we assessed the acclimation of wood anatomical traits in six peruvian Andean polylepis species with different water availability(semi-dry with high moisture and semiarid with dry winters).We selected hydraulic diameter,vessel density,vessel grouping index,solitary vessel index,vulnerability index,mesomorphy index,vessel element length,fiber length,fiber wall thickness,fiber lumen diameter,and total fiber diameter that can provide relevant eco-wood anatomical acclimation to hydric *** performed multivariate analysis to determine the leading dimensions of covariation among polylepis species and climatic *** wood anatomical traits(vessel grouping index,vulnerability index,and fiber wall thickness)were dissimilar between xeric-and mesic-polyelpis *** study demonstrates that wood anatomical traits in peruvian Andean polylepis species provides high-resolution and long-term eco-wood anatomical signals on how climate oscillations drive the acclimation processes of fiber and vessel *** findings underscore the significance of xylem hydraulic adjustment to various hydrological environments in Andean puna *** evaluating the effects of drought on wood anatomical characteristics and ecological function,we demonstrate the capacity of tree species to adapt and endure climate-related changes,thereby emphasizing their resilience and ada

关键词： Carlquist indices Climatic resilience Vessel traits Fiber Functional trait Hydric stress

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Morphometric Attributes of Two Native Forage Species According to Water Source Distance in Semiarid Central Grasslands of Argentina

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phyton-International Journal of Experimental Botany 2024年第8期93卷 2063-2074页

作者： Carla Etel Suárez María Sol Rossini ernesto Francisco Atilio Morici Héctor Daniel Esterlich Laboratorio de Ecología en Ambientes Semiáridos Ecología VegetalFacultad de AgronomíaUNLPamSanta Rosa6300Argentina Facultad de Ciencias Veterinarias UNLPamGeneral Pico6360Argentina Becaria Doctoral CONICET APNFacultad de AgronomíaUNLPamSanta Rosa6300Argentina

The semiarid grasslands of Argentina’s central region have been modified by domestic livestock grazing,both in their composition and *** increase in the proportion of woody and non-forage species and the decrease in forage species are some of the most evident results of this *** is limited available information about the effect of differential grazing pressures on morphometric attributes of native species,and it also depends on the life histories of the species in this *** objective of this work was to evaluate some morphometric aspects in the grasses poa ligularis Nees ex Steud and piptochaetium napostaense(Speg.).Hack according to distance from the water source in communities in the central semiarid region of *** study area included areas of low grassland,golden forests,and secondary forests in grasslands(6 fields with 9 paddocks).Grazing pressure was established based on the distance to the water source,so sampling areas were designated near the water source(grazing pressure is greater)and far from the water source(grazing pressure light)in each of the *** both species,specimens were selected at random,and the following attributes were measured:crown diameter at ground level(cm),burial depth(cm),average tiller weight per plant(***^(−1)),and the density of tillers per unit of crown surface(***^(−2)crown).The morphometric attributes evaluated showed differences according to the distance to the watering hole and in the different *** species presented similar behaviors for the *** were significant differences in the depth of burial and the average weight of tillers per plant,being greater in the areas close to the water *** the distance to the watering hole,there were no significant differences in crown diameter and tiller density,but the highest values were recorded for the former near the watering hole and for the second far from the watering *** pastures with low

关键词： Grazing pressure tiller density tiller weight crown burial depth poa ligularis piptochaetium napostaense

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Wood anatomical acclimation in the endemic genus polylepis in peruvian Andean forests

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Journal of Mountain Science 2024年第09期 2986-3000页

作者： Anthony GUERRA Fressia N.AMES-MARTíNEZ ernesto C.RODRíGUEZ-RAMíREZ postgraduate programme in Agronomy/plant physiology Department of Biology-Institute of Natural Sciences Federal University of Lavras Laboratory of Biotechnology and Molecular Biology Continental University Ecology and Biodiversity Research programme ANDINUS Association Dendrochronology Laboratory Continental University

polylepis(Que?ua) is a dominant woody plant genus in Andean puna forests that occurs in a wide range of montane habitats and is ecologically diverse in endemism, which may be particularly threatened by climate change. Wood anatomical traits are essential for understanding how plants adjust their ecophysiological requirements and maximize their resilience, resistance, and recovery to extreme climates. Although the effects of extreme climatic conditions in high altitude ecosystems have been studied extensively, our knowledge is relatively limited to quantitative differences in the main xylem tissues. To address this gap, we assessed the acclimation of wood anatomical traits in six peruvian Andean polylepis species with different water availability(semi-dry with high moisture and semiarid with dry winters). We selected hydraulic diameter, vessel density, vessel grouping index, solitary vessel index, vulnerability index, mesomorphy index, vessel element length, fiber length, fiber wall thickness, fiber lumen diameter, and total fiber diameter that can provide relevant eco-wood anatomical acclimation to hydric stress. We performed multivariate analysis to determine the leading dimensions of covariation among polylepis species and climatic factors. Specific wood anatomical traits(vessel grouping index, vulnerability index, and fiber wall thickness) were dissimilar between xeric-and mesicpolyelpis species. This study demonstrates that wood anatomical traits in peruvian Andean polylepis species provides high-resolution and long-term eco-wood anatomical signals on how climate oscillations drive the acclimation processes of fiber and vessel traits. Our findings underscore the significance of xylem hydraulic adjustment to various hydrological environments in Andean puna forests. By evaluating the effects of drought on wood anatomical characteristics and ecological function, we demonstrate the capacity of tree species to adapt and endure climate-related changes, thereby emphasi

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Characterization of the molecular dysfunctions occurring in Aicardi-Goutieres syndrome patients with mutations in ADAR1

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Genes & Diseases 2024年第3期11卷 116-119页

作者： Sofan Al wardat Loredana Frasinlli Elisa Orecchini Federica Rey Silvia Anna Ciafre Silvia Galardi Jessica Garau Stella Gagliardi Simona Orcesi Davide Tonduti Stephana Carelli Cristina Cereda ernesto picardi Alessandro Michienzi Department of Biomedicine and prevention University of Rome Tor VergataRome 00133Italy pediatric Clinical Research Center"Romeo ed Enrica Invernizzi" Department of Biomedical and Clinical SciencesUniversity of MilanoMilano 20157Italy Center of Functional Genomics and Rare Diseases Department of PediatricsBuzzi Children's HospitalMilano20154Italy Department of Child Neurology and psychiatry IRccs Mondino FoundationPavia 27100Italy Unit of pediatric Neurology C.O.A.L.A(Center for Diagnosis and Treatment of Leukodystrophies)Buzzi Children's HospitalMilano 20154Italy Department of Biosciences Biotechnologies and EnvironmentUniversityof Bari"AldoMoro"Bari 70125Italy Institute of Biomembranes Bioenergetics and Molecular Biotechnologies(IBIOM)National Research Council(CNR)Bari 70126Italy Biostructures and Biosystems National Institute(INBB) Rome00136Italy Institute of Biochemistry and Cell Biology IBBC-CNRCampus Adriano Buzzati TraversoRome 00015Italy

Aicardi-Goutieres syndrome(AGS)is a systemic inflammatory disorder caused by mutations in any one of the nine different genes,whose deficiency provokes a type I(interferon)IFN response probably central to pathogenesis.^(1) ADAR1,one of the genes mutated in AGS(AGS6),encodes for an enzyme that belongs to the ADAR family(ADAR1,ADAR2,and ADAR3)that catalyzes the conversion of adenosine to inosine within double-stranded RNAs(dsRNAs)(RNA editing A-to-1).

关键词： ADAR1 interferon res

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