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Risk of venous congestion in live donors of extended right liver graft

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World Journal of Gastroenterology 2015年第19期21卷 6008-6017页

作者： Arnold Radtke George Sgourakis ernesto p molmenti Susanne Beckebaum Vito R Cicinnati Hartmut Schmidt Heinz-Otto peitgen Christoph E Broelsch Massimo Malagó Tobias Schroeder Department of General and Transplantation Surgery University Hospital Tuebingen Department of General Surgery of Red Cross Hospital Department of Surgery North Shore University Hospital Manhasset Department of General Visceral and Transplantation SurgeryUniversity Hospital Essen Department of Transplant Medicine University Hospital Muenster MeVis Center for Medical Diagnostic Systems and Visualization University of Bremen Department of Surgery-UCL Division of Surgical and Interventional Sciences University College London Department of Diagnostic and Interventional Radiology University Hospital Essen

AIM: To investigate middle hepatic vein(MHV)management in adult living donor liver transplantation and safer remnant volumes(RV).METHODS: There were 59 grafts with and 12 grafts without MHV(including 4 with MHV-5/8 reconstructions).All donors underwent our five-step protocol evaluation containing a preoperative protocol liver biopsy Congestive vs non-congestive RV, remnantvolumebody-weight ratios(RVBWR) and postoperative outcomes were evaluated in 71 right graft living donors. Dominant vs non-dominant MHV anatomy in total liver volume(d-MHV/TLV vs nd-MHV/TLV) was constellated with large/small congestion volumes(CVindex).Small for size(SFS) and non-SFS remnant considerations were based on standard cut-off- RVBWR and RV/TLV. Non-congestive RVBWR was based on non-congestive ***: MHV and non-MHV remnants showed no significant differences in RV, RV/TLV, RVBWR, total bilirubin, or INR. SFS-remnants with RV/TLV pectively(p = 0.423 and p = 0.919. Mean left RV/TLV was 35.8% ± 3.9%.Non-MHV(n = 59) and MHV-containing(n = 12)remnants(34.1% ± 3% vs 36% ± 4% respectively,p = 0.148. Eight SFS-remnants with RVBWR p p ped reversible liver *** and RV/TLV were concordant in 25%-33%of SFS and in 92%-94% of non-SFS remnants. MHV management options including complete MHV vs MHV-4A selective retention were necessary in n = 12 vs n =2 remnants based on particularly risky congestive and non-congestive

关键词： Living donor liver transplantation Livervolume Remnant volume Small-for-size Small-forsizesyndrome

Are acute exacerbations of chronic inflammatory appendicitis triggered by coprostasis and/or coproliths?

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World Journal of Gastroenterology 2008年第20期14卷 3179-3182页

作者： George Sgourakis Georgios C Sotiropoulos ernesto p molmenti Charis Eibl Stylianous Bonticous Jurgen Moege Christoph Berchtold Department of General Visceral and Transplantation Surgery Department of General Surgery Marien Hospital Bottrop Institute of pathology Marien Hospital Bottrop

AIM: To examine the role of coprostasis and coproliths in recurrent appendicitis. METHODS: We evaluated four hundred and twenty seven consecutive pathology reports of all appende- ctomy specimens from January 2003 to December 2004. Findings were categorised as showing acute appen- dicitis, acute recurrent appendicitis, subacute recurrent appendicitis, chronic appendicitis, or appendices without inflammation. All patients had presented with acute right lower quadrant pain. In 94 instances, there was a history of recurrent similar episodes in the past. RESULTS: Of the 427 histology reports, 294 were inter- preted as showing acute appendicitis, 56 acute recurrent appendicitis, 34 subacute recurrent appen-dicitis, 28 chronic appendicitis, and 15 non-inflamed appendices. Coprostasis was observed in 58 patients (13.58%) and the presence of coprolith in 6 (1.4%). Coprostasis, and age, were among the predictors in the final model. CONCLUSION: Coprostasis but not coproliths seems to be a contributing factor to acute exacerbations of chronic inflammatory appendicitis.

关键词： Chronic inflammatory appendicitis Coprostasis Coproliths Recurrent appendicitis

Outcomes following operative vs. non-operative management of blunt traumatic pancreatic injuries: a retrospective multi-institutional study

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Burns & Trauma 2016年第4期4卷 316-322页

作者： poppy Addison Toni Iurcotta Leo I.Amodu Geoffrey Crandall Meredith Akerman Daniel Galvin Annemarie Glazer Nathan Christopherson Jose prince Matthew Bank Christopher Sorrentino Joaquin Cagliani Jeffrey Nicastro Gene Coppa ernesto p.molmenti Horacio L.Rodriguez Rilo Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA pancreas Disease Center Northwell HealthManhassetNYUSA Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA Department of Biostatistics Feinstein Institute for Medical ResearchManhassetNYUSA pancreas Disease Center Northwell HealthManhassetNYUSA Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA pancreas Disease Center Northwell HealthManhassetNYUSA Northwell Health 900 Northern BoulevardSuite 150Great NeckNY 11020USA

Background:Traumatic pancreatic injuries are rare,and guidelines specifying management are controversial and difficult to apply in the acute clinical *** to sparse data on these injuries,we carried out a retrospective review to determine outcomes following surgical or non-surgical management of traumatic pancreatic *** hypothesize a higher morbidity and mortality rate in patients treated surgically when compared to patients treated ***:We performed a retrospective review of data from four trauma centers in New York from 1990–2014,comparing patients who had blunt traumatic pancreatic injuries who were managed operatively to those managed *** compared continuous variables using the Mann-Whitney U test and categorical variables using the chi-square and Fisher’s exact *** analysis was performed to determine the possible confounding factors associated with mortality in both treatment ***:Twenty nine patients were managed operatively and 32 *** was a significant difference between the operative and non-operative groups in median age(37.0 vs.16.2 years,p=0.016),grade of pancreatic injury(grade I;30.8 vs.85.2%,p value for all comparisonsp=0.002),blood transfusion(55.2 vs.15.6%,p=0.0012),other abdominal injuries(79.3 vs.38.7%,p=0.0014),pelvic fractures(17.2 vs.0.00%,p=0.020),intensive care unit(ICU)admission(86.2 vs.50.0%,p=0.003),median length of stay(LOS)(16.0 vs.4.0 days,pp=0.010).Conclusions:patients with traumatic pancreatic injuries treated operatively were more severely injured and suffered greater complications than those treated *** greater morbidity and mortality associated with these patients warrants further study to determine optimal triage strategies and which subset of patients is likely to benefit from surgery.

关键词： Injury Management Non-operative Operative pancreas Trauma

Correlation of abnormal histology with endoscopic findings among mycophenolate mofetil treated patients

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World Journal of Gastrointestinal Endoscopy 2017年第8期9卷 405-410页

作者： Mitchell A Izower Merajur Rahman ernesto p molmenti Madhu C Bhaskaran Viren G Amin Sundas Khan Keith Sultan Department of Medicine North Shore University Hospital Division of Gastroenterology Department of MedicineNorth Shore University Hospital Department of Surgery North Shore University Hospital Divison of Nephrology Department of MedicineNorth Shore University Hospital the Feinstein Institute for Biomedical Research

To describe all abnormal histological findings and their associated endoscopic presentation in patients using mycophenolate mofetil (MMF). METHODSA retrospective review of all individuals prescribed MMF within 6 mo of a colonoscopy or flexible sigmoidoscopy between 07/2009 and 09/2015 was performed within Northwell Health system. Records were analyzed for age, gender, procedure indication, MMF indication, and both gross and microscopic findings. Only reports with abnormal histology were included. RESULTSOne hundred and eighty-four procedures from 170 patients were found, of which 39 met inclusion criteria. Fifty-one point three percent were female. MMF was used for solid organ transplant in 71.8%. Diarrhea was the indication for 71.8% of colonoscopies. Fifty-nine percent of reports revealed gross and microscopic abnormalities while 41.0% had only microscopic findings. Only 11 patients’ reports (28.2%) indicated a specific histopathology of MMF colitis. Among the entire group, only 23.1% of abnormal histology was isolated proximal to the splenic flexure. CONCLUSIONOur results demonstrate a high rate of left sided disease and microscopic findings without gross mucosal abnormalities among patients using MMF. Also, a broader definition of MMF-colonopathy may be appropriate, with a majority of our abnormal histology falling outside of the more narrowly defined MMF-colitis category. Given the high frequency of isolated microscopic abnormalities and distal disease, sigmoidoscopy with random biopsies may be an appropriate, less invasive initial endoscopic examination in selected MMF patients.

关键词： Mycophenolate mofetil Colitis Colonoscopy Diarrhea

Assessing the Environmental Impact of Extensive Beef production in Grazing Lands of Argentina

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phyton-International Journal of Experimental Botany 2024年第8期93卷 1943-1962页

作者： ernesto Viglizzo Florencia Ricard Instituto de Ciencias de la Tierra y Ambientales de La pampa Consejo Nacional de Investigaciones Científicas y TécnicasSanta Rosa6300La PampaArgentina Universidad Austral Rosario2000Santa FeArgentina Secretaría de Ambiente y Cambio Climático del Gobierno de La pampa Santa Rosa6300La PampaArgentina Facultad de Ciencias Exactas y Naturales Universidad Nacional de La PampaSanta Rosa6300La PampaArgentina

Because of environmental constraints,beef cattle was for more than a century the only viable farming option in the extensive semiarid and subhumid lands of Argentina and the main source of nutrients for humans as ***,a growing concern and criticism have risen today about its possible negative impact on the climate and the *** worries tend to affect current public opinions,national policies,and international *** on 40 beef cattle farms scattered across different semiarid and subhumid regions of Argentina,here we evaluated the impact of extensive cattle production on carbon,water,and nutrient ***-Cycle Assessment(LCA)and Land-Based Assessment(LBA)were the two approaches we used here to compare the environmental impact of beef *** the environmental footprint(EF)resulting from LCA expresses the impact per unit of food,the environmental balance(EB),derived from LBA,aims at quantifying the impact per unit of *** such,the EB considers both negative and positive impacts on the farm as an integrated *** standardized procedures,we evaluated EF and EB up to the farm gate,leaving aside delocalized post-farm impacts such as those of processing,packaging,and transportation that occur beyond the farm *** agreement with previous evidence,our results show that the EF tends to decrease as per-head production *** coefficients and statistical significance were the following for carbon(R=−0.574;pppphosphorus(p)pollution(R=−0.802;pper-hectare beef production *** were the following for carbon emissions(CE:R=0.955;pption(WC:R=0.822;ppphosphorus excretion(pE:R=0.945;ppact in intensive beef

关键词： Beef production extensive cattle raising grazing conditions environmental impact assessment

Weight trends in United States living kidney donors:Analysis of the UNOS database

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World Journal of Transplantation 2015年第3期5卷 137-144页

作者： Mala Sachdeva Lisa M Rosen Jeny Varghese Steven Fishbane ernesto p molmenti Department of Medicine Division of Kidney Diseases and HypertensionNorth Shore University Hospital and LIJ Medical CenterHofstra North Shore-LIJ School of Medicine Department of Biostatistics Feinstein Institute For Medical ResearchNorth Shore University Hospital and LIJ Medical CenterHofstra North Shore-LIJ School of Medicine Department of Surgery North Shore University Hospital and LIJ Medical CenterHofstra North Shore-LIJ School of Medicine

AIM: To analyze the national trends associated with body mass index(BMI) and living kidney ***: Forty-seven thousand seven hundred and five adult living kidney donors as reported to the Organ procurement and Transplantation Network from 1999 to 2011 were analyzed using their pre-donation BMI. predictor variables of interest included age, gender, ethnicity, relationship, education status, and transplant ***: Sixteen thousand nine hundred and seventyone of the living kidney donors were normal weight(35.6%); 19337 were overweight(40.5%); 9007 were mildly obese(18.9%); 1992 were moderate to morbidly obese(4.2%). Overweight and mildly obese kidney donors have increased through time by 12% and 20% every 5 years, respectively(p panic males or females and black females, those with high school diploma or general Education Degree, and biologically related or partner/spouses were more likely to be ***: Over the past 13 years, the majority of living kidney donors have spanned the overweight to obese categories. paralleling the national rise is an increase in overweight and mildly obese kidney donors. A fair number of moderate to morbidly obese living kidney donors are still allowed to donate.

关键词： Transplantation Obesity Donor Kidney Living

Efficient removal of the recalcitrant metamizole contaminant from drinking water by using a CaLaCoO_(9) perovskite supported on recycled polyethylene

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Journal of Environmental Sciences 2024年第2期136卷 56-67页

作者： ernesto Valadez-Renteria Christian perez-Carrasco Dulce Yolotzin Medina-Velazquez Vicente Rodriguez-Gonzalez Jorge Oliva CONACYT-División de Materiales Avanzados Instituto Potosino de Investigación Científica y Tecnológica A.C.San Luis PotosíSLP 78216México División de Ciencias Básicas e Ingeniería Universidad Autónoma Metropolitana AzcapotzalcoCol.Reynosa-TamaulipasC.P.MéxicoDF 02200México

Metamizole(MZ)is a widely used anti-inflammatory *** to its common use,this contaminant is found in sewage and *** order to reduce the contamination produced by the MZ,we fabricated in this work a photocatalytic composite using recycled polyethylene(RpE)and the CaLaCoO_(9)(LCCO)*** nanoparticles had a microplate-like morphology and sizes of 1.4–5.5μm according to the analysis of *** photocatalytic properties of the LCCO powders were evaluated under ultraviolet-visible(UV-Vis)irradiation and found a removal efficiency of 96%.When the RpE+LCCO composite was employed for the photocatalytic degradation of MZ,a maximum degradation of 92.5%was *** influence of the pH on the photocatalytic activity was also studied and found that an initial pH=3 produced a total degradation of MZ after 240 min of UV-Vis ***,three reuse cycles were carried out for the pure LCCO powders and for the RpE+LCCO composites and found that the maximum loss of degradation was 5%.Furthermore,scavenger experiments demonstrated that the super oxide and hydroxyl radicals are formed during the photocatalytic reaction and were responsible for the degradation of ***,the X-ray photoelectron-spectroscopy and Raman analysis demonstrated the formation of defects(oxygen vacancies),those ones delayed the electron-hole recombination,which in turn,enhanced the degradation of the ***,the studies performed in this work proved that composites made with recycled plastics and LCCO perovskites are a low-cost and feasible alternative for the cleaning of water sources polluted with pharmaceutical compounds.

关键词： photocatalysis Metamizole pharmaceutical contaminant UV-Vis irradiation perovskite

From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： ernesto Doncel-pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

Use of bio-based products towards more sustainable road paving binders: A state-of-the-art review

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Journal of Road Engineering 2024年第2期4卷 151-162页

作者： Alessio Musco Giulia Tarsi piergiorgio Tataranni ernesto Salzano Cesare Sangiorgi Department of Civil ChemicalEnvironmental and Materials Engineering(DICAM)Alma Mater Studiorum-University of BolognaBologna 40131Italy

Many industrial sectors exploit fossil sources to develop useful and necessary materials for our needs,such as bituminous paving ***,a key component of asphalt mixtures,is derived from oil refining and its properties are influenced by the crude oil source and refining process,resulting in a significant carbon *** growing awareness of resource depletion and environmental concerns,pavement researchers are exploring sustainable alternatives to reduce dependence on fossil *** includes a rising trend in using renewable materials like biomasses to produce bio-based binders as substitutes for bitumen,aiming for a more sustainable ***,including vegetal and animal wastes,and waste cooking oils,as substitutes for crude oil in the production of *** thermochemical conversion(TCC),such as pyrolysis,biomasses can be converted into bio-char and bio-oils,which can replace fossil-based components in *** have utilized these bio-products to reduce the dependency on fossil fuels in ***,there are no set minimum requirements for bio-components in bio-based *** the percentage of replaced bitumen increases,various types of binders are produced,including modified bitumen,extended bitumen,and alternative binders,where the fossil replacement is *** rheological tests on bio-binders,reveal that those containing biochar exhibit increased viscosity,stiffness,rutting resistance,and sometimes antioxidant ***,bio-binders with bio-oils as bitumen substitutes show poorer performance at high temperatures but improved behavior at low *** results suggest that bio-binders could provide versatile solutions for various climatic and loading conditions in road ***,the development of pavement mixtures based on bio-binders has not been studied in depth and requires further attention to unlock its full *** sustainability considerations,includin

关键词： Biomass Chemical process Bitumen replacement Bio-binder paving material