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Antiviral therapy in cytomegalovirus-positive ulcerative colitis:A systematic review and meta-analysis

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World Journal of Gastroenterology 2014年第10期20卷 2695-2703页

作者： Uri Kopylov Noa Eliakim-Raz Andrew Szilagy ernest seidman Shomron Ben-Horin Lior Katz Department of Gastroenterology Sheba Medical Center Tel Hashomer Ramat Gan 5262 Israel Division of Gastroenterology McGill University Health Center Montreal Quebec H3G 1A4Canada Sackler School of Medicine Tel-Aviv University Ramat-Aviv Tel-Aviv 69978Israel Department of Medicine E Beilinson Hospital Rabin Medical Center Petach Tikva 49100 Israel Division of Gastroenterology Jewish General Hospital McGill University Montreal Quebec H3T 1E2Canada

AIM: To evaluate the impact of antiviral treatment on cytomegalovirus (CMV)-positive ulcerative colitis patients.

关键词： Ulcerative colitis Cytomegalovirus Colectomy Antiviral treatment Gancyclovir Foscarnet

Benefits of implementing a rapid access clinic in a high-volume inflammatory bowel disease center:Access, resource utilization and outcomes

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World Journal of Gastroenterology 2020年第7期26卷 759-769页

作者： Sofia Nene Lorant Gonczi Zsuzsanna Kurti Isabelle Morin Kelly Chavez Christine Verdon Jason Reinglas Rita Kohen Talat Bessissow Waqqas Afif Gary Wild ernest seidman Alain Bitton Peter Laszlo Lakatos Division of Gastroenterology McGill University Health CentreQuebecMontreal H3G1A4Canada First Department of Medicine Semmelweis UniversityBudapest H-1083Hungary

BACKGROUND Emergency situations in inflammatory bowel diseases(IBD)put significant burden on both the patient and the healthcare *** To prospectively measure Quality-of-Care indicators and resource utilization after the implementation of the new rapid access clinic service(RAC)at a tertiary IBD *** Patient access,resource utilization and outcome parameters were collected from consecutive patients contacting the RAC between July 2017 and March 2019 in this observational *** comparing resource utilization and healthcare costs,emergency department(ED)visits of IBD patients with no access to RAC services were evaluated between January 2018 and January *** to appointment,diagnostic methods,change in medical therapy,unplanned ED visits,hospitalizations and surgical admissions were calculated and *** 488 patients(Crohn’s disease:68.4%/ulcerative colitis:31.6%)contacted the RAC with a valid medical *** time to visit with an IBD specialist following the index contact was 2 *** had objective clinical and laboratory assessment(C-reactive protein and fecal calprotectin in 91%and 73%).Fast-track colonoscopy/sigmoidoscopy was performed in 24.6%of the patients,while computed tomography/magnetic resonance imaging in only 8.1%.Medical therapy was changed in 54.4%.ED visits within 30 d following the RAC visit occurred in 8.8%(unplanned ED visit rate:5.9%).Diagnostic procedures and resource utilization at the ED(n=135 patients)were substantially different compared to RAC users:Abdominal computed tomography was more frequent(65.7%,P<0.001),coupled with multiple specialist consults,more frequent hospital admission(P<0.001),higher steroid initiation(P<0.001).Average medical cost estimates of diagnostic procedures and services per patient was$403 CAD vs$1885 CAD comparing all RAC and ED *** Implementation of a RAC improved patient care by facilitating easier access to IBD specific medical care,optimized resource uti

关键词： Crohn’s disease Ulcerative colitis Rapid access Quality-of-care Emergency department

Non-conventional humanitarian interventions on Ebola outbreak crisis in West Africa: health, ethics and legal implications

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Infectious Diseases of Poverty 2014年第1期3卷 386-396,385页

作者： ernest Tambo Sydney Brenner Institute for Molecular Bioscience Wits 21st Century InstituteFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa Center for Sustainable Malaria Control Department of BiochemistryFaculty of Natural and Agricultural SciencesUniversity of PretoriaPretoriaSouth Africa National Institute of Parasitic Diseases Chinese Centre for Disease Control and Preventionand the WHO Collaborating Centre on MalariaSchistosomiasis and FilariasisShanghai 200025People’s Republic of China Facultédes Sciences Biomédicales et Pharmaceutiques Universitédes MontagnesBangangtéRépublique du Cameroun

Due to the lack of Ebola outbreak early warning alert,preparedness,surveillance and response systems,the most deadly,complex and largest ever seen Ebola war has been devastating West African *** unparalleled Ebola tsunami has prompted interrogations into,and uncertainties about,the effectiveness and efficiency of national,regional and international community’s illed-responses using conventional humanitarian control and containment approaches and *** late humanitarian and local non-government organisations emergency responses and challenges to curb transmission dynamics and stop the ongoing spread in the Ebola outbreak in West Africa have led to an unprecedented toll of 14,413 reported Ebola cases in eight countries since the outbreak began,with 5,177 reported deaths including 571 health-care workers and 325 died as 14 November *** indications the need of further evaluation of monitoring as substantial proportion of infections outside the context of Ebola epicentres,Ebola health centres treatment and care,infection prevention and control quality assurance checks in these *** the same time,exhaustive efforts should target ensuring an sufficient supply of optimal personal protective equipment(PPE)to all Ebola treatment facilities,along with the provision of training and relevant guidelines to limit to the minimum possible level of *** continent hosts a big proportion of the world’s wealth,yet its people live in abject poverty,with governments unable to feed and govern them effectively,and who are condemned to endure even darker moments with the Ebola outbreak in West *** of practical and operational non-conventional emergency response models efficient health systems,and tailored programmes can clearly support to prevent,control and eventually stamp out Ebola geo-distribution in addition to population mental health services that are requisite to address the massive range of the health,socio-psychological a

关键词： Non-conventional Response Ethics Legal Ebola Humanitarian crisis Africa

The impact of dielectrics on the electrical capacity, concentration, efficiency ozone generation for the plasma reactor with mesh electrodes

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Plasma Science and Technology 2018年第8期20卷 89-95页

作者： ernest GNAPOWSKI Sebastian GNAPOWSKI Jaroslaw PYTKA University College of Enterprise and Administration in Lublin Bursaki 12 20-150 Lublin Poland Fundamentals of Technology Faculty Lublin University of Technology ul. Nadbystrzycka 38 20-618 Lublin Poland Faculty of Mechanical Engineering Lublin University of Technology ul. Nadbystrzycka 36 20-618 Lublin Poland

This paper presents experimental results concerning the effect of dielectric type on ozone concentration and the efficiency of its generation in plasma reactor with two mesh *** types of dielectric solid were used in the study; glass, micanite and Kapton insulating foil. The experiments were conducted for voltage ranges from 2.3 to 13 k V. A plasma reactor equipped with two 0.3×0.3 mm^2 mesh electrodes made of acid resistant AISI 304 mesh was used in the experiments. The influence of the dielectric type on the concentration and efficiency of ozone generation was described. The resulting maximum concentration of the ozone was about 2.70–9.30 g O3 m^-3, depending on the dielectrics used. The difference between the maximum and the minimum ozone concentration depends on the dielectric used,this accounts for 70% at the variance. The reactor capacity has also been described in the paper; total Ct and dielectric capacitance Cd depending on the dielectric used and its thickness.

关键词： ozone generation efficiency dielectric mesh electrode ozone generator electrical capacity

Building-Back-Better in Post-Disaster Recovery: Lessons Learnt from Cyclone Idai-Induced Floods in Zimbabwe

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International Journal of Disaster Risk Science 2021年第5期12卷 700-712页

作者： ernest Dube Gayan Wedawatta Kanchana Ginige Department of Development Sciences Faculty of Agribusiness and EntrepreneurshipMarondera University of Agricultural Sciences and Technology(MUAST)Marondera.Zimbabwe Department of Civil Engineering School of Infrastructure and Sustainable EngineeringAston UniversityBirmingham B47ET.UK Department of Architecture and Built Environment Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle upon Tyne NE48STUK

This study evaluated the build-back-better considerations in post-disaster recovery,following the devastation of Chipinge and Chimanimani communities by Cyclone Idai-induced floods in *** in 2020,the study assessed the impact of Cyclone Idai-induced floods on communities in Chipinge and Chimanimani Districts of Zimbabwe;evaluated the build-back-better considerations;and analyzed the lessons *** on a qualitative approach and case study design,the study depended on focus group discussions,interviews,and researcher observations to gather data from 85 *** findings indicate that Cyclone Idai-induced floods seriously impacted human lives,infrastructure,and livelihoods of communities that had been living with flood risk and ***-back-better considerations were absent in much of the post-disaster recovery effort to address the cyclone disaster *** are important early lessons for both practitioners and community members to learn from the Cyclone Idai *** lessons still can inform policy and disaster risk reduction practice in the medium and long ***-back-better should be a mandatory objective in the recovery from any disaster *** training is also recommended to improve the disaster knowledge of stakeholders and increase local ability to cope with future disaster events.

关键词： Build-back-better Cyclone Idai Flood hazard Post-disaster recovery Zimbabwe

PROXIMAL-PROXIMAL-GRADIENT METHOD

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Journal of Computational Mathematics 2019年第6期37卷 778-812页

作者： ernest K.Ryu Wotao Yin Department of Mathematics University of CaliforniaLos AngelesCA 90095USA

In this paper,we present the proximal-proximal-gradient method(PPG),a novel optimization method that is simple to implement and simple to *** generalizes the proximal-gradient method and ADMM and is applicable to minimization problems written as a sum of many differentiable and many non-differentiable convex *** non-differentiable functions can be *** furthermore present a related stochastic variation,which we call stochastic PPG(S-PPG).S-PPG can be interpreted as a generalization of Finito and MISO over to the sum of many coupled non-differentiable convex *** present many applications that can benefit from PPG and S-PPG and prove convergence for both *** demonstrate the empirical effectiveness of both methods through experiments on a CUDA GPU.A key strength of PPG and S-PPG is,compared to existing methods,their ability to directly handle a large sum of non-differentiable nonseparable functions with a constant stepsize independent of the number of *** non-diminishing stepsizes allows them to be fast.

关键词： Proximal-gradient ADMM Finito MISO SAGA Operator splitting Firstorder methods Distributed optimization Stochastic optimization Almost sure convergence linear convergence

Acquired immunity and asymptomatic reservoir impact on frontline and airport ebola outbreak syndromic surveillance and response

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Infectious Diseases of Poverty 2014年第1期3卷 375-384,374页

作者： ernest Tambo Zhou Xiao-Nong Sydney Brenner Institute for Molecular Bioscience School of Medical Sciences&School of Public HealthUniversity of the WitwatersrandJohannesburgSouth Africa Chinese Center for Disease Control and Prevention National Institute of Parasitic DiseasesShanghai 200025People’s Republic of China WHO Collaborating Centre for Malaria Schistosomiasis and FilariasisKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai 200025People’s Republic of China Département de Biochimie et Science Pharmaceutiques Universitédes MontagnesBagangtéRépublique du Cameroun

The number of surveillance networks for infectious disease diagnosis and response has been *** 2000,the World Health Organization(WHO)established the Global Outbreak Alert and Response Network,which has been endorsed by each of the 46 WHO African members since ***,taming the dynamics and plague of the vicious Ebola virus disease(EVD)in African countries has been patchy and erratic due to inadequate surveillance and contact tracing,community defiance and resistance,a lack of detection and response systems,meager/weak knowledge and information on the disease,inadequacies in protective materials protocols,contact tracing nightmare and differing priorities at various levels of the public health *** the widespread acceptance of syndromic surveillance(SS)systems,their ability to provide early warning alerts and notifications of outbreaks is still *** is often too limited for any outbreak,or emerging or otherwise unexpected disease,to be recognized at either the community or the national ***,little is known about the role and the interactions between the Ebola infection and exposure to other syndemics and the development of acquired immunity,asymptomatic reservoir,and Ebola *** lessons be learnt from smallpox,polio,and influenza immunity,and can immunization against these serve as a guide?In most endemic countries,community health centers and disease control and prevention at airports solely relies on passive routine immunization control and reactive syndromic *** frontline and airport Ebola SS systems in West Africa have shown deficiencies in terms of responding with an alarming number of case fatalities,and suggest that more detailed insights into Ebola,and proactive actions,are *** quest for effective early indicators(EEE)in shifting the public and global health paradigm requires the development and implementation of a comprehensive and effective community or regional integrated pandemic p

关键词： Immunity Asymptomatic Reservoir Syndromic Surveillance Ebola Response

Importance of Modeling Heterogeneities and Correlation in Reservoir Properties in Unconventional Formations: Examples of Tight Gas Reservoirs

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Journal of Earth Science 2021年第4期32卷 809-817页

作者： Shengli Li Y.Zee Ma ernest Gomez School of Energy Resources China University of GeoscienceBeijing 100083China Information Solution SchlumbergerDenver CO 80202USA

We present lithofacies classifications for a tight gas sandstone reservoir by analyzing hierarchies of *** use principal component analysis(PCA)to overcome the two level of heterogeneities,which results in a better lithofacies classification than the traditional cutoff *** classical volumetric method is used for estimating oil/gas in-place resources in the petroleum industry since its inception is not accurate because it ignores the heterogeneities of and correlation between the petrophysical *** present the importance and methods of accounting for the heterogeneities of and correlation between petrophysical properties for more accurate hydrocarbon volumetric *** also demonstrate the impacts of modeling the heterogeneities and correlation in porosity and hydrocarbon saturation for hydrocarbon volumetric estimations with a tight sandstone gas ***,geoscientists have traditionally considered that small-scale heterogeneities only impact subsurface fluid flow,but not impact the hydrocarbon resource volumetric *** show the importance of modeling small-scale heterogeneities using fine cell size in reservoir modeling of unconventional resources for accurate resource assessment.

关键词： heterogeneity petrophysical property correlations Simpson’s paradox porosity gas saturation hydrocarbon volumetrics change of support problem

Alternatives to left lateral sector in paediatric liver transplantation-a systematic review on monosegmental and reduced grafts

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 567-576,I0005页

作者： Paschalis Gavriilidis ernest Hidalgo Department of Hepatopanceaticobiliary Surgery.Imperial College Healthcare NHS Trust Hammersmith HospitalLondonUK Department of Hepato-Pancreatic-Biliary Surgery and Liver Transplantation Hospital Universitari Vall d’HebronBarcelonaSpain

Background: Paediatric liver transplantation (pLT) is the treatment of choice for many liver conditions. However, it still poses relevant challenges, mainly related to the size of the recipients. Unlike in adults, excessive graft volume might represent an issue when the estimated graft-recipient-weight-ratio (GRWR) is significantly disproportionate. In this situation, the traditional left lateral sector (LLS) grafts are too big and other alternatives are required, such as monosegmental or reduced (including hyper-reduced) grafts (RLLS/HRLLS). Results with conventional LLS-pLT are excellent and replicating them with monosegmental or RLLS is challenging given (I) the technical complexity and (II) the need to overcome the large-for-size scenario. This article is to review the existing experience with monosegmental, RLLS/HRLLS grafts and appraise its results. Methods: Systematic search of the electronic databases, conducted from their inception until May 2020. Results: After scrutiny of the available literature, 16 studies were included reporting 330 patients transplanted with monosegmental and RLLS/HRLLS grafts. There were 10 re-grafts (6 of them <90 days);90% of grafts were LDLT. Overall, median recipient’s age and weight were 7 months (range, 5 days-22 months) and 5.8 kg (range, 2.6-8 kg) respectively. Median graft weight was 209 grams (range, 124-264 grams) and median GRWR was 3.5% (range, 2.7-5.6%). Hepatic artery and portal vein thrombosis overall incidence were 1.5% and 4.2%;120 out of the 330 pLT were monosegmental (37%) producing a smaller graft (median of 164 grams) and accordingly a lower GRWR (median 3.2%) compared to reduced LLS. With a median follow-up of 39 months (range, 6-87 months), the overall graft and patient survival were 84% (285/340) and 89% (295/330). Discussion: Monosegmental and RLLS/HRLLS grafts provide access to liver transplantation for very small recipients with excellent results comparable to the standard LLS.

关键词： Monosegmental monosegment(MSG) reduced hyper-reduced left lateral sector graft liver transplantation