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Experimental verification of PET imaging by photonuclear reactions for High energy X-ray in radiation therapy

Experimental verification of PET imaging by photonuclear rea...

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长城2008国际医学物理大会暨第14届中国医学物理学术年会

作者： erik.joreskog IBA China

Purpose The utility of positron emitter nuclei generated by photonuclear reactions from MM50 is verified for dose delivery and location monitoring in a phantom and patient after 50 MV high energy photon in radiation therapy. Materials and methods The technique is based on the activation of body tissues by high energy bremsstrahlung beams,energies well above 20 MeV,resulting primarily in C and O but also N,all positron-emitting radionuclides produced by photoneutron reactions in the nuclei of C,O and *** relations of cross section for different photonuclear reactions with energy are *** the carbon and oxygen radionuclides are the most abundant elements in soft tissue photonuclear reactions we study these two radionuclides.A solid water phantom and a frozen animal tissue were irradiated with an X-ray beam energy of 50 MV from *** 3D radiation treatment planning system,Nucletron-TPP,was used to calculate the delivered dose *** phantom or tissue was directly simulated in the Nucletron-TPP after CT scan. These radiations are similar to RT .in three fields with some different dose *** induced positron activity distributions images were scanned off-line in a PET/CT a couple of minutes after *** measured PET images change with time post irradiation,as a result of the different decay times of the radionuclides,the signals from activated C,O within the irradiated volume could be separated from each *** information is obtained from the carbon and oxygen radionuclides which are the most abundant elements in soft tissue. Results A comparison was made between measured activity and dose distributions for each *** measured times of annihilation gamma rays from the positron emitter nucleus were 3 and 5 rain for the O nucleus in the HO target and the O,C nucleus in the tissue target,*** activity distributions of the O and C positron emitter nuclei were similar to the measured dose distributions for bot

关键词： High-energy photon therapy-Beam monitoring-Photonuclear reaction-PET-CT imaging

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