Thick Mesozoic sediments are found offshore Norway and Denmark, and Mesozoic rocks are present and well exposed in Denmark, along the coast of East Greenland and on the arctic islands of Svalbard. During the Mesozoic...
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Thick Mesozoic sediments are found offshore Norway and Denmark, and Mesozoic rocks are present and well exposed in Denmark, along the coast of East Greenland and on the arctic islands of Svalbard. During the Mesozoic, Scandinavia and Greenland were subject to major extension in the Late Permian-Early Triassic and Late Jurassic-Early Cretaceous, prior to Cenozoic opening of the North Atlantic. Deep basins developed along the rift zones of the North Sea and between East Greenland and Norwa); and were .filled with sediments derived from mainland Scandinavia and Greenland. The marginal areas bordering the rift zones suffered less subsidence, as did the epicontinental Barents Sea.
BACKGROUND Antipsychotic drugs remain the mainstay of schizophrenia treatment;however,their effectiveness has been questioned,and it is not possible to predict the response to a specific antipsychotic drug in an indiv...
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BACKGROUND Antipsychotic drugs remain the mainstay of schizophrenia treatment;however,their effectiveness has been questioned,and it is not possible to predict the response to a specific antipsychotic drug in an individual ***,it is important to compare the effectiveness of the various antipsychotics and search for possible response *** To investigate the effectiveness of antipsychotic drugs,we examined response trajectories and predictors for belonging to different trajectory *** The Bergen-Stavanger-Innsbruck-Trondheim(BeSt InTro)trial compared the effectiveness of three atypical antipsychotics-amisulpride,aripiprazole,and olanzapine-in a prospective,semirandomized,rater-blind,head-to-head *** participants with a schizophrenia spectrum disorder diagnosis,according to international classification of diseases,Tenth Revision(ICD-10)F20–29,were *** were followed for a period of 12 mo,with assessments at baseline;after one,three and six weeks;and after three,six,nine and 12 mo.A latent class mixed model was fitted to our *** three-trajectory model based on the Positive and Negative Syndrome Scale(PANSS)total score reduction was found to have adequate fit,and the study drugs,as well as various demographic and clinical parameters,were tested as predictors for belonging to the different trajectory *** Overall,144 participants were included,and 41%completed the 12-mo study *** largest trajectory group,consisting of 74%of participants,showed a PANSS total score reduction of 59%from baseline to 12 mo(Good response group).A trajectory group comprising 13%of participants had their PANSS total score reduced by 82.5%at 12 mo(Strong response group),while the last response trajectory group comprising 13%of the participants had a PANSS total score reduction of 13.6%(Slight response group).The largest part of the total reduction for the Good and Strong response groups occurred at six weeks of treatment,
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