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步长脑心通治疗血管性认知障碍患者的疗效分析

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中华脑科疾病与康复杂志（电子版） 2012年第1期2卷 12-15页

作者：闫福岭张婧婧 erica Limbenga 东南大学附属中大医院神经内科南京210009

目的探讨步长脑心通对血管性认知障碍(VcI)患者的治疗效果及其作用机制。方法选取东南大学附属中大医院神经内科60例轻、中度VcI患者,随机分为治疗组30例,采用步长脑心通胶囊治疗,每次1.2 g,每日3次,口服,连续12周;对照组30例,采用尼莫... 详细信息

目的探讨步长脑心通对血管性认知障碍(VcI)患者的治疗效果及其作用机制。方法选取东南大学附属中大医院神经内科60例轻、中度VcI患者,随机分为治疗组30例,采用步长脑心通胶囊治疗,每次1.2 g,每日3次,口服,连续12周;对照组30例,采用尼莫地平片治疗,每次30 mg,每日3次,口服,连续12周。治疗期间,两组均不服用其他降脂药物、脑血管扩张药物及脑细胞代谢药物。所有入选的患者均观察其治疗前、治疗后4周、8周、12周的简易精神状态检查量表(MMSE)和长谷川痴呆量表(HDS)评分,并在上述4个时间点采集外周静脉血标本,检测血脂包括三酰甘油(TG)、总胆固醇(Tc)、低密度脂蛋白胆固醇(LDL-c)和高密度脂蛋白胆固醇(HDL-c)以及超敏c反应蛋白(hscRP)。检测结果输入Excel表,采用SPSS 11.5统计软件包进行统计学分析。结果与自身治疗前相比,治疗组的MMSE评分在治疗8周(t=-4.367,P=0.000)、治疗12周(t=-8.354,P=0.000)明显升高;对照组在治疗4周(t=-2.610,P=0.012)、治疗8周(t=-5.491,P=0.000)和治疗12周(t=-10.627,P=0.000)均明显升高;两组间MMSE评分差异无统计学意义。治疗组的HDS评分在治疗12周(t=-2.734,P=0.008)明显升高;对照组在治疗8周(t=-2.886,P=0.005)、治疗12周(t=-5.775,P=0.000)明显升高;两组间的HDS评分无统计学差异。治疗组于治疗12周的血脂水平和hscRP水平较治疗前有明显改善(TG:t=2.465,P=0.017;Tc:t=2.828,P=0.006;LDL-c:t=3.174,P=0.002;HDL-c:t=-3.338,P=0.002;hscRP:t=4.168,P=0.000);而对照组各时间点TG、Tc、LDL-c、HDL-c及hscRP水平治疗前后差异无统计学意义。结论步长脑心通对VcI有效,虽显效缓慢,但对认知功能总体的改善作用与尼莫地平相当,步长脑心通对VcI患者认知障碍的疗效,可能部分与调节血脂,降低血hscRP水平有关。

关键词：认知障碍,血管性尼莫地平步长脑心通

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晚古新世冰后高温期的全球沟鞭藻事件

海洋地质动态 2001年第6期17卷 21-23页

作者： erica M crouch 周立君

晚古新世的气候环境在地质上具有全球快速变暖、时间间隔短暂的特征。这个时间间隔为晚古新世高温期，或称为 LPTM。该时期深海快速变暖 4～ 8 ℃ ，赤道和高纬大洋 ... 详细信息

晚古新世的气候环境在地质上具有全球快速变暖、时间间隔短暂的特征。这个时间间隔为晚古新世高温期，或称为 LPTM。该时期深海快速变暖 4～ 8 ℃ ，赤道和高纬大洋表层水变暖 1～ 6 ℃ 。在深海底栖有孔虫中出现了大范围灭绝事件，而表栖浮游生物和陆生哺乳动物也经历了明显的种交替和多样性变化。经过测年， LPTM始于 54.93～ 54.98 Ma， LPTM中也可观察到明显的碳同位素负偏移 (cIE)(2‰ ～ 3‰ )，这在海洋和陆生化石记录中已得到证实。同位素异常的特征表明了极度富含 12c的储层 (例如甲烷气体水合物 )曾向海洋 — 大气层中大量、快速地输入碳，随后又逐渐恢复到较早的环境。最新研究表明，富含 12c的碳的初期释放持续了 20 ka，整个 δ 13c异常持续了 210～ 220 ka。

关键词：晚古新世冰后高温期全球沟鞭藻事件碳同位素气候环境

cHINA MUSIc cORNER Two New Homegrown Albums on Our RadarThis Month

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城市漫步（GBA版） 2018年第9期 34-34页

作者： erica Martin 不详

Peach Illusion EP by Peach Illusion While they may have met at Xiamen University,O.o and c.c of Peach Illusion put together their first album an ocean *** release of their first self-titled EP is a bedroom dream・pop gem,written,recorded and mixed while one was in Singapore and the other in *** pictures as seen through rose-colored glasses,the duo has reunited and settled in the Paris of the East,with plans to work on a few artistic projects and a second *** urban sweetener aura and adorable pastel photo shoots are in and of themselves reasons to add them to your summer playlist,and we can't wait to see what's next for two of Shanghai's new・est residents.

关键词： Xiamen glasses settled

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哈佛谈判心理学

作者： (美)艾莉卡·爱瑞儿·福克斯(erica Ariel Fox)

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中亚的叙利亚基督教

吐鲁番学研究 2019年第1期 110-116页

作者：艾丽卡c.D.亨特祁晓庆(译) 剑桥大学敦煌研究院

“当欧洲基督教第一次朦胧地听到穆斯林塞尔柱帝国和花拉子模沙遭受失败的时候,他们以为一个伟大的基督教政权在中亚崛起了。”——《伊朗剑桥史》第5卷《塞尔柱和蒙古时期》,第147页这段引文反映了12世纪蒙古帝国获得全面胜利,他们在... 详细信息

“当欧洲基督教第一次朦胧地听到穆斯林塞尔柱帝国和花拉子模沙遭受失败的时候,他们以为一个伟大的基督教政权在中亚崛起了。”——《伊朗剑桥史》第5卷《塞尔柱和蒙古时期》,第147页这段引文反映了12世纪蒙古帝国获得全面胜利,他们在其统治时期对基督教采取的宽容政策。然而,欧洲人并没有完全弄错他们的信仰,因为有一个基督教势力遍布中亚各地。诚然,它不是政治权力,而是操叙利亚语的教堂遍布这一区域的广大地区;从位于西面的里海到位于鄂尔浑河东部的喀喇昆仑,以及更远的地方。

关键词：基督教叙利亚中亚蒙古帝国蒙古时期 12世纪宽容政策政治权力

Production, Detection and cross-Reactivity of Anti-Polysaccharide Antibodies from Environmental Fungi

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Advances in Bioscience and Biotechnology 2014年第10期5卷 815-822页

作者： Rafael Andrade Menolli Thais Soprani Ayala Pablo Rodrigo da Rosa claudia Rejane Lima de Macedo costa erica Fernanda Osaku Rosiane G. Mello Zibetti centro de ciências Médicas e Farmacêuticas Universidade Estadual do Oeste do Paraná Cascavel Brasil centro de ciências Biológicas e da Saúde Universidade Estadual do Oeste do Paraná Cascavel Brasil Faculdades Pequeno Príncipe Curitiba Brasil

The diagnosis of Invasive Fungal Disease (IFD) is difficult because the sensitivity of conventional culture and cytology methods for the detection of Aspergillus is poor, and because serological methods exhibit cross-reactivity with environmental fungi. Fungal polysaccharides are of particular interest in the serologic diagnosis of IFD, especially galactomannan (GM) and glucan, which have been recognized as useful tools for the diagnosis of fungal infections. Further investigation into polysaccharide antibody cross-reactivity is important in improving diagnostic tests. Our aim was to verify the production of antibodies against fungal antigens in mice immunized with exopolysaccharides (EPS) obtained from three fungal species (Aspergillus terreus, Paecilomyces variotii and curvularia brachyspora). ELISA assays were performed to evaluate homologous and heterologous reactions and showed anti-polysaccharide antibodies production. EPS from A. terreus was immunogenic enough to immunize the animal and lead to antibody production against this EPS. In addition, no cross-reactivity was observed with EPS obtained from P. variotii and c. brachyspora. The EPS from P. variotii did not exhibit good immunogenicity, whereas EPS from c. brachyspora showed good immunogenicity, and heterologous reactions were detected on the ELISA assays performed using the EPS from this species. The results indicate that immunization can occur for environmental fungal polysaccharides, generating antibodies may be interfere in serological diagnosis that are based on detection of fungal polysaccharides, mainly glucans and galactomannans.

关键词： Exopolysaccharides Environmental Fungi Immunization

“In Vitro”Antibacterial Activity of the Hidroalcoholic Extract of the Schinus terebinthifolius Raddi Barks

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Advances in Microbiology 2014年第12期4卷 761-765页

作者： erica Renata Nogueira Sá cássio Ilan Soares Medeiros Juliana Raquel de Morais Santos Oliveira Antonio José de Jesus Evangelista Maria Iranilda Silva Magalhaes Geraldo Goncalves de Almeida Filho Andréa Maria Rolim da Paz Hilzeth de Luna Freire Pessoa Department of Microbiology Research Integrated College of PatosPatosBrazil Department of Medical Sciences Federal University of CearáCearáBrazil Department of Health Sciences Cruzeiro of Sul UniversitySao PauloBrazil Department of Pharmaceutical Technology Federal University of ParaíbaJoao PessoaBrazil Department of cell and Molecular Biology Federal University of ParaíbaJoao PessoaBrazil

The Schinus terebinthifolius Raddi is a native plant of South America popularly known in Brazil as aroeira. It is a medium-sized plant, which demonstrates a high adaptive potential in various environments, besides having various medicinal properties such as anti-inflammatory and antidiarrheal. Bacterial susceptibility tests were carried out and the minimal inhibitory concentration (MIc) was obtained. The results were interpreted based on the conventionally microbiological protocols and data from the cLSI. For the microbiological tests, microorganisms obtained from the American Type culture collection (ATcc), specifically, (Pseudomonas aeruginosa, Staphylococcus aureus and Encherichia coli) were used. Of the tested bacterial strains, only the Staphylococcus aureus 6538 presented susceptibility to the aroeira’s hydroalcoholic extract, forming zones of inhibition of 8.0 mm of diameter up to the MIc of 35.3 mg/mL, while the other tested strains showed to be resistant in all the concentrations of hydroalcoholic extract of the Schinus terebinthifolius Raddi bark. Our aim is to analyze the “in vitro” antibacterial potential of the 70% hydroalcoholic extract of the Schinus terebinthifolius Raddi.

关键词： Aroeira Antibacterial Activity Schinus terebinthifolius Raddi Hydroalcoholic Extract

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Boceprevir is highly effective in treatment-experienced hepatitis c virus-positive genotype-1 menopausal women

作者： (美)艾丽卡.爱瑞儿.福克斯(erica Ariel Fox)

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World Journal of Gastroenterology 2014年第44期20卷 16726-16733页

作者： Veronica Bernabucci Alessia ciancio Salvatore Petta Aimilia Karampatou Laura Turco Silvia Strona Rosina critelli Paola Todesca caterina cerami caterina Sagnelli Mario Rizzetto calogero cammà erica Villa Division of Gastroenterology Azienda Ospedaliero-Universitaria Policlinico di Modena Italy Università degli Studi di Modena e Reggio Emilia Division of Gastroenterology University of Turin Division of Gastroenterology Di Bi MIS University of Palermo Dipartimento Medico-chirurgico di Internistica clinica e Sperimentale "F. Magrassi-A. Lanzara" Second University of Naples

AIM: To investigate the safety/efficacy of Boceprevirbased triple therapy in hepatitis c virus(HcV)-G1 menopausal women who were historic relapsers, partial-responders and null-responders. METHODS: In this single-assignment, unblinded study, we treated fifty-six menopausal women with HcV-G1, 46% F3-F4, and previous PEG-α/RBV failure(7% null, 41% non-responder, and 52% relapser) with 4 wk lead-in with PEG-IFNα2b/RBV followed by PEGIFNα2b/RBV+Boceprevir for 32 wk, with an additional 12 wk of PEG-IFN-α-2b/RBV if patients were HcV-RNApositive by week 8. In previous null-responders, 44 wk of triple therapy was used. The primary objective of retreatment was to verify whether a sustained virological response(SVR)(HcV RNA undetectable at 24 wk of follow-up) rate of at least 20% could be obtained. The secondary objective was the evaluation of the percent of patients with negative HcV RNA at week 4(RVR), 8(RVR BOc), 12(EVR), or at the end-of-treatment(ETR) that reached SVR. To assess the relationship between SVR and clinical and biochemical parameters, multiple logistic regression analysis was ***: After lead-in, only two patients had RVR; HcV-RNA was unchanged in all but 62% who had ≤1 log10 decrease. After Boceprevir, HcV RNA became undetectable at week 8 in 32/56(57.1%) and at week 12 in 41/56(73.2%). Of these, 53.8% and 52.0%, respectively, achieved SVR. Overall, SVR was obtained in 25/56(44.6%). SVR was achieved in 55% previous relapsers vs. 41% non-responders(P = 0.250), in 44% F0-F2 vs 54% F3-F4(P = 0.488), and in 11/19(57.9%) of patients with cirrhosis. At univariate analysis for baseline predictors of SVR, only previous response to antiviral therapy(OR = 2.662, 95%cI: 0.957-6.881, P = 0.043), was related with SVR. When considering "on treatment" factors, 1 log10 HcV RNA decline at week 4(3.733, 95%cI: 1.676-12.658, P = 0.034) and achievement of RVR BOc(7.347, 95%cI: 2.156-25.035, P = 0.001) were significantly related with the SVR, although RVR BOc only(6.794

关键词： Hepatitis c virus treatment Pegylated In-terferon