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集成电路应用 2009年第6期26卷 36-38页

作者： jan Provoost eric Beyne IMEC www.imec.be

采用3维（3D）芯片层叠的生产技术用于制造更复杂、性能更强大、更具成本效率的系统，是一个具有前景的方向。采用穿透硅通孔（Thmugh Silicon Via，TSV）的连接技术可以有效地实现这种3D芯片层叠。这个技术很快已经初具雏形：公司和研... 详细信息

采用3维（3D）芯片层叠的生产技术用于制造更复杂、性能更强大、更具成本效率的系统，是一个具有前景的方向。采用穿透硅通孔（Thmugh Silicon Via，TSV）的连接技术可以有效地实现这种3D芯片层叠。这个技术很快已经初具雏形：公司和研究中心已经找到许多可能的方法实现TSV，并与3D模块集成。

关键词：生产技术成本效率通孔穿透 Silicon 3D芯片硅连接技术

Decision modelling for economic evaluation of liver transplantation

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World Journal of Hepatology 2018年第11期10卷 837-848页

作者： Zhi Qu Christian Krauth Volker eric Amelung Alexander Kaltenborn Jill Gwiasda Lena Harries jan Beneke Harald Schrem Sebastian Liersch Core Facility Quality Management and Health Technology Assessment in Transplantation Integrated Research and Treatment Facility Transplantation (IFB-Tx) Hannover Medical School Hannover 30625 Germany Institute for Epidemiology Social Medicine and Health Systems Research Hannover Medical School Hannover 30625 Germany Visceral and Transplant Surgery Hannover Medical School Hannover 30625 Germany

As the gap between a shortage of organs and the im-mense demand for liver grafts persists, every available donor liver needs to be optimized for utility, urgency and equity. To overcome this challenge, decision modelling might allow us to gather evidence from previous studies as well as compare the costs and consequences of alternative options. For public health policy and clinical intervention assessment, it is a potentially powerful tool. The most commonly used types of decision analytical models include decision trees, the Markov model, microsimulation, discrete event simulation and the system dynamic model. Analytic models could support decision makers in the field of liver transplantation when facing specifc problems by synthesizing evidence, comprising all relevant options, generalizing results to other contexts, extending the time horizon and exploring the uncertainty. For modeling studies of economic evaluation for transplantation, understanding the current nature of the disease is crucial, as well as the selection of appropriate modelling techniques. The quality and availability of data is another key element for the selection and development of decision analytical models. In addition, good practice guidelines should be complied, which is important for standardization and comparability between economic outputs.

关键词： Cost benefit analysis Decision tree Liver transplantation Decision analysis Decision support models Resource allocation Cost effectiveness

Disease modifying treatment of spinal cord injury with directly reprogrammed neural precursor cells in non-human primates

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World Journal of Stem Cells 2021年第5期13卷 452-469页

作者： Vladimir P Baklaushev Oleg V Durov Vladimir A Kalsin Eugene V Gulaev Sergey V Kim Ilya L Gubskiy Veronika A Revkova Ekaterina M Samoilova Pavel A Melnikov Dzhina D Karal-Ogly Sergey V Orlov Alexander V Troitskiy Vladimir P Chekhonin Alexander V Averyanov jan-eric Ahlfors Biomedical Research Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBA of RussiaMoscow 115682MoskvaRussia Department of Neurosurgery Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBAMoscow 115682MoskvaRussia Department of Anesthesiology N.N.Blokhin Russian Cancer Research CentreMoscow 115478MoskvaRussia Radiology and Clinical Physiology Scientific Research Center Federal center of brain research and neurotechnologies of the Federal Medical Biological AgencyMoscow 117997Russia Department of Neurobiology Serbsky National Medical Research Center for Psychiatry and NarcologyMoscow 119992MoskvaRussia Department of Primatology Russian Acad Med SciResearch Institute of Medical PrimatologySochi 119992SochiRussia Department of Vascular Surgery Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBA of RussiaMoscow 115682MoskvaRussia Department of Basic and Applied Neurobiology V.P.Serbsky Federal Medical Research Center for Psychiatry and NarcologyRussia Department of Medical Nanobiotechnology Pirogov Russian National Research Medical University(RNRMU)Moscow 115682MoskvaRussia New World Laboratories Laval H7V 4A7QuebecCanada

BACKGROUND The development of regenerative therapy for human spinal cord injury(SCI)is dramatically restricted by two main challenges:the need for a safe source of functionally active and reproducible neural stem cells and the need of adequate animal models for preclinical *** reprogramming of somatic cells into neuronal and glial precursors might be a promising solution to the first *** use of non-human primates for preclinical studies exploring new treatment paradigms in SCI results in data with more translational relevance to human *** To investigate the safety and efficacy of intraspinal transplantation of directly reprogrammed neural precursor cells(drNPCs).METHODS Seven non-human primates with verified complete thoracic SCI were divided into two groups:drNPC group(n=4)was subjected to intraspinal transplantation of 5 million drNPCs rostral and caudal to the lesion site 2 wk post injury,and lesion control(n=3)was injected identically with the equivalent volume of *** Follow-up for 12 wk revealed that animals in the drNPC group demonstrated a significant recovery of the paralyzed hindlimb as well as recovery of somatosensory evoked potential and motor evoked potential of injured *** resonance diffusion tensor imaging data confirmed the intraspinal transplantation of drNPCs did not adversely affect the morphology of the central nervous system or cerebrospinal fluid *** immunohistochemical analysis showed that drNPCs maintained SOX2 expression characteristic of multipotency in the transplanted spinal cord for at least 12 wk,migrating to areas of axon growth *** Our data demonstrated that drNPC transplantation was safe and contributed to improvement of spinal cord function after acute SCI,based on neurological status assessment and neurophysiological recovery within 12 wk after *** functional improvement described was not associated with neuronal differentiation of th

关键词： Direct cell reprogramming Neural precursor cells Directly reprogrammed neural precursor cells Spinal cord injury Nonhuman primates Regenerative therapy,Evoked potentials

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圆桌论坛：中国债券市场开放2.0

债券 2019年第12期 24-28页

作者： Ricco Zhang Sophia Chung 竹下大介 eric jan eric Ching 国际资本市场协会亚太区汇丰银行证券服务中国区三菱日联银行(中国)有限公司霸菱投资管理(上海)有限公司中国区彭博电子交易解决方案团队

Ricco Zhang:汇丰银行是最早参与中国债券市场的外资银行,请谈一谈最近几年汇丰银行在中国债券市场的发展情况。Sophia Chung:在中国债券市场不断开放的进程中,汇丰银行非常自豪地见证并且深度参与了这一历程。从全球通(即直接投资)模... 详细信息

Ricco Zhang:汇丰银行是最早参与中国债券市场的外资银行,请谈一谈最近几年汇丰银行在中国债券市场的发展情况。Sophia Chung:在中国债券市场不断开放的进程中,汇丰银行非常自豪地见证并且深度参与了这一历程。从全球通(即直接投资)模式来看,汇丰银行所服务的境外机构已超过100家,机构类型越来越多样化。多个全球主流指数纳入了中国市场的资产,越来越多的境外资管公司因此加快了进入中国资本市场的步伐。

关键词：外资银行境外机构中国资本市场中国债券市场汇丰银行深度参与全球通债券市场开放

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工件材料可切削加工性评价的图示法研究

机械制造 2010年第2期48卷 36-38页

作者：徐林红江征风 jan-eric Stahl 武汉理工大学机电工程学院武汉430070 中国地质大学(武汉)机电工程学院武汉430074 Division of Production and Materials Engineering Lund University Divisionof Production and Materials Engineering Lund University

在分析影响工件材料切削加工性的主要因素的基础上,提出了用图示法直观地描述和评价工件材料的切削加工性的新的表达方法。该切削加工性图与工件材料的机械性能和物理性能直接关联,图上5根轴分别代表了材料的5种物理机械性能。在对材料... 详细信息

在分析影响工件材料切削加工性的主要因素的基础上,提出了用图示法直观地描述和评价工件材料的切削加工性的新的表达方法。该切削加工性图与工件材料的机械性能和物理性能直接关联,图上5根轴分别代表了材料的5种物理机械性能。在对材料的性能量化的基础上,通过和参考材料性能的比较,得到其他材料的切削加工性图。该切削加工性图可以帮助工程技术人员了解材料在切削过程中的表现,通过比较不同材料的切削加工性图,在新材料或未知材料的切削加工过程中指导选择切削刀具、切削参数及其他切削条件。

关键词：工件材料机械性能可切削加工性评价图示法

用于3D WLP和3D SIC的穿透硅通孔技术

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集成电路应用 2008年第7期25卷 45-47页

作者： jan Provoost Deniz Sabuncuoglu Tezcan Bart Swinnen eric Beyne IMEC

数家研究小组和公司已经展示了通过芯片叠层和穿透硅通孔（TSV）互连来实现复杂3D芯片的可行性。

关键词： 3D芯片通孔穿透 WLP SIC 技术硅

Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients

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World Journal of Gastroenterology 2009年第23期15卷 2887-2892页

作者： Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel jan Knol Kaouther Ben-Amor Louis MA Akkermans Gastrointestinal Research Unit Department of Gastroenterology and Surgery University Medical Center Utrecht Heidelberglaan 100 F02.618 3584CX Utrecht The Netherlands BioVisible BV LJ Zielstraweg 1 9713 GX Groningen The Netherlands Danone Research-Centre for Specialized Nutrition Bosrandweg 20 6704PH Wageningen The Netherlands

AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy ***: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology.

关键词： Irritable bowel syndrome Gut microbiota Bifidobacteria Bifidobacterium catenulatum

Screening for Anal Dysplasia in HIV-Infected Men Who Have Sex with Men By Anal Cytology, Human Papillomavirus Testing and Anoscopy

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World Journal of AIDS 2011年第2期1卷 37-42页

作者： Eefje Jong jan Willem Mulder Anne Catherina Theresia Maria Depla eric Cornelis Maria van Gorp Johan Westerga Claudie Flohil Anja Johanna Heijne-Tol Paulus Henricus Marinus Smits 不详

The incidence of anal cancer in HIV-infected men who have sex with men (MSM) is increasing and screening is advo-cated. In a cross-sectional study anal cytology specimens from 58 HIV-infected MSM were analyzed for adequacy, cy-tology and HPV DNA testing results and compared to findings on anoscopy. The adequacy of cytology specimens was high. In 34 (63%) of anal swab samples any grade of dysplasia was observed compared to 41 (71%) of biopsy speci-mens. The cytology specimens revealed high-grade dysplasia in 4 (7%) compared to 29 (50%) of biopsy specimens. The prevalence of high-risk HPV types was 90% by using the SPF10 PCR and 81% by using the Hybrid Capture II assay. Because of the high HPV prevalence, HPV DNA testing alone is not a suitable diagnostic screening tool for detecting anogenital lesions in this specific MSM population. Screening should include both anal cytology and anoscopy.

关键词： HIV Men Human Papillomavirus Anal Cancer Screening

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用原子力显微镜研究钢丝组织性能

金属制品 2004年第B5期30卷 59-62页

作者： Hilde Delrue eric Bruneel jan Van Humbeeck Etienne Aernoudt 窦光聚

原子力显微镜(AFM-Atomic Force Micro-scope)可以分辨变形珠光体的纳米级组织结构,结合扫描电子显微镜(SEM),定量和定性信息联系起来,对力学性能的径向梯度进行观察.

关键词：原子力显微镜力学性能显微组织梯度