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Rare etiology of colonic intussusception involving an adult with emphysematous cystic enteropathy:A case report and review of literature

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World journal of Clinical Cases 2024年第17期12卷 3161-3167页

作者： eric Bergeron Maude Pichette Geneviève Boisvert Thibaut Manière Étienne Désilets Department of Surgery Charles LeMoyne HospitalGreenfield Park J4V 2H1QuebecCanada Department of Medical Imaging Charles LeMoyne HospitalGreenfield Park J4V 2H1QuebecCanada Department of Gastroenterology Charles LeMoyne HospitalGreenfield Park J4V 2H1QuebecCanada

BACKGROUND Pneumatosis cystoides intestinalis(PCI),characterized by a collection of gas-filled cysts in the intestinal wall,is an uncommon but well-known condition in *** pain is the most frequent symptom associated with *** represents a potential cause of recurrent abdominal pain or emergency ***,the occurrence of colonic intussusception secondary to PCI is very unusual in *** SUMMARY A 52-year-old male,known with idiopathic PCI,presented seventeen months after initial diagnosis with a new right upper quadrant pain.A computed tomographyscan demonstrated a colonic intussusception at the hepatic *** did not progress compared with initial *** patient underwent an emergency right *** Resection was recommended in this case because PCI proved to be persisting with no identified curable *** allowed to address the underlying pathology,the potential relapse of intussusception,and the likely cause of recurrent abdominal pain,either invagination or PCI itself.

关键词： Pneumatosis cystoides intestinalis Colonic intussusception Colonic obstruction Colonoscopy Case report

A One Health approach to fight antimicrobial resistance in Uganda: Implementation experience, results, and lessons learned

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Biosafety and Health 2024年第2期6卷 125-132页

作者： Reuben Kiggundu j.P.Waswa Niranjan Konduri Hassan Kasuja Marion Murungi Patrick Vudriko Harriet Akello eric Lugada Cecilia Muiva Esther Were Dinah Tjipura Henry Kajumbula Kate Kikule Emmanuel Nfor Mohan P.joshi USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthKampala 256Uganda USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthArlingtonVA 22203USA College of Veterinary Medicine Animal Resources and BiosecurityMakerere UniversityKampala 256Uganda Ministry of Health Uganda Kampala 256Uganda USAID Strengthening Supply Chain Systems Activity Management Sciences for HealthKampala 256Uganda USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthNairobi 254Kenya Department of Microbiology College of Health SciencesMakerere UniversityKampala 256Uganda

Uganda has been implementing the Global Health Security Agenda(GHSA)since 2015 to build its capacity according to World Health Organization(WHO)Benchmarks on International Health Regulations *** country remains prone to outbreaks,with more than 20 disease outbreaks reported in the past five years,including Ebola virus disease,Crimean-Congo haemorrhagic fever,Marburg haemorrhagic fever,measles,yellow fever,coronavirus disease 2019(COVID-19),and *** resistance(AMR)is an ongoing *** scored capacity level 3 on infection prevention and control(IPC)and antimicrobial stewardship(AMS)in the 2017 joint External Evaluation(jEE)*** gaps were being addressed after a self-assessment in *** paper describes the technical assistance approaches provided to Uganda by the Medicines,Technologies,and Pharmaceutical Services Program,funded by the United States(U.S.)Agency for International Development,and implemented by Management Sciences for *** program,through a One Health approach,supported systematic capacity strengthening based on the jEE's capacity advancement framework for global health security,specifically relating to *** program's interventions impacted 32 WHO benchmark actions(7 for AMR multisectoral coordination,16 for IPC,and 9 for AMS),contributing to Uganda's strengthened GHSA *** success built on the AMR platform,the program trained 745 health workers in IPC for the Ebola virus and provided support for simulation exercises by eight district IPC *** program also worked with the Ministry of Health to coordinate IPC for the COVID-19 response in five health regions,covering 45 districts and reaching 5,452 health workers at 858 health facilities.

关键词： One health Antimicrobial resistance Antibiotic resistance jointexternal evaluation Global health security Uganda Africa WHO Benchmarks for International Health Regulations Capacities

Gαq takes centre stage in multiple sclerosis pathogenesis

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Cellular & Molecular Immunology 2017年第5期14卷 401-402页

作者： eric j Downer School of Medicine Discipline of PhysiologyTrinity Biomedical Sciences Institute Trinity Col-lege Dublin Dublin 2 Ireland

There is no cure for multiple sclerosis （MS）; however, a number of strategies exist for disease management, including medications that reduce the frequency of relapses and long-term accrual of disability.1 However, the fact that MS therapies can be partially effective and have the risk of side effects, in addition to the observation that disability often continues to worsen despite immunotherapy, has highlighted the need for novel therapeutic targets in the disease.

关键词： Gαq centre stage multiple sclerosis

Microstructural evolution of a heat-treated H23 tool steel

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International journal of Minerals,Metallurgy and Materials 2015年第3期22卷 272-284页

作者： Meilinda Nurbanasari Panos Tsakiropoulos eric j.Palmiere Department of Mechanical Engineering Institut Teknologi Nasional Department of Materials Science and Engineering The University of Sheffield

The microstructure and the stability of carbides after heat treatments in an H23 tool steel were investigated. The heat treatments consisted of austenization at two different austenizing temperatures （1100℃ and 1250℃）, followed by water quenching and double-aging at 650℃, 750℃, and 800℃with air cooling between the first and second aging treatments. Martensite did not form in the as-quenched micro- structures, which consisted of a ferrite matrix, M6C, M7C3, and MC carbides. The double-aged microstructures consisted of a ferrite matrix and MC, M6C, M7C3, and M23C6 carbides. Secondary hardening as a consequence of secondary precipitation of fine M2C carbides did not occur. There was disagreement between the experimental microstructure and the results of thermodynamic calculations. The highest double-aged hardness of the H23 tool steel was 448 HV after austenization at 1250℃ and double-aging at 650℃, which suggested that this tool steel should be used at temperatures below 650℃.

关键词： tool steel microstruc^ral evolution heat treatment carbides stability hardness

Effects of pH on rheological characteristics and stability of petroleum coke water slurry

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Petroleum Science 2016年第4期13卷 782-787页

作者： Fu-Yan Gao eric-j.Hu Ningbo Institute of Technology Zhejiang University School of Mechanical Engineering University of Adelaide

In this study, the effects of pH on slurrying properties of petroleum coke water slurry（PCWS） were investigated. The slurrying concentration, rheological characteristics and stability of PCWS were studied with four different types of additives at pH varying from 5 to *** results showed that the slurrying concentration, rheological characteristics and stability of PCWS all increased at first and then decreased with increasing pH from 5 to 11,and a pH of around 9 was found to be the most favorable acid–alkali environment to all these three slurrying properties. It was also indicated that only in a moderate alkaline environment can the additives be active enough to react with particle surfaces sufficiently to obtain good slurrying concentration and form a stable three-dimensional network structure, which can support strong pseudoplastic characteristics and good stability. An acid environment was a very unfavorable factor to the slurrying properties of PCWS.

关键词： Petroleum coke Petroleum coke water slurry pH Slurrying concentration Rheological characteristics Stability

Inherent relations between yield stress and stability of bubble petroleum coke water slurry

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Petroleum Science 2018年第1期15卷 157-163页

作者： Fu-Yan Gao eric j.Hu Ningbo Institute of Technology Zhejiang University School of Mechanical Engineering The University of Adelaide

The stability of petroleum coke water slurry（PCWS） is currently a hot topic. The inherent relationship between yield stress and stability of bubble-PCWS was studied through orthogonal experiments and range analysis in this work. The results showed that the stability of bubble-PCWS was positively related to the yield stress and that the yield stress could be greatly impacted by the operation conditions during preparation of bubble-PCWS. The main factors affecting the yield stress of bubble-PCWS were solid concentration, aeration time and dosage of frother. However, the effects of aperture size of air distribution plates and type of frother on the yield stress were slight within the experimental range. The optimal conditions for the greatest yield stress were as follows： aeration time of 30 min, solid concentration of 65 wt%, frother dosage of0.030 wt% of the air-dried pulverized petroleum coke, aperture size of air distribution plate of 2-5 lm and AOS *** yield stress and the pour rate of bubble-PCWS under this optimum operation condition could reach maxima of more than 0.4 Pa and 96%, respectively.

关键词： Petroleum coke Petroleum coke water slurry (PCWS) Stability Yield stress Orthogonal experiment

Retrograde jejunoduodenogastric intussusception due to a replacement percutaneous gastrostomy tube presenting as upper gastrointestinal bleeding

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World journal of Gastroenterology 2007年第39期13卷 5282-5284页

作者： eric Ibegbu Manish Relan Kenneth j Vega Divisions of Gastroenterology and General Internal Medicine University of Florida Health Science Center/Jacksonville Jacksonville FL32207 United States

Percutaneous endoscopic gastrostomy (PEG) tube complications can be serious or life threatening. Retrograde intussusception is a very rare complication of PEG tubes with only 9 cases reported in the literature. We describe a case of retrograde intussusception, associated with the use of a Foley catheter as a replacement gastrostomy tube, presenting with upper gastrointestinal bleeding. To our knowledge, this is the first reported case of PEG-related retrograde intussusception successfully managed in a non-surgical manner. Retrograde intussusception likely occurred due to migration of the replacement tube with resultant securing and invagination of the proximal jejunum when the gastrostomy tube was anchored to the abdominal wall.

关键词： Percutaneous endoscopic gastrostomy Intussusception Migration and upper gastrointestinal bleeding

Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease

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World journal of Gastroenterology 2008年第1期14卷 22-28页

作者： eric R Kallwitz Alan McLachlan Scott j Cotler Department of Medicine University of Illinois Chicago United States Department of Microbiology and Immunology University of Illinois Chicago United States

Nonalcoholic fatty liver disease （NAFLD） is highly prevalent and can result in nonalcoholic steatohepatitis （NASH） and progressive liver disease including cirrhosis and hepatocellular carcinoma. A growing body of literature implicates the peroxisome proliferators- activated receptors （PPARs） in the pathogenesis and treatment of NAFLD. These nuclear hormone receptors impact on hepatic triglyceride accumulation and insulin resistance. The aim of this review is to describe the data linking PPARα and PPART to NAFLD/NASH and to discuss the use of PPAR ligands for the treatment of NASH.

关键词： Non-alcoholic fatty liver disease Peroxisome proliferators-activated receptors Insulin resiatance Metabolic syndrome Pharmacologic ligands

Diurnal Regulation of Lipid Metabolism and Applications of Circadian Lipidomics

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journal of Genetics and Genomics 2014年第5期41卷 231-250页

作者： joshua j.Gooley eric Chern-Pin Chua Program in Neuroscience and Behavioral Disorders Duke-NUS Graduate Medical SchoolSingapore Division of Sleep and Circadian Disorders Departments of Medicine and Neurology Brigham and Women's Hospital Division of Sleep Medicine Harvard Medical School Program in Neuroscience and Behavioral Disorders Duke-NUS Graduate Medical School Singapore

The circadian timing system plays a key role in orchestrating lipid metabolism. In concert with the solar cycle, the circadian system ensures that daily rhythms in lipid absorption, storage, and transport are temporally coordinated with rest-activity and feeding cycles. At the cellular level, genes involved in lipid synthesis and fatty acid oxidation are rhythmically activated and repressed by core clock proteins in a tissue-specific manner. Consequently, loss of clock gene function or misalignment of circadian rhythms with feeding cycles （e.g., in shift work） results in impaired lipid homeostasis. Herein, we review recent progress in circadian rhythms research using lipidomics, i.e., large-scale profiling of lipid metabolites, to characterize circadian-regulated lipid pathways in mammals. In mice, novel regulatory circuits involved in fatty acid metabolism have been identified in adipose tissue, liver, and muscle. Extensive diversity in circadian regulation of plasma lipids has also been revealed in humans using lipidomics and other metabolomics approaches. In future studies, lipidomics platforms will be increasingly used to better understand the effects of genetic variation, shift work, food intake, and drugs on circadian-regulated lipid pathways and metabolic health.

关键词： Circadian Metabolism Lipids Lipidomics Metabolomics Chronobiology