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Cellular & Molecular Immunology 2016年第1期13卷 82-93页

作者： Zhuting hu Michael j Molloy Edward j Usherwood _Department of Microbiology and Immunology Geisel School of Medicine at Dartmouth Lebanon NH USA

CD4^＋ T-cell help （CD4 help） plays a pivotal role in CD8^＋ T-cell responses against viral infections. However, the role in primary CD8^＋ T-cell responses remains controversial. We evaluated the effects of infection route and viral dose on primary CD8^＋ T-cell responses to vaccinia virus （VACV） in MHC class II^-/- mice. CD4 help deficiency diminished the generation of VACV-specific CD8^＋ T cells after intraperitoneal （i.p.） but not after intranasal （i.n.） infection. A large viral dose could not restore normal expansion of VACV-specific CD8^＋ T cells in i.p. infected MHC II-/- mice. In contrast, dependence on CD4 help was observed in i.n. infected MHC II-/- mice when a small viral dose was used. These data suggested that primary CD8~ T-cell responses are less dependent on CD4 help in i.n. infection compared to i.p. infection. Activated CD8~ T cells produced more I FN-y, TNF-a and granzyme B in i.n. infected mice than those in i.p. infected mice, regardless of CD4 help. IL-2 signaling via CD25 was not necessary to drive expansion of VACV-specific CD8~ T cells in i.n. infection, but it was crucial in i.p. infection. VACV-specific CD8^＋ T cells underwent increased apoptosis in the absence of CD4 help, but proliferated normally and had cytotoxic potential, regardless of infection route. Our results indicate that route of infection and viral dose are two determinants for CD4 help dependence, and intranasal infection induces more potent effector CD8^＋ T cells than i.D. infection.

关键词： CD4 help MHC II^-/- mice primary CD8^+ T-cell response vaccinia virus

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插秧机自主驾驶控制系统设计与试验

农机化研究 2025年第4期47卷 102-109页

作者：胡聪魏新华江苏大学农业工程学院江苏镇江212013 现代农业装备与技术教育部重点实验室江苏镇江212013

为了满足插秧机自动驾驶作业需求,提高插秧机路径跟踪精度与作业效果,设计了插秧机自主驾驶控制系统。以电控化改造的久富2ZG-6D(G6)型插秧机为研究平台,基于北斗/GNSS定位建立了插秧机路径跟踪模型,提出一种改进的变论域模糊PID控制算... 详细信息

为了满足插秧机自动驾驶作业需求,提高插秧机路径跟踪精度与作业效果,设计了插秧机自主驾驶控制系统。以电控化改造的久富2ZG-6D(G6)型插秧机为研究平台,基于北斗/GNSS定位建立了插秧机路径跟踪模型,提出一种改进的变论域模糊PID控制算法,并结合仿真和田间实车试验,对控制系统性能进行验证。仿真试验中,插秧机路径跟踪过程中横向偏差绝对值始终控制在0.03 m之内;田间试验时,插秧机按照规划的目标路径进行路径跟踪,横向偏差绝对值多控制在0.05 m之内,正、负横向偏差均值为0.031、0.034 m。试验结果表明:插秧机在作业行直线跟踪精度较高,设计的控制系统满足插秧作业需求。

关键词：插秧机自动驾驶路径跟踪

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碳普惠制的实践检视与立法完善

河北大学学报（哲学社会科学版） 2025年第1期50卷 150-160页

作者：胡帮达华中科技大学法学院湖北武汉430074

碳普惠制是促进社会全面绿色转型的必要制度手段,属于生活消费端的自愿碳减排激励机制。从碳普惠的参与主体范围、行为类型、价值转化方式以及管理与监督等方面考察各省市实践发现,我国碳普惠制存在立法缺失、主体范围不清晰、行为缺乏... 详细信息

碳普惠制是促进社会全面绿色转型的必要制度手段,属于生活消费端的自愿碳减排激励机制。从碳普惠的参与主体范围、行为类型、价值转化方式以及管理与监督等方面考察各省市实践发现,我国碳普惠制存在立法缺失、主体范围不清晰、行为缺乏界定标准、价值转化方式体系化不足等问题。对此,有必要构建央地协同的碳普惠法律规范体系,通过拓宽碳普惠的参与主体类型、厘清碳普惠行为的边界、建立多元互通的价值转化体系来完善碳普惠制的内部要件,并通过建立碳普惠技术研发鼓励与支持机制、拓展资金来源渠道、强化数据安全风险监控以及创新宣传推广机制等措施来健全碳普惠制的外部保障体系。

关键词：碳普惠碳达峰碳中和自愿减排公众参与生态环境法典

水锤钻机应力释放法防范隧洞岩爆风险的试验研究与示范

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水利建设与管理 2025年第1期45卷 49-54页

作者：胡奎四川二滩国际工程咨询有限公司四川成都610503

在隧道施工中,岩爆会威胁施工人员的安全,是施工进程中的严重安全隐患。当前,岩爆预防和治理已成为国际性的技术难题,特别是在高强度岩爆频发的区域,其关乎隧道掘进机械(TBM)的安全与连续作业。为有效应对这一挑战,在引汉济渭岭南TBM第... 详细信息

在隧道施工中,岩爆会威胁施工人员的安全,是施工进程中的严重安全隐患。当前,岩爆预防和治理已成为国际性的技术难题,特别是在高强度岩爆频发的区域,其关乎隧道掘进机械(TBM)的安全与连续作业。为有效应对这一挑战,在引汉济渭岭南TBM第二掘进段施工中采用水锤钻机进行超前应力释放试验。通过收集和分析试验数据,初步确定了在何种地质条件下需要实施水锤钻机超前应力释放孔,并制定了相应的施工参数。这些成果将为隧道施工的工程实践提供有力的参考依据,确保工程的安全高效推进。

关键词：不良地质 TBM 岩爆水锤钻机超前应力释放

GraphFlow+:Exploiting Conversation Flow in Conversational Machine Comprehension with Graph Neural Networks

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Machine Intelligence Research 2024年第2期21卷 272-282页

作者： jing hu Lingfei Wu Yu Chen Po hu Mohammed j.Zaki School of Computer Science Central China Normal UniversityWuhan 430079China Pinterest San Francisco 94016USA Meta Mountain View 94039USA Rensselaer Polytechnic Institute Troy 12180USA

The conversation machine comprehension(MC)task aims to answer questions in the multi-turn conversation for a single ***,recent approaches don’t exploit information from historical conversations effectively,which results in some references and ellipsis in the current question cannot be *** addition,these methods do not consider the rich semantic relationships between words when reasoning about the passage *** this paper,we propose a novel model GraphFlow+,which constructs a context graph for each conversation turn and uses a unique recurrent graph neural network(GNN)to model the temporal dependencies between the context graphs of each ***,we exploit three different ways to construct text graphs,including the dynamic graph,static graph,and hybrid graph that combines the *** experiments on CoQA,QuAC and DoQA show that the GraphFlow+model can outperform the state-of-the-art approaches.

关键词： Conversational machine comprehension(MC) reading comprehension question answering graph neural networks(GNNs) natural language processing(NLP)

Deep learning automation of radiographic patterns for hallux valgus diagnosis

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World journal of Orthopedics 2024年第2期15卷 105-109页

作者： Angela hussain Cadence Lee eric hu Farid Amirouche Department of Orthopaedic Surgery University of Illinois College of MedicineChicagoIL 60612United States Department of Orthopaedics Surgery University of Illinois at ChicagoChicagoIL 60612United States Department of Orthopaedic Surgery Northshore University Health SystemSkokieIL 6007United States

Artificial intelligence(AI)and deep learning are becoming increasingly powerful tools in diagnostic and radiographic *** learning has already been utilized for automated detection of pneumonia from chest radiographs,diabetic retinopathy,breast cancer,skin carcinoma classification,and metastatic lymphadenopathy detection,with diagnostic reliability akin to medical *** the World journal of Orthopedics article,the authors apply an automated and AIassisted technique to determine the hallux valgus angle(HVA)for assessing HV foot *** the U-net neural network,the authors constructed an algorithm for pattern recognition of HV foot deformity from anteroposterior highresolution *** performance of the deep learning algorithm was compared to expert clinician manual performance and assessed alongside clinician-clinician *** authors found that the AI tool was sufficient in assessing HVA and proposed the system as an instrument to augment clinical *** further sophistication is needed to establish automated algorithms for more complicated foot pathologies,this work adds to the growing evidence supporting AI as a powerful diagnostic tool.

关键词： Artificial intelligence Hallux valgus Deep learning Automated radiography

An SBFEM-Based Model for Hydraulic Fracturing in Quasi-Brittle Materials

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Acta Mechanica Solida Sinica 2018年第4期31卷 416-432页

作者： F. Yao Z.j. Yang Y.j. hu College of Civil Engineering and Architecture Zhejiang University Hangzhou 310058 China School of Civil Engineering Shaoxing University Shaoxing 312000 China

A numerical model based on the scaled boundary finite element method is devel- oped to simulate the hydraulic fracturing in concrete-like quasi-brittle materials using cohesive interface elements. The shadow domain method developed previously （Yang and Deeks in Eng Fract Mech 143（4）：333 354, 2007） is extended to consider crack-width-dependent hydraulic pres- sure and cohesive traction, so that the stress intensity factors caused by both crack-face forces are semi-analytically calculated separately in the same way. The crack propagation is determined by the criterion of KI ≥ 0, and the propagation direction by the linear elastic fracture mechanics criteria. Two examples of concrete structures are modeled, and the results are in good agreement with the experimental data and others numerical results.

关键词： Scaled boundary finite element method Hydraulic fracture Cohesive crackmodel Crack propagation

Retrograde jejunoduodenogastric intussusception due to a replacement percutaneous gastrostomy tube presenting as upper gastrointestinal bleeding

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World journal of Gastroenterology 2007年第39期13卷 5282-5284页

作者： eric Ibegbu Manish Relan Kenneth j Vega Divisions of Gastroenterology and General Internal Medicine University of Florida Health Science Center/Jacksonville Jacksonville FL32207 United States

Percutaneous endoscopic gastrostomy (PEG) tube complications can be serious or life threatening. Retrograde intussusception is a very rare complication of PEG tubes with only 9 cases reported in the literature. We describe a case of retrograde intussusception, associated with the use of a Foley catheter as a replacement gastrostomy tube, presenting with upper gastrointestinal bleeding. To our knowledge, this is the first reported case of PEG-related retrograde intussusception successfully managed in a non-surgical manner. Retrograde intussusception likely occurred due to migration of the replacement tube with resultant securing and invagination of the proximal jejunum when the gastrostomy tube was anchored to the abdominal wall.

关键词： Percutaneous endoscopic gastrostomy Intussusception Migration and upper gastrointestinal bleeding

Nonlinear characteristics analyses of particle motion for predicting flow regimes

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Particuology 2020年第6期18卷 134-141页

作者： Panxing Kang Yujian Lu Lei Yang Libin Liu Xiayi(eric)hu Xiao Luo Hongbo Chen Yefeng Zhou Rui Zhang National and Local United Engineering Research Centre for Chemical Process Simulation and Intensification Chemical Process Simulation and Optimization Engineering Research Center of the Ministry of EducationXiangtan UniversityXiangtan 411105China College of Chemistry and Chemical Engineering Hunan UniversityChangsha 410082China

Gas-solid flow regimes have a significant impact on particle transport and separation in a fluidized bed *** this study,to determine flow regime transitions in gas-solid fluidized beds,an acoustic technique was used to detect and analyze the behavior of gas and *** complexity,fluctuation complexity,and Shannon entropy analyses of acoustic emission signals were performed to examine non linear system characteristics,and to determine the flow regime transiti on velocities uc,uk,and ufd-Moreover,using the standard deviation of pressure signals,pressure measurements and acoustic measurements were *** relative deviations(RDs)between the experimental and empirical values of uk were 8.8%,13.7%,8.8%,and 30.4%for the algorithm complexity,fluctuation complexity,Shannon entropy,and pressure signal standard deviation,respectively,while the respective RDs for Ufd were 15.7%,23.9%,15.7%,and 97.8%.The RDs between the experimental and empirical values of uc were all 6.4%.The experimental values obtained from acoustic signal measurements were therefore closer to the empirical *** summary,the integration of non-intrusive acoustic measurements,complexity analysis,and Shannon entropy analysis is suitable for identifying flow regime transitions.

关键词： Acoustic emission Nonlinear characteristics Complexity analysis Shannon entropy Flow regime transition

Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease

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World journal of Gastroenterology 2008年第1期14卷 22-28页

作者： eric R Kallwitz Alan McLachlan Scott j Cotler Department of Medicine University of Illinois Chicago United States Department of Microbiology and Immunology University of Illinois Chicago United States

Nonalcoholic fatty liver disease （NAFLD） is highly prevalent and can result in nonalcoholic steatohepatitis （NASH） and progressive liver disease including cirrhosis and hepatocellular carcinoma. A growing body of literature implicates the peroxisome proliferators- activated receptors （PPARs） in the pathogenesis and treatment of NAFLD. These nuclear hormone receptors impact on hepatic triglyceride accumulation and insulin resistance. The aim of this review is to describe the data linking PPARα and PPART to NAFLD/NASH and to discuss the use of PPAR ligands for the treatment of NASH.

关键词： Non-alcoholic fatty liver disease Peroxisome proliferators-activated receptors Insulin resiatance Metabolic syndrome Pharmacologic ligands