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Vestibular migraine in low-and lower-middle-income countries:A scoping review

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Journal of Otology 2023年第3期18卷 173-184页

作者： eric k.kim Amina Seguya May Htoo Thaw Peggy Tahir eric J.Formeister Christopher J.Waterworth Ali F.Jaffer The Global Otolaryngology-Head and Neck Surgery Initiative USA Department of Otolaryngology-Head and Neck Surgery University of CaliforniaSan FranciscoSan FranciscoCAUSA Ear Nose and Throat SurgeonMulago National Referral HospitalKampalaUganda Eye ORL-HNS HospitalMandalayMyanmar UCSF Library University of CaliforniaSan FranciscoCAUSA Department of Otolaryngology-Head and Neck Surgery Duke UniversityDurhamNCUSA Department of Audiology and Speech Pathology The University of MelbourneVictoriaAustralia Nossal Institute for Global Health University of MelbourneVictoriaAustralia HearWell Audiology Clinic Dar es SalaamTanzania

Background:Vestibular migraine(VM)is a common cause of dizziness that is underrecognized,underdiagnosed,and challenging to effectively *** prevalence,appropriate diagnostic workup,and therapies for VM in low-and lower-middle-income countries(LLMICs)remain *** objective of this scoping review is to evaluate the current state of VM research in ***:PubMed,Embase,and Web of Science databases were searched to execute a scoping review of ***“vestibular diseases”and“vertigo”were used in combination with terms referring to LLMICs as defined by the World *** and abstract screening,full-text review,and data collection were conducted by two authors ***:Twenty-six studies were included in the scoping *** studies were cross-sectional(57.7%)or case studies/series(23.1%)and were conducted in urban settings only(92.3%).Geographic distribution of studies was skewed,with 65.4%of articles originating from *** prevalence of VM among clinic patients ranged from 0.3%to 33.3%.VM most frequently presented as headache,nausea and vomiting,and *** imaging,audiometry,and electronystagmography/videonystagmography were the three most commonly utilized diagnostic modalities in the dizziness *** most studied pharmacotherapies included calcium channel blockers,followed by beta-blockers and *** studies and series discussed less common VM pharmacotherapies,such as ayurvedic ***:There is a need for more VM research in LLMICs,including innovative diagnostic approaches and therapies that can improve VM care *** partnerships between LLMIC and highincome country researchers must expand vestibular research capacity and productivity in LLMICs.

关键词： Vestibular migraine Migraine Global Otolaryngology Scoping review

Impact of an oligosaccharide-based polymer on the metabolic profiles and microbial ecology of weanling pigs experimentally infected with a pathogenic ***

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Journal of Animal Science and Biotechnology 2024年第2期15卷 749-764页

作者： kwangwook.kim Cynthia Jinno Xunde Li David Bravo eric Cox Peng Ji Yanhong Liu Department of Animal Science University of CaliforniaDavisCA 95616USA Department of Animal Science Michigan State UniversityEast LansingMI 48824USA Cedars-Sinai Medical Center Los AngelesCA 90084USA School of Veterinary Medicine University of CaliforniaDavisCA 95616USA Pancosma|ADM 1180 RolleSwitzerland Nutreco Exploration NutrecoThe Netherlands Department of Virology Parasitology and ImmunologyGhent University9000 GhentBelgium Department of Nutrition University of CaliforniaDavisCA 95616USA

Background Our previous study has reported that supplementation of oligosaccharide-based polymer enhances gut health and disease resistance of pigs infected with enterotoxigenic ***(ETEC)F18 in a manner similar to *** objective of this study was to investigate the impacts of oligosaccharide-based polymer or antibiotic on the host metabolic profiles and colon microbiota of weaned pigs experimentally infected with ETEC *** Multivariate analysis highlighted the differences in the metabolic profiles of serum and colon digesta which were predominantly found between pigs supplemented with oligosaccharide-based polymer and *** relative abundance of metabolic markers of immune responses and nutrient metabolisms,such as amino acids and carbohydrates,were significantly differentiated between the oligosaccharide-based polymer and antibiotic groups(q2.0).In addition,pigs in antibiotic had a reduced(P<0.05)relative abundance of Lachnospiraceae and Lactobacillaceae,whereas had greater(P<0.05)Clostridiaceae and Streptococcaceae in the colon digesta on d 11 post-inoculation(PI)compared with d 5 *** The impact of oligosaccharide-based polymer on the metabolic and microbial profiles of pigs is not fully understood,and further exploration is ***,current research suggest that various mechanisms are involved in the enhanced disease resistance and performance in ETEC-challenged pigs by supplementing this polymer.

关键词： Carbadox Colon microbiota Enterotoxigenic E.coli F18 Metabolomics Oligosaccharide-based polymer Weaned pigs

Supplementation of oligosaccharide-based polymer enhanced growth and disease resistance of weaned pigs by modulating intestinal integrity and systemic immunity

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Journal of Animal Science and Biotechnology 2022年第3期13卷 802-815页

作者： kwangwook.kim Yijie He Cynthia Jinno Lauren kovanda Xunde Li David Bravo eric Cox Yanhong Liu Department of Animal Science University of CaliforniaDavisCA 95616USA School of Veterinary Medicine University of CaliforniaDavisCA 95616USA Pancosma ADM 1180 RolleSwitzerland Department of Virology Parasitology and ImmunologyGhent University9000 GhentBelgium

Background:There is a great demand for antibiotic alternatives to maintain animal health and *** objective of this experiment was to determine the efficacy of dietary supplementation of a blood group A6 type 1antigen oligosaccharides-based polymer(Coligo)on growth performance,diarrhea severity,intestinal health,and systemic immunity of weaned pigs experimentally infected with an enterotoxigenic Escherichia coli(ETEC),when compared with ***:Pigs in antibiotic carbadox or Coligo treatment groups had greater(Peric lymph nodes on d 5 and 11 PI,whereas pigs in antibiotics or Coligo groups had reduced(P<0.05)total coliforms in spleen on d 11 PI compared with pigs in the control *** d 5 PI,pigs in the Coligo group had greater(P<0.05)gene expression of ZO1 in jejunal mucosa,but less(P<0.05)m RNA expression of IL1B,IL6,and TNF in ileal mucosa,in comparison with pigs in the control *** of antibiotics enhanced(P<0.05)the gene expression of OCLN in jejunal mucosa but decreased(P<0.05)IL1B and IL6 gene expression in ileal mucosa,compared with the *** d 11 PI,supplementation of antibiotics or Coligo up-regulated(P<0.05)gene expression of CLDN1 in jejunal mucosa,but Coligo reduced(P<0.05)IL6 gene expression in ileal mucosa compared to pigs in the control ***:Supplementation of Coligo improved growth performance,al

关键词： Enterotoxigenic E.coli Growth rate Intestinal barrier function Oligosaccharide-based polymer Systemic immunity Weaned pigs

A critical readability and quality analysis of internet-based patient information on neck dissections

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第1期9卷 59-65页

作者： Elysia M.Grose Hyun Joo kim Justine Philteos Marc Levin Jong Wook Lee eric A.Monteiro Department of Otolaryngology-Head and Neck Surgery University of Toronto6 Queen's Park Crescent WestTorontoM5S 3H2ONCanada Temerty Faculty of Medicine University of Toronto1 King's College CircleTorontoM5S 1A8ONCanada Department of Otolaryngology-Head and Neck Surgery Sinai Health System600 University AvenueTorontoM5G 1×5ONCanada

Objective:Patients are increasingly turning to the Internet as a source of healthcare *** that neck dissection is a common procedure within the field of Otolaryngology-Head and Neck Surgery,the aim of this study was to evaluate the quality and readability of online patient education materials on neck ***:A Google search was performed using the term"neck dissection."The first 10 pages of a Google search using the term"neck dissection"were *** DISCERN instrument was used to assess quality of *** was calculated using the Flesch-Reading Ease,Flesch-kincaid Grade Level,Gunning-Fog Index,Coleman-Liau Index,and Simple Measure of Gobbledygook ***:Thirty-one online patient education materials were ***-five percent(n=17)of results originated from academic institutions or *** mean Flesch-Reading Ease score was 61.2±***-two percent(n=16)of patient education materials had Flesch-Reading Ease scores above the recommended score of *** average reading grade level was 10.5±*** average total DISCERN score was 43.6±*** 26%of patient education materials(PEMs)had DISCERN scores corresponding to a"good quality"*** was a significant positive correlation between DISCERN scores and both Flesch-Reading Ease scores and average reading grade ***:The majority of patient education materials were written above the recommended sixth-grade reading level and the quality of online information pertaining to neck dissections was found to be *** research highlights the need for patient education materials regarding neck dissection that are high quality and easily understandable by patients.

关键词： Health literacy Neck dissection Online patient education materials Quality Readability

Meta-Analysis of the Expansion in the Field of Structural Biology of ABC Transporters

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BioDesign Research 2022年第1期2022卷 124-135页

作者： Soomi kim Teena Bajaj Cole Chabon eric Tablante Tatyana kulchinskaya Tae Seok Moon Ruchika Bajaj Stem Cell Technology Certificate Program City College of San FranciscoUSA Biotechnology Certificate Program City College of San FranciscoUSA Comparative Biochemistry Program University of California BerkeleyUSA Department of Energy Environmental and Chemical EngineeringWashington University in St.LouisUSA Department of Bioengineering and Therapeutics Sciences University of California San FranciscoUSA

ABC transporters are molecular machines which power the solute transport using ATP *** structural biology of ABC transporters has been exploding for the last few years,and this study explores timelines and trends for various attributes such as structural tools,resolution,fold,sources,and group *** study also evidences the significance of mammalian expression systems,advancements in structural biology tools,and the developing interest of group leaders across the world in the remarkably progressing *** field started in 2002 and bloomed in 2016,and COVID years were really productive to the ***,the study explores 337 structures of 58 unique ABC transporters deposited in the PDB database from which P-glycoprotein has the largest number of ***,62%of total structures are determined at the resolution of 3-4Åand 53%of structures belong to fold IV *** progressive advancements in the field,the field is shifting from prokaryotic to eukaryotic sources and X-ray crystallography to cryoelectron *** the nutshell,this study uniquely provides the detailed snapshot of the field of structural biology of ABC transporters with real-time data.

关键词： uniquely really shifting

Economic burden and healthcare utilization in nonalcoholic fatty liver disease

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 181-183页

作者： eric RYoo Aijaz Ahmed Donghee kim Department of Internal Medicine Santa Clara Valley Medical CenterSan JoseCAUSA Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordCAUSA

In the United States(US),the shift in the treatment paradigm following the introduction of second generation direct-acting antiviral(DAA)agents for hepatitis C virus(HCV)infection has favorably transformed the landscape of end-stage liver disease(ESLD)with a rapid decline in HCV-related liver transplantation;HCV had been the leading indication for liver transplantation for the last two decades(1).While the rate of liver transplantation in patients with HCV infection has plummeted in the US following the widespread application of DAA-based regimens in the pre-transplant setting,the rise in alcohol use disorder and obesity has catapulted alcoholic liver disease(ALD)to become the leading indication for liver transplantation in the US in 2016 followed closely by nonalcoholic steatohepatitis(NASH),a progressive subset of nonalcoholic liver disease(NAFLD)(1).Despite the decline in HCV-related liver transplantation in the US,the total number of liver transplants per year are on an upward trajectory as a result of marked increase in ESLD associated with ALD and NASH—an ominous trend.

关键词： nonalcoholic landscape spite

Bioreactor design and validation for manufacturing strategies in tissue engineering

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Bio-Design and Manufacturing 2022年第1期5卷 43-63页

作者： Diana Lim eric S.Renteria Drake S.Sime Young Min Ju Ji Hyun kim Tracy Criswell Thomas D.Shupe Anthony Atala Frank C.Marini Metin N.Gurcan Shay Soker Joshua Hunsberger James J.Yoo Wake Forest Institute for Regenerative Medicine Wake Forest School of MedicineWinston-SalemNC 27157USA Center for Biomedical Informatics Wake Forest School of MedicineWinston-SalemNC 27157USA RegenMed Development Organization(ReMDO) Winston SalemNC 27106USA

The fields of regenerative medicine and tissue engineering offer new therapeutic options to restore,maintain or improve tissue function following disease or *** maximize the biological function of a tissue-engineered clinical product,specific conditions must be maintained within a bioreactor to allow the maturation of the product in preparation for ***,the bioreactor should be designed to mimic the mechanical,electrochemical and biochemical environment that the product will be exposed to in ***-time monitoring of the functional capacity of tissue-engineered products during manufacturing is a critical component of the quality management *** present review provides a brief overview of bioreactor engineering *** addition,strategies for bioreactor automation,in-line product monitoring and quality assurance are discussed.

关键词： Bioreactor Monitoring sensors and automation Manufacturing Tissue engineering Regenerative medicine

Speed vernalization to accelerate generation advance in winter cereal crops

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Molecular Plant 2022年第8期15卷 1300-1309页

作者： Jin-kyung Cha kathryn O'Connor Samir Alahmad Jong-Hee Lee eric Dinglasan Hyeonjin Park So-Myeong Lee Dominique Hirsz Soon-Wook kwon Youngho kwon kyeong-Min kim Jong-Min ko Lee T.Hickey Dongjin Shin Laura E.Dixon National Institute of Crop Science RDAMiryang 50424Korea School of Biology Faculty of Biological SciencesUniversity of LeedsLeeds LS29JTUK Queensland Alliance for Agriculture and Food Innovation The University of QueenslandSt.LuciaQLDAustralia Department of Plant Bioscience Pusan National UniversityMiryang 60463Korea

There are many challenges facing the development of high-yielding,nutritious crops for future *** limiting factor is generation time,which prolongs research and plant breeding *** advances in speed breeding protocols have dramatically reduced generation time for many short-day and long-day species by optimizing lightand temperature conditions during plant ***,winter crops with a vernalization requirement stillrequire upto 6-10weeks in low-temperature conditions before thetransition to ***,we tested a suite of environmental conditions and protocols to investigate whether the vernalization process can be *** identified a vernalization method consisting of exposing seeds at the soil surface to an extended photoperiod of 22 h day:2 h night at 10°C with transfer to speed breeding conditions that dramatically reduces generation time in both winter wheat(Triticum aestivum)and winter barley(Hordeum vulgare).Implementation of the speedvernalization protocolfollowed byspeedbreedingallowed the completion ofuptofivegenerations per yearforwinter wheat or barley,whereas only two generations can be typically completed under standard vernalization and plant growth *** speed vernalization protocol developed in this study has great potential to accelerate biological research and breeding outcomes for winter crops.

关键词： speed breeding photoperiod temperature wheat barley breeding

Clinical epidemiology and disease burden of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2017年第47期23卷 8263-8276页

作者： Brandon J Perumpail Muhammad Ali khan eric R Yoo George Cholankeril Donghee kim Aijaz Ahmed Department of Medicine College of MedicineDrexel University Division of Gastroenterology and Hepatology Health Science CenterUniversity of Tennessee Department of Medicine Santa Clara Valley Medical Center Division of Gastroenterology and Hepatology Stanford University School of Medicine

Nonalcoholic fatty liver disease(NAFLD) is defined as the presence of hepatic fat accumulation after the exclusion of other causes of hepatic steatosis, including other causes of liver disease, excessive alcohol consumption, and other conditions that may lead to hepatic steatosis. NAFLD encompasses a broad clinical spectrum ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis(NASH), advanced fibrosis, cirrhosis, and finally hepatocellular carcinoma(HCC). NAFLD is the most common liver disease in the world and NASH may soon become the most common indication for liver transplantation. Ongoing persistence of obesity with increasing rate of diabetes will increase the prevalence of NAFLD, and as this population ages, many will develop cirrhosis and end-stage liver disease. There has been a general increase in the prevalence of NAFLD, with Asia leading the rise, yet the United States is following closely behind with a rising prevalence from 15% in 2005 to 25% within 5 years. NAFLD is commonly associated with metabolic comorbidities, including obesity, type Ⅱ diabetes, dyslipidemia, and metabolic syndrome. Our understanding of the pathophysiology of NAFLD is constantly evolving. Based on NAFLD subtypes, it has the potential to progress into advanced fibrosis, end-stage liver disease and HCC. The increasing prevalence of NAFLD with advanced fibrosis, is concerning because patients appear toexperience higher liver-related and non-liver-related mortality than the general population. The increased morbidity and mortality, healthcare costs and declining health related quality of life associated with NAFLD makes it a formidable disease, and one that requires more in-depth analysis.

关键词： Nonalcoholic fatty liver disease Hepatic steatosis Fatty liver Prevalence Incidence Fibrosis Risk factor Epidemiology Outcomes Nonalcoholic steatohepatitis