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Ombitasvir/paritaprevir/ritonavir + dasabuvir +/-ribavirin in real world hepatitis C patients

第十届全国疑难及重症肝病大会

作者： K.Rajender REDDY Ira M.jacobson Armand Abergel Barbara A.Leggett Charles S.Landis Robert Hyland Frances Chen Liyun Ni Anu O.Osinusi Diana Brainard jose Luis Calleja eric j.lawitz Andrew joseph Muir Alessandra Mangia UniversityofPennsylvania QIMRBerghoferMedicalResearchInstitute UniversityofWashington CentroDeInvestigacionBiomedicaEnRedDeEnfermedadesHepaticasyDigestivas(CIBERehd) Irccs-OspedaleCasaSollievoDellaSofferenza CHUClermontFerrand GileadSciencesInc. DukeClinicalResearchInstitute NewYorkUniversity GileadSciences Inc. TexasLiverInstitute UniversityofTexasHealthSanAntonio

背景一些研究表明,使用直接作用抗病毒药物(DAA)实现持续病毒学应答(SVR)与肝细胞癌(HCC)发生的减少相关。本研究评估了在吉利德登记处的一支包括6700余名患者的特征良好的队列中的SVR后新发HCC的发生率和预测因素。方法本研究进行了一...

背景一些研究表明,使用直接作用抗病毒药物(DAA)实现持续病毒学应答(SVR)与肝细胞癌(HCC)发生的减少相关。本研究评估了在吉利德登记处的一支包括6700余名患者的特征良好的队列中的SVR后新发HCC的发生率和预测因素。方法本研究进行了一项汇总分析,评估了吉利德SVR和肝硬化登记处的患者中的新发HCC的

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World journal of Gastroenterology 2019年第18期25卷 2229-2239页

作者： Nicole Loo eric lawitz Naim Alkhouri jennifer Wells Carmen Landaverde Angie Coste Rossalynn Salcido Michael Scott Fred Poordad Academic and Clinical Affairs Texas Liver Institute

BACKGROUND The hepatitis C virus(HCV) NS5A inhibitor ABT-267(ombitasvir, OBV), the HCV NS4/4A protease inhibitor ABT-450(paritaprevir, PTV), the CYP3A inhibitor ritonavir(r) and the non-nucleoside NS5B polymerase inhibitor ABT-333(dasabuvir, DSV)(OBV/PTV/r + DSV) with or without ribavirin(RBV) is a direct-acting antiviral regimen approved in the United States and other major countries for the treatment of HCV in genotype 1(GT1) infected patients. Patients with HCV who are considered "hard-to-cure" have generally been excluded from registration trials due to rigorous study inclusion criteria, presence of comorbidities and previous treatment *** To investigate the efficacy of this regimen in HCV G1-infected patients historically excluded from clinical *** Patients were ≥ 18 years old and chronically infected with HCV GT1(GT1a, GT1b or GT1a/1b). Patients were treatment-na?ve or previously failed a regimen including pegylated interferon/RBV +/-telaprevir, boceprevir, or *** hundred patients were treated with the study drug regimen, which was administered for 12 or 24 wk +/-RBV according to GT1 subtype and presence/absence of cirrhosis. Patients were evaluated every 4 wk from treatment day 1 and at 4 and 12 wk after *** Many of the patients studied had comorbidities(44.2% hypertensive, 33.7%obese, 20.2% cirrhotic) and 16% previously failed HCV treatment. Ninety-six patients completed study follow-up and 99% achieved 12-wk sustained virologic response. The majority(88.4%) of patients had undetectable HCV RNA by week 4. The most common adverse events were fatigue(12%), headache(10%),insomnia(9%) and diarrhea(8%); none led to treatment discontinuation. Physical and mental patient reported outcomes scores significantly improved after treatment. Almost all(98%) patients were treatment *** In an all-comers HCV GT1 population, 12 or 24-wk of OBV/PTV/r + DSV +/-RBV is highly effective and tolerable and results

关键词： Hepatitis C Ombitasvir Paritaprevir Ritonavir Dasabuvir Genotype 1

Gαq takes centre stage in multiple sclerosis pathogenesis

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Cellular & Molecular Immunology 2017年第5期14卷 401-402页

作者： eric j Downer School of Medicine Discipline of PhysiologyTrinity Biomedical Sciences Institute Trinity Col-lege Dublin Dublin 2 Ireland

There is no cure for multiple sclerosis （MS）; however, a number of strategies exist for disease management, including medications that reduce the frequency of relapses and long-term accrual of disability.1 However, the fact that MS therapies can be partially effective and have the risk of side effects, in addition to the observation that disability often continues to worsen despite immunotherapy, has highlighted the need for novel therapeutic targets in the disease.

关键词： Gαq centre stage multiple sclerosis

Chromate and selenate hydrocalumite solid solutions and their applications in waste treatment

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Science China(Life Sciences) 2005年第z1期48卷 165-173页

作者： eric j. Reardon Department of Earth Sciences University of Waterloo Waterloo Ontario Canada N2L 3G1

Hydrocalumite, a calcium aluminate hydrate phase, consists of positively-charged structure units, and is therefore an ideal candidate for accommodating anionic contaminants. In this study, a series of batch experiments was carried out to examine the uptake of chromate and selenate by hydrocalumite. To determine the uptake capacity and long-term stability, hydrocalumite solid solutions between chromate/selenate and hydroxyl were synthesized over a reaction time of more than one year. At a ratio of water to initial solids added (CaAl2O4+CaO) of 75: 1, the maximum uptake capacities were over 77 and 114 g/kg for Cr and Se, *** values are very close to the theoretical uptake capacities of chromate and selenate hydrocalumite end-members (81 and 118 g/kg, respectively). The oxyanion removal efficiency from solution was above 95%. Due to the high uptake capacity and anion removal efficiency of hydrocalumites, their application in wastewater treatment is promising. Hydrocalumites are also important hydration products of cementitious materials and the long-term stability of these phases is of significance for application in solidification/stabilization technology.

关键词： chromate, selenate, hydrocalumite, uptake capacity, stability.

Characterization of patients with both alcoholic and nonalcoholic fatty liver disease in a large United States cohort

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World journal of Hepatology 2019年第10期11卷 710-718页

作者： George Khoudari Amandeep Singh Mazen Noureddin Danielle Fritze Rocio Lopez Imad Asaad eric lawitz Fred Poordad Kris V Kowdley Naim Alkhouri Department of Hospital Medicine Cleveland Clinic FoundationClevelandOH 44195United States Department of Gastroenterology and Hepatology Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology and Hepatology Cedars Sinai Medical CenterLos AngelesCA 90048United States Department of General Surgery Texas Liver Institute and University of Texas HealthSan AntonioTX 78215United States Department of Quantitative Health Sciences Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology Metro Health SystemClevelandOH 44109United States Texas Liver Institute and University of Texas Health San AntonioTX 78215United States Swedish Liver Care Network Swedish Medical CenterSeattleWA 98122United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is the hepatic manifestation of the metabolic syndrome(MetS)and is characterized by steatosis in the absence of significant alcohol ***,MetS and significant alcohol intake coexist in certain individuals which may lead to the development of *** To assess the clinical characteristics of patients with both alcoholic and NAFLD(BAFLD)in a large cohort in the United *** Adults from the National Health and Nutrition Examination Survey between 2003-2014 were *** was diagnosed based on elevated alanine aminotransferase(ALT)and being overweight or obese in the absence of other liver *** patients met the criteria for NAFLD but also had either MetS or type 2 diabetes and consumed excessive amounts of *** and multivariable analysis were performed to assess differences between NAFLD and BAFLD and to compare severity based on a validated fibrosis score(FIB4 index).RESULTS The prevalence of NAFLD was at 25.9%(95%CI;25.1-26.8)and that of BAFLD was 0.84%(0.67,1.02)which corresponds to an estimated 1.24 million Americans affected by *** to NAFLD,patients with BAFLD were more likely to be male,smokers,have higher ALT,aspartate aminotransferase,triglycerides,and lower platelets;Pjusting for MetS components,BAFLD patients were significantly more likely to have advanced fibrosis[adjusted OR(95%CI)based on FIB4 index>2.67 was 3.2(1.4,7.0),P=0.004].CONCLUSION A significant percentage of the American general population is afflicted by BAFLD and these patients tend to have more advanced liver fibrosis.

关键词： Non-alcoholic fatty liver disease Alcoholic liver disease Fatty liver disease

Microstructural evolution of a heat-treated H23 tool steel

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International journal of Minerals,Metallurgy and Materials 2015年第3期22卷 272-284页

作者： Meilinda Nurbanasari Panos Tsakiropoulos eric j.Palmiere Department of Mechanical Engineering Institut Teknologi Nasional Department of Materials Science and Engineering The University of Sheffield

The microstructure and the stability of carbides after heat treatments in an H23 tool steel were investigated. The heat treatments consisted of austenization at two different austenizing temperatures （1100℃ and 1250℃）, followed by water quenching and double-aging at 650℃, 750℃, and 800℃with air cooling between the first and second aging treatments. Martensite did not form in the as-quenched micro- structures, which consisted of a ferrite matrix, M6C, M7C3, and MC carbides. The double-aged microstructures consisted of a ferrite matrix and MC, M6C, M7C3, and M23C6 carbides. Secondary hardening as a consequence of secondary precipitation of fine M2C carbides did not occur. There was disagreement between the experimental microstructure and the results of thermodynamic calculations. The highest double-aged hardness of the H23 tool steel was 448 HV after austenization at 1250℃ and double-aging at 650℃, which suggested that this tool steel should be used at temperatures below 650℃.

关键词： tool steel microstruc^ral evolution heat treatment carbides stability hardness

Effects of pH on rheological characteristics and stability of petroleum coke water slurry

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Petroleum Science 2016年第4期13卷 782-787页

作者： Fu-Yan Gao eric-j.Hu Ningbo Institute of Technology Zhejiang University School of Mechanical Engineering University of Adelaide

In this study, the effects of pH on slurrying properties of petroleum coke water slurry（PCWS） were investigated. The slurrying concentration, rheological characteristics and stability of PCWS were studied with four different types of additives at pH varying from 5 to *** results showed that the slurrying concentration, rheological characteristics and stability of PCWS all increased at first and then decreased with increasing pH from 5 to 11,and a pH of around 9 was found to be the most favorable acid–alkali environment to all these three slurrying properties. It was also indicated that only in a moderate alkaline environment can the additives be active enough to react with particle surfaces sufficiently to obtain good slurrying concentration and form a stable three-dimensional network structure, which can support strong pseudoplastic characteristics and good stability. An acid environment was a very unfavorable factor to the slurrying properties of PCWS.

关键词： Petroleum coke Petroleum coke water slurry pH Slurrying concentration Rheological characteristics Stability

Inherent relations between yield stress and stability of bubble petroleum coke water slurry

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Petroleum Science 2018年第1期15卷 157-163页

作者： Fu-Yan Gao eric j.Hu Ningbo Institute of Technology Zhejiang University School of Mechanical Engineering The University of Adelaide

The stability of petroleum coke water slurry（PCWS） is currently a hot topic. The inherent relationship between yield stress and stability of bubble-PCWS was studied through orthogonal experiments and range analysis in this work. The results showed that the stability of bubble-PCWS was positively related to the yield stress and that the yield stress could be greatly impacted by the operation conditions during preparation of bubble-PCWS. The main factors affecting the yield stress of bubble-PCWS were solid concentration, aeration time and dosage of frother. However, the effects of aperture size of air distribution plates and type of frother on the yield stress were slight within the experimental range. The optimal conditions for the greatest yield stress were as follows： aeration time of 30 min, solid concentration of 65 wt%, frother dosage of0.030 wt% of the air-dried pulverized petroleum coke, aperture size of air distribution plate of 2-5 lm and AOS *** yield stress and the pour rate of bubble-PCWS under this optimum operation condition could reach maxima of more than 0.4 Pa and 96%, respectively.

关键词： Petroleum coke Petroleum coke water slurry (PCWS) Stability Yield stress Orthogonal experiment

An ensemble method for gene discovery based on DNA microarray data

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Science China(Life Sciences) 2004年第5期47卷 396-405页

作者： Kathy L. MOSER eric j. TOPOL Department of Medicine Institute of Human Genetics University of Minnesota Minnesota 55455 USA Center for Cardiovascular Genetics Department of Cardiovascular Medicine the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USADepartment of Molecular Cardiology the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USA

The advent of DNA microarray technology has offered the promise of casting new insights onto deciphering secrets of life by monitoring activities of thousands of genes simulta-neously. Current analyses of microarray data focus on precise classification of biological types, for example, tumor versus normal tissues. A further scientific challenging task is to extract dis-ease-relevant genes from the bewildering amounts of raw data, which is one of the most critical themes in the post-genomic era, but it is generally ignored due to lack of an efficient approach. In this paper, we present a novel ensemble method for gene extraction that can be tailored to fulfill multiple biological tasks including (i) precise classification of biological types; (ii) disease gene mining; and (iii) target-driven gene networking. We also give a numerical application for (i) and (ii) using a public microarrary data set and set aside a separate paper to address (iii).

关键词： microarrays,ensemble decision,recursive partition tree,feature gene selection.