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Exploring treatment options for biliary tract cancers:moving beyond the era of gemcitabine and platinum doublet

hepatobiliary Surgery and Nutrition 2024年第3期13卷 562-565页

作者： Jung Sun kim hong Jae Chon Department of Medical Oncology CHA Bundang Medical CenterCHA University School of MedicineSeongnamRepublic of Korea

Biliary tract cancers(BTCs)refer to invasive adenocarcinomas arising from the bile duct(intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma)and gallbladder(gallbladder cancer).Patients with BTCs typically present at an advanced stage due to a lack of early detection methods and non-specific symptoms;systemic chemotherapy is the cornerstone of treatment for these advanced *** plus cisplatin(GC)has been the standard treatment since the pivotal ABC-02 randomized phase 3 trial conducted in 2010(1).Moving beyond the era of GC,several triplet combination regimens have been proposed in recent years(Table 1).The combination of nab-paclitaxel(nab-P)and GC showed promising survival outcomes in a phase 2 trial(2),although it eventually failed to meet the primary endpoint of overall survival(OS)in a randomized phase 3 trial(3).Around the same time,TOPAZ-1(5)demonstrated that the programmed death ligand 1(PD-L1)inhibitor durvalumab combined with GC significantly improved the median OS[11.5 vs.12.8 months;hazard ratio(hR),0.80;95%confidence interval(CI):0.66–0.97;P=0.021]and median progression-free survival(PFS)(5.7 vs.7.2 months;hR,0.75;95%CI:0.63–0.89;P=0.001),with an objective response rate(ORR)of 26.7%.Moreover,KEYNOTE-966(6)found that the addition of programmed death-1(PD-1)inhibitor pembrolizumab also improved median OS(10.9 vs.12.7 months;hR,0.83;95%CI:0.72–0.95;P=0.0034),whereas the median PFS only showed numerical improvements(5.6 vs.6.5 months;hR,0.86;95%CI:0.75–1.00;P=0.023),with an ORR of 29%.Consequently,the combination of PD-1/PD-L1 inhibitors and GC has become the new standard of care for first-line treatment of patients with BTCs,establishing the new era of triplet combinations.

关键词： Biliary tract cancer cholangiocarcinoma gallbladder cancer

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Optimal timing of invasive intervention for high-risk non-ST-segment-elevation myocardial infarction patients

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Journal of Geriatric Cardiology 2024年第8期21卷 807-815页

作者： Juan-Juan ZhENG Yue-Qiao SI Tian-Yang XIA Bing-Jun LU Chun-Yu ZENG Wei-eric WANG Department of Geriatrics Southwest HospitalThird Military Medical UniversityChongqingChina Department of Cardiology Daping HospitalThird Military Medical UniversityChongqingChina

OBJECTIVE To compare the immediate,early,and delayed percutaneous coronary intervention(PCI)strategies in non-ST-segment-elevation myocardial infarction(NSTEMI)patients with *** Medical records of patients treated at the Daping hospital,Third Military Medical University,Chongqing,China between 2011 and 2021 were retrospectively *** patients with complete available information were *** patients assigned into three groups based on the timing of PCI including immediate(h),early(2–24 h)and delayed(≥24 h)*** Cox hazards regression and simpler nonlinear models were *** A total of 657 patients were included in the *** median follow-up length was 3.29(interquartile range:1.45–4.85)*** PCI strategy improved the major adverse cardiac event(MACE)outcome compared to the immediate or delayed PCI *** PCI,diabetes mellitus,and left main or/and left anterior descending or/and left circumflex stenosis or/and right coronary artery≥99%were predictors for MACE *** optimal timing range for PCI to reduce MACE risk is 3–14 h *** high-risk NSTEMI patients,early PCI reduced primary clinical outcomes compared to immediate or delayed PCI,and the optimal timing range was 3–14 h *** PCI was superior for NSTEMI with chronic kidney *** Delayed invasive strategy was helpful to reduce the incidence of MACE for high-risk NSTEMI with chronic kidney *** immediate PCI strategy might increase the rate of MACE.

关键词： patients infarction Chongqing

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Tidal effects based on a GUP-induced effective metric

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Communications in Theoretical Physics 2024年第9期76卷 63-72页

作者： Soon-Tae hong Yong-Wan kim Young-Jai Park Center for Quantum Spacetime and Department of Physics Sogang UniversitySeoul 04107Republic of Korea Department of Physics and Research Institute of Physics and Chemistry Jeonbuk National UniversityJeonju 54896Republic of Korea Department of Physics Sogang UniversitySeoul 04107Republic of Korea

In this paper,we study tidal forces in the Schwarzschild black hole,whose metric explicitly includes a generalized uncertainty principle(GUP)*** also investigate interesting features of the geodesic equations and tidal effects that are dependent on the GUP parameterαrelated to a minimum ***,by solving the geodesic deviation equations explicitly with appropriate boundary conditions,we show thatαin the effective metric affects both the radial and angular components of the geodesic equation,particularly near the singularities.

关键词： generalized uncertainty principle geodesic deviation equation effective metric

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Surface-modified Ag@Ru-P25 for photocatalytic CO_(2) conversion with high selectivity over Ch_(4) formation at the solid–gas interface

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Carbon Energy 2024年第1期6卷 182-196页

作者： Chaitanya B.hiragond Sohag Biswas Niket SPowar Junho Lee Eunhee Gong hwapyong kim hong Soo kim Jin-Woo Jung Chang-hee Cho Bryan M.Wong Su-Il In Department of Energy Science&Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of Chemical&Environmental Engineering Materials Science&Engineering ProgramDepartment of ChemistryDepartment of Physics&AstronomyUniversity of California-RiversideRiversideCaliforniaUSA Department of Physics and Chemistry Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea NiceScience Corporation DaeguRepublic of Korea

Systematic optimization of the photocatalyst and investigation of the role of each component is important to maximizing catalytic activity and comprehending the photocatalytic conversion of CO_(2) reduction to solar fuels.A surface-modified Ag@Ru-P25 photocatalyst with h_(2)O_(2) treatment was designed in this study to convert CO_(2) and h_(2)O vapor into highly selective *** doping followed by Ag nanoparticles(NPs)cocatalyst deposition on P25(TiO_(2))enhances visible light absorption and charge separation,whereas h_(2)O_(2) treatment modifies the surface of the photocatalyst with hydroxyl(–Oh)groups and promotes CO_(2) ***-resonance transmission electron microscopy,X-ray photoelectron spectroscopy,X-ray absorption near-edge structure,and extended X-ray absorption fine structure techniques were used to analyze the surface and chemical composition of the photocatalyst,while thermogravimetric analysis,CO_(2) adsorption isotherm,and temperature programmed desorption study were performed to examine the significance of h_(2)O_(2) treatment in increasing CO_(2) reduction *** optimized Ag1.0@Ru1.0-P25 photocatalyst performed excellent CO_(2) reduction activity into CO,Ch4,and C2h6 with a~95%selectivity of Ch4,where the activity was~135 times higher than that of pristine TiO_(2)(P25).For the first time,this work explored the effect of h_(2)O_(2) treatment on the photocatalyst that dramatically increases CO_(2) reduction activity.

关键词： gas-phase CO_(2) reduction h_(2)O_(2) treatment plasmonic nanoparticles solar fuel photocatalyst surface modification

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Periodontitis-induced systemic inflammation exacerbates atherosclerosis partly via endothelial–mesenchymal transition in mice

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International Journal of Oral Science 2019年第3期11卷 201-212页

作者： Jin Sook Suh Sol kim Kristina I.Bostrom Cun-Yu Wang Reuben h.kim No-hee Park The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of DentistryLos AngelesCAUSA Department of Medicine David Geffen School of Medicine at UCLALos AngelesCAUSA Division of Oral Biology and Medicine UCLA School of DentistryLos AngelesCAUSA UCLA Jonsson Comprehensive Cancer Center Los AngelesCAUSA Department of Bioengineering UCLA Samueli School of EngineeringLos AngelesCAUSA

Growing evidence suggests close associations between periodontitis and *** further understand the pathological relationships of these associations,we developed periodontitis with ligature placement around maxillary molars or ligature placement in conjunction with Porphyromonas gingivalis lipopolysaccharide injection at the ligature sites (ligature/***) in Apolipoprotein E knock out mice and studied the atherogenesis process in these *** mice were fed with high fat diet for 11 weeks and sacrificed for analyzing periodontitis,systemic inflammation,and *** did not develop periodontitis or systemic inflammation and had minimal lipid deposition in the aortas,but mice receiving ligature or ligature/*** showed severe periodontitis,systemic inflammation,and aortic plaque *** aortic plaque contained abundant macrophages and cells expressing both endothelial and mesenchymal cell *** severity of periodontitis was slightly higher in mice receiving ligature/*** than ligature alone,and the magnitude of systemic inflammation and aortic plaque formation were also notably greater in the mice with ligature/*** observations indicate that the development of atherosclerosis is due to systemic inflammation caused by severe *** vitro,*** enhanced the secretion of pro-inflammatory cytokines from macrophages and increased the adhesion of monocytes to endothelial cells by upregulating the expression of adhesion molecules from endothelial ***,secretory proteins,such as TNF-α,from macrophages induced endothelial–mesenchymal transitions of the endothelial *** together,systemic inflammation induced by severe periodontitis might exacerbate atherosclerosis via,in part,causing aberrant functions of vascular endothelial cells and the activation of macrophages in mice.

关键词： via aortic cells TNF-α did had but was

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Storylines of family medicine Ⅲ:core principles—primary care,systems and family

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Family Medicine and Community health 2024年第S3期12卷 23-32页

作者： William B Ventres Leslie A Stone Timothy A Joslin John W Saultz Sommer Aldulaimi Paul R Gordon John C Lane eric R Lee Jacob Prunuske Limor Gildenblatt Michael h Friedman Colleen T Fogarty Susan h McDaniel Tessa Rohrberg Amy Odom Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine Oregon Health&Science UniversityPortlandOregonUSA Family and Community Medicine University of Arizona Medical Center–South CampusTucsonArizonaUSA Family and Community Medicine University of Arizona Medical Center–University CampusTucsonArizonaUSA UAMS West Regional Campus Family Medicine Residency Program Fort SmithArkansasUSA Medical College of Wisconsin–Central Wisconsin Campus WausauWisconsinUSA Family and Community Medicine Medical College of Wisconsin–Central Wisconsin CampusWausauWisconsinUSA Family Medicine Advocate Illinois Masonic Medical CenterChicagoIllinoisUSA Family Medicine Presence Saints Mary and Elizabeth Medical CenterChicagoIllinoisUSA Family Medicine University of Rochester Medical CenterRochesterNew YorkUSA Psychiatry and Family Medicine University of Rochester Medical CenterRochesterNew YorkUSA Family and Community Medicine University of Kansas School of Medicine-WichitaWichitaKansasUSA Sparrow/Michigan State University Family Medicine Residency Program LansingMichiganUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅲ:core principles—primary care,systems,and family’,authors address the following themes:‘Continuity of care—building therapeutic relationships over time’,‘Comprehensiveness—combining breadth and depth of scope’,‘Coordination of care—managing multiple realities’,‘Access to care—intersectional,systemic,and personal’,‘Systems theory—a core value in patient-centered care’,‘Family-oriented practice—supporting patients’health and well-being’,‘Family physician as family member’and‘Family in the exam room’.May readers develop new understandings from these essays.

关键词： individual Storyline principles

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电沉积Mo和Mo-Co合金纳米线用于互联电阻的电阻率改性

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Engineering 2024年第1期32卷 127-137页

作者： Jun hwan Moon Taesoon kim Youngmin Lee Seunghyun kim Yanghee kim Jae-Pyoung Ahn Jungwoo Choi hyuck Mo Lee Young Keun kim Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and EngineeringDaejeon 34141Republic of Korea Advanced Analysis Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Research Resources Division Korea Institute of Science and TechnologySeoul 02792Republic of Korea

Achieving historically anticipated improvement in the performance of integrated circuits is challenging,due to the increasing cost and complexity of the required technologies with each new *** overcome this limitation,the exploration and development of novel interconnect materials and processes are highly desirable in the microelectronics ***(Mo)is attracting attention as an advanced interconnect material due to its small resistivity size effect and high cohesive energy;however,effective processing methods for such materials have not been widely ***,we investigate the electrochemical behavior of ions in the confined nanopores that affect the electrical properties and microstructures of nanoscale Mo and Mo-Co alloys prepared via template-assisted *** in an electrolyte allow the deposition of extremely pure metal materials,due to their interac-tion with metal ions and *** this study,boric acid and tetrabutylammonium bisulfate(TBA)were added to an acetate bath to inhibit the hydrogen evolution *** accelerated the reduction of Mo at the surface by inducing surface conduction on the *** Mo nanowires with a 130 nm diameter synthesized through high-aspect-ratio nanopore engineering exhibited a resistivity of(63.0±17.9)μΩ*** also evaluated the resistivities of Mo-Co alloy nanowires at various compo-sitions toward replacing irreducible conventional barrier/liner *** intermetallic compound formed at a Mo composition of 28.6 at%,the resistivity of the Mo-Co nanowire was(58.0±10.6)μΩcm,indicat-ing its superior electrical and adhesive properties in comparison with those of conventional barriers such as TaN and ***,density functional theory and non-equilibrium Green's function calcula-tions confirmed that the vertical resistance of the via structure constructed from Mo-based materials was 21%lower than that of a conventional Cu/Ta/TaN structure.

关键词： Molybdenum Molybdenum-cobalt Interconnect Microstructure Electrodeposition Density functional theory

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Interfacial engineering through lead binding using crown ethers in perovskite solar cells

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Journal of Energy Chemistry 2024年第5期92卷 263-270页

作者： Sun-Ju kim YeonJu kim Ramesh Kumar Chitumalla Gayoung ham Thanh-Danh Nguyen Joonkyung Jang hyojung Cha Jovana Milić Jun-ho Yum Kevin Sivula Ji-Youn Seo Department of Nano Fusion Technology Pusan National UniversityBusan 46241Republic of Korea Laboratory for Molecular Engineering of Optoelectronic Nanomaterials Institute of Chemical Sciences and EngineeringÉcole Polytechnique Fédérale de Lausanne(EPFL)1015 LausanneSwitzerland Department of Energy Convergence and Climate Change Kyungpook National UniversityDaegu 41566Republic of Korea Department of hydrogen and Renewable Energy Kyungpook National UniversityDaegu 41566Republic of Korea Adolphe Merkle Institute University of FribourgCH-1700 FribourgSwitzerland

In the domain of perovskite solar cells(PSCs),the imperative to reconcile impressive photovoltaic performance with lead-related issue and environmental stability has driven innovative *** study pioneers an approach that not only rectifies lead leakage but also places paramount importance on the attainment of rigorous interfacial *** ethers,notably benzo-18-crown-6-ether(B18C6),were strategically integrated at the perovskite-hole transport material *** ethers exhibit a dual role:efficiently sequestering and immobilizing Pb^(2+)ions through host-guest complexation and simultaneously establishing a robust interfacial passivation *** crown ether candidates,guided by density functional theory(DFT)calculations,demonstrated proficiency in binding Pb2+ions and optimizing interfacial *** devices incorporating these materials achieved exceptional power conversion efficiency(PCE),notably 21.7%for B18C6,underscoring their efficacy in lead binding and interfacial *** techniques,including time-of-flight secondary ion mass spectrometry(ToF-SIMS),ultraviolet photoelectron spectroscopy(UPS),time-resolved photoluminescence(TRPL),and transient absorption spectroscopy(TAS),unequivocally affirmed Pb^(2+)ion capture and suppression of non-radiative ***,these PSCs maintained efficiency even after enduring 300 h of exposure to 85%relative *** research underscores the transformative potential of crown ethers,simultaneously addressing lead binding and stringent interfacial passivation for sustainable PSCs poised to commercialize and advance renewable energy applications.

关键词： Perovskite solar cells Interfacial passivation Crown ether materials Stability

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Vapors in the ambient-A complication in tribological studies or an engineering solution of tribological problems?

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Friction 2015年第2期3卷 85-114页

作者： Ala ALAZIZI Anthony J.BARThEL Nicholas D.SURDYKA Jiawei LUO Seong h.kim Department of Chemical Engineering and Materials Research Institute Pennsylvania State UniversityUniversity ParkPA 16802USA

Tribology involves not only two-body contacts of two solid materials-a substrate and a counter-surface;it often involves three-body contacts whether the third body is intentionally introduced or inevitably added during the sliding or *** intentionally added third body could be lubricant oil or engineered nano-material used to mitigate the friction and wear of the sliding *** inevitably added third body could be wear debris created from the substrate or the counter surface during *** in the absence of any solid third-body between the sliding surfaces,molecular adsorption of water or organic vapors from the surrounding environment can dramatically alter the friction and wear behavior of solid surfaces tested in the absence of lubricant *** review article covers the last case:the effects of molecular adsorption on sliding solid surfaces both inevitably occurring due to the ambient test and intentionally introduced as a solution for engineering *** will review how adsorbed molecules can change the course of wear and friction,as well as the mechanical and chemical behavior,of a wide range of materials under sliding conditions.

关键词： vapor phase lubrication environmental effect

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Mixed-dimensional stacked nanocomposite structures for a specific wavelength-selectable ambipolar photoresponse

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Nano Research 2024年第6期17卷 5549-5558页

作者： Young Jae Park Jaeho Shim Joo Song Lee Kyu Seung Lee Ji-Yeon kim Kang Bok Ko Sang-Youp Yim Seongjun kim hoon-Kyu Shin Donghee Park Yong Ju Yun Dong Ick Son Institute of Advanced Composite Materials Korea Institute of Science and TechnologyJeollabuk-do 55324Republic of Korea National Institute for Nanomaterials Technology Pohang University of Science and TechnologyGyeongsangbuk-do 37673Republic of Korea Department of Semiconductor Science and Technology Semiconductor Physics Research CenterJeonbuk National UniversityJeonju 54896Republic of Korea Advanced Photonics Research Institute Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Center for Opto-Electronic Materials and Devices Post-Silicon Semiconductor InstituteKorea Institute of Science and TechnologySeoul 02792Republic of Korea Graduate School of Energy and Environment(KU-KIST Green School) Korea UniversitySeoul 02841Republic of Korea KIST School Department of Nanomaterials and Nano ScienceUniversity of Science and Technology(UST)Daejeon 34113Republic of Korea

Mixed-dimensional composite structures using zero-dimensional(0D)quantum dots(QDs)and two-dimensional(2D)transition metal dichalcogenides(TMDs)materials are expected to attract great interest in optoelectronics due to the potential to generate new optical ***,we report on the unique optical characteristics of a devices with mixed dimensional vertically stacked structures based on tungsten diselenide(WSe_(2))/CdSeS QDs monolayer/molybdenum disulfide(MoS_(2))(2D/0D/2D).Specifically,it exhibits an ambipolar photoresponse characteristic,with a negative photoresponse observed in the 400-600 nm wavelength range and a positive photoresponse appeared at 700 nm *** resulted in the high negative responsivity of up to 52.22 mA·W^(−1)under 400 nm,which is 163 times higher than that of the photodetector without CdSeS *** also demonstrated the negative photoresponse,which could be due to increased carrier collision probability and non-radiative *** modeling and simulation reveal that Auger recombination among the types of non-radiative recombination is the main cause of negative photocurrent ***,we discovered ambipolar photoresponse near a specific wavelength corresponding to the energy of quantum *** study revealed interesting phenomenon in the mixed low-dimensional stacked structure and paved the way to exploit it for the development of innovative photodetection materials as well as for optoelectronic applications.

关键词： mixed-dimension quantum dot heterostructure photodetector ambipolar photoresponse

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