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EGFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe Metges erick Gamelin Alain Volant Olivier Capitain Jean-François Ramée Jean-Luc Raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux Marie-Aude Coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel Martin Claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-Rémi De Ybarlucea Serge Eloit Pierre Marie Girardot Nathalie heresbach Christian Laboisse eric Lavoine Gilles Lemasson Claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian Riché Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre hospitalier Régional Universitaire (ChRU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CRLCC Eugène Marquis Rennes France ICO René Gauducheau Nantes France Centre CARIO-hCPA Plérin France Centre hospitalier Bretagne Sud (ChBS) Lorient France Clinique Victor hugo Le Mans France Centre hospitalier Départemental (ChD) La Roche-sur-Yon France Ch Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France ChIC Quimper France Clinique Pasteur Lanroze Brest France Ch MORLAIX France Ch Saint-Brieuc France ChBA Vannes France ChP Saint-Grégoire France ChU Nantes France hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France Ch Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ARMOR Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France ChU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France ChU Rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large cohort of mCRC patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IhC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available IhC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFR Expression

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利用光衍射测量长丝纱的变形结构

国际纺织导报 2016年第9期44卷 14-17页

作者： E.S.Südhoff L.Debicki M.Decius L.Merten V.Niebel G.Seide T.Gries 周书法亚琛工业大学纺织技术研究所

无变形的长丝纱倾向于以一种平行且均匀的方式排列在一起。相比于表面不太均匀且包含毛羽的短纤维纱线,无变形的长丝纱表面很光滑。在很多应用中,人们期望可在保留长丝纱连续性的同时获得短纤纱的某些特性。通过变形丝工艺,可以使长丝... 详细信息

无变形的长丝纱倾向于以一种平行且均匀的方式排列在一起。相比于表面不太均匀且包含毛羽的短纤维纱线,无变形的长丝纱表面很光滑。在很多应用中,人们期望可在保留长丝纱连续性的同时获得短纤纱的某些特性。通过变形丝工艺,可以使长丝纱获得特定的性能,如高膨松性、高弹性和孔隙度。在实验室中,可以离线测量变形纱的性能,但还没有实现对运行过程中的纱线进行性能的实时在线光学检测。离线测量方法成本高,且只能获得随机纱线样本质量的统计信息。除介绍了最先进的变形纱参数的测量外,还提出了一种直接光学测量变形纱的潜在方法。

关键词：长丝纱变形光学测量在线测量

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阻击朊病毒

环球科学 2020年第7期 44-49页

作者：索尼娅·米尼克尔·瓦拉布埃里克·瓦拉布·米尼克尔祝岸凯(翻译) 张哲(翻译) 师润(翻译) 高振兴(翻译) 李朝阳(审校) 不详李朝阳实验室广州医科大学附属肿瘤医院

朊病毒病作为一种发病速度极快的神经退行性疾病,不仅难以确诊,而且没有特效药,患者发病后数月就会死亡。而想要挽救那些患病风险高的人,最好的办法就是提前阻击朊病毒,预防疾病的发生。

关键词：朊病毒神经退行性疾病患病风险发病速度预防疾病特效药

Impact of exercise on neuro-cognitive function and hippocampal plasticity in early psychosis—a preliminary data analysis

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Impact of exercise on neuro-cognitive function and hippocamp...

Epidemiological and Prognostic Aspects of Anemia during heart Failure in Brazzaville (The Republic of the Congo)

中华医学会精神病学分会第九次全国学术会议

作者： LIN Jing-xia,~1 May Mei-Ling Lam,~1 Kit-Wa Chan,~1 Wing-Chung Chang,~1 Glen Joe,~2 Gloria hoi-Yan Wong,~1 Cindy Pui-Yu Chiu,~1 Pek-Lan Khong,~3 William G honer,Wayne Su,~4 Cecilia Lai-Wan Chan,~5 Kwok-Fai So,~6 Michael Tse~2 and eric Yu-hai Chen~1 1 Department of Psychiatry,the University of hong Kong 2 Institute of human Performance,the University of hong Kong 3 Department of Diagnostic Radiology,the University of hong Kong 4 Department of Psychiatry,University of British Columbia,Vancouver,Canada 5 Department of Social Work and Social Administration,the University of hong Kong 6 Department of Anatomy,the University of hong Kong

Objectives hippocampal volume is lower in schizophrenic patients than in normal *** present study aimed to investigate whether physical exercise would increase hippocampal volume in patients with early psychosis,and whether this effect would be related to improved neuro-cognitive functions. Methods A total of 60 female psychosis patients aged 18-55 years old with less than 5 years illness duration were

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World Journal of Cardiovascular Diseases（心血管病） 2023年第7期

作者： StéphaneMéoIkama Joffode Mobet Memougame Thibaut Oko Jospin Makani Lydie Ocini Ngolet Bijou Moualengue eric Gibrel Kimbally Kaky Thibaut Gankama Suzy Gisèle Kimbally Kaky

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黑猩猩不自私

环球科学 2011年第11期 16-16页

作者：埃里克·迈克尔·约翰避（eric Michael Johnson）高瑞雪（翻译）

达尔文和黑猩猩的共同点，甚至比他认识到的还要多。在因自然选择理论而声名远播之前，这位年青的博物学家曾做出过一个决定——长期以来。这样的决定一直被看作是人类和类人猿的根本区别所在。

关键词：黑猩猩自私选择理论博物学家达尔文类人猿

Advances in tropical cyclone prediction on subseasonal time scales

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Tropical Cyclone Research and Review 2023年第2期12卷 136-150页

作者： Carl J.Schreck III Frederic Vitart Suzana J.Camargo Joanne Camp James Darlow Russell Elsberry Jon Gottschalck Paul Gregory Kurt hansen Justyn Jackson Matthew A.Janiga Philip J.Klotzbach Chia-Ying Lee Lindsey Long Masuo Nakano Kazuto Takemura Yuhei Takaya Michael J.Ventrice Zhuo Wang Cooperative Institute for Satellite Earth System Studies North Carolina State UniversityUSA European Centre for Medium-Range Weather Forecasts UK Lamont-Doherty Earth Observatory Columbia UniversityUSA Bureau of Meteorology Australia Joint Typhoon Warning Center USA Naval Postgraduate School USA Climate Prediction Center NOAAUSA hNational Research CouncilUSA U.S.Air Force USA Naval Research Laboratory USA Colorado State University USA ERT Inc.USA Japan Agency for Marine-Earth Science and Technology Japan Climate Prediction Division Japan Meteorological AgencyJapan Meteorological Research Institute Japan Meteorological AgencyJapan DRW holdings USA University of Illinois at Urbana-Champaign USA

This review describes advances in understanding and forecasting tropical cyclone(TC)subseasonal variability during the past four years.A large effort by the scientiﬁc community has been in understanding the sources of predictability at subseasonal timescales beyond the well-known modulation of TC activity by the Madden-Julian Oscillation(MJO).In particular,the strong modulation of TC activity over the western North Paciﬁc by the Boreal Summer Intra-Seasonal Oscillation(BSISO)has been *** has also been realized in understanding the role of tropical-extratropical interactions in improving subseasonal *** addition,several recent publications have shown that extratropical wave breaking may have a role in the genesis and development of *** of multi-model ensemble data sets such as the Subseasonal to Seasonal(S2S)and Subseasonal Experiment(SubX)have shown that the skill of S2S models in predicting the genesis of TCs varies strongly among models and regions but is often tied to their ability to simulate the MJO and its *** skill in select models has led to an increase over the past four years in the number of forecasting centers issuing subseasonal TC forecasts using various techniques(statistical,statistical-dynamical and dynamical).More extensive veriﬁcation studies have been published over the last four years,but often only for the North Atlantic and eastern North Paciﬁc.

关键词： Tropical cyclones Subseasonal Forecasts hurricanes MJO

Aetiologic Factors of Anemia During heart Failure in Brazzaville (The Republic of the Congo)

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Epidemiological Aspects of Osteoarticular and Rheumatological Diseases Related to Diabetes in Niger

World Journal of Cardiovascular Diseases（心血管病） 2023年第9期

作者： Stéphane MéoIkama Joffode Mobet Memougame Jospin Makani Thibaut Oko eric Gibrel Kimbally Kaky Lydie Ocini Ngolet Bijou Moualengue Thibaut Gankama Suzy Gisèle Kimbally Kaky

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