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Comparison of conventional and non-invasive diagnostic tools for detecting Plasmodium falciparum infection in southwestern Cameroon:a cross-sectional study

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Infectious Diseases of Poverty 2021年第3期10卷 104-105页

作者： Tobias O.Apinjoh Veronica N.Ntasin Phil Collins C.Tataw Vincent N.Ntui Dieudonne L.Njimoh Fidelis Cho-Ngwa eric a.achidi Department of Biochemistry and Molecular Biology University of BueaBueaCameroon 不详

Background:Malaria remains a significant health challenge in sub-Saharan Africa,with early diagnosis critical to reducing its morbidity and *** the increasing Plasmodium *** capabilities,access to testing is limited in some cases by the almost absolute requirement for blood from potentially infected subjects as the only sample source for all conventional methods.A rapid test on non-invasive specimen with comparable performance to microscopy for the screening or diagnosis of all participants is *** study sought to compare conventional and non-invasive diagnostic tools for detecting Plasmodium falciparum.

关键词： Plasmodium falciparum Microscopy Nested PCR Rapid diagnostic test Blood Saliva Urine

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Molecular markers for artemisinin and partner drug resistance in natural Plasmodium falciparum populations following increased insecticide treated net coverage along the slope of mount Cameroon:cross-sectional study

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Infectious Diseases of Poverty 2017年第1期6卷 1205-1214页

作者： Tobias O.Apinjoh Regina N.Mugri Olivo Miotto Hanesh F.Chi Rolland B.Tata Judith K.Anchang-Kimbi Eleanor M.Fon Delphine A.Tangoh Robert V.Nyingchu Christopher Jacob Roberto Amato Abdoulaye Djimde Dominic Kwiatkowski eric a.achidi Alfred Amambua-Ngwa Department of Biochemistry and Molecular Biology University of BueaBueaCameroon Department of Microbiology and Parasitology University of BueaBueaCameroon Mahidol-Oxford Research Unit Faculty of Tropical MedicineMahidol UniversityBangkokThailand Department of Zoology and Animal Physiology University of BueaBueaCameroon Department of Medical Laboratory Science University of BueaBueaCameroon Wellcome Trust Sanger Institute HinxtonCambridge CB101SAUK Malaria Research and Training Centre BamakoMali MRC Unit FajaraThe Gambia

Background:Drug resistance is one of the greatest challenges of malaria control programmes,with the monitoring of parasite resistance to artemisinins or to Artemisinin Combination Therapy(ACT)partner drugs critical to elimination *** of resistance to a wide panel of antimalarials were assessed in natural parasite populations from southwestern ***:Individuals with asymptomatic parasitaemia or uncomplicated malaria were enrolled through crosssectional surveys from May 2013 to March 2014 along the slope of mount *** falciparum malaria parasitaemic blood,screened by light microscopy,was depleted of leucocytes using CF11 cellulose columns and the parasite genotype ascertained by sequencing on the Illumina HiSeq ***:A total of 259 participants were enrolled in this study from three different *** some alleles associated with drug resistance in pfdhfr,pfmdr1 and pfcrt were highly prevalent,less than 3%of all samples carried mutations in the pfkelch13 gene,none of which were amongst those associated with slow artemisinin parasite clearance rates in Southeast *** most prevalent haplotypes were triple mutants PfdhfrI51R59N108I164(99%),pfcrt-C72V73I74E75T76(47.3%),and single mutants PfdhpsS_(436)G_(437)K_(540)A_(581)A_(613)(69%)and Pfmdr1 N_(86)F)(184)D_(1246)(53.2%).Conclusions:The predominance of the Pf pfcrt CVIET and Pf dhfr IRN triple mutant parasites and absence of pfkelch13 resistance alleles suggest that the amodiaquine and pyrimethamine components of AS-AQ and SP may no longer be effective in their role while chloroquine resistance still persists in southwestern Cameroon.

关键词： Molecular markers Drug resistance Plasmodium falciparum

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