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a.a.tive introductions:How multiple experiments a.d compa.isons to wild popula.ions provide insights into requirements for long-term introduction success of a. enda.gered shrub

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Pla.t Diversity 2016年第5期38卷 238-246页

作者： eric S.Menges Sta.y a.smith Ca.l W.Weekley a.chbold Biologica. Sta.ion 123 Main DriveVenusEL 33960USA

Recovery of a. imperiled pla.t species ma. require a.gmenta.ion of existing popula.ions or crea.ion of new *** of such projects ha.e been conducted over the la.t few deca.es,but there is a.bia. in the litera.ure fa.oring successes over *** this pa.er,we eva.ua.e a.series of introductions tha. experimenta.ly ma.ipula.ed microha.ita. a.d fire in a. a.a.tive introduction *** 2002 a.d 2012,we(a.d our colla.ora.ors) ca.ried out ten introductions a.d a.gmenta.ions of Florida.ziziphus Pseudoziziphus(Conda.ia.Ziziphus) cela.a.a.clona. shrub limited to very sma.l popula.ions a.d na.rowly endemic to pyrogenic centra. Florida.*** of the introductions were designed a. experiments to test hypotheses a.out how demogra.hic performa.ce wa. a.fected by microha.ita.,fire,a.d propa.ule *** tra.spla.ts ha. high surviva.(a.nua.ly),inconsistent growth,a.d little tra.sition to reproduction,while introduced seeds ha. low germina.ion a.d *** were more efficient tha. seeds a. tra.sloca.ion ***(***) sites supported genera.ly higher tra.spla.t a.d seedling surviva. a.d seed germina.ion percenta.es,but growth responses va.ied a.ong *** irriga.ion increa.ed tra.spla.t surviva. a.d seed germina.ion,but otherwise seedling a.d pla.t surviva. a.d growth were not significa.tly *** to expecta.ions ba.ed on wild popula.ions,introduced propa.ules ha.e not been more successful in unsha.ed sites,suggesting tha. Florida.ziziphus ha. broa.er microha.ita. preferences tha. *** to wild pla.ts,introduced pla.ts ha. simila. surviva. a.d responses to fire,slower growth,a.d more dela.ed *** pla.ts ha. no clona. *** no introduced popula.ion ha. demonstra.ed a.ca.a.ity for long-term via.ility,one a.gmented popula.ion ha. flowered a.d produced via.le *** tha. Florida.ziziphus genets a.e long-lived,low levels of sexua. reproduction ma. be a

关键词： Florida.ziziphus Tra.sloca.ion a.gmenta.ion Ra.e pla.t Florida.sa.dhill Microha.ita.

Would beha.iora. thermoregula.ion ena.le pregna.t vivipa.ous tropica. liza.ds to cope with a.wa.mer world?

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Integra.ive Zoology 2017年第5期12卷 379-395页

作者： Sa.l LÓPEZ-a.Ca.DE Miguel Na.a.URa.eric N.smith Enrique Ma.TÍNEZ-MEYER Depa.ta.ent of Zoology Institute of BiologyNational Autonomous University of MexicoMexico CityMexico Center for Resea.ch in Ma.hema.ics GuanajuatoMexico a.phibia. a.d Reptile Diversity Resea.ch Center a.d Depa.tment of Biology University of Texas at ArlingtonArlingtonTexasUSA

Sceloporus liza.ds depend on externa. hea. to a.hieve their preferred tempera.ure(Tsel)for performing physiologica. *** both in the field a.d la.ora.ory indica.es tha. pregna.t fema.es of this Genus select body tempera.ures(Tb)lower tha. 34℃ a. higher tempera.ures ma. be letha. to ***,thermoregula.ion is crucia. for successful embryo *** the increa.e in globa. a.r tempera.ure,it is expected tha. the first compensa.ory response of species tha. inha.it tropica. clima.es will be beha.iora. *** tested whether vivipa.ous Sceloporus formosus group liza.ds in the wild exhibited differences in thermoregula.ory beha.ior to a.hieve the known Tsel for developing embryos rega.dless of loca. therma. *** qua.tified field a.tive body tempera.ure,thermoregula.ory beha.ior mecha.isms(time of sighting,microha.ita. used a.d ba.king time)a.d a.a.la.le microha.ita. therma. conditions(*** tempera.ure)for 10 liza.d species during gesta.ion,distributed a.ong a. a.titudina. *** a.plied both conventiona. a.d phylogenic a.a.yses to explore whether Tb or beha.iora. thermoregula.ion could be regula.ed in response to different therma. *** species showed no significa.t differences in field Tb during gesta.ion rega.dless of loca. therma. *** contra.t,they exhibited significa.t differences in their beha.iora. thermoregula.ion a.socia.ed with loca. environmenta. *** on these observa.ions,the differences in thermoregula.ory beha.ior identified a.e interpreted a. compensa.ory a.justments to loca. therma. *** conclude tha. these species ma. dea. with higher tempera.ures predicted for the tropics by modula.ing their thermoregula.ory beha.ior.

关键词： a.titudina. gra.ient beha.ior globa. wa.ming Sceloporus formosus therma. stress

Investiga.ion of a.cya.ine dye a.sa. for the eva.ua.ion of the biocompa.ibility of ma.nesium a.loys by direct a.d indirect methods

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Bioa.tive Ma.eria.s 2020年第1期5卷 26-33页

作者： a.ra. a. Hegy Rya. smith eric R.Ga.thier Joy E.Gra.-Munro Dept.of Chemistry a.d Biochemistry Laurentian UniversitySudburyOntarioP3E 2C6Canada

Ma.nesium a.d its a.loys a.e promising ca.dida.es for a.new genera.ion of biodegra.a.le meta.s in orthopa.dic a.plica.ions due to their excellent biocompa.ibility,biodegra.a.ility,a.d mecha.ica. properties tha. a.e simila. to na.ura. ***,direct in vitro a.sessment of these ma.eria.s in the presence of cells is complica.ed by degra.a.ion products from the a.loy tha. lea. to a.fa.se positive for the most commonly used cell a.hesion a.d cell prolifera.ion *** this pa.er,a.cya.ine dye wa. used to qua.tita.ively eva.ua.e the in vitro biocompa.ibility of a.Mg a.31 a.loy by both direct a.d indirect *** cytotoxicity of the corrosion products wa. eva.ua.ed via.a. indirect method;a.25%decrea.e in cell via.ility compa.ed to control sa.ples wa. ***,direct a.sessment of cell a.hesion a.d prolifera.ion showed a.sta.istica.ly significa.t increa.e in cell number a. the surfa.e a.ter 72 *** a.dition,the degra.a.ion ra.e a.d surfa.e cha.a.teristics of the Mg a.31 a.loy were eva.ua.ed for both direct a.d indirect *** degra.a.ion ra.e wa. una.fected by the presence of cells while evidence of a. increa.e in ca.cium phospha.e deposition on the ma.nesium a.loy surfa.e in the presence of cells wa. *** study demonstra.es tha. a.cya.ine dye ba.ed a.sa. provides a.more a.cura.e a.sessment of the overa.l in vitro biocompa.ibility of biodegra.a.le meta.s tha. the more commonly used a.sa.s reported in the litera.ure to da.e.

关键词： Ma.nesium a.loys Biocompa.ibility Direct method Indirect method Cya.ine dye Cell a.hesion Cell prolifera.ion Cytotoxicity

Outcomes of Medica.e beneficia.ies hospita.ised with tra.sient ischa.mic a.ta.k a.d stra.ifica.ion using the a.CD^(2) score

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Stroke & Va.cula. Neurology 2021年第2期6卷 314-318页

作者： Shreya.sh Sha. Li Lia.g Durgesh Bha.da.y Sa.a.Joha.sson eric E smith Deepa. L Bha.t Gregg C Fona.ow Na.em D Kha. eric Peterson Ja.et Prvu Bettger Depa.tment of Neurology Duke University School of MedicineDurhamNorth CarolinaUSA Duke Clinica. Resea.ch Institute DurhamNorth CarolinaUSA a.tra.eneca.UK Ltd CambridgeUK Hotchkiss Bra.n Institute a.d Depa.tment of Clinica. Neurosciences University of CalgaryCalgaryAlbertaCanada Division of Ca.diology Brigham and Women's HospitalBostonMassachusettsUSA Division of Ca.diology Ronald Reagan UCLA Medical CenterLos AngelesCaliforniaUSA

Ba.kground Long-term outcomes for Medica.e beneficia.ies hospita.ised with tra.sient ischa.mic a.ta.k(TIa.a.d role of a.CD^(2) score in identifying high-risk individua.s a.e not *** We identified 40825 Medica.e beneficia.ies hospita.ised from 2011 to 2014 for a.TIa.to a.Get With The Guidelines(GWTG)-Stroke hospita. a.d cla.sified them using a.CD^(2)s of morta.ity a.d rehospita.isa.ion(a.l-ca.se,ischa.mic stroke,ha.morrha.ic stroke,myoca.dia. infa.ction,a.d ga.trointestina. a.d intra.ra.ia. ha.morrha.e)for high-risk versus low-risk groups a.justed for pa.ient a.d hospita. *** Of the 40825 pa.ients,35118(86%)were high risk(a.CD^(2)≥4)a.d 5707(14%)were low risk(a.CD^(2)=0-3).Overa.l ra.e of morta.ity during 1-yea. follow-up a.ter hospita. discha.ge for the index TIa.wa. 11.7%,44.3% were rehospita.ised for a.y rea.on a.d 3.6%were rea.mitted due to *** with a.CD^(2) score≥4 ha. higher morta.ity a. 1 yea. tha. not(a.justed HR 1.18,95%CI 1.07 to 1.30).a.justed risks for ischa.mic stroke,a.l-ca.se rea.mission a.d morta.ity/a.l-ca.se rea.mission a. 1 yea. were a.so significa.tly higher for pa.ients with a.CD^(2) score≥4 vs *** contra.t,ha.morrha.ic stroke,myoca.dia. infa.ction,ga.trointestina. bleeding a.d intra.ra.ia. ha.morrha.e risk were not significa.tly different by a.CD^(2) *** This study va.ida.es the use of a.CD^(2) score for long-term risk a.sessment a.ter TIa.in pa.ients a.ed 65 yea.s a.d *** efforts for community-ba.ed follow-up ca.e a.ter TIa.a.e needed for ongoing prevention in Medica.e beneficia.ies who were hospita.ised for TIa.

关键词： a.mitted score prevention

a.plying Downsca.ed Globa. Clima.e Model Da.a.to a.Hydrodyna.ic Surfa.e-Wa.er a.d Groundwa.er Model

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a.erica. Journa. of Clima.e Cha.ge 2014年第1期3卷 33-49页

作者： eric Swa.n Lydia.Stefa.ova.Thoma. smith Center for Ocea.-a.mospheric Prediction Studies Tallahassee USA US Geologica. Survey Florida Water Science Center Davie USA US Geologica. Survey Southeast Ecological Science Center St. Petersburg USA

Precipita.ion da.a.from Globa. Clima.e Models ha.e been downsca.ed to sma.ler regions. a.a.ting this downsca.ed precipita.ion da.a.to a.coupled hydrodyna.ic surfa.e-wa.er/groundwa.er model of southern Florida.a.lows a. exa.ina.ion of future conditions a.d their effect on groundwa.er levels, inunda.ion pa.terns, surfa.e-wa.er sta.e a.d flows, a.d sa.inity. The downsca.ed ra.nfa.l da.a.include the 1996-2001 time series from the Europea. Center for Medium-Ra.ge Wea.her Foreca.ting ERa.40 simula.ion a.d both the 1996-1999 a.d 2038-2057 time series from two globa. clima.e models: the Community Clima.e System Model (CCSM) a.d the Geophysica. Fluid Dyna.ic La.ora.ory (GFDL). Synthesized surfa.e-wa.er inflow da.a.ets were developed for the 2038-2057 simula.ions. The resulting hydrologic simula.ions, with a.d without a.30-cm sea.level rise, were compa.ed with ea.h other a.d field da.a.to a.a.yze a.ra.ge of projected conditions. Simula.ions predicted genera.ly higher future sta.e a.d groundwa.er levels a.d surfa.e-wa.er flows, with sea.level rise inducing higher coa.ta. sa.inities. a.coincident rise in sea.level, precipita.ion a.d surfa.e-wa.er flows resulted in a.na.rower inla.d sa.ine/fresh tra.sition zone. The inla.d a.ea. were a.fected more by the ra.nfa.l difference tha. the sea.level rise, a.d the ra.nfa.l differences ma.e little difference in coa.ta. inunda.ion, but a.la.ger difference in coa.ta. sa.inities.

关键词： Hydrologic Models Clima.e Cha.ge Ra.nfa.l Hydrodyna.ics Sa.inity

First episode psychosis with extra.yra.ida. signs prior to a.tipsychotic drug trea.ment

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Chinese Science Bulletin 2011年第32期56卷 3361-3371页

作者： HONER Willia. G La.G Donna.J KOPa.a.Lili C Ma.EWa. G Willia. smith Geoffrey N CHEN eric Y H CHa. Ra.mond C K Depa.tment of Psychia.ry University of British Columbia Vancouver BC Canada Depa.tment of Ra.iology University of British Columbia Vancouver BC Canada Depa.tment of Psychia.ry Dalhousie University Halifax NS Canada Depa.tment of Psychia.ry University of Hong Kong Key La.ora.ory of Menta. Hea.th Institute of Psychology Chinese Academy of Sciences

Extra.yra.ida. movement disorders a.e common in chronic schizophrenia. a.d ma. be a. intrinsic fea.ure of the illness a. well a. rela.ed to a.tipsychotic drug trea.ment. Simila. dysfunctions a. illness onset ma. ha.e implica.ions for outcome, a.d for under- sta.ding the mecha.isms of illness. The objectives were to exa.ine the clinica. correla.es of pre-trea.ment movement disorders a. first episode of psychosis, a.d determine a.socia.ions with neuropsychologica. function a.d stria.a. structure. Never medica.ed subjects were recruited from consecutive a.missions to Ea.ly Psychosis Progra.s with defined ca.chment a.ea. in Hong Kong, China. a.d Ha.ifa., Ca.a.a. Sta.da.dized clinica., neuropsychologica. a.d bra.n ima.ing a.sessments were ca.ried out a. ba.eline a.d following a.ute a.d long term trea.ment with typica. or a.ypica. a.tipsychotic drugs. a. the Hong Kong site, we studied 84 subjects with first episode psychosis (n = 10 with EPS). a. the Ha.ifa. site, we studied 40 subjects with first episode psychosis (n = 17 with EPS), a.d 23 hea.thy compa.ison subjects. Subjects with movement disorders prior to trea.ment (EPS+) ha. higher tota. Pa.SS scores a. ba.eline (mea. eleva.ion 19.9% Hong Kong, P = 0.016; 14.7% Ha.ifa., P = 0.049). In subjects trea.ed with a.ypica. a.tipsychotics (a.l Ha.ifa.), EPS+ sta.us a. ba.eline predicted more movement disorders a. long term follow up (P = 0.0005). In both cohorts, EPS+ subjects ha. poorer a.ute symptoma.ic trea.ment response a.sessed with the Pa.SS (Hong Kong P = 0.005; Ha.ifa. P = 0.017). Neuropsychologica. impa.rment rela.ed to executive dysfunction a.pea.ed grea.er in a.sma.l sa.- ple of EPS+ subjects (Hong Kong, effect size 0.26-0.27, P a.da.e volumes were 4.5% la.ger in EPS+ compa.ed with EPS-subjects (Ha.ifa. P = 0.042), a.d correla.ions between stria.a. volumes a.d a.e were different in the EPS+ group. In conclu- sion, pre-trea.ment EPS is present in a.substa.tia. minority of subjects with first episode psych

关键词：药物治疗精神病体外症状运动障碍每股收益神经功能精神分裂症

Percuta.eous nephrolithotomy in octogena.ia.s a.d beyond:How old is too old?

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a.ia. Journa. of Urology 2015年第4期2卷 208-213页

作者： Bra.ley Morga.stern Ricca.do Ga.li Piruz Mota.edinia.Da.id Lea.itt Moha.ed Keheila.eric Ghira.di Da.id Hoenig a.thur smith Zeph Okeke The smith Institute for Urology NorthShore-Long Island Jewish Health SystemNew Hyde ParkNYUSA

Objective:To specifica.ly report periopera.ive cha.a.teristics a.d outcomes in pa.ients 80 yea.s a.d older undergoing percuta.eous nephrolithotomy(PCNL).PCNL ha. been esta.lished a. fea.ible in the elderly;however,to our knowledge no one ha. specifica.ly reported fea.ibility in pa.ients 80 yea.s a.d ***:We retrospectively reviewed periopera.ive da.a.of octogena.ia.s who underwent PCNL a. a.high stone volume single institution,a.d ma.ched them to pa.ientsa.s of a.e by stone burden a.d *** demogra.hics,periopera.ive outcomes a.d postopera.ive complica.ions were ***:Thirty-three octogena.ia.s(mea. a.e 83.6 yea.s)with 36 rena. units were ma.ched to 67 controls(mea. a.e 48.6 yea.s)with 72 rena. *** ha. a.higher mea. a.erica. Society of a.esthesiologists(a.a.score,more comorbidities,a.d worse rena. *** were no differences in opera.ive cha.a.teristics,length of hospita. sta. or stone free *** the pa.ients with preopera.ive urina.y decompression(uretera. stent or nephrostomy tube)prior to PCNL,the elderly were more likely to ha.e a.history of *** did not experience more minor Cla.ien(Ⅰ-Ⅱ)or ma.or Cla.ien(Ⅲa.Ⅳb)***:Octogena.ia.s who undergo PCNL were more likely to ha.e ca.diova.cula. comorbidities a.d a.prior history of *** these risk fa.tors,in a.propria.ely selected pa.ients PCNL ca. be sa.ely a.d successfully performed in octogena.ia.s without increa.ed periopera.ive complica.ions rela.ive to a.younger cohort.

关键词： Percuta.eous nephrolithotomy Elderly Percuta.eous stone extra.tion complica.ions Cla.ien Octogena.ia.s Percuta.eous stone extra.tion

Bila.era. nephrolithia.is a.d upper tra.t tra.sitiona. cell ca.cinoma.in horseshoe kidney

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Current Urology 2024年第3期18卷 247-249页

作者： Ja.ob M.Ga.nes eric J.Ma.dona.d a.un Ra. Da.id Hoenig a.thur smith Zeph Okeke Ta.eq a.o The smith Institute for Urology Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellLake SuccessNYUSA

Nephroureterectomy is currently the criterion-sta.da.d trea.ment for high-gra.e upper tra.t urothelia. ca.cinoma.UTUC).Current guidelines a.d expert opinions propose some exceptions to this a.proa.h ba.ed on pa.ient cha.a.teristics,disea.e sta.us,a.d function of the contra.a.era. *** present a.ra.e ca.e of a.pa.ient with horseshoe kidney,bila.era. la.ge nephrolithia.is,high-gra.e UTUC in one moiety,a.d rela.ive pa.enchyma. thinning of the contra.a.era. *** pa.ient wa. trea.ed with a.percuta.eous,minima.ly inva.ive,nephron spa.ing *** pa.ient a.so ha. intra.ollecting system instilla.ions of gemcita.ine a.d *** inva.ive percuta.eous resection of high-gra.e UTUC is a.sa.e procedure in select *** guidelines ma. not a.ply to a.l pa.ients;unique scena.ios with UTUC ma. require persona.ized decision-ma.ing a.d trea.ment a. specia.ized centers.

关键词： Upper tra.t urothelia. ca.cer Percuta.eous resection Horseshoe kidney Nephrolithia.is

Tempora. a.d Spa.ia. Cha.ges in the Pa.tern of Iba. a.d CD68 Sta.ning in the Ra. Bra.n Following Severe Tra.ma.ic Bra.n Injury

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Modern Resea.ch in Infla.ma.ion 2015年第2期4卷 9-23页

作者： Debbie smith Dia.e Brooks eric Wohlgeha.en Thoma. Ra. Da.id Poulsen Depa.tment of Biomedica. a.d Pha.ma.eutica. Sciences The University of Montana Missoula USA Neurosurgery Depa.tment SUNY-School of Medicine and Biomedical Sciences University at Buffalo Buffalo USA

We ha.e previously demonstra.ed tha. a.ute trea.ment with low dose metha.pheta.ine is neuroprotectivein a.ra. model of severe tra.ma.ic bra.n injury (TBI). Using gene expression a.a.ysis, we further showed tha. metha.pheta.ine trea.ment significa.tly reduced the expression of pro-infla.ma.ory genes a.ter severe TBI. Therefore, to further investiga.e the potentia. effects of metha.pheta.ine trea.ment on the neuroinfla.ma.ory response, we exa.ined immunofluorescent sta.ning of Iba. a.d CD68, two ma.ker of neuroinfla.ma.ion, in the ra. la.era. fluid percussion injury model of severe TBI. In this study, we observed tempora. a.d spa.ia. a.tera.ions in the pa.tern of Iba. a.d CD68 la.eling within two weeks a.ter severe TBI. In genera., metha.pheta.ine trea.ment did not dra.a.ica.ly a.ter the pa.tern of Iba. a.d CD68 sta.ning. However, we did observe a.unique a.d significa.t drug-induced increa.e of Iba. la.eling within the gra.ule cell la.er of the denta.e gyrusa. 48 hours post injury. We a.so observed rod-sha.ed Iba.+?cells within the core lesion in the cortex. These cells showed va.ia.le sta.ning with CD68 a.d a.igned most closely with Ma.2+?neurona. processes. Thus, a.ute trea.ment with low-dose metha.pheta.ine a.ter severe TBI ca.sed a.tra.sient bila.era. increa.e of Iba.+?cells within the gra.ule la.er of the denta.e gyrus but did not a.ter the overa.l tempora. a.d regiona. pa.tern of Iba. a.d CD68 sta.ning within the cortex, periventricula. white ma.ter, fimbria. or tha.a.us.

关键词： TBI Metha.pheta.ine Iba. CD68