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Insight into crystal growth and upconversion luminescence property of tetragonal Ba_(3)Sc_(2)F_(12) nanocrystals

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Rare Metals 2021年第1期40卷 113-122页

作者： Juan Xie Guang-Chao zheng Yang-Ming Hu Farhat Nosheen Zhi-Cheng Zhang er-Jun Liang School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Division of Science and technology Department of ChemistryUniversity of EducationLahore 54770Pakistan Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin University and Collaborative Innovation Center of Chemical Science and EngineeringTianjin 300072China

Sc-based nanomaterials have attracted considerable attention due to their unique optical properties different from those of Ln/Y-based ***,studies on Sc-based nanomaterials are far from ***,nanoscale alkaline(Ca,Sr and Ba)scandium fluorides were almost ignored for their stringent synthetic ***,we synthesize high-quality tetragonal phase Ba_(3)Sc_(2)F_(12) nanocrystals with uniform morphology and good dispersibility by carefully tailoring the reaction conditions,such as the molar ratio of reactants,temperature and reaction ***,the upconversion(UC)luminescence property of Ba_(3)Sc_(2)F_(12):Yb/er(Ho)samples is investigated in *** doping concentrations of sensitizer(Yb^(3+))and activator(er^(3+)and Ho^(3+))are optimized for the strongest UC luminescence,of which the corresponding energy transfer processes are also ***,tetragonal Ba_(3)Sc_(2)F_(12) nanocrystals can gradually transform into hexagonal Ba_(4)Yb_(3)F_(17) nanocrystals with the increase in Yb^(3+)doping *** work provides a novel type of Sc-based nanomaterials with strong red UC emissions which are promising in high-resolution 3-dimensional color displays,laser,bioimaging and biolabels.

关键词： Ba_(3)Sc_(2)F_(12)nanocrystals Crystal growth Upconversion Sc-based nanomaterials

基于SPOC的案例教学法联合情景模拟教学法在口腔急诊护理带教中的应用

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中国高等医学教育 2024年第7期 115-117页

作者：郑娇尔陈小兰刘煜朱乐园胡济安浙江大学医学院附属口腔医院·浙江大学口腔医学院·浙江省口腔疾病临床医学研究中心·浙江省口腔生物医学研究重点实验室·浙江大学癌症研究院·口腔生物材料与器械浙江省工程研究中心浙江杭州310000

目的:探讨基于SPOC的案例教学法联合情景模拟教学法在口腔急诊护理教学中的应用效果。方法:选取2022年和2023年在浙江大学医学院附属口腔医院急诊科工作的30名护理人员(含轮转实习生)为研究对象。将2022年15名护理人员作为对照组,采用... 详细信息

目的:探讨基于SPOC的案例教学法联合情景模拟教学法在口腔急诊护理教学中的应用效果。方法:选取2022年和2023年在浙江大学医学院附属口腔医院急诊科工作的30名护理人员(含轮转实习生)为研究对象。将2022年15名护理人员作为对照组,采用传统教学模式;将2023年15名护理人员作为试验组,采用基于SPOC的案例教学法联合情景模拟教学法。比较两组理论操作考核成绩、带教满意度、综合能力、应急能力。结果:试验组学生的理论操作考核成绩、带教满意度、综合能力、应急能力均优于对照组(P<0.05)结论:基于SPOC的案例教学法联合情景模拟教学法有效提高口腔急诊科临床带教质量,提升了口腔急诊护理服务能力。

关键词：口腔急诊 SPOC 案例教学法情景模拟教学法护理教学

2013-2023年热浪对上海居民中暑的影响

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环境与职业医学 2024年第6期41卷 610-616页

作者：陈非儿东春阳张江华钱海雷吴筝施烨闻孙晓冬上海市疾病预防控制中心健康危害因素监测与控制所上海200336

[背景]热浪带来的巨大健康损害和气候变暖背景下不断增强的热浪强度和频率,凸显了对热浪健康效应探究的重要性。[目的]计算2013-2023年夏季上海热浪相关的超额中暑病例,分析热浪与居民中暑发生风险的关联,并进一步探讨热浪特征对中暑风... 详细信息

[背景]热浪带来的巨大健康损害和气候变暖背景下不断增强的热浪强度和频率,凸显了对热浪健康效应探究的重要性。[目的]计算2013-2023年夏季上海热浪相关的超额中暑病例,分析热浪与居民中暑发生风险的关联,并进一步探讨热浪特征对中暑风险的修饰效应。[方法]采用回顾性生态学研究设计,从中国疾病预防控制中心的高温中暑病例报告系统中收集中暑个案资料,并收集徐家汇气象观测站的同期气象数据。将日最高气温≥35℃且持续时间不少于3 d的高温过程定义为高温热浪。以热浪期间实际报告的每日中暑病例数与31 d(该日及其前后各15 d)移动平均病例数之差,计算热浪相关的超额中暑病例数;并基于时间序列研究,采用广义线性模型等方法分析上海市热浪相关的中暑风险。[结果]研究期间共发生25次热浪过程,引起792.6例超额中暑病例。热浪期间居民中暑风险升高(RR=2.60,95%CI:2.08~3.26),但不同性别、年龄和地区间居民的中暑风险差异未见统计学意义;从热浪发生的先后次序来看,夏季第1次热浪期间中暑风险最高(RR=3.58,95%CI:2.82~4.55),且明显高于第2次热浪(RR=2.19,95%CI:1.66~2.90),第3次及以后的热浪过程的中暑风险差异无统计学意义;热浪对居民中暑的影响持续超过4 d,且第4天及以上时的中暑风险更高(RR=2.95,95%CI:2.28~3.83),明显高于热浪第1天时的中暑风险(RR=1.74,95%CI:1.18~2.56)。[结论]2013-2023年夏季热浪期间上海市居民中暑风险升高,应加以关注,尤其是发生时间早,持续时间长的热浪过程。

关键词：热浪中暑超额病例热浪特征

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PerK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(er)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between er stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the er stress pathway protein kinase-like endoplasmic reticulum kinase(PerK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of er stress using inhibitors or by si RNA knockdown of the PerK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and er stress and suggesting PerK as an essential target for regulating *** autophagy with chloroquine exacerbated er stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal er stress and promote autophagy,and suggest that PerK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PerK

Visualization of the protective role of estrogen against female liver fibrosis via an er viscosity NIR fluorescent probe

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Science China Chemistry 2024年

作者： zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu Xiang Xia Ning Xu Wen Sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of technology

Endoplasmic reticulum(er) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first er-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle er and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring er viscosity-involved physiological and pathological processes.

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基于信誉评分的共识网络重组机制设计

网络安全与数据治理 2024年第6期43卷 1-7,15页

作者：郑儿陈麓竹赵静姚旺君文新华北计算机系统工程研究所北京100083 中国电子信息产业集团有限公司广东深圳518057

针对共识算法对良性节点占比的依赖,设计了一种基于信誉评分的共识网络重组机制,使得网络能在遭受攻击或发生故障时迅速自我修复和重组,显著提升了抗攻击能力和服务连续性。首先基于信誉机制理论,开发了一个分布式信誉评分系统,实时评... 详细信息

针对共识算法对良性节点占比的依赖,设计了一种基于信誉评分的共识网络重组机制,使得网络能在遭受攻击或发生故障时迅速自我修复和重组,显著提升了抗攻击能力和服务连续性。首先基于信誉机制理论,开发了一个分布式信誉评分系统,实时评估节点信誉,有效处理潜在恶意节点。此外,提出了一种基于信誉评分的共识网络重组机制,通过识别和隔离恶意节点来增强网络的弹性和安全性。该机制设计了网络弹性重组算法,整合了冗余设置、故障诊断和服务节点重新配置功能,确保网络稳定运行和高可靠性。该研究对金融服务、云计算和物联网等广泛使用共识技术的高安全需求领域具有重要应用价值。

关键词：信誉机制分布式系统网络重组

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基于巢式PCR的紫草鉴别引物筛选

药物分析杂志 2024年第5期44卷 756-765页

作者：刘杰谷海媛戴胜云乔菲连超杰郑健加沙尔·斯哈克中国食品药品检定研究院北京102629 沈阳药科大学沈阳110016 伊犁哈萨克自治州检验检测认证研究院伊型835000

目的:基于巢式聚合酶链式反应(PCR)理念设计并筛选出可用于高效扩增与鉴别紫草市场样品真伪的特异性引物。方法:针对新疆紫草的ITS序列和紫草非《中华人民共和国药典》品ITS2序列,利用Primer Premier 5软件进行巢式引物设计;比较ITS2通... 详细信息

目的:基于巢式聚合酶链式反应(PCR)理念设计并筛选出可用于高效扩增与鉴别紫草市场样品真伪的特异性引物。方法:针对新疆紫草的ITS序列和紫草非《中华人民共和国药典》品ITS2序列,利用Primer Premier 5软件进行巢式引物设计;比较ITS2通用引物PCR和巢式PCR对紫草药材基因组DNA的扩增效率;基于巢式引物直接扩增紫草基因组DNA,并进行琼脂糖凝胶电泳检测;基于扩增产物片段长度、变异位点覆盖情况对设计的紫草药材特异性引物进行评价。结果:经过Primer Premier 5软件进行引物设计共选出11对引物进行合成;巢式PCR对紫草药材基因组DNA的扩增效率明显优于ITS2通用引物PCR;基于巢式引物直接扩增紫草基因组DNA琼脂糖凝胶电泳检测的结果明显优于ITS2引物直接扩增紫草基因组DNA,且呈单一条带;确定AE-9S/AE-2A、AE-4S/AE-10A、AE-12S/10A、AE-29S/AE-29A共4对引物适用于紫草正伪品鉴定。结论:在DNA条形码鉴定和巢式PCR技术的基础上,确定了4对可以用于有效区分药材市场中主流的新疆紫草和紫草非《中华人民共和国药典》品的特异性引物,为后续紫草药材及其他中药民族药品种的鉴定方法研究与开发提供了可参考的依据。

关键词：紫草聚合酶链式反应(PCR) 内部转录间隔区2(ITS2) DNA条形码巢式PCR(nPCR)

Diastereodivergent synthesis of fully disubstituted spiro[indoline-3,2’-pyrrolidin]-2-ones via tuneable Lewis base/Brønsted base-promoted(3+2)cycloadditions

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Organic Chemistry Frontiers 2022年第1期9卷 19-24页

作者： Ke Li Zhipeng Zhang Jiahui Zhu Yuxin Wang Jing Zhao er-Qing Li zheng Duana College of Chemistry Green Catalysis CenterInternational Phosphorus LaboratoryInternational Joint Research Laboratory for Functional Organophosphorus Materials of Henan ProvinceZhengzhou UniversityZhengzhou 450001P.R.China Xuchang Environmental Monitoring Center Henan ProvinceP.R.China

Herein we report a diastereodivergent synthesis of fully disubstituted spiro[indoline-3,2’-pyrrolidin]-2-ones through base-promoted(3+2)***,the catalysts are found to have full control over the configuration of the *** a Lewis base(PCy3)is used as a catalyst,good yields and excellent diastereoselectivities are obtained,regardless of the properties of the substituents,whereas spiro[indoline-3,2’-pyrrolidin]-2-ones of a different diastereoisomer are produced in good yields when a Brønsted base(K_(2)CO_(3))is ***-MS experiments proved the existence of key zwitterionic intermediates.

关键词： base stereo substituted

Synergistic Pd/Cu catalysis enabled cross-coupling of glycosyl stannanes with sulfonium salts to access C-aryl/alkenyl glycals

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Chinese Chemical Letters 2023年第7期34卷 102-106页

作者： Weitao Yan Mingwen zheng Peihsuan Chuang Hao Sun Shiping Wang Chunfa Xu Fen-er Chen Institute of Pharmaceutical Science and technology College of ChemistryFuzhou UniversityFuzhou 350108China National Engineering Research Center of Chemical Fertilizer Catalyst College of Chemical EngineeringFuzhou UniversityFuzhou 350108China Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs Fudan University.Shanghai 200433China

A highly efficient coupling of glycosyl stannanes and sulfonium salts enabled by synergistic Pd/Cu catalysis is disclosed, facilitating the construction of C-aryl/alkenyl glycals under mild conditions in high *** protocol tolerates a wide scope of functional groups including ketone, cyano, ester, amide, nitro,halide. The one-pot formal C–H glycosylation starting from arene is demonstrated with a reaction sequence of dibenzothiophenylation/Stille coupling. Besides, a gram-scale reaction is performed successfully,showing the high applicability of this protocol.

关键词： C-glycals Sulfonium salts Synergistic catalysis Carbohydrate Glycosyl stannanes Stille coupling