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Silent Sinus Syndrome: Clinical Findings and Differential Diagnosis

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Case Reports in Clinical Medicine 2014年第5期3卷 293-303页

作者： Paolo Bossolesi Barbara Pedruzzi enzo Emanuelli U.O. di Otorinolaringoiatria Azienda ULSS 8 Asolo Ospedale di Castelfranco Veneto e Montebelluna (TV) Italy U.O.A. Chirurgia Endoscopica delle Vie Aeree Azienda Ospedaliera di Padova Padova Italy U.O.C. Otorinolaringoiatria e Otochirurgia Azienda Ospedaliera di Padova Padova Italy

The Silent Sinus Syndrome (SSS) is a rare condition that causes facial asymmetry, unilateral enophthalmos and diplopia. It is thought to be secondary to chronic maxillary sinus atelectasis (CMA) with reabsorbed bone and subsequent displacement of the orbital floor. Such anatomic modifications occur over time, and therefore it is possible to encounter different stages of the same disease with or without orbital displacement. Clinical findings can be unclear so it makes sense to recognize potentially evolving SSS while other disturbances have to be ruled out. Our purpose is to underline clinical findings for different diagnosis and proper management. We consider Functional Endoscopic Sinus Surgery (FESS) indicated in CMA and SSS to halt the progression of the disease. Nevertheless restitution treatment of enophtalmos due to orbital floor displacement involves plastic reconstruction of the floor of the orbit via transconjunctival approach. We report a case of SSS and discuss distinctive features of non-neoplastic lesions involving the maxillary sinus that should be considered for differential diagnosis.

关键词： Silent Sinus Syndrome SSS Unilateral Enophthalmos Diplopia Chronic Maxillary Sinus Atelectasis Displacement of the Orbital Floor Functional Endoscopic Sinus Surgery

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低能耗绿色环保的镁合金阳极氧化处理技术

铸造技术 2007年第12期28卷 1554-1559页

作者：陈晓阳 enzo Strazzi 深圳市亚美科技有限公司 Italfinish SpA Via Lungo Serio 124050 Grassobbio(BG)Italy

1 镁合金的特点、应用及表面防护在许多领域（比如汽车工业），镁逐渐与铝相匹配，或者成为铝的竞争对手。

关键词：阳极氧化处理镁合金绿色环保低能耗技术表面防护汽车工业竞争对手

Massive carcinoma of the cornea in an immunocompetent patient

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Health 2011年第4期3卷 245-248页

作者： Irene Pecorella Pierluigi Grenga enzo Maria Vingolo 不详

A case of massive well-differentiated, superficially invasive, squamous cell carcinoma of the cornea is described. This patient did not have any common identifiable risk factors in the development of SCC of the ocular surface, such as excessive solar exposure, HPV infection, immunocompromised state, or chronic ocular irritation. A perforating injury in the cornea of the same eye had occurred 11 years before. The possible role of trauma in causing subsequent neoplastic development is discussed, as well as the immunohistochemical results for p53 and p63.

关键词： Squamous Cell Carcinoma Cornea HPV Trauma Solar Elastosis

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酒精对男性生殖功能有何影响？一个文献综述

Asian Journal of Andrology 2013年第2期15卷 221-225,I0006页

作者： Sandro La Vignera Rosita A Condorelli Giancarlo Balercia enzo Vicari Aldo E Calogero Section of Endocrinology Andrology and Internal Medicine Department of Medical and Pediatric Sciences University of Catania Catania 95123 Italy Department of tnternat Medicine and Applied Biotechnologies Politechnic University of Marche Ancona 60100 Italy

Although alcohol is widely used, its impact on the male reproductive function is still controversial. Over the years, many studies have investigated the effects of alcohol consumption on sperm parameters and male infertility. This article reviews the main preclinical and clinical evidences. Studies conducted on the experimental animal have shown that a diet enriched with ethanol causes sperm parameter abnormalities, a number of alterations involving the reproductive tract inhibition, and reduced mouse oocyte in vitro fertilization rate. These effects were partly reversible upon discontinuation of alcohol consumption. Most of the studies evaluating the effects of alcohol in men have shown a negative impact on the sperm parameters. This has been reported to be associated with hypotestosteronemia and low-normal or elevated gonadotropin levels suggesting a combined central and testicular detrimental effect of alcohol. Nevertheless, alcohol consumption does not seem to have much effect on fertility either in in vitro fertilization programs or population-based studies. Finally, the genetic background and other concomitant, alcohol consumption-related conditions influence the degree of the testicular damage. In conclusion, alcohol consumption is associated with a deterioration of sperm parameters which may be partially reversible upon alcohol consumption discontinuation.

关键词： alcohol HPT hypothalamic-pituitary-testicular axis male infertility reproductive function sperm parameters spermatogenesis teratozoospermia

Assessment of microbial pools by an innovative microbiological technique during the co-composting of olive mill by-products

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Agricultural Sciences 2011年第2期2卷 104-110页

作者： Teresa Casacchia Pietro Toscano Adriano Sofo enzo Perri 不详

Different mixtures of olive pomace (OP), olive mill wastewater (OMWW) and olive pruning residues (OPR) were aerobically co-composted under natural conditions. Compost temperature showed a sharp increase in the first 40-60 days, followed by a stabilization at 60°C and a decline after 150 days, whereas compost water content ranged from 50-55% to 25-30%. Total and selec-tive microbial counts were followed throughout the experiment by means of innovative (IMT) and conventional (CMT) microbiological techniques. Pseudomonas spp., anaerobic bacteria, actino-mycetes, and fungi reached levels of 8, 7, 5 and 6 log CFU g–1 compost, respectively, with a slight depression after 30-80 days. Total and fecal coliforms strongly decreased during the com-posting process. The use of IMT allowed to de-tect a higher and more stable growth of micro-organisms if compared to CMT. IMT was dem-onstrated to be an appropriate and reliable method for monitoring the microbial pools dur-ing the co-composting process.

关键词： Composting Olive Mill Wastewater Olive Pomace Pruning Residues

Impact of new technologies on diabetes care

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World Journal of Diabetes 2015年第8期6卷 999-1004页

作者： Elisa Giani Andrea enzo Scaramuzza Gian Vincenzo Zuccotti Department of Pediatrics Ospedale dei Bambini-V. Buzzi Università degli Studi di Milano Department of Pediatrics Ospedale L. Sacco Center for Research in Nutrition (CURN) Biomedical and Clinical Science Department Università degli Studi di Milano

Technologies for diabetes management,such as continuous subcutaneous insulin infusion(CSII)and continuous glucose monitoring(CGM)systems,have improved remarkably over the last *** developments are impacting the capacity to achieve recommended hemoglobin A1c levels and assisting in preventing the development and progression of microand macro vascular *** improvements in metabolic control and decreases in risk of severe and moderate hypoglycemia have been described with use of these technologies,large epidemiological international studies show that many patients are still unable to meet their glycemic goals,even when these technologies are *** editorial will review the impact of technology on glycemic control,hypoglycemia and quality of life in children and youth with type 1 *** reviewed include CSII,CGM systems and sensoraugmented insulin *** addition,the usefulness of advanced functions such as bolus profiles,bolus calculators and threshold-suspend features will be also ***,the current editorial will explore the challenges of using these ***,despite the evidence currently available of the potential benefits of using advanced technologies in diabetes management,many patients still report barriers to using *** this article will highlight the importance of future studies tailored toward overcome these barriers to optimizing glycemic control and avoiding severe hypoglycemia.

关键词： Diabetes Technology Glycemic control Quality of life Outcomes Management

Soluble ST2:A new and promising activity marker in ulcerative colitis

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World Journal of Gastroenterology 2011年第17期17卷 2181-2190页

作者： David Díaz-Jiménez Lucía E Núez Caroll J Beltrán enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera Disciplinary Program of Immunology Institute of Biomedical SciencesFaculty of MedicineUniversidad de ChileSantiagoCL 8380453Chile Department of Clinical Investigation Hospital Clínico de la Universidad de ChileSantiagoCL 8380456Chile Laboratory of Oncology and Molecular Genetics Colorectal Surgery UnitClínica Las CondesLo Fontecilla 441SantiagoCL 7591046Chile Department of Gastroenterology Pontificia Universidad Católica de ChileSantiagoCL 8380074Chile Cell and Molecular Biology Program Biomedical Sciences InstituteFaculty of MedicineUniversidad de ChileSantiagoCL 8380453Chile Gastroenterology Unit Department of Internal MedicineHospital Clínico de la Universidad de ChileSantiagoCL 8380456Chile Gastroenterology Unit Clínica Las CondesLo Fontecilla 441SantiagoCL 7591046Chile

AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive ***:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or *** serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to *** sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of ***:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of *** of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,*** AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r =

关键词：煽动性的肠疾病 Ulcerative 大肠炎可溶的 ST2 Biomarkers

Helicobacter pylori-induced inflammation masks the underlying presence of low-grade dysplasia on gastric lesions

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World Journal of Gastroenterology 2020年第26期26卷 3834-3850页

作者： Alba Panarese Giovanni Galatola Raffaele Armentano Pedro Pimentel-Nunes enzo Ierardi Maria Lucia Caruso Francesco Pesce Marco Vincenzo Lenti Valeria Palmitessa Sergio Coletta Endrit Shahini Department of Gastroenterology and Digestive Endoscopy National Institute of Gastroenterology"S De Bellis"Research HospitalCastellana Grotte 70013Italy Department of Clinical Pathology National Institute of Gastroenterology"S De Bellis"Research HospitalCastellana Grotte 70013Italy Center for Research in Health Technologies and Information Systems Faculty of MedicinePorto 4200072Portugal Surgery and Physiology Department Faculty of Medicine of the University of PortoPorto 4200072Portugal Department of Emergency and Organ Transplantation University of BariBari 70124Italy Nephrology Section Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy First Department of Internal Medicine San Matteo Hospital FoundationUniversity of PaviaPavia 27100Italy Laboratory of Microbiology and Virology National Institute of Gastroenterology"S De Bellis"Research HospitalCastellana Grotte 70013Italy Gastroenterology Unit Institute for Cancer Research and TreatmentTurin 10121Italy

BACKGROUND Helicobacter pylori(***)infection has been associated with a long-term risk of precancerous gastric conditions(PGC)even after *** *** To investigate the efficacy of High-Resolution White-Light Endoscopy with Narrow-Band Imaging in detecting PGC,before/after *** *** We studied 85 consecutive patients with ***-related gastritis with/without PGC before and 6 mo after proven *** ***-Takemoto modified and endoscopic grading of gastric intestinal metaplasia classifications,were applied to assess the endoscopic extension of atrophy and intestinal *** histological result was considered to be the gold *** Sydney System,the Operative-Link on Gastritis-Assessment,and the Operative-Link on Gastric-Intestinal Metaplasia were used for defining histological gastritis,atrophy and intestinal metaplasia,whereas dysplasia was graded according to World Health Organization *** anti-parietal cell antibody and anti-intrinsic factor were measured when autoimmune atrophic gastritis was *** After *** eradication histological signs of mononuclear/polymorphonuclear cell infiltration and Mucosal Associated Lymphoid Tissue-hyperplasia,disappeared or decreased in 100%and 96.5%of patients respectively,whereas the Operative-Link on Gastritis-Assessment and Operative-Link on Gastric-Intestinal Metaplasia stages did not ***-Grade Dysplasia prevalence was similar on random biopsies before and after *** eradication(17.6%vs 10.6%,P=0.19),but increased in patients with visible lesions(0%vs 22.4%,P<0.0001).At a multivariate analysis,the probability for detecting dysplasia after resolution of ***-related active inflammation was higher in patients with regression or reduction of Mucosal Associated Lymphoid Tissue hyperplasia,greater alcohol consumption,and anti-parietal cell antibody and/or anti-intrinsic factor positivity[odds ratio(OR)=3.88,95%confidence i

关键词： Autoimmune gastritis Dysplasia Diagnosis Malignancy Gastric cancer Symptoms Signs

Liver involvement in inflammatory bowel disease: What should the clinician know?

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World Journal of Hepatology 2021年第11期13卷 1534-1551页

作者： Giuseppe Losurdo Irene Vita Brescia Chiara Lillo Martino Mezzapesa Michele Barone Mariabeatrice Principi enzo Ierardi Alfredo Di Leo Maria Rendina Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy

Inflammatory bowel disease(IBD)may show a wide range of extraintestinal *** this context,liver involvement is a focal point for both an adequate management of the disease and its prognosis,due to possible serious *** association between IBD and primary sclerosing cholangitis is the most known *** association is relevant because it implies an increased risk of both colorectal cancer and ***,drugs such as thiopurines or biologic agents can cause drug-induced liver damage;therefore,this event should be considered when planning IBD ***,particular consideration should be given to the evidence that IBD patients may have concomitant chronic viral hepatitis,such as hepatitis B and hepatitis *** immunosuppressive regimens may cause a hepatitis flare or reactivation of a healthy carrier state,therefore careful monitoring of these patients is ***,the spread of obesity has involved even IBD patients,thus increasing the risk of non-alcoholic fatty liver disease,which has already proven to be more common in IBD patients than in the non-IBD *** phenomenon is considered an emerging issue,as it will become the leading cause of liver cirrhosis.

关键词： Inflammatory bowel disease Liver Primary sclerosing cholangitis Viral hepatitis Immunosuppression Non-alcoholic fatty liver disease