检索结果-南通市图书馆

往复压缩机气阀设计和维修

引用

压缩机技术 2013年第4期 52-53,83页

作者：马西莫.斯基亚沃尼克劳迪奥.瓦格里尼恩佐.嘉柯麦利柯赞尼(北京)压缩机气阀有限化司北京102209

阐述了压缩机气阀的设计和维修方法

关键词：气阀维修

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

在煽动性的肠疾病的 Fibrogenesis 和纤维变性: 一样的硬币的好、坏的方面？

引用

World Journal of Gastrointestinal Pathophysiology 2013年第4期4卷 100-107页

作者： Mariabeatrice Principi Floriana Giorgio Giuseppe Losurdo Viviana Neve Antonella Contaldo Alfredo Di Leo enzo Ierardi Gastroenterology Department of Emergency and Organ TransplantationUniversity of Bari

Fibrogenesis in inflammatory bowel diseases is a complex phenomenon aimed at mucosal repair. However, it may provoke intestinal fibrosis with the development of strictures which require surgery. Therefore, fibrogenesis may be considered as a 'two-faced' process when related to chronic intestinal inflammation. Many types of cells may be converted into the fibrogenic phenotype at different levels of the intestinal wall. A complex interaction of cytokines, adhesion molecules and growth factors is involved in the process. We report an overview of recent advances in molecular mechanisms of stricturizing Crohn’s disease(CD) including the potential role of trasforming growth factor beta, protein kinase C and Ras, Raf and ERK proteins. Fibrotic growth factors such as vascular endothelial growth factor and platelet-derived growth factor, as well as the Endothelial-to-Mesenchymal Transition induced by transforming growth factor-β, are considered. Finally, our experience, focused on tumor necrosis factor α(the main cytokine of inflammatory bowel diseases) and the link between syndecan 1(a heparan sulphate adhesion molecule) and basic fibroblast growth factor(a strong stimulator of collagen synthesis) is described. We hypothesize a possible molecular pattern for mucosal healing as well as how its deregulation could be involved in fibrotic complications of CD. A final clinical point is the importance of performing an accurate evaluation of the presence of fibrotic strictures before starting anti-tumor necrosis α treatment, which could worsen the lesions.

关键词： Fibrogenesis Fibrosis Tumor necrosis factor-α Syndecan 1 Basic fibroblast growth factor Cellular fibrogenic phenotype Inflammatory bowel diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

主要 clarithromycin 抵抗到 Helicobacter pylori : 这是为三倍的治疗失败的主要原因？

引用

World Journal of Gastrointestinal Pathophysiology 2013年第3期4卷 43-46页

作者： Floriana Giorgio Mariabeatrice Principi Vincenzo De Francesco Angelo Zullo Giuseppe Losurdo Alfredo Di Leo enzo Ierardi Division of Gastroenterology Department of Medical and Surgical Sciences University of Foggia 71100 Foggia Italy Division of Gastroenterology Department of Emergency and Organ Transplantation University of Bari 70124 Bari Italy Department of Gastroenterology and Digestive Endoscopy 'Nuovo Regina Margherita' Hospital 00153 Rome Italy

Conventional triple therapies for Helicobacter pylori (H. pylori ) eradication have recently shown a disappointing reduction in effectiveness in many countries. The main reason for failure was found to be bacterial resistance to one of the most commonly used antibiotics, clarithromycin. An additional problem for conventional triple therapy is the high rate of resistance to metronidazole found in Europe, America and Asia. In Italy, in the last 15 years a 2-fold increase in resistance has occurred. A recent study of the whole of Italy included about 20 patients from each region at the first endoscopic diagnosis of H. pylori infection. The most surprising result was the patchy distribution of resistance, which was almost absent in two regions (one northern and one southern), although the highest prevalence was found in some regions of the South. In the paediatricpopulation we found a 25% prevalence of resistance in a sample of H. pylori positive children observed between 2002 and 2007, mirroring data obtained in southern European countries. Clarithromycin resistance assessment is currently based on phenotypic detection performed after culture the agar dilution method or E-test, and genotypic methods based on polymerase chain reaction (PCR). In a recent comparative study we found a 71.2% agreement between the two methods. Culture-free techniques are highly accurate in finding even minimal traces of genotypically resistant strains. Moreover, PCR-based tools are accurate in detecting a heteroresistant status, defined as the co-existence of some strains that are susceptible and some resistant to the same antibiotic in an individual patient. Three point mutations, namely A2143G , A2142G and A2142C , are responsible for 90% of cases of primary clarithromycin resistance in H. pylori strains isolated in Western countries, although we previously demonstrated that the presence of the A2143G mutation, but not A2142G or A2142C , significantly lowered the H. pylori eradication rate

关键词： Helicobacter pylori Clarithromycin Genotypic resistance Phenotypic resistance Therapy failure cost Resistance epidemiology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

作为可持续和电气化应用的软磁材料

引用

家电科技 2019年第2期 9-9页

作者： Josefina M. Silveyra enzo Ferrara Dale L. Huber Todd C. Monson 李巧红(编译) 不详

软磁材料是下一代电力电子和电机(电动机和发电机)高效运行的关键。自从迈克尔·法拉第发现磁感应以来,己经引入了许多新材料,当时铁是唯一的选择。然而,随着宽带隙半导体器件在电力电子和电机控制器中越来越普遍,软磁材料的进一步改进... 详细信息

软磁材料是下一代电力电子和电机(电动机和发电机)高效运行的关键。自从迈克尔·法拉第发现磁感应以来,己经引入了许多新材料,当时铁是唯一的选择。然而,随着宽带隙半导体器件在电力电子和电机控制器中越来越普遍,软磁材料的进一步改进迫在眉睫。

关键词：软磁材料电气化应用电力电子电机控制器半导体器件高效运行发电机

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：