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Endoscopic submucosal dissection training with pig models in a Western country

World Journal of Gastroenterology 2010年第23期16卷 2895-2900页

作者： Adolfo Parra-Blanco María Rosa Arnau David Nicolás-Pérez Antonio Z Gimeno-García Nicolás González Juan A Díaz-Acosta Alejandro Jiménez enrique Quintero Department of Gastroenterology University Hospital of the Canary Islands Ofra s/n Endoscopy Unit Department of GastroenterologyAsturias Central University HospitalCelestino Villamil s/n Research Animal Laboratory Ofra s/nLa Laguna University Department of Gastroenterology Montevideo Clinic HospitalAvda Italia s/n Research Unit University Hospital of the Canary IslandsOfra s/n

AIM:To test a strategy for endoscopic submucosal dissection(ESD) training in animal models designed to overcome the initial learning ***:ESD was attempted in ex vivo and in vivo pig *** ESD procedures were attempted in the esophagus(n=9) or the stomach(n=21).The ex vivo model was used until initial competence was *** the in vivo model,several ESD procedures were performed in up to 3 *** following variables were analyzed:specimen size,complete and en bloc resection rate,time for circumferential incision,time for submucosal dissection,total ESD duration,and ***:Complete resection was achieved in 28 cases(en bloc 27);2 could not be completed(one perforation,one technical diff iculty).The mean ± SD time for circumferential incision was 36.2±16.8 min(range:8-87 min),and the mean±SD time for submucosal dissection was 45.1±35.7 min(range:9-196 min).The mean±SD size of the resected specimens was 45.2±17.8 *** mean±SD total resection time was signif icantly increased for the gastric cases performed in the f irst half of the study(n=13) than in the second half(n=8)(98.9±62.4 min vs 61.7±17.6 min,P=0.04),although the specimen size did not ***:Training in animal models could help endoscopists overcome the learning curve before starting ESD in humans.

关键词： Endoscopic submucosal dissection Training Animal model

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Parametrization to Improve the Solution Accuracy of Problems Involving the Bi-Dimensional Dirac Delta in the Forcing Function

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Journal of Applied Mathematics and Physics 2015年第9期3卷 1168-1177页

作者： enrique J. Chicurel-Uziel Francisco A. Godínez Instituto de Ingeniería Universidad Nacional Autónoma de México México D.F. México

The representation of the Dirac delta, obtained by differentiating the parametric equation of the unit step with a riser, is used to solve two examples referring to problems of a different physical nature, each with the product of two deltas as a forcing function. Each problem was solved by an entirely different procedure. In comparison with non-parametric solutions, the present solutions are both more accurate and truer representations of the physics involved.

关键词： Dirac Delta Partial Differential Equations Parametric Representation

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Sequential treatment in disseminated well-and intermediate-differentiated pancreatic neuroendocrine tumors:Common sense or low rationale?

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World Journal of Clinical Oncology 2016年第2期7卷 149-154页

作者： enrique Grande Department of Medical Oncology Ramón y Cajal University Hospital

Fortunately,the landscape of the systemic treatment for grade 1 and 2 pancreatic neuroendocrine tumors has changed in the last decade with at least four different alternatives approved in the ***,somatostatin analogues,sunitinib and everolimus remind valid options according to the most referenced international ***,and although this is something done in the routine practice,there is a lack of evidence for the use of any of these strategies after failure to the ***,further sequential alternatives in third or fourth line have never been tested *** need for a better understanding of the rationale to sequence different systemic options is even greater in non-pancreatic neuroendocrine tumors since available therapies are *** strategies in other solid tumors have led to a clear improvement in overall *** is also believed to occur in neuroendocrine tumors but no clear data on it has been delivered *** postulate that the different mode of action of the systemic options available for the treatment of neuroendocrine tumors may avoid the complete resistance of one option after the other and that sequential use of these agents will be translated into a longer overall survival of *** and randomized trials that seek for the activity of drugs after failure to another systemic alternatives are highly needed in this field of neuroendocrine tumors.

关键词： Carcinoids Everolimus Neuroendocrine tumors Pancreas Overcoming resistance Sequentialtreatment Sunitinib

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Impact of liver enzymes on SARS-CoV-2 infection and the severity of clinical course of COVID-19

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Liver Research 2021年第1期5卷 21-27页

作者： Fátima Higuera-de la Tijera Alfredo Servín-Caamaño Daniel Reyes-Herrera Argelia Flores-López enrique J.A.Robiou-Vivero Felipe martínez-Rivera Victor Galindo-Hernández Oscar Chapa-Azuela Alfonso Chávez-Morales Victor H.Rosales-Salyano Multidisciplinary Team for the Attention and Care of Patients with COVID-19 Hospital General de México Dr.Eduardo LiceagaMexico CityMexico Gastroenterology and Hepatology Department Hospital General de México Dr.Eduardo LiceagaMexico CityMexico Internal Medicine Department Hospital General de México Dr.Eduardo LiceagaMexico CityMexico Hepatobiliary and Pancreatology Clinic Surgery DepartmentHospital General de México Dr.Eduardo LiceagaMexico CityMexico Intensive Care Unit Hospital General de México Dr.Eduardo LiceagaMexico CityMexico

Background and aim Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the virus responsible for the current pandemic,can have multi-organ *** studies show that liver injury could be a manifestation of the disease,and that liver disease could also be related to a worse *** aim was to compare the characteristics of patients with severe coronavirus disease 2019(COVID-19)due to SARS-CoV-2 who required intubation versus stable hospitalized patients to identify the early biochemical predictive factors of a severe course of COVID-19 and subsequent requirement for intubation,specifically in *** This was an observational case-control study nested in a cohort *** medical records of patients admitted for confirmed COVID-19 at a tertiary level center in Mexico City were *** and biochemical data were collected,and the characteristics of patients who required invasive mechanical ventilation(IMV)(cases)were compared with stable hospitalized patients without ventilation(controls).Results We evaluated 166 patients with COVID-19 due to SARS-CoV-2 infection;114(68.7%)were men,the mean age was 50.6±13.3 years,and 27(16.3%)required *** comparative analysis between cases and controls showed(respectively)significantly lower blood oxygen saturation(SpO_(2))(73.5±12.0%vs.83.0±6.8%,P<0.0001)and elevated alanine aminotransferase(ALT)(128(14–1123)IU/L vs.33(8–453)IU/L,P=0.003),aspartate aminotransferase(AST)(214(17–1247)vs.44(12–498)IU/L,P=0.001),lactic dehydrogenase(LDH)(764.6±401.9 IU/L vs.461.0±185.6 IU/L,P=0.001),and D-dimer(3463(524–34,227)ng/mL vs.829(152–41,923)ng/mL,P=0.003)*** in the cases group were older(58.6±12.7 years vs.49.1±12.8 years,P=0.001).Multivariate analysis showed that important factors at admission predicting the requirement for IMV during hospitalization for COVID-19 were AST≥250 IU/L(odds ratio(OR)=64.8,95%confidence interval(CI)7.5–560.3,P<0.0001)and D-dimer≥3500 ng/mL(OR=4.1,95

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Liver enzymes D-dimer Disease severity Invasive mechanical ventilation(IMV) Multi-organ failure

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Renal function and choroidal thickness using swept-source optical coherence tomography in diabetic patients

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 985-989页

作者： Antonio Manuel Garrido-Hermosilla Mariola Méndez-Muros Estanislao Gutiérrez-Sánchez Cristóbal Morales-Portillo María Jesús Díaz-GrANDa Eduardo Esteban-González Isabel Relimpio-López María Asunción martínez-Brocca enrique Rodríguez-de-la-Rúa-Franch Department of Ophthalmology Virgen Macarena University HospitalSeville 41009Spain OftaRed Institute of Health Carlos IIIMadridSpain Department of Endocrinology and Nutrition Virgen Macarena University HospitalSeville 41009Spain

AIM: To assess the relationship between choroidal thickness and renal function in diabetic patients. METHODS: Cross-sectional retrospective clinical study of 42 eyes of 21 ocular treatment-na?ve diabetic patients. Demographic data included: age, sex, type and course of diabetes. Ocular data included: severity of diabetic retinopathy;retinal thickness at the central macular region, as well as choroidal thickness at the central and paracentral quadrants, using automatically generated maps by swept-source optical coherence tomography;presence of cystic macular edema;and ocular axial length(AXL). Lab-test parameters included: glycated hemoglobin(HbA1c), albuminuria, albumin/creatinine ratio in urine, and glomerular filtration rate. RESULTS: A significant negative correlation was mainly observed between several choroidal thicknesses, age(P<0.020) and ocular AXL(P<0.030). On the contrary, a significant positive correlation was found between all choroidal thicknesses, HbA1 c(P<0.035) and albuminuria(P<0.040). CONCLUSION: Choroidal thickness can represent an additional tool to help clinicians predicting the renal status in ocular treatment-na?ve diabetic patients.

关键词： choroidal thickness renal function swept-source optical coherence tomography spectral-domain optical coherence tomography diabetes mellitus

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Is X(3872) a bound state?

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Chinese Physics C 2019年第12期43卷 115-120页

作者： Pablo G.Ortega enrique Ruiz Arriola Grupo de Fisica Nuclear and Instituto Universitario de Fisica Fundamental y Matematicas(IUFFyM) Universidad de SalamancaE-37008 SalamancaSpain Departamento de Fisica Atomica Molecular y Nuclear and Instituto Carlos I de Fisica Teorica y ComputacionalUniversidad de GranadaE-18071 GranadaSpain

All existing experimental evidence for the bound state nature of X(3872)relies on observing its decay products,which are measured with a finite experimental mass resolution that is typically△m≥2 MeV,and much larger than its alleged binding energy,BX=0.00(18)*** the other hand,we have found recently that there is a clear cancellation in the 1^++channel of the invariant DD^*mass around the threshold between continuum and the bound *** is very much like a similar cancellation in the proton-neutron continuum with the deuteron in the 1^++*** on comparative fits with a common Tsallis distribution of the experimental cross-sections for prompt production of deuterons and X(3872)in pp collisions with a finite pT,we find a strong argument for questioning the bound state nature of this state,which also suggests that the large observed production rate could be consistent with a half-bound state.

关键词： charmonium molecular states particle production Tsallis distribution

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Parametric Dirac Delta to Simplify the Solution of Linear and Nonlinear Problems with an Impulsive Forcing Function

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Journal of Applied Mathematics and Physics 2013年第7期1卷 16-25页

作者： enrique J. Chicurel-Uziel Francisco A. Godínez-Rojano Instituto de Ingeniería Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de México México D.F. México

The Laplace transform is a very useful tool for the solution of problems involving an impulsive excitation, usually represented by the Dirac delta, but it does not work in nonlinear problems. In contrast with this, the parametric representation of the Dirac delta presented here works both in linear and nonlinear problems. Furthermore, the parametric representation converts the differential equation of a problem with an impulsive excitation into two equations: the first equation referring to the impulse instant (absent in the conventional solution) and the second equation referring to post-impulse time. The impulse instant equation contains fewer terms than the original equation and the impulse is represented by a constant, just as in the Laplace transform, the post-impulse equation is homogeneous. Thus, the solution of the parametric equations is considerably simpler than the solution of the original equation. The parametric solution, involving the equations of both the dependent and independent variables in terms of the parameter, is readily reconverted into the usual equation in terms of the dependent and independent variables only. This parametric representation may be taught at an earlier stage because the principle on which it is based is easily visualized geometrically and because it is only necessary to have a knowledge of elementary calculus to understand it and use it.

关键词： Dirac Delta Parametric Representation Nonlinear Differential Equations Impulsive Problems

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Presacral venous bleeding during mobilization in rectal cancer

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World Journal of Gastroenterology 2017年第9期23卷 1712-1719页

作者： Jose enrique Casal Núnez Vincenzo Vigorita Alejandro Ruano Poblador Ana María Gay Fernández Maria ángeles Toscano Novella Nieves Cáceres Alvarado Lucinda Pérez Dominguez Coloproctology Unit and General and Digestive Surgery Unit Vigo University Hospital Complex36212 VigoSpain

To analyze the anatomy of sacral venous plexus flow, the causes of injuries and the methods for controlling presacral hemorrhage during surgery for rectal *** review of the databases MEDLINE® and Embase™ was conducted, and relevant scientific articles published between January 1960 and June 2016 were examined. The anatomy of the sacrum and its venous plexus, as well as the factors that influence bleeding, the causes of this complication, and its surgical management were *** is a review of 58 published articles on presacral venous plexus injury during the mobilization of the rectum and on techniques used to treat presacral venous bleeding. Due to the lack of cases published in the literature, there is no consensus on which is the best technique to use if there is presacral bleeding during mobilization in surgery for rectal cancer. This review may provide a tool to help surgeons make decisions regarding how to resolve this serious *** series of alternative treatments are described; however, a conventional systematic review in which optimal treatment is identified could not be performed because few cases were analyzed in most publications.

关键词： Presacral hemorrhaging Rectal surgery Sacral venous plexus Pelvic surgery Sacral anatomy

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Epigallocatechin-3-gallate treatment to promote neuroprotection and functional recovery after nervous system injury

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Neural Regeneration Research 2015年第9期10卷 1390-1392页

作者： Pere Boadas-Vaello enrique Verdú Research Group of Clinical Anatomy Embryology and Neuroscience (NEOMA) Universitat de Girona Faculty of Medicine Department of Medical Sciences

Traumatic spinal cord injury （SCI） causes motor paralysis, sensory anesthesia and autonomic dysfunction below the le- sion site and additionally some SCI patients refer neuropathic pain together with these signs and symptoms. Clinical and experimental studies have revealed the main pathological changes of injured spinal cord implicated in all these signs and symptoms, including neuropathic pain. After few hours of traumatic SCI, it is usual to observe broken blood brain barrier with plasma and blood cells extravasation, cell necrosis, disruption of ascending and descending spinal cord pathways and increased potassium and glutamate. Glutamate contributes to excitotoxicity of neurons whereas potassium facilitates ectopic depolarization of survival neurons and activation of resident microglia.

关键词： EGCG JAK STAT NF Epigallocatechin-3-gallate treatment to promote neuroprotection and functional recovery after nervous system injury SCI

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Development and characterization of photovoltaic tandemjunction nanowires using electron-beam-induced current measurements

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Nano Research 2022年第9期15卷 8510-8515页

作者： Lukas Hrachowina enrique Barrigón Magnus T.Borgström NanoLund and Divison of Solid State Physics Lund UniversityBox 11822100 LundSweden Universidad de Málaga Andalucía TechDepartamento de Física Aplicada ⅠCampus de Teatinoss/nMálaga 29071Spain

Nanowires have many interesting properties that are of advantage for solar cells,such as the epitaxial combination of latticemismatched materials without plastic *** could be utilized for the synthesis of axial tandem-junction nanowire solar cells with high efficiency at low material ***-beam-induced current measurements have been used to optimize the performance of single-junction nanowire solar ***,we use electron-beam-induced current measurements to break the barrier to photovoltaic tandem-junction *** particular,we identify and subsequently prevent the occurrence of a parasitic junction when combining an InP n-i-p junction with a tunnel ***,we demonstrate how to use optical and electrical biases to individually measure the electron-beam-induced current of both sub-cells of photovoltaic tandem-junction *** show that with an applied voltage in forward direction,all junctions can be analyzed *** development of this characterization technique enables further optimization of tandem-junction nanowire solar cells.

关键词： Ⅲ-Ⅴnanowire nanowire solar cell tandem-junction Esaki tunnel diode electron-beam induced current(EBIC)

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