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The relationship between transport-to-school habits and physical activity in a sample of New Zealand adolescents

Journal of Sport and Health Science 2019年第5期8卷 463-470页

作者： Chiew Ching Kek enrique García Bengoechea John C.Spence Sandra Mandic Active Living Laboratory School of Physical EducationSport and Exercise SciencesUniversity of OtagoDunedin 9054New Zealand Department of Physical Education and Sport Sciences Faculty of Education and Health SciencesUniversity of LimerickLimerickV94 T9PXIreland Institute for Health and Sport(IHES) Victoria UniversityMelbourneVIC 8001Australia Faculty of Kinesiology Sportand RecreationUniversity of AlbertaEdmontonAlbertaT6G 2H9Canada Centre for Sustainability University of OtagoDunedin 9054New Zealand

Objectives:Adolescents using active transport(AT)to school have higher levels of physical activity(PA)compared with motorized transport(MT)*** study compared school day and weekend day PA in adolescents using AT,MT,or combined AT and MT(AT + MT)to travel to ***:Adolescents(n= 314;age:14.7±1.4 years;32.8% boys)from Dunedin(New Zealand)wore an accelerometer for 7 days and completed a self-reported survey regarding mode of transport to school(73 AT,56 AT + MT,and 185 MT).Data were analyzed using t tests,analysis of variance,and χ2 ***:Although the proportion of adolescents meeting PA guidelines significantly differed among transport groups(AT,47.9%;AT + MT,46.4%;MT,33.5%;p=0.048;overall,39.2%),the observed differences were due mainly to *** with MT,AT and AT+MT engaged in more moderate-to-vigorous PA(MVPA)per day(AT:61.2 ± 23.2 min;AT+MT:59.6 ± 21.7 min;MT:52.5 ± 19.6 min;p = 0.004;p<0.001,adjusted for gender),per school day and before *** after school(15:00-16:00),AT engaged in significantly more MVPA compared with AT + MT and *** differences in MVPA between the groups were observed in the late afternoon/early evening period during school days or on weekend ***:Compared with MT users,adolescent girls using AT or AT + MT accumulated more MVPA during school commute *** + MT to school is also a plausible way to increase adolescent girls’ PA when AT only is not feasible.

关键词： Accelerometer Adolescent Physical activity Schools Transportation Walking

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Risk prediction model for cutaneous squamous cell carcinoma in adult cardiac allograft recipients

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World Journal of Transplantation 2021年第3期11卷 54-69页

作者： Nandini Nair Zhiyong Hu Dongping Du enrique Gongora Division of Cardiology Department of Internal MedicineTexas Tech Health Sciences CenterLubbockTX 79430United States Department of Industrial Manufacturing and Systems EngineeringTexas Tech UniversityLubbockTX 79409United States Department of Cardiothoracic Surgery University of Alabama at BirminghamBirminghamAL 35233United States

BACKGROUND Heart transplant recipients are at higher risk of developing skin cancer than the general population due to the long-term immunosuppression *** has been reported as one of the major causes of morbidity and mortality for patients after heart *** different types of skin cancers,cutaneous squamous cell carcinoma(cSCC)is the most common one,which requires timely screening and better *** To identify risk factors and predict the incidence of cSCC for heart transplant *** We retrospectively analyzed adult heart transplant recipients between 2000 and 2015 extracted from the United Network for Organ Sharing *** whole dataset was randomly divided into a derivation set(80%)and a validation set(20%).Uni-and multivariate Cox regression were done to identify significant risk factors associated with the development of *** operating characteristics curves were generated and area under the curve(AUC)was calculated to assess the accuracy of the prediction *** on the selected risk factors,a risk scoring system was developed to stratify patients into different risk groups.A cumulative cSCC-free survival curve was generated using the Kaplan-Meier method for each group,and the log-rank test was done to compare the intergroup cSCC *** There were 23736 heart-transplant recipients during the study period,and 1827 of them have been reported with *** predictors of post-transplant cSCC were older age,male sex,white race,recipient and donor human leukocyte antigen(HLA)mismatch level,malignancy at listing,diagnosis with restrictive myopathy or hypertrophic myopathy,heart re-transplant,and induction therapy with OKT3 or *** multivariate model was used to predict the 5-,8-and 10-year incidence of cSCC and respectively provided AUC of 0.79,0.78 and 0.77 in the derivation set and 0.80,0.78 and 0.77 in the validation *** risk scoring system assigned each patient with a

关键词： Cutaneous squamous cell carcinoma Heart transplantation Cox proportional hazard model Risk assessment Squamous cell carcinoma Mortality outcomes

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Evanescence:Time in Modern Plastic Art

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Fudan Journal of the Humanities and Social Sciences 2020年第4期13卷 535-558页

作者： Juan Antonio Roche Carcel Angel enrique Carretero Pasin University of Alicante AlicanteSpain University of Santiago de Compostela Santiago de CompostelaSpain

The Article follows the trail of Max Weber's comprehensive sociology and uses the hermeneutic and iconological analysis methods applied to significant contemporary plastic art works(painting and sculpture)which are representative of modern and late modern *** from these theoretical and methodological bases,it pursues three specific objectives:(a)to analyze the construction of Time in plastic art,(b)to verify how this theme has evolved in artistic practices from the first modernity to the second and(c)to verify the way in which the complementary visual language the conceptual of contemporary sociological *** this regard,our paper provides evidence that the selected works prioritize a kind of temporality determined by the logic of capitalist industrial *** likewise becomes obvious that time—focused on an accelerated and instantaneous omnipresent—lacks both an origin and a telos\it has neither a past nor a future and,in parallel,a gap has opened between the time of natural life and the artificial one,as well as between space and time,which is only transiently bridged at the imaginary level of ***,the experience of time has been emptied,in such a way that the latter has lost some of its solidity and让s sense of permanence,while the contingent,the fleeting and the ephemeral now occupy in its place.

关键词： Evanescent time Plastic art Iconological analysis Social hermeneutic Social sciences

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Integrated transmission and generation planning model in a leregulated environment

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Frontiers in Energy 2013年第2期7卷 182-190页

作者： enrique B. CEDENO Sant ARORA Industrial and Systems Engineering Division Mechanical EngineeringDepartment University of Minnesota Minneapolis MN 55455 USA

After the deregulation of the Power Sector in the U.S., planning for generation and transmission capacities is decentralized. There is, however, still need for the long term integrated planning of generation and transmission capacities at the macro level, since these two sectors must operate in a coordinated manner. This paper presents a model for integrating generation and transmission expansion planning to identify an indicative expansion plan for the total sector at the macro level. The argument for an integrated model is supported using evidence from integrated planning efforts in real life systems. The application of the proposed model is illustrated using an example that requires expansion of generation and transmission capacities over three regions in a deregulated power system. The example considers that addition of generating capacity should come from renewable sources. The test results show the potential cost saving from integrated planning.

关键词： integrated planning indicative plans powergeneration transmission deregulation

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Role of vitamin B_(12) on methylmalonyl-CoA mutase activity

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第6期13卷 423-437页

作者： Tóshiko TAKAHASHI-IIGUEZ enrique GARCíA-HERNANDEZ Roberto ARREGUíN-ESPINOSA María Elena FLORES Department of Molecular Biology and Biotechnology Institute of Biomedical ResearchNational Autonomous University of MexicoD.F.04510Mexico Department of Chemistry of Biomacromolecules Institute of ChemistryNational Autonomous University of MexicoD.F.04510Mexico

Vitamin B 12 is an organometallic compound with important metabolic derivatives that act as cofactors of certain enzymes,which have been grouped into three subfamilies depending on their *** them,methylmalonyl-CoA mutase (MCM) has been extensively *** enzyme catalyzes the reversible isomerization of L-methylmalonyl-CoA to succinyl-CoA using adenosylcobalamin (AdoCbl) as a cofactor participating in the generation of radicals that allow isomerization of the *** crystal structure of MCM determined in Propionibacterium freudenreichii *** has helped to elucidate the role of this cofactor AdoCbl in the reaction to specify the mechanism by which radicals are generated from the coenzyme and to clarify the interactions between the enzyme,coenzyme,and *** existence of human methylmalonic acidemia (MMA) due to the presence of mutations in MCM shows the importance of its role in *** recent crystallization of the human MCM has shown that despite being similar to the bacterial protein,there are significant differences in the structural organization of the two *** studies have identified the involvement of an accessory protein called MMAA,which interacts with MCM to prevent MCM's inactivation or acts as a chaperone to promote regeneration of inactivated *** interdisciplinary studies using this protein as a model in different organisms have helped to elucidate the mechanism of action of this isomerase,the impact of mutations at a functional level and their repercussion in the development and progression of MMA in *** is still necessary to study the mechanisms involved in more detail using new methods.

关键词： Vitamin B 12 Methylmalonyl-CoA mutase (MCM) MMAA MeaB Methylmalonic academia (MMA) Protectase Reactivase

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Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion

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Science China Chemistry 2018年第1期61卷 54-63页

作者： Haolan Zhang Danyu Wang Xue Lin Nikolaos Politakos Jimena S. Tuninetti Sergio enrique Moya Changyou Gao Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of Education Department of Polymer Science and Engineering Zhej iang University Hangzhou 310027 China Centre for Cooperative Research in Biomaterials San Sebastian 20009 Gipuzkoa Spain Dr. Li Dak Sum & Iqp Chin Center for Stem Cell and Regenerative Medicine Zhejiang University Hangzhou 310058 China

Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer(LbL) self-assembly are much attractive due to their advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate(PA) was synthesized, and was copolymerized with acrylic acid(AA) to obtain the amphiphilic and photodegradable P(PA-co-AA)polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride(PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549, HepG2 and endothelial cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected significantly until 5 d.

关键词： biomaterials multilayers surfaces photo-responsive cell adhesion

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Viability,behavior,and color expression in the offspring of matings between common wall lizard Podarcis muralis color morphs

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Current Zoology 2022年第1期68卷 41-55页

作者： Javier ABALOS Guillem PEREZ I DE LANUZA Alicia BARTOLOME Fabien AUBRET Tobias ULLER enrique FONT Ethology Lab Instituto Cavanilles de Biodiversidad y Biologı´a EvolutivaUniversitat de ValenciaValenciaSpain CIBIO/InBIO Centro de Investigacao em Biodiversidade e Recursos Geneticos da Universidade do PortoPortoPortugal SETE Station d’Ecologie Theorique et ExperimentaleUPR2001Centre National de la Recherche ScientifiqueParisFrance Department of Biology Lund UniversityLundSweden

Color polymorphisms are widely studied to identify the mechanisms responsible for the origin and maintenance of phenotypic variability in *** of the mechanisms of balancing selection currently thought to explain the long-term persistence of polymorphisms are the evolution of alternative phenotypic optima through correlational selection on suites of traits including color and *** of these mechanisms can generate differences in offspring viability and fitness arising from different morph ***,we examined the effect of parental morph combination on fertilization success,embryonic viability,newborn quality,antipredator,and foraging behavior,as well as inter-annual survival by conducting controlled matings in a polymorphic lacertid Podarcis muralis,where color morphs are frequently assumed to reflect alternative phenotypic optima(e.g.,alternative reproductive strategies).Juveniles were kept in outdoor tubs for a year in order to study inter-annual growth,survival,and morph *** agreement with a previous genome-wide association analysis,morph frequencies in the year-old juveniles matched the frequencies expected if orange and yellow expressions depended on recessive homozygosity at 2 separate *** findings also agree with previous literature reporting higher reproductive output of heavy females and the higher overall viability of heavy newborn lizards,but we found no evidence for the existence of alternative breeding investment strategies in female morphs,or morphcombination effects on offspring viability and *** conclude that inter-morph breeding remains entirely viable and genetic incompatibilities are of little significance for the maintenance of discrete color morphs in *** from the Pyrenees.

关键词： alternative breeding strategies color polymorphism controlled matings lizard behavior morph ontogeny newborn viability

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Challenges of bone tissue engineering in orthopaedic patients

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World Journal of Orthopedics 2017年第2期8卷 87-98页

作者： enrique Guerado enrique Caso Department of Orthopaedic Surgery and Traumatology Hospital Costa del SolUniversity of Malaga Research Unit Hospital Costa del SolUniversity of Malaga

Bone defects may impede normal biomechanics and the structural stability of bone as an organ. In many cases, the correction of bone defects requires extensive surgical intervention involving the use of bone-grafting techniques and other procedures in which healing is slow, there is a high risk of infection and considerable pain is provoked- with no guarantee of complete correction of the defect. Therefore, the search for surgical alternatives continues to present a major challenge in orthopaedic traumatology. The reamer-irrigator-aspirator(RIA) system, which was devised to avoid the problems that can arise with autograft harvesting from the iliac crest, consists of collecting the product of the femoral canal after reaming. The RIA technique improves osteogenic differentiation of mesenchymal stem cells, compared to bone marrow aspiration or cancellous bone harvesting from the iliac crest using a spoon. Another approach, the Masquelet technique, consists of reconstructing a long bone defect by means of an induced membrane grown onto an acrylic cement rod inserted to fill the defect; in a second surgical step, once the membrane is constituted, the cement rod is removed and cancellous autograft is used to fill the defect. Both in RIA and in the Masquelet technique, osteosynthesis is usually needed. Bone transportation by compression-distraction lengthening principles is commonly implemented for the treatment of large bone loss. However, complications are frequently encountered with these techniques. Among new techniques that have been proposed to address the problem of large bone loss, the application of stem cells in conjunction with tissue engineering techniques is very promising, as is the creation of personalised medicine(or precision medicine), in which molecular profiling technologies are used to tailor the therapeutic strategy, to ensure the right method is applied for the right person at the right time, after determining the predisposition to disease among the g

关键词： Bone loss Mesenchymal stem cells Reamerirrigator-aspirator Autograft Personalised medicine Bone transportation Precision medicine Masquelet technique

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Imaging the influence of oxides on the electrostatic potential of photovoltaic InP nanowires

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Nano Research 2021年第11期14卷 4087-4092页

作者： Lukas Hrachowina Xianshao Zou Yang Chen Yuwei Zhang enrique Barrigón Arkady Yartsev Magnus T.Borgström NanoLund Lund UniversityBox 11822100LundSweden Divison of Solid State Physics Lund UniversityBox 11822100LundSweden Divison of Chemical Physics Lund UniversityBox 12422100LundSweden Toyota Technological Institute NagoyaAichi 468-8511Japan

Nanowires require surface passivation due to their inherent large surface to volume ratio. We investigate the effect of embedding InP nanowires in different oxides with respect to surface passivation by use of electron beam induced current measurements enabled by a nanoprobe based system inside a scanning electron microscope. The measurements reveal remote doping due to fixed charge carriers in the passivating PO_(x)/Al_(2)O_(3) shell in contrast to results using SiO_(x). We used time-resolved photoluminescence to characterize the lifetime of charge carriers to evaluate the success of surface passivation. In addition, spatially resolved internal quantum efficiency simulations support and correlate the two applied techniques. We find that atomic-layer deposited PO_(x)/Al_(2)O_(3) has the potential to passivate the surface of InP nanowires, but at the cost of inducing a field-effect on the nanowires, altering their electrostatic potential profile. The results show the importance of using complementary techniques to correctly evaluate and interpret processing related effects for optimization of nanowire-based optoelectronic devices.

关键词： InP nanowires oxides MOVPE electron beam induced current(EBIC) time-resolved photoluminescence(TRPL) field-effect

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Altered expression patterns of syndecan-1 and ,2 predicl biochemical recurrence in prostate cancer

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Asian Journal of Andrology 2011年第3期13卷 476-480,514页

作者： Rodrigo Ledezma Federico Cifuentes Ivan Gallegos Juan Fulla enrique Ossandon enrique A Castellon Hector R Contreras Laboratory of Molecular and Cellular Andrology Physiology and Biophysics Program. Institute of Biomedical Sciences Faculty of Medicine University of Chile Santiago 70005 Chile pathology Service Clinic Hospital University of Chile Santiago 70005 Chile Urology Service Clinic Hospital University of Chile Santiago 70005 Chile

The clinical features of prostate cancer do not provide an accurate determination of patients undergoing biochemical relapse and are therefore not suitable as indicators of prognosis for recurrence. New molecular markers are needed for proper pre-treatment risk stratification of patients. Our aim was to assess the value of altered expression of syndecan-1 and -2 as a marker for predicting biochemical relapse in patients with clinically localized prostate cancer treated by radical prostatectomy. The expression of syndecan-1 and -2 was examined by immunohistochemical staining in a series of 60 paraffin-embedded tissue samples from patients with localized prostate cancer. Ten specimens from patients with benign prostatic hyperplasia were used as non-malignant controls. Semiquantitative analysis was performed to evaluate the staining patterns. To investigate the prognostic value, Kaplan-Meier survival curves were performed and compared by a log-rank test. In benign samples, syndecan-1 was expressed in basal and secretory epithelial cells with basolateral membrane Iocalisation, whereas syndecan-2 was expressed preferentially in basal cells. In prostate cancer samples, the expression patterns of both syndecans shifted to granular-cytoplasmic Iocalisation. Survival analysis showed a significant difference （P〈0.05） between normal and altered expression of syndecan-1 and -2 in free prostate-specific antigen recurrence survival curves. These data suggest that the expression of syndecan-1 and -2 can be used as a prognostic marker for patients with clinically localized orostate cancer, improving the larostate-specific antigen recurrence risk stratification.

关键词： biochemical recurrence prostate cancer syndecans

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