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In situ forming injectable MSC-loaded GelMA hydrogels combined with PD for vascularized sweat gland regeneration

Military Medical Research 2024年第1期11卷 152-155页

作者： enhe jirigala Bin Yao Zhao Li Yi-Jie Zhang Chao Zhang Li-Ting Liang Fan-Liang Zhang Xing-Yu Yuan Xian-Lan Duan Wei Song Meng-De Zhang Yi Kong Xiao-Bing Fu Sha Huang Research Center for Tissue Repair and Regeneration Medical Innovation Research DepartmentChinese PLA General Hospital and PLA Medical CollegeBeijing 100048China Institute of Basic Medical Research Inner Mongolia Medical UniversityHohhot 010110China Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China School of Medicine Nankai UniversityTianjin 300071China

Dear Editor,Three dimensional(3D)bioprinted extracellular matrix(ECM)can be used to provide both biochemical and biophysical cues to direct mesenchymal stem cells(MSCs)differentiation,and then differentiated cells were isolated for implantation in vivo using surgical ***,the reduced cell activity after cell isolation from 3D constructs and low cell retention in injured sites limit its application[1].Methacrylated gelatin(GelMA)hydrogel has the advantage of fast crosslinking,which could resemble complex architectures of tissue construct in vivo[2].Here,we adopted a noninvasive bioprinting procedure to imitate the regenerative microenvironment that could simultaneously direct the sweat gland(SG)and vascular differentiation from MSCs and ultimately promote the replacement of glandular tissue in situ(Fig.1a).

关键词： Sweat gland GelMA In situ niche Cell differentiation Tissue incorporation Vascularization

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Modeling human hypertrophic scars with 3D preformed cellular aggregates bioprinting

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Bioactive Materials 2022年第4期7卷 247-254页

作者： Yao Bin Zhu Dongzhen Cui Xiaoli enhe jirigala Song Wei Li Zhao Hu Tian Zhu Ping Li Jianjun Wang Yuzhen Zhang Yijie Fu Xiaobing Huang Sha Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical College28 Fu Xing RoadBeijing100853PR China PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury Repair and RegenerationResearch Unit of Trauma CareTissue Repair and RegenerationChinese Academy of Medical Sciences2019RU05151 Fu Cheng RoadBeijing100048PR China Academy of Medical Engineering and Translational Medicine Tianjin University300072PR China Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong510100PR China General Surgery Department Yangzhou Hongquan HospitalJiangsu225200PR China Institute of Basic Medical Research Inner Mongolia Medical UniversityHohhotInner Mongolia010110PR China College of Graduate Tianjin Medical University22 Qi Xiang Tai Road Tianjin300050PR China MRC Human Immunology Unit MRC Weatherall Institute of Molecular MedicineUniversity of OxfordJohn Radcliffe HospitalOxfordOX39DUUK

The therapeutic interventions of human hypertrophic scars(HHS)remain puzzle largely due to the lack of accepted *** HHS models are limited by their inability to mimic native scar architecture and associated pathological ***,we create a 3D functional HHS model by preformed cellular aggregates(PCA)bioprinting,firstly developing bioink from scar decellularized extracellular matrix(ECM)and alginate-gelatin(Alg-Gel)hydrogel with suitable physical properties to mimic the microenvironmental factors,then pre-culturing patient-derived fibroblasts in this bioink to preform the topographic cellular aggregates for sequent *** confirm the cell aggregates preformed in bioink displayed well defined aligned structure and formed functional scar tissue self-organization after bioprinting,hence showing the potential of creating HHS ***,these HHS models exhibit characteristics of early-stage HHS in gene and protein expression,which significantly activated signaling pathway related to inflammation and cell proliferation,and recapitulate in vivo tissue dynamics of scar *** also use the in vitro and in vivo models to define the clinically observed effects to treatment with concurrent anti-scarring drugs,and the data show that it can be used to evaluate the potential therapeutic target for drug *** ideal humanized scar models we present should prove useful for studying critical mechanisms underlying HHS and to rapidly test new drug targets and develop patient-specific optimal therapeutic strategies in the future.

关键词： Hypertrophic scar model Preformed cell aggregates 3D bioprinting Microenvironmental cues Drug screening

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基于儿童解剖学教材编撰的思考和建议

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解剖学杂志 2019年第4期42卷 430-431页

作者：王星张少杰史君高尚李筱贺王海燕恩和吉日嘎拉齐连枝陈杰和雨洁李琨李志军内蒙古医科大学基础医学院解剖学教研室呼和浩特010059 内蒙古医科大学基础医学院数字医学中心呼和浩特010059 内蒙古医科大学基础医学院生理学教研室呼和浩特010059

随着国家"全面二孩政策"的放开,社会对儿科医护、预防保健及科研人员的需求将不断扩大,儿科医护和相关研究人员短缺已成为多年全国性难题.2016年后全国恢复儿科学本科招生,由初期的8所院校逐渐发展到20余所高校加入儿科专业招生培养阵营... 详细信息

随着国家"全面二孩政策"的放开,社会对儿科医护、预防保健及科研人员的需求将不断扩大,儿科医护和相关研究人员短缺已成为多年全国性难题.2016年后全国恢复儿科学本科招生,由初期的8所院校逐渐发展到20余所高校加入儿科专业招生培养阵营,但随之而来所面临的亟待解决的难题是所需各专业课教材的编辑与规划[1].

关键词：教材解剖学编撰儿童儿科学科研人员预防保健研究人员

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