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Difference between papillary and follicular thyroid carcinoma outcomes:an experience from Egyptian institution

Cancer Biology & medicine 2015年第1期12卷 53-59页

作者： engy m.aboelnaga Rehab Allah Ahmed Clinical Oncology and Nuclear medicine Department Mansoura University Pathology Department Faculty of MedicineMansoura University

Objective： Differentiated thyroid carcinomas （DTCs） are classified into papillary thyroid carcinoma （PTC） and follicular thyroid carcinoma （FTC）. DTCs are analyzed as a single group in clinical studies that investigated the prognostic factors and prognosis of these malignancies. However, the biological behaviors of these carcinomas significantly differ. In the present study, we aimed to detect differences in the outcomes between PTC and FTC in mansoura University Hospital in Egypt. methods： A total of SS8 patients with histologically proven thyroid carcinomas from January 2003 to December 2012 were retrospectively enrolled. The clinical and pathological data of patients were reviewed. Results： Large primary tumor size, lymph node involvement, extrathyroid extension, and distant metastasis were significant poor prognostic factors for overall survival （OS） in old PTC patients. Cox hazard analysis showed that the patient＇s age, extra thyroid extension, and distant metastasis were the only independent prognostic factors. In FTC patients, only the distant metastasis and degree of tumor invasion were significant poor prognostic factors in OS univariate analysis. However, these factors were nonsignificant in multivariate analysis. The 10-year OS rates were 97% and 89% for PTC and FTC, respectively （P=0.003）. The 10-year disease-free survival （DFS） rates were 77.2% in PTC vs. 65% in FTC （P=0.179）. Conclusion： The significant prognostic factors vary between the two types of DTCs. Therefore, PTC and FTC patients need to be analyzed and reported independently. PTC survival is widely and significantly affected by age, extrathyroid extension, and distant metastasis. By contrast, these factors were nonsignificant in FTC, which showed poorer survival than PTC.

关键词： Thyroid cancer differentiated thyroid papillary follicular Egypt

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Second-line panitumumab as a triweekly dose for patients with wild-type KRAS exon 2 metastatic colorectal cancer:a single-institution experience

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Cancer Biology & medicine 2016年第1期13卷 136-141页

作者： mohamed A.Daoud engy m.aboelnaga Wael m.mohamed Department of Radiation Oncology Mansoura Faculty of Medicine King Abdullah Medical City

Objective: Panitumumab administered as monotherapy in colorectal cancer(CRC) has shown response and disease stabilization rates of approximately 30%. The current study aimed to evaluate the progression-free survival(PFS) and overall survival(OS) of patients with metastatic colorectal cancer(mCRC) treated with panitumumab every 3 weeks as a second line ***: This study is a retrospective analysis of 18 patients, aged more than 18 years, with wild-type KRAS exon 2 mCRC treated with panitumumab as a second-line single agent after progression on first-line ***: The median number of courses received was 10(range, 4-29), and the median duration of treatment was 30 weeks(range,12-96 weeks). After a median follow-up period of 13 months, the median PFS was 6 months(range, 4.3-7.7 months) and the median OS was 11 months(range, 7.4-14.5 months). The median PFS was 4 months for patients with months(range, 4.5-7.5 months) for patients with ≥ grade 2 skin rash(P=0.05). The median OS was 9 months(range, 6.4-11.5months) and 14 months(range, 11.6-16.3 months) for the two groups of patients(P=0.002).Conclusions: Panitumumab given every 3 weeks is effective and well tolerated in patients with advanced CRC that progressed after standard chemotherapy.

关键词： metastatic colorectal carcinoma panitumumab second-line KRAS

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modulation of oxidative damage and genotoxicity of biosynthesized zinc oxide nanoparticles via supplementation with modified cinnamaldehyde-loaded chitosan nanoparticles in mice

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Food Science and Human Wellness 2024年

作者： mosaad A.Abdel-Wahhab Aziza A.El-Nekeety Asmaa S.Salman Zeinab K.Hamza engy m.Akl Soher E.Aly Wenyi Kang Department of Food Toxicology & Contaminants， National Research Centre Dokki， Cairo， Egypt Genetic and Cytology Department， National Research Centre Dokki， Cairo， Egypt Department of Fats and Oils， National Research Centre Dokki， Cairo， Egypt National R & D Center for Edible Fungus Processing Technology， Henan University Joint International Research Laboratory of Food & medicine Resource Function Functional Food Engineering Technology Research Center Henan

Synthesis of zinc oxide nanoparticles (Zn-NPs) via green method is an outstanding alternative to conventional/regular methods; however， the safety or toxicity of the biosynthesized ZnO-NPs in vivo is not fully explored. This study was conducted to evaluate the protective efficiency of cinnamaldehyde-loaded chitosan nanoparticles (Cin@CSNPs) against oxidative damage and genotoxicity of zinc oxide nanoparticles (ZnO-NPs) in mice. ZnO-NPs were biosynthesized using the extract of fresh leaves of mentha pulegium L. Cin was extracted from cinnamon essential oil， and was loaded into chitosan nanoparticle (Cin@CSNPs). Both ZnO-NPs， Cin@CSNPs and CSNPs were characterized. The in vitro release of Cin@CSNPs was determined. In the biological study， 6 groups of male Balb/c mice were treated by gavage for 3 weeks as follows， control group， the group received ZnO-NPs (25 mg/kg b.w)， the groups received Cin@CSNPs at low dose (50 mg/kg b.w) or high dose (100 mg/kg b.w)， and the groups received ZnO-NPs plus Cin@CSNPs at the two tested doses. Blood and tissue samples were collected for different biochemical， genetical and histological studies. The particle size of ZnO-NPs， CSNPs， and Cin@CSNPs were (20.78 ± 2.6)， (170.0 ± 3.7)， and (218.23 ± 2.9) nm， and ξ-potential were (32.7 ± 4.6)， (8.32 ± 0.27) and (4.8 ± 0.21)， respectively. ZnO-NPs disturbed the biochemical and oxidative stress indices， AFP， CEA， TNF-α， chromosomal aberrations in somatic and germ cells， and sperm abnormality along with severe pathological changes in the hepatic， renal， and testicular tissues. Cin@CSNPs improved significantly all the parameters tested and the histological picture in a dose-dependent. Therefore， the biosynthesized ZnO-NPs exhibit oxidative damage and genotoxicity， and Cin@CSNPs have potential protective effects against the risks of ZnO-NPs and may be a promising tool to overcome the challenges of using Cin in food and pharmaceuticals applications.

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male Breast Cancer:10-Year Experience at mansoura University Hospital in Egypt

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Clinical oncology and cancer researeh 2012年第1期9卷 23-28页

作者： Wafaa El-Beshbeshi engy m Abo-Elnaga Department of Clinical Oncology and Nuclear medicine Faculty of MedicineMansoura University

Objective male breast cancer （mBC） is a rare disease representing less than 1% of all malignancies. The objective of the study is to report clinicopathological characteristics, treatment patterns, and outcomes of mBC in mansoura University Hospital, Egypt. methods This retrospective study focused on male breast cancer patients during 10 years （2000-2009）. The studied variables were data regarding general characteristics of patients, treatment modalities and survival. Results The series included 37 patients （0.8% of all breast cancer）. The median age was 57.7 years （range： 26-86 years）. The main clinical complaint was a mass beneath the areola ill 94.5% of the cases. most patients had a locally advanced disease. 94.5% of tumors were invasive duct carcinomas. The treatment was essentially surgery in 91.8%, followed by adjuvant radiotherapy （in 89.2%）, hormonal therapy （in 56.7%） and chemotherapy （in 91.8%）. Follow-up period ranged from 6-115 months. Local recurrence occurred in 4 cases and metastasis in 11 cases. The 2-year and 5-year overall survival （OS） rates were 81.6% and 60.5%, respectively. The 2-year and 5-year disease-free survival （DFS） rates were 68.4%, and 52.6%, respectively. OS was not significantly affected by any of the studied parameters. Factors influencing DFS were： T stage （P=0.05）, positive lymph nodes （P=0.043）, metastasis （P=0.004）, and chemotherapy （1＇=0.046）. Conclusions mBC is a rare disease and often diagnosed at a locally advanced stage. The management of male and female breast carcinoma is identical. Future research for better understanding of this disease is needed to improve the management and prognosis of male breast cancer patients.

关键词： breast neoplasms male therapeutics Egypt

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Approach for Training Quantum Neural Network to Predict Severity of COVID-19 in Patients

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Computers, materials & Continua 2021年第2期66卷 1745-1755页

作者： engy El-shafeiy Aboul Ella Hassanien Karam m.Sallam A.A.Abohany Department of Computer Science Faculty of Computers and Artificial IntelligenceUniversity of Sadat CitySadat City32897Egypt Faculty of Computers and Artificial Intelligence Cairo University12613Egypt Faculty of Computers and Information Zagazig University44519Egypt Faculty of Computers and Information Kafrelsheikh University33516Egypt

Currently,COVID-19 is spreading all over the world and profoundly impacting people’s lives and economic *** this paper,a novel approach called the COVID-19 Quantum Neural Network(CQNN)for predicting the severity of COVID-19 in patients is *** consists of two phases:In the first,the most distinct subset of features in a dataset is identified using a Quick Reduct Feature Selection(QRFS)method to improve its classification performance;and,in the second,machine learning is used to train the quantum neural network to classify the *** is found that patients’serial blood counts(their numbers of lymphocytes from days 1 to 15 after admission to hospital)are associated with relapse rates and evaluations of COVID-19 ***,the severity of COVID-19 is classified in two categories,serious and *** experimental results indicate that the proposed CQNN’s prediction approach outperforms those of other classification algorithms and its high accuracy confirms its effectiveness.

关键词： Predict COVID-19 lymphocytic count quantum neural network dynamic change

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Surgical outcomes of complicated cataract with pediatric trematode granulomatous uveitis

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 354-360页

作者： mahmoud m.Farouk Amr mounir mortada Ahmed Abozaid engy mohamed mostafa marwa mahmoud Abdellah Department of Ophthalmology Sohag Faculty of MedicineSohag UniversitySohag 82524Egypt

AIm:To describe the clinical characteristics and surgical outcomes of complicated cataract with pediatric trematodal granulomatous uveitis(TGU).mETHODS:Patients of cataract with TGU in the membranous(inactive) stage underwent cataract surgery with intraocular lens(IOL) *** history and ophthalmic examination were conducted for all cases,whereas Schimphlug imaging and corneal topography were done for some *** follow up was done on the 1st,2nd,and 5th postoperative days after ***,it was done at least at one,three,and six months *** and postoperative complications and the methods of their management were ***:Twelve eyes of 12 male children were included in this study ranging from 8 to *** mean best corrected Snellen visual acuity(BCVA) was significantly improved from 0.09±0.06 preoperatively to 0.37±0.11 at the final visit 6mo postoperatively(Pmphlug imaging and corneal topography showed flattening of the anterior surface of the inferior *** difficulties and complications included the poor dilatability of the drown down pupil,strong posterior synechia between the anterior lens capsule and the iris at the site of the inferior retrocorneal vascularized membrane and *** cases underwent primary hydrophobic IOL ***:Surgery for this type of cataract is relatively safe and *** is associated with some specific difficulties and complications that should be considered during surgery and follow up.

关键词： complicated cataract trematode granulomatous uveitis surgical outcomes

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Ameliorative effects of melatonin and zinc oxide nanoparticles treatment against adverse effects of busulfan induced infertility in male albino mice

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BIOCELL 2022年第2期46卷 535-545页

作者： AmOURA m.ABOU-EL-NAGA SHAKER A.mOUSA FAYEZ ALTHOBAITI EmAN FAYAD engy S.FAHIm Department of Zoology Faculty of ScienceMansoura UniversityMansouraEgypt The Pharmaceutical Research Institute Albany College of Pharmacy and Health SciencesRensselaerUSA Department of Biotechnology Faculty of SciencesTaif UniversityTaifSaudi Arabia

Testicular damage is one of the most hazardous effects as it’s associated with ***(Bu)is a highly toxic chemotherapeutic drug that affects *** male Swiss albino mice divided into six groups of 5 animals ***(oral 0.9%saline daily for 75 days);mel(20 mg/kg/day orally for 30 days);ZnO NPs(5 mg/kg/day *** 30 days);BU(single *** of 40 mg/kg and then left for 45 days);BU+mel(single 40 mg/kg dose of BU and left for 45 days followed by 20 mg/kg/day mel for 30 days);BU+ZnO NPs(single dose of 40 mg/kg of BU and left for 45 days,then 5 mg/kg/day ZnO NPs for 30 days).Preparation and Characterization of ZnO *** from testis prepared for ultrastructural investigations using TEm after masson’s trichrome and toluidine blue *** induced histological and ultrastructural damage of the ***,the present results could be concluded that mel or ZnO NPs can protect the testicular tissue against ultrastructural alterations induced by BU by its antioxidant and anti-apoptotic effects.

关键词： Busulfan melatonin Zinc oxide nanoparticles Ultrastructure Testis mice

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Efficacy and Safety of Ombitasvir plus Paritaprevir,Ritonavir and Ribavirin in Non-cirrhotic Treatment-naive and Treatment-experienced Egyptians with Chronic HCV Genotype-4 Infection

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Current medical Science 2021年第3期41卷 581-586页

作者： manar Ahmed Azza E.mansey engy A.Wahsh Ahmed A.Gomaa Hoda m.Rabea Department of Clinical Pharmacy Faculty of PharmacyBeni Suef UniversityBeni Suef 62521Egypt Department of Clinical Pharmacy Faculty of PharmacyMenoufia UniversityAl Menoufia 32511Egypt Department of Clinical Pharmacy Faculty of PharmacyOctober 6 universityGiza 12573Egypt Department of Tropical medicine Faculty of MedicineFayoum UniversityFayoum 63511Egypt

Hepatitis C virus genotype 4(HCV-GT4)is a risk factor for cirrhosis,hepatocellular carcinoma and liver failure.A combination of three new direct-acting antivirals ombitasvir,paritaprevir,and ritonavir has been recommended for treatment of HCV-GT4 *** current study was aimed to assess the efficacy and safety of this combination plus ribavirin in non-cirrhotic,treatment-naive and-experienced Egyptians with HCV-GT4 infection in a real-world setting.A total of 255 Egyptians with HCV-GT4 infection were enrolled,including 82 treatment-experienced and 173 treatment-naive *** of them completed 12-week treatment protocol of ombitasvir,paritaprevir and ritonavir as an oral dose combination with *** response(VR)was measured,as well as the biochemical parameters related to treatment efficacy and adverse events at baseline and after treatment,at 4(VR4)and 12(VR12)weeks *** results showed that the VR4 rates were 98.8%in both groups,and VR12 rates were 97.7%and 96.3%in treatment-naive and-experienced patients,respectively,with no significant differences found between the groups concerning VR4(P=0.9)and VR 12(P=0.3).The most common adverse events were headache and fatigue,which were significantly more common(P=0.001 and 0.003,respectively)in treatment-experienced than in treatment-naive *** quadruple regimen was well-tolerated,and the reported adverse events were generally mild to *** real-world setting study confirms that the combination of ombitasvir,paritaprevir,ritonavir,and ribavirin is highly effective in the treatment of HCV-GT4 infection with a good safety and tolerability profile.

关键词： hepatitis C virus genotype-4 ombitasvir paritaprevir ribavirin

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Effect of Laser Cladding Processing Parameters on Nitinol’s Clad Dimensions, microstructure, and Hardness

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materials Sciences and Applications 2021年第12期12卷 603-613页

作者： engy m. Zain Ahmed Farid Youssef Ahmad El Sabbagh Sisa Pityana mohamed A. Taha Design and Production Engineering Department Faculty of Engineering Ain Shams University Cairo Egypt National Laser Centre The Council for Scientific and Industrial Research Pretoria South Africa

Nickel Titanium alloy (Nitinol) is characterized by its good mechanical properties, good damping properties in addition to its distinctive shape-memory effect and superelasticity effect besides its great bio-mechanical compatibility and corrosion resistance. These properties have empowered its applications, particularly within the bio-medical and aerospace industry. Despite these exceptional properties, the manufacturing of Nitinol by conventional methods is exceptionally troublesome and costly and consequently must be inspected. Therefore, additive manufacturing specifically laser-based ones were used recently. In this research, the effect of processing parameters of laser cladding/laser direct deposition on Nitinol’s microstructure, Hardness and Clad Dimensions was evaluated. Systematic characterization of Nitinol samples was done utilizing Optical microscopy and Vickers hardness tester. Samples of Nitinol were synthesized with different processing parameters using laser cladding and its properties were investigated and compared to one another to get the optimum processing parameters to synthesize a near net shape, fully dense Nitinol component with reliable properties. The results showed that there’s a processing parameter window at which the alloy possesses its best mechanical and functional properties which were of Laser power of value 1.25 Kw, Scan speed of 1.5 m/min and powder deposition rate of 1.5/1.5 RPm, these conditions resulted in the formation of martensite phase which is responsible for its functional properties with 40% volume fraction and a hardness value of 598 HV.

关键词： Nitinol Shape memory Alloy Additive manufacturing Hardness microstructure

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Community Based management of Severe Acute malnutrition: The mSF Experience from an Urban Slum Setting in Bangladesh

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Food and Nutrition Sciences 2020年第6期11卷 578-589页

作者： engy Ali Pascale Delchevalerie Zubair Shams Petra Alders Rony Zachariah Luxembourg Operational Research Unit (LuxOR) Medical Department Médecins Sans Frontières—Operational Centre Brussesl Luxembourg Luxembourg medical Department Médecins Sans Frontières—Operational Centre Brussels Brussels Belgium Bangladesh mission Médecins Sans Frontières—Operational Centre Brussels Dhaka Bangladesh

Background: Until recently, the experience on implementing community based management of acute malnutrition (CmAm) among children has been largely based in African settings. While the government in Bangladesh is yet t... 详细信息

Background: Until recently, the experience on implementing community based management of acute malnutrition (CMAM) among children has been largely based in African settings. While the government in Bangladesh is yet to scale up CMAM approach, there is still paucity of knowledge on the experience of CMAM within the complex milieu of an urban slum context. In Kamrangirchar slum, Dhaka, Bangladesh, this paper describes a CMAM programme performance and outcomes run by Médecins Sans Frontières (MSF)/Doctors without Borders, in light to performance indicators set by MSF and the Sphere minimum standards. Methods: This was a descriptive retrospective study using routinely collected programme data of children admitted with severe acute malnutrition between May 2010 and November 2011. Kamrangirchar is an urban slum of a large migrant population in Dhaka, Bangladesh. Results: There was a total of 640 new admissions, of whom 333 (52%) were males. The median age was 18 months (Inter-quartile range (IQR) 12 - 41). 599 children had a reported nutritional outcome at discharge from ambulatory therapeutic feeding centre (ATFC), this included: cure rate of 69% with an average length of stay of 68.8 (SD ± 46.0) days and average weight gain of 3.8 g/kg/day (SD ± 2.7). The lost-to-follow-up rate was 18% and 5% reported to the programme that they will leave the slum and go back to their villages. These performance indicators did not meet the threshold level indicators set by MSF and Sphere standards. Conclusions:mily:Verdana;"> Our experience highlights the need for developing more adapted and contextualised indicators for as

关键词： Severe Acute malnutrition Community Based management Nutrition Outcomes Urban Slum Bangladesh

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