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Imaging probes for non-invasive tumoral detection and functional monitoring of cancer multidrug resistance

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cancer Drug Resistance 2020年第2期3卷 209-224页

作者： Filipa Mendes Lurdes Gano Jorge Grilo Susana cunha célia Fernandes António Paulo DEcN-Department of Nuclear Engineering and Sciences and c2TN-center for Nuclear Sciences and Technologies Instituto Superior TécnicoUniversidade de LisboaEstrada Nacional 10Bobadela LRS 2695-066Portugal (Present adress)iMed.Ulisboa-Research Institute for Medicines Faculdade de FarmáciaUniversidade de LisboaAv.Professor Gama PintoLisboa 1649-003Portugal

Aim:Several cationic radiotracers originally developed as myocardial perfusion agents have shown potential for both early detection of cancer and non-invasive monitoring of multiple drug resistance(MDR)by single photon emission computed *** have introduced two cationic complexes,^(99m)Tc-DMEOP[di-methoxy-tris-pyrazolyl-^(99m)Tc-(cO)_(3)]and ^(99m)Tc-TMEOP[tri-methoxy-tris-pyrazolyl-^(99m)Tc-(cO)_(3)],which showed excellent preclinical results as cardiac imaging probes,namely a persistent heart uptake with rapid blood and liver *** study aimed at the evaluation of their usefulness for tumoral detection and functional assessment of ***:The uptake and efflux kinetics of ^(99m)Tc-DMEOP and ^(99m)Tc-TMEOP were evaluated in human prostate,lung,and breast cancer cell lines,including drug-resistant cell lines that are known to overexpress the MDR P-glycoprotein(Pgp).The effects of MDR modulators were also *** vivo studies were performed in xenografted tumor models,and the MDR phenotype of the tumors was confirmed by Western ***:The uptake kinetics of both complexes in human cancer cell lines is comparable with the one found for ^(99m)Tc-Sestamibi,increasing over *** uptake of ^(99m)Tc-TMEOP is greatly reduced in cells overexpressing Pgp and increased in the presence of a Pgp *** nude mice,the tumor uptake of ^(99m)Tc-TMEOP was higher in the McF-7 xenografts compared with the McF7 Pgp ***:The uptake kinetics of both complexes in human cancer cell lines is comparable with the one found for ^(99m)Tc-Sestamibi,increasing over *** uptake of ^(99m)Tc-TMEOP is greatly reduced in cells overexpressing Pgp,and increased in the presence of a Pgp *** nude mice,the tumor uptake of ^(99m)Tc-TMEOP was higher in the McF-7 xenografts compared with the McF7 Pgp tumors.

关键词： Noninvasive imaging imaging probes tumoral detection multiple drug resistance P-glycoprotein

在玉米品系的杂种优势群分类中分子标记和正交组合效果的比较

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国外作物育种 2003年第6期22卷 19-19页

作者： R．deM．c．pinto 郭元林

Intravenous vs intraperitoneal mesenchymal stem cells administration:What is the best route for treating experimental colitis?

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World Journal of Gastroenterology 2014年第48期20卷 18228-18239页

作者： Fabiany da costa Goncalves Natália Schneider Fernanda Otesbelgue pinto Fabíola Schons Meyer Fernanda Visioli Bianca Pfaffenseller Patrícia Luciana da costa Lopez Eduardo Pandolfi Passos Elizabeth Obino cirne-Lima Luíse Meurer Ana Helena Paz centro de Pesquisa Experimental do Hospital de clínicas de Porto Alegre Porto Alegre 90035-903Rio Grande do SulBrazil Programa de Pós-Gradua??o:ciências em Gastroenterologia e Hepatologia Universidade Federal do Rio Grande do SulPorto Alegre 90035-903Rio Grande do SulBrazil Faculdade de Odontologia Universidade Federado Rio Grande do SulPorto Alegre 90035-003Rio Grande doSulBrazil

AIM:To investigate the therapeutic effects of mesenchymal stem cells(MScs)transplanted intraperitoneally andintravenously in a murine model of ***:MScs were isolated from c57BL/6 mouse adipose *** cultures were analyzed according to morphology,cellular differentiation potential,and surface molecular *** acute colitis was induced in c57BL/6 mice by oral administration of2%dextran sulfate sodium(DSS)in drinking water ad libitum from days 0 to *** mice were treated with1×106 MScs via intraperitoneal or intravenous injection on days 2 and *** disease activity index was determined daily based on the following parameters:weight loss,stool consistency and presence of blood in the feces and *** compare morphological and functional differences in tissue regeneration between different MSc injection modalities,mice were euthanized on day 8,and their colons were examined for length,weight,and histopathological *** responses were determined by measuring the levels of different serum cytokines using a cBA Th1/Th2/Th17 *** rates were evaluated by terminal deoxynucleotidyl transferase-mediated d UDPbiotin nick end labeling ***:Intravenous infusion of MScs was more effective than intraperitoneal treatment(Pcing the clinical and histopathologic severity of colitis,which includes weight loss,diarrhea and *** histological evaluation demonstrated decreased colonic inflammation based on reduced crypt loss and reduced infiltration of inflammatory *** therapeutic effect was most likely mediated by the down-regulation of pro-inflammatory cytokines[interleukin(IL)-6 and tumor necrosis factor(TNF)];and by the up-regulation of anti-inflammatory cytokines(IL-10 and IL-4).Intravenous transplantation alsoinduced high levels of IFN that lead to activation of the immunosuppressive activity of the MScs,which did not occur with intraperitoneal transplantation(P=0.006).An increase in a

关键词： Ulcerative colitis Dextran sulfate sodium Inflammatory bowel disease Mesenchymal stem cell cell transplantation Intravenous injection Immunomodulation

肝淋巴解剖结构及其在系统性淋巴疾病中的作用

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国际医学放射学杂志 2022年第2期 240-240页

作者： c.L.Smith M.Liu M.Saravanan A.G.Dewitt D.M.Biko E.M.pinto 汤双燕

摘要目的通过肝内淋巴管造影方法，对罹患系统性淋巴疾病的病人由肝脏到全身淋巴系统的连接特征进行阐述，并比较淋巴干预后的结果。方法本回顾性研究纳入了2014

关键词：

chinese expert consensus on organ protection of transplantation(2022 edition)

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 516-526页

作者： Jian-Hui Li Xiao Xu Yan-Feng Wang Hai-Yang Xie Jing-Yu chen Nian-Guo Dong Mitesh Badiwala Li-Ming Xin Roberto Vanin pinto Ribeiro Hao Yin Hao Zhang Jian-Zheng Zhang Feng Huo Jia-Yin Yang Hong-Ji Yang Hui Pan Shao-Guang Li Yin-Biao Qiao Jia Luo Hao-Yu Li Jun-Jun Jia Hao Yu Han Liang Si-Jia Yang Hao Wang Zhong-Yang Liu Li-cheng Zhang Xiao-Yi Hu Hao Wu Yi-Qing Hu Pei-Fu Tang Qi-Fa Ye Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310000China Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan UniversityTransplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationWuhan 430062China NHc Key Laboratory of combined Multi-organ Transplantation Hangzhou 310003China Wuxi Lung Transplantation center Wuxi People’s Hospital Affiliated with Nanjing Medical UniversityWuxi 214023China Department of cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Peter Munk cardiac centre Toronto General Hospital-University Health NetworkTorontoCanada School of computer Engineering and Science Shanghai UniversityShanghai 200444China Organ Transplant center Shanghai Changzheng HospitalShanghai 200003China Department of Orthopedics Chinese PLA General HospitalBeijing 100039China National clinical Research center for Orthopedics Sports Medicine&RehabilitationBeijing 100039China Department of Surgery General Hospital of Guangzhou Military Command of PLAGuangzhou 510040China Department of Liver Surgery Liver Transplantation CenterWest China Hospital of Sichuan UniversityChengdu 610041China Organ Transplantation center Sichuan Provincial People’s Hospital and School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Lung Transplantation The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Introduction Organ transplantation increases survival and improves qual-ity of life to many patients with end-stage organ ***-gan shortage is a worldwide problem that restricts organ trans-plantation[1].Organ procurement and preservation as well as ischemia-reperfusion injury(IRI)after transplantation are the im-portant factors affecting prognosis of *** the de-velopment of organ transplantation technology in the 20th cen-tury,organ protection technology has been a most promising con-cept in this *** preservation solutions such as the collins solution,University of Wisconsin(UW)solution,and histidine-tryptophan-ketoglutarate(HTK)solution were developed sequen-tially[2],which developed rapidly in static cold storage(ScS)*** remains the standard preservation technique for organ transplantation[2].

关键词： organ preservation transplantation

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Non-Hodgkin’s Lymphoma Associated with Metastatic Lung cancer: case Report

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Advances in Lung cancer 2021年第3期10卷 40-47页

作者： Miriam Viviane Baron Gabriela Di Lorenzo Garcia Scherer célia Regina Martins Korzenieski Julia Braga da Silveira carolina Boeira Soares carina Marangoni Marcus Vinicius de Mello pinto Aline Ronis Sampaio Alexandre Gomes Sancho Esteban Fortuny Pacheco Felice Picariello Joice Nedel Ott Isabel cristina Reinheimer carolina Gonçalves Pinheiro Nathália Ken Pereira Iketani cristine Brandenburg Danielle de Mello Florentino Patrícia Froes Meyer Bartira Ercília Pinheiro da costa Postgraduate Program in Medicine and Health Sciences of the Pontifical catholic University of Rio Grande do Sul (PUc/RS) Porto Alegre Brazil School of Medicine of the Pontifical catholic University of Rio Grande do Sul (PUc/RS) Porto Alegre Brazil School of Health and Life Sciences of the Pontifical catholic University of Rio Grande do Sul (PUc/RS) Porto Alegre Brazil celulare Institute Rio de Janeiro Brazil Unigranrio Rio de Janeiro Brazil Universidad Finis Terrae Santiago Chile Università degli Studi di Napoli Federico II Napoli Italy Postgraduate Program in Health Sciences of the Faculty of Medicine of ABc (FMABc) S&#227 o Paulo Brazil Hospital Beneficiente Portuguesa of Belém Pará Brazil Federal University of ceará (UFc) Fortaleza Brazil Uniredentor University Rio de Janeiro Brazil centro Universitário do Rio Grande do Norte Natal RN Brazil

Lymphomas are neoplastic transformations that affect lymphoid cells. Diffuse large B-cell non-Hodgkin’s lymphoma has a high degree of cell proliferation, accounting for 30% of all lymphomas. Lung cancer is the leading cause of death worldwide and the recommended treatment is chemotherapy. Among the main complications resulting from non-Hodgkin’s lymphoma, lung cancer and chemotherapy used in their treatment, we can mention sepsis, acute kidney injury and febrile neutropenia. Febrile neutropenia can occur by suppressing the production of neutrophils. Sepsis, a widespread infection, is the main cause of acute kidney injury, which can also be caused by hydroelectrolytic complications or by nephrotoxicity. This is a report of a smoking patient with metastatic lung cancer who sought care due to progressive dysphagia, cough with chest pain, fever, and lower airways critical obstruction due to mediastinal lymphadenopathy, being diagnosed with diffuse large B-cell non-Hodgkin’s lymphoma. The patient evolved to death because of a significant worsening of the ventilatory pattern of multifactorial cause, mainly due to sepsis, acute kidney injury, and febrile neutropenia. The patient had mostly classic characteristics of her comorbidities, however, the overlapping of interrelated comorbidities led to the outcome of death. What is unusual about the present case report is that the patient’s characteristics, such as age, sex, and ethnicity, are opposite to those described as risk factors for diffuse large B-cell non-Hodgkin’s lymphoma.

关键词： Acute Kidney Injury Febrile Neutropenia Sepsis chemotherapy

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棉棉细语

现代装饰（家居） 2015年第5期 54-61页

作者： Audrey Benzonana & Piment de Mer AMR Internacional Lda Arpin Anatology Anne couderc cline Richard & Guillaume Grimbert coral & Tusk Dan Duchars ferm LIVING Jan Gustav Sφrensen Lina Rickardsson Mikabarr No More Twist Nicolò Bottarelli Row pinto 伏平范嘉苑

布艺软饰在家居空间中独具魅力,包括窗帘、地毯、织物、布艺沙发、靠垫、抱枕、床上用品等。它们柔化了家居空间生硬的线条,以柔软、放松、多变等特性营造家居温馨的格调,给人慰贴的温暖,低调、不动声色地彰显着独特的魅力。柔和的质感... 详细信息

布艺软饰在家居空间中独具魅力,包括窗帘、地毯、织物、布艺沙发、靠垫、抱枕、床上用品等。它们柔化了家居空间生硬的线条,以柔软、放松、多变等特性营造家居温馨的格调,给人慰贴的温暖,低调、不动声色地彰显着独特的魅力。柔和的质感与丰富的色彩赋予布艺沙发极具亲和力与＂表情＂多变的特点。

关键词：布艺沙发家居空间棉棉有机棉抱枕色彩力几何图 cotton Basket 寻找自我

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Performance Evaluation of Quicksort with GPU Dynamic Parallelism for Gene-Expression Quantile Normalization

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通讯和计算机（中英文版） 2013年第12期10卷 1522-1528页

作者： Roberto pinto Souto carla Osthoff Douglas Augusto Oswaldo Trelles Ana Tereza Ribeiro de Vasconcelos National Laboratory for Scientific computing Petropolis Petropolis 25651-075 Brazil computer Architecture Department University of Malaga Malaga 29017 Spain

High-density oligonucleotide microarrays allow several millions of genetic markers in a single experiment to be observed. current bioinformatics tools for gene-expression quantile data normalization are unable to process such huge data sets. In parallel with this reality, the huge volume of molecular data produced by current high-throughput technologies in modern molecular biology has increased at a similar pace, challenging our capacity to process and understand data. On the other hand, the arrival of cUDA (compute unified device architecture) has unveiled the extraordinary power of GPUs (graphics processing units) to accelerate data intensive general purpose computing more and more as time goes by. In this work, we have evaluated the use of dynamic parallelism for ordering gene-expression data, where the management of kernels launching can be done not only by the host, but also by the device. Each sample has more than 6.5 million genes. We optimized the Quicksort parallel implementation available in the cUDA-5.5 Toolkit Samples and compared the performance of the sequential Quicksort algorithm from the GNU c Library (glibc) and with the parallel radix sort implementation available in the cUDPP-2.1 library. The Quicksort parallel implementation is designed to run on the GPU Kepler architecture, which supports dynamic parallelism. The results show that in the studied application the GPU parallel version with dynamic parallelism attains speed-ups in the data-sorting step. However, to achieve an effective overall speed-up considering the radix sort algorithm, performance of the whole application needs further optimizations.

关键词：快速排序算法基因表达数据并行实现 GPU 绩效评估位数现代分子生物学寡核苷酸微阵列

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用大型扁千斤顶技术测定变形模量的建议方法

岩石力学与工程学报 1987年第1期 69-79页

作者： J.Loureiro-pinto J.Franklin K.Drozd P.Londe A.Silverio W.van Heerden J.Szlavin R.Atkinson 黄杰藩

范围 1.(a)本试验方法旨在用扁千斤顶评价岩体的原地变形模量;千斤顶安放在岩体内的一些狭槽中,狭槽系用圆盘锯切割或成排地打一系列钻孔而成.用此法也可以做蠕变试验. (b)通常是在多达四个的共平面且互相邻接的狭槽内进行同步试验,槽... 详细信息

范围 1.(a)本试验方法旨在用扁千斤顶评价岩体的原地变形模量;千斤顶安放在岩体内的一些狭槽中,狭槽系用圆盘锯切割或成排地打一系列钻孔而成.用此法也可以做蠕变试验. (b)通常是在多达四个的共平面且互相邻接的狭槽内进行同步试验,槽内设置的扁千斤顶以“并连”方式接到同一台压力发生器上. (c)这些试验通常构成坝、隧道、洞室等的勘测调查工作的一部份内容.其结果为上述结构提供设计数据.

关键词：扁千斤顶狭槽变形模量割线模量技术测定