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Transcarotid transcatheter aortic valve implantation with a novel balloon expandable Myval^(■) THV under the local anesthesia

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Journal of Geriatric Cardiology 2022年第7期19卷 562-564页

作者： Hüseyin Ayhan Bilge Duran Karaduman Telat Keles Emrah Uğuz Emre Boysan engin bozkurt Department of Cardiology Medicana International Ankara HospitalAtilim UniversityAnkaraTurkey Department of Cardiology Ankara City HospitalAnkara Yıldırım Beyazıt UniversityAnkaraTurkey Department of Cardiovascular Surgery Ankara City HospitalAnkara Yıldırım Beyazıt UniversityAnkaraTurkey Department of Cardiovascular Surgery Medicana International Ankara HospitalAnkaraTurkey Department of Cardiology Medicana International Ankara HospitalAnkaraTurkey

Since it was first acquainted to us in 2002,tr-anscatheter aortic valve implantation(TAVI)was rapidly applied and earned worldwide *** is the standard of care for patients with symptomatic severe aortic stenosis(AS),at in-termediate to high-risk and in some low-risk pa-tients in light of the recent data,principally if it can be performed transfemoral approach.

关键词： anesthesia aortic balloon

Evaluation of CA125 and NT-proBNP values in patients undergoing transcatheter aortic valve implantation

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Journal of Geriatric Cardiology 2015年第2期12卷 100-106页

作者： Huseyin Ayhan Haca Ahmet Kasapkara Tahir Durmaz Telat Keles Cenk San Serdal Bastug Kemal Esref Erdogan Nihal Akar Bayram Emine Bilen Murat Akgay engin bozkurt Faculty of Medicine Department of Cardiology Ytldtrtm Beyaztt University Ankara 06800 Turkey Department of Cardiology Ankara Ataturk Education and Research Hospital Ankara 06800 Turkey Faculty of Medicine Department of Cardiovascular Surgery Yddtrtm Beyaztt University Ankara 06800 Turkey

Background Transcatheter aortic valve implantation （TAVI） is a minimally invasive, emerging therapy in surgically high risk, or in- operable patients. Parameters used for risk classification have some deficiencies in the selection of patients. The objective of this study is to evaluate the impact of TAVI on carbohydrate antigen 125 （CA125） and N-terminal pro brain-type natriuretic peptide （NT-proBNP） as biomarkers that have been used frequently in recent years, and also the relationship of these biomarkers to prognosis. Methods ＆ Results Transcatheter aortic valve implantation was practiced on 31 patients in this study. Then, CA125 and NT-proBNP levels studied in patients prior to and after the TAVI were evaluated. The patients were also grouped in accordance with their left ventrieular ejection fraction （LVEF） and CA125 levels （LVEF 〉 40% and 〈 40%; CA125 ≤ 35 U/L and 〉 35 U/L）. The TAVI operation was successfully performed in all patients. There was no in-hospital mortality and substantial improvement in functional capacity was detected at follow ups. In addition, a statistically significant decrease was detected in post-TAVI CA 125 and NT-proBNP levels of all patients （CA 125 83.8 ± 18.1 U/L vs. 64.3 ±14.2 U/L, P = 0.008; NT-proBNP： 4633.6± 627.6 pg/mL vs. 2866.3±536.8 pg/mL, P 〈 0.001）. In groups divided according to the CA125 levels, there was also statistically significant post-TAVI decline in CA125 levels. Within CA125 〉 35 U/L and LVEF 〈 40% groups, the permanent need for a pacemaker was required in one （3.2%） patient and mortality was observed in two （6.4%） patients after TAVI at follow up. Conclusions The results show that TAVI can be performed effectively and reliably in patients with high baseline levels of CA125 and NT-proBNP. These biomarkers are reduced substantially with TAVI, while high biomarker levels are associated with undesired events, and certainly, these biomarkers can be used for risk classifications in patient selection for TAVI.

关键词： B-type natriuretic peptide Biomarker Carbohydrate antigen Heart failure Transcatheter aortic valve implantation Risk score

Photorefractive keratectomy in the correction of astigmatism using Schwind Amaris 750s laser

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 356-361页

作者： Okkes Baz Necip Kara Ercument bozkurt engin Bilge Ozgurhan Alper Agca Kema Yuksel Yavuz Ozpinar Ahmet Demirok Department of Ophthalmology Beyoglu Eye Research and Education Hospital Department of Ophthalmology Kanuni Sultan Suleyman Education and Research Hospital

AIM: To evaluate the results of three photorefractive keratectomy (PRK) procedures in the treatment of astigmatism. · METHODS: In this retrospective comparative case series, 89 eyes of 50 patients who underwent PRK treatment for astigmatism were enrolled. The patients were divided into 3 groups based on the PRK procedure: Group 1: PRK without mitomycin -C (MMC) application, Group 2: PRK with MMC application, and Group 3: Trans-Photorefractive Keratectomy (T-PRK). The efficacy, safety, predictability, and complications of treatment were assessed at 1, 3 and 6 months after the treatment. ·RESULTS: At postoperative 6 months, the percentage of postoperative uncorrected visual acuity (UCVA) of 20/ 20 or better was 55.6% (20 eyes) in group 1, 75% (15 eyes) in group 2, and 75.8% (25 eyes) in group 3 (P = 0.144). The percentage of postoperative best corrected visual acuity (BCVA) of unchanged or gained ≥1 lines was 80.6% (29 eyes) in group 1, 70% (14 eyes) in group 2, and 90.9% (30 eyes) in group 3 (P =0.151). The percentage of postoperative BCVA of lost ≥2 lines was 11.1% (4 eyes) in group 1, 20% (4 eyes) in group 2, and 6.1% (2 eyes) in group 3. The mean manifest refractive spherical equivalent (MRSE) and mean cylindrical refraction were not significantly different among the each groups (P >0.05). At postoperative 6 months, the percentage of MRSE of within ±0.50 D was 100% (36 eyes) in Group 1, 100% (20 eyes) in Group 2, and 93.9% (31 eyes) in Group 3. At the each follow-up period, there was no significant difference in number of eyes with haze and mean haze score(P>0.05). ·CONCLUSION: The study showed that PRK without MMC, PRK with MMC and T-PRK appears to have similareffectiveness, safety and predictability in the treatment of astigmatism. The incidence of haze was also similar between the three groups.

关键词： photorefractive keratectomy mitomycin-C trans-photorefractive keratectomy astigmatism

Laser in situ keratomileusis in adult patients with anisometropic amblyopia

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 362-369页

作者： Alper Agca engin Bilge zgühan kkes Baz Ercüment bozkurt Abdullah Ozkaya Dilek Yasa Ahmet Demirok Beyoglu Eye Research and Training Hospital Department of Ophthalmology Istanbul Medeniyet University

AIM: To evaluate the increase in corrected distance visual acuity (CDVA) after laser in situ keratomileusis (LASIK) in adults with anisometropic amblyopia. · METHODS: The medical records of consecutive patients diagnosed with anisometropic amblyopia at the time of refractive evaluation who underwent LASIK were retrospectively reviewed. Patients with at least a two-line difference of visual acuity (VA) between the eyes with a spherical refractive error difference of at least 3.00 diopters (D) or an astigmatic difference of at least 2.00D were included. Patients with any other possible reason for amblyopia other than anisometropia or those who had undergone previous amblyopia treatment were excluded. Amblyopic eyes with myopia or myopic astigmatism were considered as group 1, hypermetropia or hypermetropic astigmatism constituted group 2, and mixed astigmatism patients comprised group 3. Uncorrected distance visual acuity (UDVA), subjective manifest refraction, and CDVA were analyzed at 1 week and 1 month, 3, and 6 months. ·RESULTS: The study included 57 eyes of 57 patients. There were 33 eyes in group 1, 12 eyes in group 2, and 12 eyes in group 3. The preoperative mean values for spherical equivalent of subjective manifest refraction (SE) in groups 1, 2, and 3 were (-4.66±1.97)D, (4.40±1.00)D, and (0.15±1.05)D, respectively. Mean CDVA improved 0.1 log units (1 line LogMAR) at 6 months (P 0.05). Moreover, age, the amount ofpreoperative refractive error, and the levels of preoperative corrected and UDVA had no effect on postoperative CDVA improvement (P >0.05). · CONCLUSION: Correction of refractive errors with LASIK produced significant CDVA improvement in adult patients with anisometropic amblyopia and no previous ambl

关键词： amblyopia laser in situ keratomileusis refractive surgery visual acuity

Prediction of Pretest Probability Scoring Systems in Pulmonary Embolism: Wells, Kline and Geneva

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International Journal of Clinical Medicine 2012年第7期3卷 731-735页

作者： engin Deniz Arslan Suveyda Aksakalli Yesilaras Cemil Kavalci Seyran bozkurt Fevzi Yilmaz Tamer Durdu M. Evvah Karakilic Gulsum Kavalci Department of Emergency Faculty of Medicine Mersin University Mersin Turkey Emergency Department Ankara Numune Training and Research Hospital Ankara Turkey Emergency Department Buca Medical Center Buca Turkey Yenimahalle State Hos- pital Ankara Turkey

Pulmonary embolism (PE) is a clinical entity with high mortality rate and therefore rapid diagnosis is necessary. For this purpose many diagnostic strategies have been developed for avoiding or necessitating further investigations. The hallmark of these strategies is assessing the pretest clinic probability of PE. In this study, the effectiveness of Wells, Geneva and Kline methods were investigated in a university hospital emergency department. 74 patients were enrolled in this study. The inter-group differences in scoring systems were significant for Wells and Kline but non-significant for Geneva method. The diagnosis of PE was correlated with Wells and Kline system but Geneva system lacked it. The Receiver Operating Characteristic analyses was performed for comparing the pretest clinical probability scoring systems and the greatest area under the curve was found in Wells system. Wells method seems more useful compared to Geneva and Kline methods particularly in emergency department.

关键词： Pulmonary Embolism Wells Geneva Kline Emergency Department

Lingual angioedema after alteplase treatment in a patient with acute ischemic stroke

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World Journal of Emergency Medicine 2015年第1期6卷 74-76页

作者： Seyran bozkurt engin Deniz Arslan Ataman K?se Cüneyt Ayr?k Arda Y?lmaz Güllü Akbaydogan Dündar Department of Emergency Medicine Faculty of Medicine Mersin University Department of Emergency Medicine Diskap? Y?ld?r?m Beyazit Training and Research Hospital Department of Neurology Faculty of Medicine Mersin University

BACKGROUND: In recent years, thrombolytic therapy has become the main treatment of ischemic stroke. But the increasing use of alteplase in ischemic stroke has made some complications more evident. Angioedema is a rare but potentially life-threatening complication of alteplase treatment. Only a few studies have examined the incidence of angioedema after treatment with alteplase for ***: A 75-year-old man complaining of right hemiparesis was admitted to our emergency department. He was diagnosed as having acute ischemic stroke, and alteplase infusion was given two hours after the onset of stroke symptoms. Immediately after the completion of infusion he was noted to have a large swollen ***: His neurological symptoms resolved gradually within 4 hours, whereas his upper extremity strength improved to 4/5 and lower extremity 5/5. Lingual edema resolved within 16 hours without any complication. He died from presumed nosocomial infection 5 days ***: Lingual angioedema may appear as a possible complication in patients who were treated with alteplase. The management of these patients should be very careful.

关键词： Angioedema Alteplase Ischemic stroke