检索结果-南通市图书馆

From blood to brain:amoeboid microglial cell,a nascent macrophage and its functions in developing brain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第8期28卷 1087-1096页

作者： Charanjit KAUR S Thameem DHEEN eng-ang LING Department of Anatomy Yong Loo Lin School of Medicine National University of Singapore117597Singapore

Amoeboid microglial cells(AMC)in the developing brain are active *** macrophagic nature of these cells has been demonstrated by many methods,such as the localization of various hydrolytic enzymes and the presence of comple-ment type 3 surface receptors in *** importantly is the direct visualizationof these cells engaged in the phagocytosis of degenerating cells at the ultrastruc-tural *** evidence of them being active macrophages is the avid inter-nalization of tracers administered by the intravenous or intraperitoneal routes indeveloping *** potential involvement of AMC in immune functions is sup-ported by the induced expression of major histocompatibility complex class I andII antigens on them when challenged by lipopolysaccharide or interferon-γ.Im-munosuppressive drugs,such as glucocorticoids and immune function-enhanc-ing drugs like melatonin,affect the expression of surface receptors and antigensand the release of cytokines by *** studies in our laboratory haveshown the expression of insulin-like growth factors,endothelins,2',3'-cyclic nucle-otide 3'-phosphodiesterase,and N-methyl-D-asparate *** along withthe release of chemokines,such as stromal derived factor-la and monocytechemoattractant protein-1,suggests multiple functional roles of AMC in earlybrain development.

关键词： developing brain amoeboid microglial cells functions

Hypoxia and the developing brain： factors underlying cell damage

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

解剖学杂志 2009年第3期32卷 281-285页

作者： Charanjit Kaur Ling eng ang Department of Anatomy Yong Loo Lin School of Medicine Blk MDIO 4 Medical DriveNational University of Singapore Singapore 117597

Structural and functional integrity of brain function depends on a regular oxygen supply. The developing brain is extremely sensitive to oxygen deprivation or hypoxia which affects the normal development and maturatio... 详细信息

关键词：组织缺氧大脑细胞损害外科医学

Clinical utility,safety and tolerability of capsule endoscopy in urban Southeast Asian population

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2003年第10期9卷 2313-2316页

作者： Tiing-Leong ang Kwong-Ming Fock Tay-Meng Ng eng-Kiong Teo Yi-Lyn Tan Division of Gastroenterology Changi General HospitalSingapore

AIM:Capsule endoscopy has demonstrated its clinical utility in the evaluation of small bowel pathology in several Western *** this prospective study,we aimed to determine the clinical utility,safety and tolerability of capsule endoscopy in the evaluation of suspected small bowel disease in an urban Southeast Asian population. METHODS:We used the given (M2A) capsule endoscopy system in 16 consecutive patients with suspected small bowel *** 9 patients the indication was obscure gastrointestinal bleeding,while in 6 patients it was to determine the extent of small bowel involvement in Crohn's *** patient underwent capsule endoscopy for evaluation of chronic abdominal ***'s tolerability to the procedure was evaluated by standardized questionnaires and all patients were reviewed at one week to ensure that the capsule had been excreted without any adverse events. RESULTS:Abnormal findings were present in 8 patients (50%).The cause of obscure gastrointestinal bleeding was determined in 5 out of 9 *** included 2 cases of angiodysplasia,2 cases of jejunal ulcers and 1 case of both angiodysplasia and jejunal *** patient had small bowel erosions and loci of erythema of doubtful significance. Ileal lesions were diagnosed in 2 out of 6 patients with Crohn's *** endoscopy was well tolerated by all *** patient with Crohn's disease had a complication of capsule retention due to terminal ileum *** capsule eventually passed out spontaneously after i month. CONCLUSION:Our study,which represented the first Asian series,further confirms the diagnostic utility,safety and tolerability of wireless capsule endoscopy.

关键词： Endoscopes Adult Aged Endoscopy, Digestive System Female Humans Intestinal Diseases Intestine, Small Male Middle Aged Patient Satisfaction Prospective Studies Singapore

A comparison of the clinical, demographic and psychiatric profiles among patients with erosive and non-erosive reflux disease in a multi-ethnic Asian country

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第23期11卷 3558-3561页

作者： Tiing-Leong ang Kwong-Ming Fock Tay-Meng Ng eng-Kiong Teo Tju-Siang Chua Jessica Tan Division of Gastroenterology

AIM:To examine the clinical spectrum of gastroesophageal reflux disease (GERD) and compare erosive (ERD) with non-erosive (NERD) in terms of clinical, demographic and psychiatric profiles. METHODS: Patients with reflux symptoms were enrolled and stratified to NERD and ERD after endoscopy (LA classification). Patients with ERD presenting with dyspepsia were included. Patients on proton pump inhibitors (PPI) or H2 receptor antagonists before endoscopy were excluded. Demographic data, Helicobacter pylori(H pylori) status and presence of minor psychiatric morbidity (based on General Health Questionnaire-28) were analyzed. RESULTS: Among 690 patients screened, 533 were eligible for analysis (male to female ratio: 3:2; Chinese: 75.4%; Malay: 9.8%; Indian: 14.8%). Clinical spectrum of GERD: N: 40.5%; A: 46%; B: 9.2%; C: 2.1%; D: 0.6%; Barrett's esophagus: 1.7%. Compared to patients with NERD, patients with ERD were significantly older (45 vs 39.4 years), more likely to be male (64.4% vs 53.7%), tended to smoke (19.6% vs 9.7%), less likely to have minor psychiatric morbidity (26.4 vs 46.7%) and were more likely to respond to PPI (79.7 vs 66.8%). There was also a trend towards a higher BMI (24.5 vs 23.5). Race, alcohol consumption and H pylori status were not significant. On multivariate analysis, age and presence of minor psychiatric morbidity remained with significant differences. CONCLUSION: The majority of patients who have typical symptoms of GERD have NERD or mild erosive reflux disease. Compared to patients with erosive reflux disease, patients with NERD were younger and had a higher prevalence of minor psychiatric morbidity.

关键词： Reflux disease Clinical spectrum Psychiatric morbidity

An Overview of Self-piercing Riveting Process with Focus on Joint Failures, Corrosion Issues and Optimisation Techniques

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical engineering 2021年第1期34卷 89-113页

作者： Hua Qian ang School of engineering RMIT UniversityBundooraVictoria 3083Australia

Self-piercing riveting(SPR)is a cold forming technique used to fasten together two or more sheets of materials with a rivet without the need to predrill a *** application of SPR in the automotive sector has become increasingly popular mainly due to the growing use of lightweight materials in transportation ***,SPR joining of these advanced light materials remains a challenge as these materials often lack a good combination of high strength and ductility to resist the large plastic deformation induced by the SPR *** this paper,SPR joints of advanced materials and their corresponding failure mechanisms are discussed,aiming to provide the foundation for future improvement of SPR joint *** paper is divided into three major sections:1)joint failures focusing on joint defects originated from the SPR process and joint failure modes under different mechanical loading conditions,2)joint corrosion issues,and 3)joint optimisation via process parameters and advanced techniques.

关键词： Self-piercing riveting Mechanical joining Joint defects Failure mechanisms Corrosion Joint optimisation

维普期刊数据库

Epinephrine injection therapy versus a combination of epinepnrine injection and endoscopic hemoclip in the treatment of bleeding ulcers

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第7期11卷 1044-1047页

作者： Tju-Siang Chua Kwong-Ming Fock Tay-Meng Ng eng-Kiong Teo Jessica Yi-Lyn Tan Tiing-Leong ang Division of Gastroenterology

AIM: To assess the efficacy of hemoclip application in combination with epinephrine injection in the treatment of bleeding peptic ulcers and to compare the clinical outcomes between patients treated with such a combination therapy and those treated with epinephrine injection ***: A total of 293 patients (211 males, 82females) underwent endoscopic therapy for bleeding peptic ulcers. Of these, 202 patients (152 males, 50females) received epinephrine injection therapy while 91patients (59 males, 32 females) received combination therapy. The choice of endoscopic therapy was made by the endoscopist. Hemostatic rates, rebleeding rates, need for emergency surgery and 30-d mortality were the outcome measures ***: Patients who received combination therapy were significantly older (mean age 66±16 years, range24-90 years) and more suffered from chronic renal failure compared to those who received epinephrine injection therapy alone (mean age 61±17 years, range 21-89 years).Failure to achieve permanent hemostasis was 4% in the group who received epinephrine injection alone and 11%in the group who received combination therapy. When the differences in age and renal function between the two treatment groups were taken into account by multivariate analysis, the rates of initial hemostasis,rebleeding rates, need for surgery and 30-d mortality for both treatment options were not significantly ***: Combination therapy of epinephrine injection with endoscopic hemoclip application is an effective method of achieving hemostasis in bleeding peptic ulcer diseases. However, superiority of combination therapy over epinephrine injection alone, could not be demonstrated.

关键词： Bleeding peptic ulcer Epinephrine Endoscopic hemoclip Combination therapy

Role of interstitial flow in tumor migration through 3D ECM

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2020年第3期36卷 768-774页

作者： ang Li Ren Sun MOE Key Laboratory of Hydrodynamics School of Naval ArchitectureOcean&Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Cancer invasion in tissue is simultaneously regulated by chemical and mechanical *** suggest that interstitial flow plays a critical role in tumor *** one hand,the distribution of chemokines around cell is influenced by *** the other hand,interstitial flow may reconfigure the alignment of fiber matrix,which greatly changes the contact force between cell and extracellular *** this study,we have upgraded a model by which we can quantitatively investigate the influence of flow on tumor cell migration.A hydrodynamic analysis of shear stress on a slender body is introduced to simulate the fiber *** such as subtle flow and cell-matrix interaction which dominate tumor migration are integrated in this novel *** results show interstitial flow facilitates tumor cell migration in the flow ***,the flow-related chemical and mechanical cues have a synergistic effect on the *** model provides better understanding on cancer metastasis and helps design vitro experiment precisely.

关键词： Interstitial flow Tumor cell migration Extracellular matrix

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

数字经济、创新能力与经济高质量发展

江苏商论 2025年第1期 22-27,36页

作者：臧守芳盐城师范学院数学与统计学院盐城数字经济研究院数字金融研究所江苏盐城224002

当前,中国经济已经由高速发展转向高质量发展,数字经济作为经济发展的新动能,正成为推动经济高质量发展的重要引擎。文章基于2011—2019年省级面板数据,通过构建综合评价指标体系,利用固定效应模型,从创新视角出发,探究数字经济影响高... 详细信息

当前,中国经济已经由高速发展转向高质量发展,数字经济作为经济发展的新动能,正成为推动经济高质量发展的重要引擎。文章基于2011—2019年省级面板数据,通过构建综合评价指标体系,利用固定效应模型,从创新视角出发,探究数字经济影响高质量发展的内在机制。结果表明,数字经济有效推动了经济高质量发展;创新能力在其中发挥了正向调节作用。这种影响作用存在区域异质性,中西部地区相较于东部地区更为明显。因此,文章提出了加强科技创新,持续推进数字产业化和产业数字化建设,施行差异化数字转型策略,并加强风险防范的建议。

关键词：创新能力数字经济高质量发展

维普期刊数据库

SYNTHESIS AND CHARACTERIZATION OF A NOVEL POLYMER ELECTROLYTE BASED ON ACRYLONITRILE/N-[4-(AMINOSULFONYL)PHENYL]ACRYLAMIDE COPOLYMERS

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2010年第1期28卷 129-135页

作者： ang-ran Wang 包永忠 State Key Laboratory of Chemical engineering Zhejiang University

Acrylonitrile/N-[4-（aminosulfonyl）phenyl]acrylamide （AN/ASPAA） copolymers were synthesized and used as a host of lithium ion conducting electrolytes. The composition, molecular weight and molecular weight distribution of AN/ASPAA copolymers were determined, and the influence of copolymer composition on the glass temperature of AN/ASPAA copolymers and the ion conductivity of electrolytes were investigated. The molecular weights of AN/ASPAA copolymers were lower than those of AN and ASPAA homopolymers due to the cross-termination reaction. The glass temperatures of AN/ASPAA copolymers increased as the molar fraction of ASPAA units in copolymers increased. The lithium ion conductivities of the polymer electrolytes increased initially as the molar fraction of ASPAA units in copolymers increased, and a maximum conductivity was achieved when the molar fraction of ASPAA in the copolymer was 16.8%.

关键词： Acrylonitrile N-[4-(aminosulfonyl)phenyl]acrylamide Copolymerization Composition Polymer electrolyte

维普期刊数据库