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Predictors of poor outcome in gastrointestinal bleeding in emergency department

World Journal of Gastroenterology 2016年第16期22卷 4219-4225页

作者： ender kaya Mehmet Ali Karaca Deniz Aldemir M Mahir Ozmen Dr. Nafiz Korez State Hospital Sincan 06932 Ankara Turkey Emergency Medicine Department Faculty of Medicine Hacettepe University Sihhiye 06100 Ankara Turkey General Surgery Department Faculty of Medicine Hacettepe University Sihhiye 06100 Ankara Turkey

AIM: To determine the prognostic risk factors of gastrointestinal bleeding in emergency department ***: The trial was a retrospective single-center study involving 600 patients over 18-years-old and carried out with approval by the Institutional Ethics Committee. Patient data included demographic characteristics, symptoms at admission, past medical history, vital signs, laboratory results, endoscopy and colonoscopy results, length of hospital stay, need of intensive care unit(ICU) admission, and mortality. Mortality rate was the principal endpoint of the study, while duration of hospital stay, required interventional treatment, and admission to the ICU were secondary ***: The mean age of patients was 61.92-yearsold. Among the 600 total patients, 363(60.5%) underwent upper gastrointestinal endoscopy and the most frequent diagnoses were duodenal ulcer(19.2%) and gastric ulcer(12.8%). One-hundred-and-fifteen(19.2%) patients required endoscopic treatment, 20(3.3%) required surgical treatment, and 5(0.8%) required angiographic embolization. The mean length of hospital stay was 5.21 ± 5.85 d. The mortality rate was 6.3%. The ICU admission rate was 5.3%. Patients with syncope, higher blood glucose levels, and coronary artery disease had significantly higher ICU admission rates(P = 0.029, P = 0.043, and P = 0.002, respectively). Patients with low thrombocyte levels, high creatinine, high international normalized ratio, and high serum transaminase levels had significantly longer hospital stay(P = 0.02, P = 0.001, P = 0.019, and P = 0.005, respectively). Patients who died had significantly higher serum blood urea nitrogen and creatinine levels(P = 0.016 and P = 0.038), and significantly lower mean blood pressure and oxygen saturation(P = 0.004 and P = 0.049). Malignancy and low Glasgow coma scale(GCS) were independent predictive factors of ***: Prognostic factors for gastrointestinal bleeding in emergency room cases are malignancy, hyp

关键词： Gastrointestinal bleeding Poor prognosis Mortality Emergency department Kidney function Malignancy

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Thinning effects on biomass and element concentrations of roots in adjacent hornbeam and oak stands in Istanbul,Turkey

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Forest Ecosystems 2021年第1期8卷 1-10页

作者： Serdar Akburak ender Makineci Faculty of Forestry Soil Science and Ecology DepartmentIstanbul University-Cerrahpasa34473 BahcekoySariyerIstanbulTurkey

Background:Thinning is a commonly used treatment in forest management which affects the tree root *** effects of thinning on element concentrations and seasonal change of roots were evaluated in adjacent oak(Quercus frainetto Ten.)and hornbeam(Carpinus betulus L.)stands according to the different root diameter ***:Two replicated control and thinning plots(50m×50 m)were set for each species(hornbeam and oak).Thinning treatments(November 2010)reduced 50%of the basal area in both oak and hornbeam *** were assessed by seasonal collection over 2 years(from October 2010 to October 2012).The roots were then sorted into diameter classes of 0–2mm(fine roots),2–5mm(small roots)and>5mm(coarse roots).C,N,P,K,Ca,Na,Mg,S,Mn,Fe,Al,Zn,Pb,Ni,Cu and Cd were ***:Except coarse roots,the highest root biomasses were determined in April-2011 in all ***-root biomass in oak was found significantly higher in control *** contrast to the oak,the fine-root biomass in the thinned hornbeam plots was higher than in the *** small-root biomass did not significantly differ between the thinned and the control plots in both oak and hornbeam ***,the coarse-root biomass showed significant differences between the control(1989 g∙m^(−2))and thinned plots(1060 g∙m^(−2))in oak,while no difference was detected in *** concentrations of C,Al,Pb,Cd,Ni,Zn,Mn,Na,K,Mg and P in the fine roots of oak were significantly higher in the thinned ***,the concentration of Pb,Cd and Fe in the fine roots was significantly higher in the thinned plots of *** differences were observed between the species for all elements in the fine roots except for C,N and *** particular,elements in the fine roots tended to increase in July in the *** the hornbeam,all element concentrations in the fine roots(except C,N,and S)in the thinned plots showed a tendency to increase in *** concentrations of Pb,Ni,Al,Fe,Cu,Ca,Na,K,Mg and

关键词： Carpinus Coarse root Fine root Quercus Small root

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Litter decomposition in pure and mixed Quercus and Fagus stands as influenced by arthropods in Belgrad Forest,Turkey

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Journal of Forestry Research 2020年第4期31卷 1123-1137页

作者： Meric Caklr ender Makineci Department of Soil Science and Ecology Faculty of ForestryCanklrl Karatekin University18100 CanklrlTurkey Department of Soil Science and Ecology Faculty of ForestryIstanbul University-Cerrahpasa34473 Sariyer/IstanbulTurkey

Arthropod assemblages and decomposition rates were compared in the litter of pure and mixed Quercus(Quercus petraea L.)and Fagus(Fagus orientalis L.)*** was sampled on a monthly basis for 1 year and stored in litterbags of different mesh *** experimental objective was to test the effect of mesh size on litter decomposition,decomposition rates of litter,and diversity of the invertebrate fauna between the two types of *** rates were measured by filling three fiber litterbags of different mesh sizes with pure Quercus litter(3 g)left in the pure Quercus stand,and litterbags with Fagus litter(3 g)were left in the pure Fagus *** litter samples were prepared by mixing of equal amounts of each litter in the same litterbag and leaving them in the mixed *** residual mass of litter from the pure Quercus stand was significantly lower in fine-and coarse-mesh bags than in the medium-mesh bags in pure the Fagus *** and nitrogen levels in the pure Quercus litter were significantly different among the mesh sizes at the end of the incubation *** from 27 taxa were collected from pitfall traps every *** relative numbers differed significantly between the pure and mixed-stand litter ***-dwelling Isotomidae(Collembola)and Mesostigmata(Acarina),and soil-dwelling Mesostigmata were the most numerous in the mixed *** is significant that the abundance of macroarthropods contributed to the mass loss of litter in both the medium and coarse mesh sizes in the mixed stand,but did not significantly affect the mass of litter in the pure *** the mixed stand,there was a negative correlation between litter mass loss and total number of microarthropods in all mesh ***-stand litter decomposed more slowly than pure-stand litter.

关键词： Collembola(springtails) Mesh size Pitfall trap RDA Quercus Fagus litter decay

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The prevention role of Spirulina platensis(Arthrospira platensis)on intestinal health

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Food Science and Human Wellness 2022年第5期11卷 1342-1346页

作者： ender Deniz Asmaz Nilay Seyidoglu Department of Histology and Embryology Veterinary FacultyBursa Uludag UniversityNilufer 16059Turkey Department of Physiology Veterinary FacultyTekirdag Namik Kemal UniversitySuleymanpasa 59030Turkey

Spirulina is a popular herbal food that has a preventive effect on *** the study,it aimed to evaluate the effects of different doses of Spirulina platensis(Arthrospira platensis)on the morphological properties of the duodenum of rats,and to assign the effect of Spirulina on the expression of proliferating cell nuclear antigen(PCNA)in the rat duodenum,and thereby to observe the effects on intestinal health.30 male Wistar albino rats were divided into 3 groups for 45 *** first group was received the basal diet;the second group was given 500 mg/kg Spirulina daily by oral gavage;the third group was given 1000 mg/kg Spirulina *** duodenum segments were taken at the end of the trial and processed for histological *** the total mucosa,villus height and villus/cript ratio were found higher in high dose Spirulina,the lower cript depth was detected in same group compared to control and low dose group.A significant increase was observed at high dose compared to the control and low dose group in terms of PCNA expression intensity and proliferation *** suggest that high dose of Spirulina may support the duodenal growth,and thereby intestinal health.

关键词： Histochemistry Duodenum Spirulina platensis Intestinal health

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Interaction between Janus Green B and bovine serum albumin:Electrochemistry and spectroscopy studies

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Chinese Chemical Letters 2011年第6期22卷 717-720页

作者： Neslihan zdemir Serkan zdemir ender Bier Ondokuz Mayrs University Faculty of Arts and Sciences Department of Chemistry

In this study,voltammetric and spectroscopic investigation of the interaction between Janus Green B（JGB） and bovine serum albumin（BSA） was *** interaction was observed at Britton-Robinson buffer（pH 7.0）.When JGB was added to solution containing BSA,the peak currents of BSA decrease with the increasing of JGB concentrations which is due to the interaction of JGB and *** binding constant of JGB with BSA was obtained by voltammetric ***,this interaction was supported by means of UV-vis spectroscopic *** UV-vis absorption spectra of JGB in the presence of BSA decrease with the increasing of BSA concentrations.

关键词： Voltammetry Bovine serum albumin Janus Green B Interaction

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Impacts of low-intensity prescribed fire on microbial and chemical soil properties in a Quercus frainetto forest

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Journal of Forestry Research 2018年第3期29卷 683-692页

作者： Serdar Akburak Yowhan Son ender Makineci Meric Cakir Faculty of Forestry Soil Science and Ecology DepartmentIstanbul University34473 BahcekoySariyerIstanbulTurkey Division of Environmental Science and Ecological Engineering Korea University145 Anam-roSeongbuk-guSeoul 136-713Korea Faculty of Forestry Soil Science and Ecology DepartmentCankiri Karatekin University18100 CankkiriTurkey

Prescribed fire is a common economical and effective forestry practice, and therefore it is important to understand the effects of fire on soil properties for better soil management. We investigated the impacts of low-intensity prescribed fire on the microbial and chemical properties of the top soil in a Hungarian oak(Quercus frainetto Ten.) forest. The research focused on microbial soil parameters(microbial soil respiration(RSM), soil microbial biomass carbon(Cmic) and metabolic quotient(qCO2) and chemical topsoil properties(soil acidity(pH),electrical conductivity(EC), carbon(C), nitrogen(N), C/N ratio and exchangeable cations). Mean annual comparisons show significant differences in four parameters(C/N ratio,soil pH, Cmic and qCO2) while monthly comparisons do not reveal any significant differences. Soil pH increased slightly in the burned plots and had a significantly positive correlation with exchangeable cations Mg, Ca, Mn and *** mean annual C/N ratio was significantly higher in the burned plots(28.5:1) than in the control plots(27.0:1). The mean annual Cmic(0.6 mg g-1) was significantly lower although qCO2(2.5 lg CO2–C mg Cmic h-1) was significantly higher, likely resulting from the microbial response to fire-induced environmental stress. Low-intensity prescribed fire caused very short-lived changes. The annual mean values of C/N ratio, pH, Cmic and qCO2showed significant differences.

关键词： C/N Exchangeable cations Microbial biomass carbon qCO_2 Soil pH

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Partial virological response to three different nucleotide analogues in naive patients with chronic hepatitis B

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 602-611页

作者： ender G Yegin Osman Cavit Ozdogan Department of Gastroenterology Marmara University Faculty of Medicine

BACKGROUND： The definition of partial virological response （PVR） was proposed because of its clinical relevance. PVR relates to subsequent therapeutic failure which results in the modification of the regimen. Whether this rationale can be applied to all nucleotide analogues （NA） is not clear. This study was undertaken to analyze PVR influence on therapeutic outcomes during lamivudine, entecavir or tenofovir mono- therapy in NA-naive patients with chronic hepatitis B in routine clinical practice. METHODS： We retrospectively analyzed 150 NA-naive patients with chronic hepatitis B. These subjects received lamivudine, entecavir or tenofovir monotherapy between February 2001 and July2013. RESULTS： Sixty-nine patients were treated with lamivudine, 35 with entecavir, and 46 with tenofovir. The median therapeutic duration was 19.5 （6-147） months. PVR rates at 24 weeks were similar among three NAs （lamivudine 33.3%, entecavir 35.0%, tenofovir 32.4%, P--0.981）. For all three NAs, patients with a higher baseline viral load or HBeAg-positive status had a higher serum viral positive rate tested by polymerase chain reaction at week 24 and 48. Cumulative probability of virological breakthrough （VBR） for patients treated with lamivudine was 67% at 5 years, and PVR at 24 weeks was the independent risk factor for VBR （HR： 3.09; 95% CI： 1.09-8.74; P=0.034）; also lamivudine treated patients older than 50 years seemed to have a tendency for VBR （HR： 2.80; 95% CI： 0.99-8.18; P=0.052）. A majority of entecavir and tenofovir partial responders achieved and maintained virological response with prolonged monotherapy, except one entecavir treated patient who experienced VBR due to resistance ***： Management strategy for lamivudine treatment should include adaptation of regimen according to PVR as an on-treatment response parameter due to its relation with unacceptably high VBR probability. Similar conclusion should not be directly related to entecavir or tenofovir treatment.

关键词： partial virological response lamivudine entecavir tenofovir therapeutic outcome

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Optimization of CNC cutting parameters using design of experiment(DOE) and desirability function

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Journal of Forestry Research 2018年第5期29卷 1423-1434页

作者： ender Hazir Emine Seda Erdinler Kücük Hüseyin Koc Department of Forest Industrial Engineering Faculty of ForestryIstanbul University

In this study,2~5 （five factors at two-level factorial design） design of experiment was applied to investigate a set of optimal machining parameters to achieve a minimum surface roughness value for Abies *** specimens were prepared using different values of spindle speed,feed rate,depth of cut,tool radius,and cutting *** surface roughness （R_z） values were applied using a *** objectives were to：（1）obtain the effective variables of wood surface roughness;（2） analyze which of these factors had an impact on variability in the CNC machining process;（3） evaluate the optimal cutting values within the range of different cutting levels of machining *** results indicate that the design of experiment（DOE） based on the desirability function approach determined the optimal machining parameters successfully,leading to minimum R_a compared to the observed *** surface roughness values of tangential and radial cutting directions were 3.58 and 3.21 μm,respectively.

关键词： Wood surface roughness Optimization CNC Desirability function Pareto analysis

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Progress in surgical and nonsurgical approaches for hepatocellular carcinoma treatment

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Hepatobiliary & Pancreatic Diseases International 2016年第3期15卷 234-256页

作者： ender Gunes Yegin Erkan Oymac1 Emrah Karatay Ahmet Coker Department of Gastroenterology Bozyaka Trainingand Research HospitalIzmir Depatment of Gastroenterology Surgery Bozyaka Trainingand Research HospitalIzmir Department of Radiology Bulanlk State HospitalMus Department of General Surgery Ege University Faculty of MedicineIzmiTurk

BACKGROUND： Hepatocellular carcinoma （HCC） is a com- plex and heterogeneous malignancy, frequently occurs in the setting of a chronically diseased organ, with multiple con- founding factors making its management challenging. HCC represents one of the leading causes of cancer-related mortal- ity globally with a rising trend of incidence in some of the de- veloped countries, which indicates the need for better surgical and nonsurgical management strategies.

关键词： hepatocellular carcinoma surgical liver resection liver transplantation locoregional therapies molecular targeted systemic therapies immunotherapy gene therapy

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Reactive oxygen species and chemokines: Are they elevated in the esophageal mucosa of children with gastroesophageal reflux disease?

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World Journal of Gastroenterology 2008年第20期14卷 3218-3223页

作者： Engin Tutar Deniz Ertem Goksenin Unluguzel Sevda Tanrikulu Goncagul Haklar Cigdem Celikel Evin Ademoglu ender Pehlivanoglu Division of Pediatric Gastroenterology Hepatology and Nutrition Marmara University School of Medicine Altunizade stanbul 81190 Turkey Department of Biochemistry Marmara University School of Medicine Altunizade stanbul 81190 Turkey Department of Biochemistry Istanbul University Istanbul Faculty of Medicine apa stanbul 34390 Turkey Department of Pathology Marmara University School of Medicine Altunizade stanbul 81190 Turkey

AIM: To determine the role of inflammatory cytokines and reactive oxygen species (ROS) in childhood reflux esophagitis. METHODS: A total of 59 subjects who had complaints suggesting GERD underwent esophagogastroduoden oscopy. Endoscopic and histopathologic diagnosis of reflux esophagitis was established by Savary-Miller and Vandenplas grading systems, respectively. Esophageal biopsy specimens were taken from the esophagus 20% proximal above the esophagogastric junction for conventional histopathological examination and the measurements of ROS and cytokine levels. ROS were measured by chemiluminescence, whereas IL-8 and MCP-1 levels were determined with quantitative immunometric ELISA on esophageal tissue. Esophagealtissue ROS, IL-8 and MCP-1 levels were compared among groups with and without endoscopic/histo- pathologic esophagitis. RESULTS: Of 59 patients 28 (47.5%) had normal esophagus whereas 31 (52.5%) had endoscopic esophagitis. In histopathological evaluation, almost 73% of the cases had mild and 6.8% had moderate degree of esophagitis. When ROS and chemokine levels were compared among groups with and without endoscopic esophagitis, statistical difference could not be found between patients with and without esophagitis. Although the levels of ROS, IL-8 and MCP-1 were found to be higher in the group with histopathological reflux esophagitis, this difference was not statistically significant. CONCLUSION: These results suggest that the grade of esophagitis is usually mild or moderate during childhood and factors apart from ROS, IL-8 and MCP-1 may be involved in the pathogenesis of reflux esophagitis in children.

关键词： Gastroesophageal reflux disease Refluxesophagitis Reactive oxygen species Interleukine-8 Monocyte chemoattractant protein-1

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