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Neuroprotection by misoprostol against rotenone-induced neurotoxicity in rat brain

Asian Pacific Journal of Tropical Medicine 2018年第1期11卷 40-47页

作者： Omar M.E.Abdel-Salam Amany A Sleem Eman R Youness Nadia A Mohammed enayat a omara Department of Toxicology and Narcotics National Research Centre Department of Pharmacology National Research Centre Department of Medical Biochemistry National Research Centre Department of Pathology National Research Centre

Objective: To investigate the effect of the prostaglandin E1 analogue misoprostol on oxidative stress and neurodegeration caused by subcutaneous rotenone administration in rats. Methods:Rotenone was administered in a dose of 1.5 mg/kg every other day for 2 weeks. Starting from the 1 st day of rotenone injection, rats were subcutaneously treated with misoprostol at doses of10, 100 or 1 000 μg/kg. Rats were evaluated for brain lipid peroxidation(malondialdehyde:MDA), reduced glutathione(GSH), nitric oxide(NO) levels, and paraoxonase-1(PON-1) *** concentrations of the anti-apoptotic protein B cell/lymphoma-2(Bcl-2) were determined in the striatum. Histopathologic examination and the expression of inducible nitric oxide synthase(iNOS) in the cerebral cortex and striatum were also performed. Results: Compared with the vehicle-treated group, rotenone caused a significant increase in brain lipid proxidation(MDA)by 61%(P<0.05) accompanied by an increase in NO by 73.1%(P<0.05) and a decrease in GSH concentration by 29.4%(P<0.05). In addition, brain PON-1 activity significantly decreased by63.0%(P<0.05) and striatal Bcl-2 significantly decreased by 27.9%(P<0.05) with respect to the corresponding control value. Brain sections from rotenone treated rats showed extensive dark pyknotic and apoptotic nuclei in neurons, shrunken cytoplasm and perineuronal *** also caused pronounced expression of iNOS in the cerebral cortex and *** with misoprostol at doses of 100 and 1 000 μg/kg resulted in decreased brain MDA(by 16.5%-23.0%)(P<0.05) and NO levels(by 37.1%-40.7%)(P<0.05) and increased GSH concentrations(by 18.8%-30.1%)(P<0.05). PON-1 activity was significantly increased by80.0%-114.8%(P<0.05) by misoprostol at 100 and 1 000 μg/kg, respectively. In addition,misoprostol treatment restored striatal Bcl-2 concentrations to its normal value. Misoprostol treatment resulted in markedly reduced brain injury and decreased iNOS expression in the cereb

关键词： Misoprostol Rotenone Brain oxidative stress B cell/lymphoma-2 Paraoxonase

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Role of zinc as an antioxidant and anti-inflammatory to relieve cadmium oxidative stress induced testicular damage in rats

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Asian Pacific Journal of Tropical Biomedicine 2016年第12期6卷 1056-1064页

作者： Samir Abd El-Monem Bashandy enayat Abdel Aziz omara Hossam Ebaid Mohamed Mahmoud Amin Mahmoud Sanad Soliman Department of Pharmacology Medical DivisionNational Research Centre Department of Pathology National Research Centre Department of Zoology College of ScienceKing Saud University Department of Zoology Faculty of ScienceEl-Minia University Department of Therapeutic Chemistry National Research Centre

Objective:To investigate the role of zinc in reducing the deleterious effects of cadmium on male ***:Rats were injected subcutaneously with CdCl_2 and ZnCl_2 at dose level of2.2 mg/kg(1/40 of LD50 of cadmium per day).Results:The rats treated with cadmium exhibited a significant increase in levels of testicular malondialdehyde,tumor necrosis factor-alpha,nitrogen oxide and inducible nitrogen oxide synthase immunostaining reaction,as well as an elevation of blood hydroperoxide and follicle stimulating *** addition,a significant decrease in testicular ascorbic acid,zinc,reduced glutathione,catalase,superoxide dismutase,sex organ weight,plasma testosterone and luteinizing hormone were observed in the cadmium *** motility and count were decreased with cadmium treatment,while sperm abnormalities elevated *** treatment was found to mitigate the toxic effects of cadmium on oxidative stress,spermatogenesis,sex hormones,and inflammatory *** injected with cadmium showed intense histopathological *** manifested protective role and markedly reduced tissues damage induced by ***:The protective effect of zinc can be attributed to its antioxidant and antiinflammatory properties.

关键词： Zinc Cadmium Oxidative stress Immunohistochemistry Sperms Inflammatory markers

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Amoxicillin–clavulanic acid induced sperm abnormalities and histopathological changes in mice

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Asian Pacific Journal of Tropical Biomedicine 2017年第9期7卷 809-816页

作者： Maha A. Fahmy Ayman A. Farghaly enayat A. omara Zeinab M. Hassan Fawzia A.E. Aly Souria M. Donya Aziza A.E. Ibrahim Elsayed M. Bayoumy Department of Genetics and Cytology National Research CentreDokkiGizaEgypt Department of Pathology National Research CentreDokkiGizaEgypt Department of Chemistry of Natural Compounds National Research CentreDokkiGizaEgypt Hydrobiology Department National Research CentreDokkiGizaEgypt Biology Department Girls Science CollegeUniversity of DammamSaudi Arabia

Objective: To explore the genotoxic potential and histopathological changes induced in liver, kidney, testis, brain and heart after using the antibiotic drug amoxicillin/clavulanic acid(4:1).Methods: The study included chromosomal aberration analysis in bone-marrow and mouse spermatocytes, induction of sperm morphological abnormalities and histopathological changes in different body organs. The drug was administrated orally at a dose of81 mg/kg body weight twice daily(Total = 162 mg/kg/day) for various periods of time equivalent to 625 mg/men(twice daily).Results: The results revealed non-significant chromosomal aberrations induced after treatment with amoxicillin/clavulanic acid(AC) in both bone marrow and mouse spermatocytes after 7 and 10 days treatment. On the other hand, statistically significant percentages of sperm morphological abnormalities were recorded. Such percentage reached 8.10 ± 0.55, 9.86 ± 0.63 and 12.12 ± 0.58 at the three time intervals tested(7, 14 and 35 days after the 1 st treatment respectively)(treatment performed for 5 successive days) compared with 2.78 ± 0.48 for the control. The results also revealed histopathological changes in different body organs after AC treatment which increased with the prolongation of the period of therapy. Congestion of central vain, liver hemorrhage and hydropic changes in hepatocytes were noticed in the liver. Degenerative changes were found in kidney glomerulus and tubules while testis showed atrophy of seminiferous tubules, and reduction of spermatogenesis. AC also induced neurotoxicity and altered brain neurotransmitter levels. Hemorrhage in the myocardium, disruption of cardiac muscle fibers and pyknotic nuclei in cardiomyocytes were recorded as side effects of AC in heart ***: The results concluded that AC treatment induced sperm morphological abnormalities and histopathological changes in different body organs. Clinicians must be aware of such results while describing the drug.

关键词： Amoxicillin/clavulanic acid Genotoxicity Sperm abnormalities Histopathological changes

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Hepatoprotective activity of Dypsis lutescens against D-galactosamine-induced hepatotoxicity in rats and its phytoconstituents

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Asian Pacific Journal of Tropical Biomedicine 2019年第11期9卷 467-473页

作者： Mai M.El-Ghonemy Walaa A.El-Kashak Tahia K.Mohamed enayat A.omara Jihan Hussein Abdel-Razik H.Farrag Mahmoud I.Nassar Mohamed Y.El-Kady Chemistry of Natural Compounds Department National Research Centre33 El-Bohouth St.Dokki12622CairoEgypt Department of Pathology National Research Centre33 El Bohouth St.Dokki12622CairoEgypt Medical Biochemistry Department National Research Centre33 El Bohouth St.Dokki12622CairoEgypt Chemistry Department Faculty of ScienceAin Shams UniversityCairoEgypt

Objective:To isolate and identify the polyphenolic constituents of Dypsis lutescens,and evaluate the hepatoprotective activity of the ethanolic extract of Dypsis lutescens ***:Hepatoprotective,antioxidant and anti-inflammatory effects of two doses of Dypsis lutescens ethanolic leaf extract were investigated in five groups of six rats each administered with the ethanolic extract of Dypsis lutescens *** function parameters were assessed,histopathological study was carried out,the anti-inflammatory mediators and the antioxidant potential in the liver tissues were *** addition,the total ethanolic extract of Dypsis lutescens leaves was subjected to different chromatographic separation techniques to yield ten phenolic *** isolated compounds structures were spectroscopically ***:Hepatoprotective activity of Dypsis lutescens ethanolic extract was estimated for the first time and showed significant activity against histopathological changes induced by D-galactosamine in *** extract improved the liver *** to the D-galactosamine group,the architecture of the liver in the treated groups was improved in the histopathological *** results proved the hepatoprotective activity of Dypsis lutescens and its ability in attenuating liver oxidative damage and *** investigations of the total extract afforded ten compounds from the genus ***:The alcoholic extract of Dypsis lutescens exerted potential hepatoprotective action,maintaining liver health and functions.

关键词： Dypsis lutescens Flavonoid glycosides Phenolic acids Hepatoprotective Antioxidant Anti-inflammatory

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