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Curcumin Interferes with TGF-β1-Induced Fibrosis in NRK-49F Cells by Reversing ADAMTS18 Gene Methylation

Chinese Journal of Integrative Medicine 2024年第7期30卷 600-607页

作者： XU Ben zhang Jia-en YE Lin YUAN Chang-wei Department of Urology Peking University First Hospital and Institute of UrologyPeking UniversityNational Urological Cancer CenterBeijing100034China

Objective To explore the molecular mechanism by which curcumin affects renal interstitial fibrosis(RIF)progression by regulating ADAM metallopeptidase with thrombospondin type 1 motif 18(ADAMTS18)*** NRK-49F cells RIF model were induced with transforming growth factorβ1(TGF-β1).Effects of different concentrations of curcumin(0,10,20,and 30μmol/L)on cell proliferation,cell cycle,cell apoptosis as well as cyclin D1 expression were analyzed by cell counting kit-8,flow cytometry and Western blot,***18 methylation levels were determined by methylation-specific polymerase chain ***18,fibronectin(FN),type I collagen(Col-I)and alpha-smooth muscle actin(α-SMA)mRNA and protein expressions were analyzed by real-time PCR(RT-PCR)and Western blot,***,cells were treated with 50 mmol/L 5-aza-2′-deoxycytidine(5-aza-dC,demethylation agent)for 72 *** of curcumin on extracellular matrix(ECM)deposition was evaluated by immunochemical staining and Western ***-49F cells were transfected with ADAMTS18 small interfering RNA and grouped into a normal control,ADAMTS18-knock-out(KO),and ADAMTS18-KO+30μmol/L curcumin groups,and whether curcumin can reverse the effect of ADAMTS18 knockdown on RIF was *** Compared with the control group,TGF-β1 significantly inhibited the proliferation of NRK-49F cells,blocked the G1/G0 phase,promoted cell apoptosis and inhibited cyclin D1 expression(Pent concentrations of curcumin,30μmol/L curcumin significantly reversed these processes(P<0.01).Immunochemical staining and Western blot results showed that curcumin significantly inhibited the deposition of FN,Col-I andα-SMA(P<0.01).Curcumin and 5-zaz-dC had synergistic effects,promoting ADAMTS18 expression,removing ADAMTS18 methylation,and reducing ECM ***18 knockdown promoted ECM accumulation,and curcumin reversed this process(P<0.01).Conclusion TGF-β1-induced fibrosis in NRK-49F ***

关键词： renal fibrosis curcumin Chinese medicine ADAMTS18 methylation modification

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Numerical Simulation on Unsteady Flow Mechanism of a 1.5-Stage Axial Transonic Compressor

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Journal of Thermal Science 2024年第5期33卷 1851-1866页

作者： peng Shuxuan zhang Xiaoyu WANG Wentao zhang Hongwu LI Xinlong High Efficiency and Low Carbon Gas Turbine Digitalization Research Centre Nanjing Institute of Future Energy SystemNanjing 211135China Advanced Gas Turbine Laboratory Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China Key Laboratory of Advanced energy and Power Chinese Academy of SciencesBeijing 100190China Innovation Academy for Light-Duty Gas Turbine Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China BYD Auto Industry Company Limited Shenzhen 518116China

In this paper,a numerical simulation method is used to calculate a 1.5-stage axial transonic compressor to explore its unsteady flow *** performance curve is compared with the experimental data to verify the calculation method with a high numerical accuracy,which shows that the unsteady calculation has good *** to the analysis of the data from the monitoring points under the near-stall condition,the unsteady disturbances originate from the tip region of blade and perform the strongest at the blade pressure surface with a broadband *** analysis is conducted by combining with the characteristics of the transient flow field at the tip of *** results show that the unsteady pressure fluctuations are caused by the migration of the new vortex *** new vortex cores are generated by the breakdown of leakage vortex in the downstream,which is induced by the leakage vortex and shock wave ***,the relationship between the unsteady flow characteristics and the working conditions is also *** leakage vortex intensity and the shock wave strength gradually increase with the decrease of flow *** the combination of the leakage vortex intensity and shock wave strength reaches the first threshold,a single frequency of unsteady disturbances appears at the blade *** the combination of the leakage vortex intensity and shock wave strength reaches the second threshold,the frequency of unsteady disturbances changes to a broadband.

关键词： numerical simulation axial transonic compressor unsteady flow vortex breakdown

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Strategies of selective electroreduction of aqueous nitrate to N_(2) in chloride-free system:A critical review

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Green energy & environment 2024年第2期9卷 198-216页

作者： Fukuan Li Weizhe zhang peng zhang Ao Gong Kexun Li College of environmental Science and engineering Nankai UniversityTianjin300350China MOE Key Laboratory of Pollution Processes and environmental Criteria Tianjin Key Laboratory of Environmental Remediation and Pollution ControlTianjin Key Laboratory of Environmental Technology for Complex Trans-Media PollutionNankai UniversityTianjin300350China

Electroreduction of nitrate has been gaining wide attention in recent years owing to it's beneficial for converting nitrate into benign N_(2) from the perspective of electrocatalytic denitrification or into value-added ammonia from the perspective of electrocatalytic NH_(3) *** reason of the undesired formation of ammonia is dominant during electroreduction of nitrate-containing wastewater,chloride has been widely used to improve N_(2) ***,selective electroreduction of nitrate to N2 gas in chloride-containing system poses several *** this review,we focus on the key strategies for efficiently enhancing N_(2) selectivity of electroreduction of nitrate in chloride-free system,including optimal selection of elements,combining an active metal catalyst with another metal,manipulating the crystalline morphology and facet orientation,constructing core–shell structure catalysts,*** summarizing the strategies,four possible reaction pathways of electro-reduction of nitrate to N_(2) are ***,this review attempts to provide practical strategies for enhancing N2 selectivity without the aid of electrochlorination and highlight directions for future research for designing appropriate electrocatalyst for final electrocatalytic denitrifi-cation.

关键词： Nitrate Chloride Electroreduction Selectivity Nitrogen

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A Note on Gradient Estimates for Elliptic Equations with Discontinuous Coefficients

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 1-10页

作者： Yu peng Xiandong SUN Huichun zhang Department of Mathematics Sun Yat-Sen UniversityGuangzhou 510275China.

The authors will use a method in metric geometry to show an L^(P)-estimate for gradient of the weak solutions to elliptic equations with discontinuous coefficients,even the BMO semi-norms of the coefficients are not *... 详细信息

关键词： L^(p)-Estimate Elliptic equation Discontinuous coefficients

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Surrogate modeling for unsaturated infiltration via the physics and equality-constrained artificial neural networks

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Journal of Rock Mechanics and Geotechnical engineering 2024年第6期16卷 2282-2295页

作者： peng Lan Jingjing Su Sheng zhang School of Civil engineering Central South UniversityChangsha410075China Discipline of Civil Surveying and Environmental EngineeringPriority Research Centre for Geotechnical Science and EngineeringThe University of NewcastleCallaghanNSW2308Australia Qinghai University Qinghai810016China

Machine learning(ML)provides a new surrogate method for investigating groundwater flow dynamics in unsaturated *** pure data-driven methods(*** neural network,DNN)can provide rapid predictions,but they do require sufficient on-site data for accurate training,and lack interpretability to the physical processes within the *** this paper,we provide a physics and equalityconstrained artificial neural network(PECANN),to derive unsaturated infiltration solutions with a small amount of initial and boundary *** takes the physics-informed neural network(PINN)as a foundation,encodes the unsaturated infiltration physical laws(*** equation,RE)into the loss function,and uses the augmented Lagrangian method to constrain the learning process of the solutions of RE by adding stronger penalty for the initial and boundary *** unsaturated infiltration cases are designed to test the training performance of PECANN,***-dimensional(1D)steady-state unsaturated infiltration,1D transient-state infiltration,two-dimensional(2D)transient-state infiltration,and 1D coupled unsaturated infiltration and *** predicted results of PECANN are compared with the finite difference solutions or analytical *** results indicate that PECANN can accurately capture the variations of pressure head during the unsaturated infiltration,and present higher precision and robustness than DNN and *** is also revealed that PECANN can achieve the same accuracy as the finite difference method with fewer initial and boundary training ***,we investigate the effect of the hyperparameters of PECANN on solving RE *** provides an effective tool for simulating unsaturated infiltration.

关键词： Richards equation(RE) Unsaturated infiltration Data-driven solutions Numerical modeling Machine learning(ML)

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Downregulation of Serum PTen Expression in Mercury-Exposed Population and PI3K/AKT Pathway-Induced Inflammation

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Biomedical and environmental Sciences 2024年第4期37卷 354-366页

作者： MEI peng DING en Min YIN Hao Yang DING Xue Xue WANG Huan WANG Jian Feng HAN Lei zhang Heng Dong ZHU Bao Li School of Public Health Nanjing Medical UniversityNanjing 210000JiangsuChina Institute of Occupational Disease Prevention Jiangsu Province Center for Disease Prevention and ControlNanjing 21000JiangsuChina Suzhou Center for Disease Prevention and Control Suzhou 215004JiangsuChina Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 210000JiangsuChina

Objective This study investigated the impact of occupational mercury(Hg) exposure on human gene transcription and expression, and its potential biological *** Differentially expressed genes related to Hg exposure were identified and validated using gene expression microarray analysis and extended validation. Hg-exposed cell models and PTen lowexpression models were established in vitro using 293T cells. PTen gene expression was assessed using qRT-PCR, and Western blotting was used to measure PTen, AKT, and PI3K protein levels. IL-6 expression was determined by *** Combined findings from gene expression microarray analysis, bioinformatics, and population expansion validation indicated significant downregulation of the PTen gene in the high-concentration Hg exposure group. In the Hg-exposed cell model(25 and 10 μmol/L), a significant decrease in PTen expression was observed, accompanied by a significant increase in PI3K, AKT, and IL-6 ***, a low-expression cell model demonstrated that PTen gene knockdown led to a significant decrease in PTen protein expression and a substantial increase in PI3K, AKT, and IL-6 *** This is the first study to report that Hg exposure downregulates the PTen gene, activates the PI3K/AKT regulatory pathway, and increases the expression of inflammatory factors, ultimately resulting in kidney inflammation.

关键词： PTen Occupational mercury exposure Occupational health PI3K/AKT pathway 293T cell IL-6

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Density functional theory study of B- and Si-doped carbons and their adsorption interactions with sulfur compounds

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Carbon energy 2024年第2期6卷 195-208页

作者： peng Guo Hong zhang Shuliang Dong Libao An College of Mechanical engineering North China University of Science and TechnologyTangshanHebeiChina College of Life Sciences North China University of Science and TechnologyTangshanHebeiChina

Understanding the adsorption interactions between carbon materials and sulfur compounds has far-reaching impacts,in addition to their well-known important role in energy storage and conversion,such as lithium-ion *** this paper,properties of intrinsic B or Si single-atom doped,and B-Si codoped graphene(GR)and graphdiyne(GDY)were investigated by using density functional theory-based calculations,in which the optimal doping configurations were explored for potential applications in adsorbing sulfur *** showed that both B or Si single-atom doping and B-Si codoping could substantially enhance the electron transport properties of GR and GDY,improving their surface ***,B and Si atoms displayed synergistic effects for the codoped configurations,where B-Si codoped GR/GDY exhibited much better performance in the adsorption of sulfurcontaining chemicals than single-atom doped *** addition,results demonstrated that,after B-Si codoping,the adsorption energy and charge transfer amounts of GDY with sulfur compounds were much larger than those of GR,indicating that B-Si codoped GDY might be a favorable material for more effectively interacting with sulfur reagents.

关键词： adsorption density functional theory doping graphdiyne graphene sulfur compounds

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Supramolecular polymer network constructed by a functionalized polyimidazolium salt derived from metal-carbene template approach

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Science China Chemistry 2024年第4期67卷 1224-1228页

作者： Ming-Ming Gan Zi-en zhang Yi-Fan zhang Heng zhang Li-Ying Sun Ying-Feng Han Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China

In this study,we present a supramolecular templating approach for constructing polyimidazolium salt containing crown ether and cyclobutane *** strategy involves the formation of metal-carbene templates,photochemical cycloaddition,and subsequent demetallation of metal *** by the host-guest chemistry between crown ether units and ammonium salts,we successfully fabricated a supramolecular polymer SPN1,which features imidazolium receptors and cyclobutane *** obtained SPN1 demonstrates outstanding reversible stimulus-response,antibacterial behavior and conductivity.

关键词： metal-carbene template crown ether polyimidazolium salt host-guest chemistry

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A self-organization formation configuration based assignment probability and collision detection

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Journal of Systems engineering and Electronics 2024年第1期35卷 222-232页

作者： SONG Wei WANG Tong YANG Guangxin zhang peng School of Harbin engineering University Harbin 150001China Chinese Aeronautical Establishment Beijing 100010China

The formation control of multiple unmanned aerial vehicles(multi-UAVs)has always been a research *** on the straight line trajectory,a multi-UAVs target point assignment algorithm based on the assignment probability is proposed to achieve the shortest overall formation path of multi-UAVs with low complexity and reduce the energy *** order to avoid the collision between UAVs in the formation process,the concept of safety ball is introduced,and the collision detection based on continuous motion of two time slots and the lane occupation detection after motion is proposed to avoid collision between *** on the idea of game theory,a method of UAV motion form setting based on the maximization of interests is proposed,including the maximization of self-interest and the maximization of formation interest is proposed,so that multi-UAVs can complete the formation task quickly and reasonably with the linear trajectory assigned in ***,through simulation verification,the multi-UAVs target assignment algorithm based on the assignment probability proposed in this paper can effectively reduce the total path length,and the UAV motion selection method based on the maximization interests can effectively complete the task formation.

关键词： straight line trajectory assignment probability collision detection lane occupation detection maximization of interests

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Improved spatio-temporal alignment measurement method for hull deformation

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Journal of Systems engineering and Electronics 2024年第2期35卷 485-494页

作者： XU Dongsheng YU Yuanjin zhang Xiaoli peng Xiafu School of Automation Beijing Institute of TechnologyBeijing 100081China School of Aerospace engineering Xiamen UniversityXiamen 361005China

In this paper,an improved spatio-temporal alignment measurement method is presented to address the inertial matching measurement of hull deformation under the coexistence of time delay and large misalignment *** misalignment angle and time delay often occur simultaneously and bring great challenges to the accurate measurement of hull deformation in space and *** proposed method utilizes coarse alignment with large misalignment angle and time delay estimation of inertial measurement unit modeling to establish a brand-new spatiotemporal aligned hull deformation measurement *** addition,two-step loop control is designed to ensure the accurate description of dynamic deformation angle and static deformation angle by the time-space alignment method of hull *** experiments illustrate that the proposed method can effectively measure the hull deformation angle when time delay and large misalignment angle coexist.

关键词： inertial measurement spatio-temporal alignment hull deformation

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