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Morphology and features of Cambrian oncoids and responses to palaeogeography of the North China Platform

Journal of Palaeogeography 2020年第2期9卷 150-167页

作者： en-zhao xiao Ming-Xiang Mei Shu Jiang Tehseen Zafar School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing 100083China Key Laboratory of Tectonics and Petroleum Resources of Ministry of Education and Faculty of Earth Resources China University of Geosciences(Wuhan)Wuhan 430074China Institute of Geochemistry Chinese Academy of SciencesGuiyang 550081China Institute of Geology University of the PunjabLahore 54590Pakistan

The Cambrian strata in the North China Platform are fully exposed. A wide variety of carbonate oncoids with different shapes occur in the Xuzhuang and Zhangxia formations(Miaolingian Series) from six Cambrian sections in the study area. A comprehensive study involving outcrop description, microscopic observation, scanning electron microscopy(SEM), energy dispersive X-ray spectroscopy(EDX), X-ray diffraction(XRD), and carbon and oxygen isotope analysis is conducted to determine the facies, morphology, internal structure, and geochemical properties of the oncoids. The oncoids are divided into six types based on their morphology and internal *** and ultrastructural observations reveal typical microbial fossils(Girvanella) and microbially-related sediments(framboidal pyrite), indicating the biogenicity of the oncoids. Additionally, the XRD and carbon and oxygen isotope analysis results suggest that the formational environments of these oncoids are different due to terrestrial influences. Statistical data on the oncoids from the six sections show that there are obvious differences in the types of oncoids and the proportions of different varieties in each section. The spatial differences in the oncoid morphologies are associated with different palaeogeographic settings. The rough oncoid growth patterns developed in nearshore environments were influenced by terrigenous debris and steep terrain, whereas the delicate oncoid growth patterns developed in offshore environments were less affected by terrestrial factors and were featured by more stable depositional processes related to microbial mats.

关键词： Morphological classification Microbial m at Girvonello Carbon and oxygen isotopes Miaolingian series North China

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具有类白钨矿结构的KGd(MoO_4)_2的晶体结构和能带结构(英文)

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无机化学学报 2014年第5期30卷 1143-1150页

作者：赵丹赵恩晓辛霞李飞飞河南理工大学物理化学学院焦作454000 山东大学国家胶体材料工程技术研究中心济南250100

以Gd2O3、K2CO3、MoO3为原料,采用高温熔盐法,合成了一个含钾的稀土钼酸盐KGd(MoO4)2。通过X射线单晶衍射法测定了它在室温下的晶体结构,并测定了它的光学性质。结构分析表明它属于三斜晶系,空间群为P1,a=0.529 23(6)nm,b=0.692 10(6)nm... 详细信息

以Gd2O3、K2CO3、MoO3为原料,采用高温熔盐法,合成了一个含钾的稀土钼酸盐KGd(MoO4)2。通过X射线单晶衍射法测定了它在室温下的晶体结构,并测定了它的光学性质。结构分析表明它属于三斜晶系,空间群为P1,a=0.529 23(6)nm,b=0.692 10(6)nm,c=1.068 89(7)nm,α=75.79(8)°,β=76.79(5)°,γ=67.60(4)°,Z=2,R1(all data)=0.025 8。结构中的K和Gd原子位于各自的晶体学位置,不存在调制结构的现象。此外,我们用得到的晶体学数据,通过密度泛函理论研究了化合物的能带结构、态密度、介电常数,其结果和实验数据相吻合。

关键词：晶体结构稀土钼酸盐能带结构

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-en Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of energy Chemistry 2025年第1期100卷 770-778页

作者： xiaoqin Li Jian Xiang Lu Qiu xiaohan Chen Yinkun zhao Yujue Wang Qu Yue Taotao Gao Wenlong Liu Dan xiao zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical engineering Chengdu University College of Food and Biological engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang Xingping Quan xiaorui Geng Yujing Huang Yonghua zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin xiao Fangqing zhao Jing-Dong J.Han Qi Liu xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Calculation of f_(σ) on Quark Level

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Chinese Physics Letters 1996年第9期13卷 652-655页

作者： LÜxiao-fu LIU Yu-xin zhao en-guang Department of Physics Sichuan UniversityChengdu 610064 Department of Physics Peking UniversityBeijing 100871 Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100080

With the recently obtained vacuum configuration of the bilocal field,we have calculated the decay constant f_(σ) of σ-meson in a quantum chromodynamics-based model field *** investigating the calculated result,it ca... 详细信息

关键词： theory decay meson

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： xiao-Yu zhao Juan-Han Yu Yi-Hua Wang Yi-Xin Liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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Ko⁃LLaMA:基于LLaMA的朝鲜语大语言模型

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外语学刊 2025年第1期 1-8页

作者：庞杰闫晓东赵小兵中央民族大学北京100081 国家语言资源监测与研究民族语言中心北京100081 民族语言智能与安全治理教育部重点实验室北京100081

在本文中,我们通过扩展LLaMA现有的词表,增加额外的20,000个朝鲜语Token,从而提高其对朝鲜语的编码和语义理解的能力;并且进一步使用朝鲜语数据进行继续预训练,使用朝鲜语指令微调数据集对模型进行SFT(Supervised Fine⁃Tuning),并分析... 详细信息

在本文中,我们通过扩展LLaMA现有的词表,增加额外的20,000个朝鲜语Token,从而提高其对朝鲜语的编码和语义理解的能力;并且进一步使用朝鲜语数据进行继续预训练,使用朝鲜语指令微调数据集对模型进行SFT(Supervised Fine⁃Tuning),并分析不同数据量对指令精调效果的影响,经过继续预训练和指令微调后的模型显著提高了理解和遵循朝鲜语指令的能力。实验结果表明,新提出的模型Ko⁃LLaMA显著提高了原版LLaMA在理解和生成朝鲜语内容方面的能力。此外,在朝鲜语文本分类数据集YNAT上对Ko⁃LLaMA与擅长少数民族语言的CINO模型及CINO的多种模型组合以及原版LLaMA和GPT⁃3.5进行了效果对比。结果表明,Ko⁃LLaMA的朝鲜语文本分类能力远超CINO和CINO的组合模型以及LLaMA和GPT⁃3.5等未经过朝鲜语语料进行词表扩充和继续预训练的大语言模型。

关键词：朝鲜语大语言模型词表扩充继续预训练指令微调

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Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期 233-240页

作者： Peipei Liu Yantong Li Meng-Xiang Wu Hao Kang xiao-Li zhao Lin Xu Linlin Liu xiaodong Li Junfeng Fang Zhiwei Fang Ya Cheng Hai-Bo Yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

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