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Science China Chemistry 2024年第4期67卷 1224-1228页

作者： Ming-Ming Gan Zi-en zhang Yi-Fan zhang Heng zhang Li-Ying Sun Ying-Feng Han Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China

In this study,we present a supramolecular templating approach for constructing polyimidazolium salt containing crown ether and cyclobutane *** strategy involves the formation of metal-carbene templates,photochemical cycloaddition,and subsequent demetallation of metal *** by the host-guest chemistry between crown ether units and ammonium salts,we successfully fabricated a supramolecular polymer SPN1,which features imidazolium receptors and cyclobutane *** obtained SPN1 demonstrates outstanding reversible stimulus-response,antibacterial behavior and conductivity.

关键词： metal-carbene template crown ether polyimidazolium salt host-guest chemistry

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Factors influencing willingness to participate in ophthalmic clinical trials and strategies for effective recruitment

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International Journal of Ophthalmology(english edition) 2024年第1期17卷 157-163页

作者： Jia-en Liang Meng-Yin Liang en-en zhang Yu-Ying Peng Ling-Ling Chen Jia-Yu Deng Ting Lin Jun Fu Jia-Ni zhang Shao-Li Li Fei Li Hui-Ming Xaio Wen-Min Huang Yu-Hong Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

AIM:To explore the factors influencing individuals’willingness to participate in ophthalmic clinical ***:A questionnaire survey was conducted from January to April 2021 among patients and their family members at Zhongshan Ophthalmic Center,Sun Yat-sen University,in Guangzhou,*** survey gathered data on respondents’willingness,demographic and socioeconomic profiles,as well as their reasons and concerns regarding engagement in clinical ***:Of the 1078 residents surveyed(mean age 31.2±13.1y;65.8%females)in Guangzhou,749(69.5%)expressed a willingness to participate in future ophthalmic clinical *** characteristics associated with greater willingness included a younger age,lower annual income,higher education,prior participation experience,previous ophthalmic treatment,and a better understanding of clinical *** the exception of age,these characteristics were significantly linked to a higher *** primary barrier to participation,expressed by 64.8%of those willing and 54.4%of those unwilling,was“Uncertain efficacy”.In terms of motivations,the willing group ranked“Better therapeutic benefits”(35.0%),“Professional monitoring”(34.3%),and“Trust in healthcare professionals”(33.1%)as their top three reasons,whereas the unwilling participants indicated“Full comprehension of the protocol”(46.2%)as the key ***:This study reveals a substantial willingness to participate in ophthalmic clinical trials and demonstrates the predictive role of demographic and socioeconomic *** in motivators and concerns between willing and unwilling participants highlight the significance of tailored recruitment ***,the need for and trust in healthcare professionals stand out as powerful motivations,underscoring the importance of enhancing physician-patient relationships,adopting patient-centered communication approaches,and addressing individualized needs to improve accrual rates.

关键词： participation willingness recruitment strategy ophthalmic clinical trial

基于区块链的芝麻油防伪溯源系统的设计与实现

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食品科学 2024年第8期45卷 13-18页

作者：徐金胜张恩河南师范大学计算机与信息工程学院河南新乡453007 智慧商务与物联网技术河南省工程实验室河南新乡453007

芝麻油作为日常饮食中不可或缺的食用油之一,其质量和安全性受到了广泛关注。然而,芝麻油掺假问题日益严重,这使得保障芝麻油的质量安全成为了一个急需解决的问题,所以建立芝麻油防伪溯源对保障质量安全十分重要。本实验设计研发了一套... 详细信息

芝麻油作为日常饮食中不可或缺的食用油之一,其质量和安全性受到了广泛关注。然而,芝麻油掺假问题日益严重,这使得保障芝麻油的质量安全成为了一个急需解决的问题,所以建立芝麻油防伪溯源对保障质量安全十分重要。本实验设计研发了一套基于区块链技术的芝麻油防伪溯源系统,提出了“区块链缓存”的双存储设计,即链下存储并缓存溯源信息,链上同步存储溯源信息的哈希值;此外还设计了链码直连状态数据库的查询方案,解决了区块链网络数据存储压力大、查询效率低的问题。通过分析与验证,消费者利用微信扫码通过小程序能够快速方便地查验芝麻油真伪,有效解决了芝麻油溯源链不同环节之间在数据安全和溯源信息真实性上的问题,在实践中也取得了较好的应用效果。

关键词：区块链芝麻油防伪溯源系统质量安全

Gigahertz-rate-switchable wavefront shaping through integration of metasurfaces with photonic integrated circuit

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Advanced Photonics 2024年第1期6卷 106-114页

作者： Haozong Zhong Yong Zheng Jiacheng Sun Zhizhang Wang Rongbo Wu Ling-en zhang Youting Liang Qinyi Hua Minghao Ning Jitao Ji Bin Fang Lin Li Tao Li Ya Cheng Shining Zhu East China Normal University School of Physics and Electronic ScienceState Key Laboratory of Precision SpectroscopyShanghaiChina Nanjing University College of Engineering and Applied SciencesNational Laboratory of Solid State MicrostructuresNanjingChina China Jiliang University College of Optical and Electronic TechnologyHangzhouChina Shanxi University Collaborative Innovation Center of Extreme OpticsTaiyuanChina Chinese Academy of Sciences(CAS) Shanghai Institute of Optics and Fine Mechanics(SIOM)State Key Laboratory of High Field Laser Physics and CAS Center for Excellence in Ultra-Intense Laser ScienceShanghaiChina

Achieving spatiotemporal control of light at high speeds presents immense possibilities for various applications in communication,computation,metrology,and *** integration of subwavelength metasurfaces and optical waveguides offers a promising approach to manipulate light across multiple degrees of freedom at high speed in compact photonic integrated circuit(PIC)***,we demonstrate a gigahertz-rate-switchable wavefront shaping by integrating metasurface,lithium niobate on insulator photonic waveguides,and electrodes within a PIC *** proofs of concept,we showcase the generation of a focus beam with reconfigurable arbitrary polarizations,switchable focusing with lateral focal positions and focal length,orbital angular momentum light beams as well as Bessel *** measurements indicate modulation speeds of up to the gigahertz *** integrated platform offers a versatile and efficient means of controlling the light field at high speed within a compact system,paving the way for potential applications in optical communication,computation,sensing,and imaging.

关键词： metasurface photonic integrated circuit lithium niobate on insulator high-speed modulation

Multi-omics analysis of adamantinomatous craniopharyngiomas reveals distinct molecular subgroups with prognostic and treatment response significance

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Chinese Medical Journal 2024年第7期137卷 859-870页

作者： Xianlong Wang Chuan Zhao Jincheng Lin Hongxing Liu Qiuhong Zeng Huadong Chen Ye Wang Dapeng Xu Wen Chen Moping Xu en zhang Da Lin Zhixiong Lin Department of Bioinformatics School of Medical Technology and EngineeringKey Laboratory of Medical BioinformaticsKey Laboratory of Ministry of Education for Gastrointestinal CancerFujian Medical UniversityFuzhouFujian 350122China Department of Neurosurgery Sanbo Brain HospitalCapital Medical UniversityBeijing 100093China

Background:Adamantinomatous craniopharyngioma(ACP)is the commonest pediatric sellar *** effective drug is available and interpatient heterogeneity is *** study aimed to identify distinct molecular subgroups of ACP based on the multi-omics profiles,imaging findings,and histological features,in order to predict the response to anti-inflammatory treatment and ***:Totally 142 Chinese cases diagnosed with craniopharyngiomas were profiled,including 119 ACPs and 23 papillary ***-exome sequencing(151 tumors,including recurrent ones),RNA sequencing(84 tumors),and DNA methylome profiling(95 tumors)were *** clustering and non-negative matrix factorization were used for subgrouping,and Cox regression were utilized for prognostic evaluation,***:Three distinct molecular subgroups were identified:WNT,ImA,and *** WNT subgroup showed higher Wnt/β-catenin pathway activity,with a greater number of epithelial cells and more predominantly solid *** ImA and ImB subgroups had activated inflammatory and interferon response pathways,with enhanced immune cell infiltration and more predominantly cystic ***-activated protein kinases(MEK/MAPK)signaling was activated only in ImA samples,while IL-6 and epithelial-mesenchymal transition biomarkers were highly expressed in the ImB group,mostly consisting of *** degree of astrogliosis was significantly elevated in the ImA group,with severe finger-like protrusions at the invasive front of the *** molecular subgrouping was an independent prognostic factor,with the WNT group having longer event-free survival than ImB(Cox,P=0.04).ImA/ImB cases were more likely to respond to immune checkpoint blockade(ICB)therapy than the WNT group(Pening of subtyping markers,CD38 was significantly downregulated in WNT compared with ImA and ImB(P=0.01).Conclusions:ACP comprises three molecular subtypes with distinct

关键词： Craniopharyngioma Central nervous system tumor Precision medicine beta Catenin Proto-Oncogene Proteins B-raf

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通过合同实现算法行政问责

南昌大学学报（人文社会科学版） 2024年第3期55卷 76-87页

作者：张恩典南昌大学法学院江西南昌330031

以机器学习算法为代表的数字技术正推动算法行政的兴起。伴随着数字政府建设浪潮,当前算法行政面临多重问责困境,具体表现为算法黑箱加剧行政决策的不透明性、商业秘密阻碍算法问责、算法行政拒斥行政机构专业判断以及褫夺公民参与决策... 详细信息

以机器学习算法为代表的数字技术正推动算法行政的兴起。伴随着数字政府建设浪潮,当前算法行政面临多重问责困境,具体表现为算法黑箱加剧行政决策的不透明性、商业秘密阻碍算法问责、算法行政拒斥行政机构专业判断以及褫夺公民参与决策和获得救济权利。面对算法行政问责困境,合同规制进路因具有回应性、灵活性等优势,不失为一种可供选择的补充性算法治理方案。宜从总体原则、重点内容和组织保障三个维度来建构算法行政问责的合同规制进路:遵循以风险为基础的采购原则,将算法问责作为协商重点内容,建立专业算法系统采购小组,确保政府采购具有透明性和负责任的人工智能算法系统,从而实现算法问责,重塑算法行政合法性。

关键词：算法行政问责制算法透明合同治理政府采购

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基因编辑技术及其在糖生物学研究中的应用

中国生物化学与分子生物学报 2024年第4期40卷 433-452页

作者：章恩华邱宏中国科学院上海药物研究所南京中医药大学新中药学院

基因功能的解析是现代生物学研究的基本问题，基因的精准、高效和靶向编辑是基因功能研究不可或缺的手段。在过去的30多年，基因编辑实现了从基于同源重组修复技术的基因打靶技术(gene targeting)到基于锌指核酸酶、转录激活样效应因子... 详细信息

基因功能的解析是现代生物学研究的基本问题，基因的精准、高效和靶向编辑是基因功能研究不可或缺的手段。在过去的30多年，基因编辑实现了从基于同源重组修复技术的基因打靶技术(gene targeting)到基于锌指核酸酶、转录激活样效应因子核酸酶和CRISPR相关核酸酶等可编程核酸酶的可控编辑技术的革命性转变。这些技术的发展极大地促进了基因功能的研究并促生了疾病治疗的颠覆性技术。本文综述了CRISPR-Cas的分类、组成及其在细菌中发挥免疫防御作用的工作原理，重点综述了基于CRISPR-Cas系统的最新基因编辑工具包括基因转录编辑器、表观遗传编辑器、碱基编辑器、先导编辑器以及靶向RNA的RCas编辑系统。随后综述了基因编辑器的细胞和器官靶向递送策略，主要讨论了腺相关病毒、脂质纳米颗粒和细胞外囊泡的优劣。最后，本文综述了基因编辑技术在糖生物学研究中的应用，包括糖类物质功能、生物合成与机制，糖蛋白质组学分析，细胞糖芯片的构建和应用以及蛋白质糖基化工程改造。精确基因编辑技术的发展促进了糖类物质的生物合成机制、结构与功能研究，也正在推进转化糖科学研究。

关键词：基因编辑糖生物学细胞外囊泡 CRISPR-Cas系统

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GTF2H4 regulates partial endMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases

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The Innovation 2024年第2期5卷 27-41页

作者： Zheyan Fang Gang Zhao Shuang Zhao Xueting Yu Runyang Feng You-en zhang Haomin Li Lei Huang Zhenyang Guo Zhentao zhang Mukaddas Abdurahman Hangnan Hong Peng Li Bing Wu Jinhang Zhu Xin Zhong Dong Huang Hao Lu Xin Zhao Zhaoyang Chen Wenbin zhang Junjie Guo Hongchao Zheng Yue He Shengying Qin Haojie Lu Yun Zhao Xiangdong Wang Junbo Ge Hua Li Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Medical Examination Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology and Institute of Clinical Medicine Renmin HospitalHubei University of MedicineShiyan 442000China Clinical Data Center Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Molecular Celland Cancer BiologyUniversity of Massachusetts Chan Medical SchoolWorcesterMA 01605USA Bio-X Institute Key Laboratory for The Genetics of Developmental and Neuropsychiatric DisordersShanghai Jiao Tong UniversityShanghai 200030China Department of Cardiology Heart Center of Fujian ProvinceFujian Medical University Union HospitalFuzhou 350001China Department of Cardiology Sir Run Run Shaw Hospitalaffiliated with Zhejiang University School of MedicineHangzhou 310020China Department of Cardiology The Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Cardiology Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology Shanghai Eighth People’s HospitalShanghai 200235China Department of Chemistry and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology Shanghai Tech University100 Haike RoadShanghai 201210China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Pulmonary and Critical Care Medicine Zhongshan Hospital

Partial endothelial-to-mesenchymal transition(endMT)is an intermediate phenotype observed in endothelial cells(ECs)undergoing a transition toward a mesenchymal state to support neovascularization during(patho)physiological ***,we investigated the occurrence of partial endMT in ECs under hypoxic/ischemic conditions and identified general transcription factor IIH subunit 4(GTF2H4)as a positive regulator of this *** addition,we discovered that GTF2H4 collaborates with its target protein excision repair cross-complementation group 3(ERCC3)to co-regulate partial ***,by using phosphorylation proteomics and site-directed mutagenesis,we demonstrated that GTF2H4 was involved in the phosphorylation of receptor coactivator 3(NCOA3)at serine 1330,which promoted the interaction between NCOA3 and p65,resulting in the transcriptional activation of NF-κB and the NF-kB/Snail signaling axis during partial *** vivo experiments confirmed that GTF2H4 significantly promoted partial endMT and angiogenesis after ischemic ***,our findings reveal that targeting GTF2H4 is promising for tissue repair and offers potential opportunities for treating hypoxic/ischemic diseases.

关键词： ischemic activation GTF

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从自在、自觉到自强——中华民族发展三段论

中央民族大学学报（哲学社会科学版） 2024年第2期51卷 68-79页

作者：周大鸣张恩迅云南师范大学云南昆明650500 湘潭大学社会学系湖南湘潭411000

厘清中华民族的历史发展逻辑,是“铸牢中华民族共同体意识”理论体系的有效支撑。本文探讨了中华民族从自在、自觉到自强的三个发展阶段,以及中华民族共同体意识在中华民族不同发展阶段的凝聚动因,即中华民族共同体意识在悠久的中国历... 详细信息

厘清中华民族的历史发展逻辑,是“铸牢中华民族共同体意识”理论体系的有效支撑。本文探讨了中华民族从自在、自觉到自强的三个发展阶段,以及中华民族共同体意识在中华民族不同发展阶段的凝聚动因,即中华民族共同体意识在悠久的中国历史和灿烂的中华文化中孕育,在近代各族人民争取民族解放和拯救国家危亡中觉醒,在新时代社会主义现代化强国建设和中华民族伟大复兴的使命中强化和升华。这是客观的历史规律,为正确认识和铸牢中华民族共同体意识奠定了基础。

关键词：自在自觉自强中华民族共同体

稳定化退火温度对5059铝合金冷轧板材组织及性能的影响

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东北大学学报（自然科学版） 2024年第3期45卷 323-330页

作者：朱庆丰黄建航高扬张恩阁东北大学材料电磁过程研究教育部重点实验室辽宁沈阳110819 东北大学材料先进制备技术教育部工程研究中心辽宁沈阳110819 东北大学材料科学与工程学院辽宁沈阳110819

对5059铝合金冷轧板材进行了不同温度(125~275℃)保温1 h的稳定化退火处理,研究了稳定退火温度对板材组织性能的影响.研究结果表明:变形量为62.8%冷轧板材的变形组织内形成了穿过多个纤维状晶粒的剪切带;板材经不同温度(150~225℃)保温... 详细信息

对5059铝合金冷轧板材进行了不同温度(125~275℃)保温1 h的稳定化退火处理,研究了稳定退火温度对板材组织性能的影响.研究结果表明:变形量为62.8%冷轧板材的变形组织内形成了穿过多个纤维状晶粒的剪切带;板材经不同温度(150~225℃)保温1 h退火后,沿剪切带析出连续的β相,这些板材在晶间腐蚀过程中沿着剪切带形成了腐蚀沟壑.随着退火温度由125°C升高至275℃,5059铝合金冷轧板材的屈服强度和抗拉强度分别由386,474 MPa降低至301,407 MPa;延伸率则由10.4%升高到18.1%.5059铝合金冷轧板材单位面积内腐蚀量则先由125℃×1 h退火板材的13.7 mg/cm^(2),升至200℃×1 h退火板材的53.8 mg/cm^(2),再逐渐降至275℃×1 h退火板材的4.9 mg/cm^(2).

关键词： 5059铝合金轧制稳定化退火晶间腐蚀拉伸性能

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