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Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles

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Infectious Diseases of Poverty 2021年第1期10卷 95-96页

作者： Justus Amuche Nweze Florence N.Mbaoji Yan-Ming Li Li-Yan Yang Shu-Shi Huang Vincent N.Chigor emmanuel a.eze Li-Xia Pan Ting Zhang Deng-Feng Yang Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry National Engineering Research Center of Non-Food Biorefi neryState Key Laboratory of Non-Food Biomass and Enzyme TechnologyGuangxi Academy of SciencesNanning 530007GuangxiPeople's Republic of China Nation al Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionWHO Collaborating Center for Tropical DiseasesNatio nal Center for Inter national Research on Tropical DiseasesKey Laboratory of Parasite and Vector Biology of the Chinese Ministry of HealthShanghai 200025People's Republic of China Full list of author information is available at the end of the article

Background:Malaria and neglected communicable protozoa parasitic diseases,such as leishmaniasis,and trypanosomiasis,are among the otherwise called diseases for neglected communities,which are habitual in underprivileged populations in developing tropical and subtropical regions of Africa,Asia,and the *** of the currently available therapeutic drugs have some limitations such as toxicity and questionable efficacy and long treatment period,which have encouraged *** have prompted many researchers to focus on fin ding new drugs that are safe,effective,and affordable from marine environ *** aim of this review was to show the diversity,structural scaffolds,in-vitro or in-vivo efficacy,and recent progress made in the discovery/isolation of marine natural products(MNPs)with potent bioactivity against malaria,leishmaniasis,and *** text:We searched PubMed and Google scholar using Boolean Operators(AND,OR,and NOT)and the combination of related terms for articles on marine natural products(MNPs)discovery published only in English language from January 2016 to June *** nine articles reported the isolation,identification and antiparasitic activity of the isolated compounds from marine environment.A total of 125 compounds were reported to have been isolated,out of which 45 were newly isolated *** compounds were all isolated from bacteria,a fungus,sponges,algae,a bryozoan,cnidarians and soft *** recent years,great progress is being made on anti-malarial drug discovery from marine organisms with the isolation of these potent ***,some of these promising antikinetoplastid MNPs have potency better or similar to conventional drugs and could be developed as both antileishmanial and antitrypanosomal ***,very few of these MNPs have a pharmaceutical destiny due to lack of the following:sustainable production of the bioactive compounds,stan da rd efficient screening methods,knowledge of the me

关键词： Marine natural products Neglected tropical diseases Anti-trypanosoma Anti-leishmania Anti-plasmodia Protozoa parasites

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Exploring factors of disaster preparedness in UNESCO-designated heritage sites

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Geography and Sustainability 2024年第3期5卷 392-404页

作者： emmanuel eze Alexander Siegmund Institute of Geography&Heidelberg Center for the Environment(HCE) University of HeidelbergHeidelbergGermany Department of Geography-Research Group for Earth Observation(r geo) UNESCO Chair on Observation and Education of World Heritage&Biosphere ReserveHeidelberg University of EducationHeidelbergGermany Geographical and Environmental Education Unit Department of Social Science EducationUniversity of NigeriaNsukkaNigeria

Increased hazards threatening the United Nations Educational,Scientific and Cultural Organization(UNESCO)-designated sites and endangering cultural heritage and community well-being require attention and ***-sidering the pivotal role of UNESCO sites in conservation and development,this study assessed their levels of disaster *** absence of studies assessing disaster awareness,risk perception,and preparedness among UNESCO site actors,as well as the pivotal place of preparedness within the Disaster Risk Management(DRM)cycle justifies this *** the tenets of the Person-Relative-to-Event framework,we hypothe-sized that a strong positive correlation exists between perceived risks,resources,and disaster *** collect pertinent data,we employed an embedded mixed-method design and conducted an online questionnaire survey yielding 141 responses from 59 *** the results of relevant analyses,wildfires,floods,and droughts are top hazards occurring frequently in UNESCO sites,with significant concerns about pollution and habitat loss during future *** emerged as the most available crucial DRM resource,with higher availability of DRM resources correlating positively and significantly with sites’*** findings con-tribute valuable insights to address missing links for disaster-ready and resilient UNESCO sites,promoting their preservation for future generations.

关键词： Biosphere reserves Disaster risk management(DRM) Global geoparks Person-relative-to-event(PRE)framework Sustainability World heritage sites

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Integrated Geological and Geophysical Mapping for Groundwater Potential Studies at Ekwegbe-Agu and Environs, Enugu State, Nigeria

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Open Journal of Geology 2024年第4期14卷 513-547页

作者： Charles Chibueze Ugbor Ugochukwu Kingsley Ogbodo Osita Kelechi eze Department of Geology University of Nigeria Nsukka Nigeria

The study integrates both the geological and geophysical mapping techniques for groundwater potential studies at Ekwegbe-Agu and the environs, Enugu state, Nigeria for optimal citing of borehole. Located in the Anambra Basin between latitudes 6˚43'N and 6˚47'N and longitudes 7˚28'E and 7˚32'E, it is stratigraphycally underlain by, from bottom to top, the Enugu/Nkporo, Mamu and Ajali Formation respectively, a complex geology that make citing of productive borehole in the area problematic leading to borehole failure and dry holes due to inadequate sampling. The study adopted a field and analytic sampling approach, integrating field geological, electrical resistivity and self-potential methods. The software, SedLog v3.1, InterpexIx1Dv.3, and Surfer v10 were employed for the data integration and interpretation. The result of the geological field and borehole data shows 11 sedimentary facies consisting of sandstone, shales and heterolith of sandstone/shale, with the aquifer zone mostly prevalent in the more porous sand-dominated horizons. Mostly the AK and HK were the dominant curve types. An average of 6 geo-electric layers were delineated across all transects with resistivity values ranging from 25.42 - 105.85 Ωm, 186.38 - 3383.3 Ωm, and 2992 - 6286.4 Ωm in the Enugu, Mamu and Ajali Formations respectively. The resistivity of the main aquifer layer ranges from 1 to 500 Ωm. The aquifer thickness within the study area varies between 95 and 140 m. The western and northwestern part of the study area which is underlain mainly by the Ajali Formation showed the highest groundwater potential in the area and suitable for citing productive boreholes.

关键词： Seismic Ekwegbe-Agu Groundwater Resistivity Field Mapping Borehole Logging

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N-acetylcysteine and zinc sulphate abate di-2-ethylhexyl phthalate-mediated reproductive dysfunction in rats:Focus on oxidative and sex hormone receptors mechanisms

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Asian pacific Journal of Reproduction 2024年第5期13卷 228-240页

作者： Victor Oghenekparobo Emojevwe Mega Obukohwo Oyovwi Kayode ezekiel Adewole Peggy Ejiro Ohwin Adeniran Oluwadamilare Akinola Alexander Obidike Naiho eze Kingsley Nwangwa Victor Omo-Idonije Motunrayo Lade-Ige Benneth Ben-Azu Department of Physiology University of Medical SciencesOndo CityOndo StateNigeria Department of Physiology Delta State UniversityAbrakaDelta StateNigeria Department of Physiology Adeleke UniversityEdeOsun StateNigeria Department of Biochemistry University of Medical SciencesOndo CityOndo StateNigeria Department of Pharmacology Delta State UniversityAbrakaDelta StateNigeria

Objective:To investigate the potential of N-acetylcysteine(NAC)and zinc sulphate(ZnSO_(4))in mitigating reproductive dysfunction caused by di-2-ethylhexyl phthalate(DEHP)in rats and to understand the underlying mechanisms,specifically oxidative stress and sex hormone receptor ***:Thirty-five male Wistar rats were randomly divided into five equal groups(n=7 per group).Group 1 was administered 0.5 mL of distilled water and served as the control *** 2 was given only DEHP(750 mg/kg/day),while group 3,4 and 5 were given DEHP(750 mg/kg/day)plus NAC(100 mg/kg/day),DEHP(750 mg/kg/day)plus ZnSO_(4)(0.5 mg/kg/day),and DEHP(750 mg/kg/day)plus NAC(100 mg/kg/day)as well as ZnSO_(4)(0.5 mg/kg/day),*** treatments lasted for 21 *** were obtained after the rats were sacrificed,and hormones levels in the serum and markers of oxidative stress in the testicles were analyzed using the enzyme-linked immunosorbent *** amount of androgen receptors in the testicles was determined by immunohistochemistry,and the susceptibility of testosterone and DEHP to bind to androgen receptor and 5α-reductase was determined by molecular docking ***:DEHP decreased reproductive hormones,testicular antioxidant enzymes,increased malondialdehyde levels,and negatively impacted histology of the pituitary and *** or ZnSO_(4) treatment showed a marked improvement in testicular antioxidant status and hormone levels,as well as a positive effect on the histology of the pituitary and *** combination of both treatments appeared to be more *** affinity of DEHP to bind to androgen receptors may lead to disruption of androgen receptor signaling,which can further result in dysfunction of hormones related to ***,NAC is more likely to form stronger binding interactions with follicle stimulating hormone and luteinizing hormone receptors,as well as gonadotropin-releasing hormone receptors,when compared to ***:The pos

关键词： Di-2-ethylhexyl phthalate Testosterone Androgen receptor 5α-reductase Oestrogen Luteinizing hormone

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Public＇s knowledge of the differences between ophthalmologists and optometrists：a critical issue in eye care service utilisation

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International Journal of Ophthalmology(English edition) 2016年第9期9卷 1336-1342页

作者： Boniface Ikenna.eze Obiekwe Okoye emmanuel Nwabueze Aguwa Department of Ophthalmology University of Nigeria Teaching Hospital PMB 01139 Ituku-Ozalla EnuguNigeria Department of Community Medicine and Public Health University of Nigeria Teaching Hospital PMB 01139Ituku-Ozalla Enugu Nigeria

AIM：To assess the public＇s knowledge of the differences between ophthalmologists and optometrists and identify the factors associated with ***：The study was a population-based random survey of adults aged 18 years or older conducted in Enugu,south eastern Nigeria,between March and June,*** on respondents＇ socio-demographics,clinical profile,and knowledge of the differences between ophthalmologists and optometrists were collected using a 28-item *** were analysed using descriptive and analytical *** of P〈0.05 were considered statistically ***：The respondents（P=394） comprised 198 males and 196 females（sex ratio =1.01：1）,aged 18-70（30.9 ±10.8） *** majority of respondents were single（57.4%）,possessed secondary education（96.9%）,employed（65.2%） and had no health insurance（77.4%）.Their clinical profile showed previous eye exam 54.1%,spectacle wear 41.6%and contact lens wear 5.6%.In the multivariate analysis,participants＇ good knowledge of the differences between ophthalmologists and optometrists was significantly associated with educational status（OR：0.32,95%CI：0.23-0.44,P〈0.0001,β =-0.988）,employment status（OR：1.8,95%CI：1.45-2.25,P〈0.0001,β=0.124）and previous eye examination（OR：1.63,95%CI：1.29-2.07,P〈0.0001,β =0.549）.CONCLUSION：Participants＇ socio-demographic and clinical characteristics are important predictors of good *** findings may have implications for all stakeholders in eye care *** is need for knowledge enhancement,by the government and eye care providers,through population-based eye health literacy campaigns.

关键词： public's knowledge ophthalmologists optometrists

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Enhancing Private Healthcare Effectiveness in Lagos State, Nigeria: An Overview of the Effect of Quality Improvement Initiatives and Implications for Sustainable Healthcare Delivery

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Health 2024年第2期16卷 93-104页

作者： Nnenna Mba-Oduwusi Ifesinachi eze Tochukwu Osuji Maxwell Obubu Tolulope Oyekanmi Oluwatosin Kolade Ozioma Oguguah Jane Martins Nkata Chuku Alozie Ananaba Rodio Diallo Firdausi Umar Sadiq emmanuella Zamba Abiola Idowu InSiGHt Health Consulting Limited Ikeja Nigeria Health Systems Consult Limited Abuja Nigeria Bill & Melinda Gates Foundation Abuja Nigeria Lagos State Health Management Agency (LASHMA) Lagos Nigeria Health Facility Monitoring and Accreditation Agency (HEFAMAA) Ikeja Nigeria

Background: Nigeria, a nation grappling with rapid population growth, economic intricacies, and complex healthcare challenges, particularly in Lagos State, the economic hub and most populous state, faces the challenge of ensuring quality healthcare access. The overview of the effect of quality improvement initiatives in this paper focuses on private healthcare providers in Lagos State, Nigeria. The study assesses the impact of donor-funded quality improvement projects on these private healthcare facilities. It explores the level of participation, perceived support, and tangible effects of the initiatives on healthcare delivery within private healthcare facilities. It also examines how these initiatives influence patient inflow and facility ratings, and bring about additional benefits and improvements, provides insights into the challenges faced by private healthcare providers in implementing quality improvement projects and elicits recommendations for improving the effectiveness of such initiatives. Methods: Qualitative research design was employed for in-depth exploration, utilizing semi-structured interviews. Private healthcare providers in Lagos involved in the SP4FP Quality Improvement Project were purposively sampled for diversity. Face-to-face interviews elicited insights into participation, perceived support, and project effects. Questions covered participation levels, support perception, changes observed, challenges faced, and recommendations. Thematic analysis identified recurring themes from interview transcripts. Adherence to ethical guidelines ensured participant confidentiality and informed consent. Results: Respondents affirmed active involvement in the SP4FP Quality Improvement Project, echoing literature emphasizing private-sector collaboration with the public sector. While acknowledging positive influences on facility ratings, respondents highlighted challenges within the broader Nigerian healthcare landscape affecting patient numbers. Respondents c

关键词： Private Healthcare Quality Improvement Projects Donor-Funded Initiatives Healthcare Delivery Lagos State Nigeria

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Application of Machine Learning for Flood Prediction and Evaluation in Southern Nigeria

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Atmospheric and Climate Sciences 2024年第3期14卷 299-316页

作者： Emeka Bright Ogbuene Chukwumeuche Ambrose eze Obianuju Getrude Aloh Andrew Monday Oroke Damian Onuora Udegbunam Josiah Chukwuemeka Ogbuka Fred Emeka Achoru Vivian Amarachi Ozorme Obianuju Anwara Ikechukwu Chukwunonyelum Anthonia Nneka Nebo Obiageli Jacinta Okolo Centre for Environmental Management and Control (CEMAC) University of Nigeria Enugu Nigeria Department of Geography Enugu State University of Science and Technology ESUT Enugu Nigeria School of Civil Engineering Newcastle University Newcastle upon Tyne UK

This study explored the application of machine learning techniques for flood prediction and analysis in southern Nigeria. Machine learning is an artificial intelligence technique that uses computer-based instructions to analyze and transform data into useful information to enable systems to make predictions. Traditional methods of flood prediction and analysis often fall short of providing accurate and timely information for effective disaster management. More so, numerical forecasting of flood disasters in the 19th century is not very accurate due to its inability to simplify complex atmospheric dynamics into simple equations. Here, we used Machine learning (ML) techniques including Random Forest (RF), Logistic Regression (LR), Naïve Bayes (NB), Support Vector Machine (SVM), and Neural Networks (NN) to model the complex physical processes that cause floods. The dataset contains 59 cases with the goal feature “Event-Type”, including 39 cases of floods and 20 cases of flood/rainstorms. Based on comparison of assessment metrics from models created using historical records, the result shows that NB performed better than all other techniques, followed by RF. The developed model can be used to predict the frequency of flood incidents. The majority of flood scenarios demonstrate that the event poses a significant risk to people’s lives. Therefore, each of the emergency response elements requires adequate knowledge of the flood incidences, continuous early warning service and accurate prediction model. This study can expand knowledge and research on flood predictive modeling in vulnerable areas to inform effective and sustainable contingency planning, policy, and management actions on flood disaster incidents, especially in other technologically underdeveloped settings.

关键词： Machine Learning Flood Prediction Evaluation Southern Nigeria

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Advances in Vehicular Ad-hoc Networks(VANETs):Challenges and Road-map for Future Development

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International Journal of Automation and computing 2016年第1期13卷 1-18页

作者： Elias C.eze Si-Jing Zhang En-Jie Liu Joy C.eze Centre for Wireless Research Institute for Research in Applicable Computing (IRAC) Department of Computer Science and TechnologyUniversity of Bedfordshire

Recent advances in wireless communication technologies and auto-mobile industry have triggered a significant research interest in the field of vehicular ad-hoc networks （VANETs） over the past few years. A vehicular network consists of vehicle-to-vehicle （V2V） and vehicle-to-infrastructure （V2I） communications supported by wireless access technologies such as IEEE 802.11p. This innovation in wireless communication has been envisaged to improve road safety and motor traffic efficiency in near future through the development of intelligent transportation system （ITS）. Hence, governments, auto-mobile industries and academia are heavily partnering through several ongoing research projects to establish standards for VANETs. The typical set of VANET application areas, such as vehicle collision warning and traffic information dissemination have made VANET an interesting field of mobile wireless communication. This paper provides an overview on current research state, challenges, potentials of VANETs as well as the ways forward to achieving the long awaited ITS.

关键词： Vehicle-to-vehicle communication (V2V) vehicle-to-infrastructure (V2I) intelligent transport systems (ITS) IEEE802.11p wireless access in vehicular environment (WAVE) IEEE 1609.

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Modulated Collective Motions and Condensation of Bacteria

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Chinese Physics Letters 2022年第10期39卷 79-84页

作者： Mei-Mei Bao Isaiah eze Igwe Kang Chen Tian-Hui Zhang Center for Soft Condensed Matter Physics and Interdisciplinary Research&School of Physical Science and Technology Soochow UniversitySuzhou 215006China Department of Physics Federal University Dutsin-MaKatsina State 821101Nigeria

Bacteria can spontaneously develop collective motions by aligning their motions in dense *** we show that bacteria can also respond collectively to an alternating electrical field and form dynamic clusters oscillating at the same frequency of the *** the dynamic clusters go beyond a critical size,they split into smaller ones *** critical size for splitting depends on the frequency of electric field and the concentration of *** show that,instead of their biological activity,the physical properties of bacteria as charged particles are responsible for the formation of dynamic *** flows across the system play the key role in stabilizing the ***,to form clusters,collective hydrodynamic cooperation between bacteria is important such that no aggregation occurs in dilute *** findings in this study illustrate that bio-systems can respond collectively to an external field,promising an effective way to control and modulate the behavior of ***,the controlled aggregation and condensation of bacteria offer a robust approach to improve the local concentration of bacteria for early and rapid detection,which has wide applications in clinics.

关键词： field collective aggregation

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The effect of alcohol and eligibility for liver transplant:a critical review

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Gastroenterology & Hepatology Research 2024年第1期6卷 6-14页

作者： Wassihun Asmare Ikechukwu eze Domonick Gordon Gagan Singh Mukarrham Jamat Ali Ali Department of Internal Medicine Howard University HospitalWashington DC 20060USA

Background:Alcohol-related liver disease(ALRD)has emerged as a significant global health concern,primarily attributed to the overconsumption of *** alcoholism has the potential to impact various organs,it is the liver that is especially ***:This review comprehensively examines the challenges encountered during the pre-transplant,intra-transplant,and post-transplant phases,a significant number of which are attributable to alcohol ***,liver transplant(LT)programmes have excluded patients with alcohol-related liver disease(ARLD)due to mandatory abstinence requirements and apprehensions regarding potential graft shortages for other hepatic *** review counters these concerns by highlighting the minimal usage of grafts for early liver *** strongly advocates for the incorporation of severe alcoholic hepatitis into the model for end-stage liver disease allocation,devoid of any *** selection of ARLD individuals for LT necessitates the critical involvement of a multidisciplinary team,inclusive of addiction ***:Despite the complexities associated with LT for patients with ARLD,this review underscores its therapeutic advantages,particularly for those anticipated to experience severe adverse *** review accentuates the necessity of ensuring equitable access to medical interventions for all patients,irrespective of their lifestyle ***:The examination of genetic and epigenetic variables that play a role in the onset and advancement of *** identification of potential therapy strategies is also an important area of *** formulation of intricate eligibility rules for LT in patients with a past of alcohol abuse needs essential interactions between medical practitioners and *** use of new technologies such as genomics and epigenomics could boost the accuracy of ALD diagnostic and prognostic *** targeted investigations could potentiall

关键词： abstinence criteria alcohol-related liver disease(ALRD) liver transplantation(LT)

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