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Major gastrointestinal bleeding and antithrombotics: Characteristics and management

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World Journal of Gastroenterology 2020年第36期26卷 5463-5473页

作者： Jacques Bouget Damien Viglino Quentin Yvetot emmanuel Oger EA 7449 REPERES Pharmacoepidemiology and Health Services ResearchUniv RennesRennes 35000France Emergency Department and Mobile Intensive Care Unit-HP2 Laboratory INSERM U1042 University Grenoble AlpsLa Tronche 38700France Emergency Department CHU RennesRennes 3500France EA 7449 REPERES Universitéde Rennes 1Rennes 35000France

BACKGROUND There are few reports on major gastrointestinal(GI)bleeding among patients receiving an *** To describe clinical characteristics,bleeding locations,management and inhospital mortality related to these *** Over a three-year period,we prospectively identified 1080 consecutive adult patients admitted in two tertiary care hospitals between January 1,2013 and December 31,2015 for major GI bleeding while receiving an *** bleeding events were medically *** characteristics,causative lesions,management and fatalities were *** distribution of antithrombotics prescribed was compared across the bleeding lesions *** Of 576 patients had symptoms of upper GI bleeding and 504 symptoms of lower GI *** cause was identified for 383(35.5%)***-duodenal ulcer was the first causative lesion in the upper tract(209 out of 408)and colonic diverticulum the first causative lesion in the lower tract(120 out of 289).There was a larger proportion of direct oral anticoagulant use among patients with lower GI than among those with upper GI lesion locations(P=0.03).There was an independent association between gastro-duodenal ulcer and antithrombotic use(P=0.03),taking account of confounders and proton pump inhibitor *** wise comparisons pointed to a difference between vitamin K antagonist,direct oral anticoagulants,and antiplatelet agents in monotherapy vs dual antiplatelet *** We showed a higher rate of bleeding lesion identification and suggested a different pattern of antithrombotic exposure between upper and lower GI lesion locations and between gastro-duodenal ulcer and other identified upper GI causes of *** was similar across antithrombotics and in-hospital mortality was low(5.95%).

关键词： Real-world setting Emergency Bleeding Mortality Antithrombotics Management

Potential influences of religiosity and religious coping strategies on people with diabetes

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World Journal of Clinical Cases 2022年第25期10卷 8816-8826页

作者： Charity Neejide Onyishi Chiedu Eseadi Leonard Chidi Ilechukwu Kingsley Nwannennaya Okoro Charles Nkem Okolie emmanuel Egbule emmanuel Asogwa Department of Educational Psychology University of JohannesburgJohannesburg 2006GautengSouth Africa Department of Arts Education University of NigeriaNsukka 41001EnuguNigeria Department of Philosophy/Religion and Cultural Studies Alex Ekwueme Federal UniversityNdufu-Alike Ikwo 1010EbonyiNigeria

Diabetes is a significant health issue that threatens patients’overall wellbeing and quality of *** public health concerns center on creating the best approach for diabetes *** and caregivers have different approaches to diabetes management;however,this and the associated physiological,physical and mental health issues remain *** review explores the potential influences of religiosity and religious coping strategies on people with *** study used a literature review approach to investigate how religiosity and religious coping strategies can influence the effective management of diabetes among *** on the literature search,the researchers were able to identify and cite published papers that were analyzed using the descriptivenarrative *** important goal of the descriptive-narrative analysis was to provide descriptions of the selected literature and take implications from the *** results of studies reviewed show some religious coping strategies for managing chronic diseases such as *** studies did establish a relationship between religiosity and diabetes management and suggest that religious coping strategies could positively impact the management of diabetes;however,they reported some adverse ***,we propose a pathway for the development of religion-oriented interventions and support framework for the management of diabetes.

关键词： Diabetes mellitus Religiosity Religious belief Religious coping strategies Self-care management Social support

Model-based estimation of above-ground biomass in the miombo ecoregion of Zambia

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Forest Ecosystems 2016年第4期3卷 258-274页

作者： James Halperin Valerie LeMay emmanuel Chidumayo Louis Verchot Peter Marshall Department of Forest Resources Management The University of British Columbia 2424 Main Mall Vancouver BC V6T 1Z4 Canada Makeni Savanna Research Project P.O. Box 50323 Ridgeway Lusaka Zambia International Center for Tropical Agriculture Km 17 Recta Cali-Palmira Apartado Aereo 6713 Cali 763537. Colombia

Background：Information on above-ground biomass（AGB） is important for managing forest resource use at local levels,land management planning at regional levels,and carbon emissions reporting at national and international *** many tropical developing countries,this information may be unreliable or at a scale too coarse for use at local *** is a vital need to provide estimates of AGB with quantifiable uncertainty that can facilitate land use management and policy development ***-based methods provide an efficient framework to estimate ***：Using National Forest Inventory（NFI） data for a^1,000,000 ha study area in the miombo ecoregion,Zambia,we estimated AGB using predicted canopy cover,environmental data,disturbance data,and Landsat 8 OLI satellite *** assessed different combinations of these datasets using three models,a semiparametric generalized additive model（GAM） and two nonlinear models（sigmoidal and exponential）,employing a genetic algorithm for variable selection that minimized root mean square prediction error（RMSPE）,calculated through *** compared model fit statistics to a null model as a baseline estimation *** bootstrap resampling methods,we calculated 95% confidence intervals for each model and compared results to a simple estimate of mean AGB from the NFI ground plot ***：Canopy cover,soil moisture,and vegetation indices were consistently selected as predictor *** sigmoidal model and the GAM performed similarly;for both models the RMSPE was -36.8 tonnes per hectare（i.e.,57% of the mean）.However,the sigmoidal model was approximately 30% more efficient than the GAM,assessed using bootstrapped variance estimates relative to a null *** selecting the sigmoidal model,we estimated total AGB for the study area at 64,526,209 tonnes（＋/- 477,730）,with a confidence interval 20 times more precise than a simple designbased ***：Our findings demonstrate that NFI

关键词： National Forest Inventory Above-ground biomass Miombo REDD+ Generalized additive model Nonlinear model Landsat 8 OLI

MONTE CARLO SIMULATION ON COMPUTATIONAL FINANCE FOR GRID COMPUTING

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第3期3卷 64-93页

作者： NIKOLAOS P.PREVE emmanuel N.PROTONOTARIOS School of Electrical and Computer Engineering National Technical University of Athens Greece

Monte Carlo methods are a class of computational algorithms that rely on repeated random sampling to compute their *** Carlo methods are often used in simulating complex *** of their reliance on repeated computation of random or pseudo-random numbers,these methods are most suited to calculation by a computer and tend to be used when it is infeasible or impossible to compute an exact result with a deterministic *** finance,Monte Carlo simulation method is used to calculate the value of companies,to evaluate economic investments and financial *** the other hand,Grid Computing applies heterogeneous computer resources of many geographically disperse computers in a network in order to solve a single problem that requires a great number of computer processing cycles or access to large amounts of *** this paper,we have developed a simulation based on Monte Carlo method which is applied on grid computing in order to predict through complex calculations the future trends in stock prices.

关键词： Monte Carlo method grid computing simulation computational algorithms and software statistics financial derivatives

Portal hypertension in patients with nonalcoholic fatty liver disease:Current knowledge and challenges

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World Journal of Gastroenterology 2024年第4期30卷 290-307页

作者： Anita Madir Ivica Grgurevic emmanuel A Tsochatzis Massimo Pinzani Department of Gastroenterology Hepatology and Clinical NutritionUniversity Hospital DubravaZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Faculty of Pharmacy and Biochemistry University of ZagrebZagreb 10000Croatia UCL Institute for Liver and Digestive Health Royal Free Hospital and University College LondonLondon NW32PFUnited Kingdom

Portal hypertension(PH)has traditionally been observed as a consequence of significant fibrosis and cirrhosis in advanced non-alcoholic fatty liver disease(NAFLD).However,recent studies have provided evidence that PH may develop in earlier stages of NAFLD,suggesting that there are additional pathogenetic mechanisms at work in addition to liver *** early development of PH in NAFLD is associated with hepatocellular lipid accumulation and ballooning,leading to the compression of liver *** compression and intraluminal obstacles cause mechanical forces such as strain,shear stress and elevated hydrostatic pressure that in turn activate mechanotransduction pathways,resulting in endothelial dysfunction and the development of *** spatial distribution of histological and functional changes in the periportal and perisinusoidal areas of the liver lobule are considered responsible for the pre-sinusoidal component of PH in patients with ***,current diagnostic methods such as hepatic venous pressure gradient(HVPG)measurement tend to underestimate portal pressure(PP)in NAFLD patients,who might decompensate below the HVPG threshold of 10 mmHg,which is traditionally considered the most relevant indicator of clinically significant portal hypertension(CSPH).This creates further challenges in finding a reliable diagnostic method to stratify the prognostic risk in this population of *** theory,the measurement of the portal pressure gradient guided by endoscopic ultrasound might overcome the limitations of HVPG measurement by avoiding the influence of the pre-sinusoidal component,but more investigations are needed to test its clinical utility for this *** and spleen stiffness measurement in combination with platelet count is currently the best-validated non-invasive approach for diagnosing CSPH and varices needing *** change remains the cornerstone of the treatment of PH in NAFLD,together with correcting the comp

关键词： Non-alcoholic fatty liver disease Portal hypertension Mechanotransduction Endothelial dysfunction Hepatic venous pressure gradient

The seasonal role of field characteristics on seed-eating bird abundances in agricultural landscapes

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Current Zoology 2017年第3期63卷 279-286页

作者： emmanuel ZUFIAURRE Mariano CODESIDO Agustin M. ABBA David BILENCA Grupo de Estudios sobre Biodiversidad en Agroecosistemas (6EBA) Departamento de Biodiversidad y Biologia Experimental Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires and IEGEBA (UBA- CONICET). Ciudad Universitaria Pabellon II 4° Piso (C1428EHA). Ciudad Autonoma de Buenos Aires Argentina Centro de Estudios Parasitol6gicos y de Vectores (CEPAVE) CCT-CONICET-LA PLATA-UNLP. Calle 120 entre 61 y 62 S/N La Plata (B1902CHX) Buenos Aires Argentina

In temperate agroecosystems, avian responses in abundance and distribution to landscape attributes may be exacerbated by the coupling of natural seasons and farming practices. We assessed the sea- sonal roles of field type, field use in the surroundings, and distance from a field to the nearest woodlot on the abundance of seed-eating birds in a 225,000 km2 study area in the Pampas of central Argentina. During spring-summer and autumn of 2011-2013, we randomly selected 392 fields and used transect samples to collect data on abundance and presence of seed-eating bird species. We recorded a total of 11,579 individuals belonging to 15 seed-eating bird species. We used generalized lineal mixed models to relate bird abundance to field type, field use in the surroundings, and distance to the nearest woodlot. In spring-summer （breeding season） most bird responses were associated with their nesting requirements. Species that build their nests in trees, such as eared doves Zenaida auriculata, picazuro pigeons Patagioenas picazuro, and monk parakeets Myiopsitta monachus, were more abundant in fields closer to woodlots, whereas grassland yellow-finches Sicalis luteola, which nest at areas with tall grasses, were more abundant in fields with livestock use patches in the field surroundings. In au- tumn （non-breeding season）, most bird responses were associated with foraging and refuge needs. The high abundance of eared doves in crop stubbles and the association of pigeons at field surroundings dominated by croplands or at crop stubbles surrounded by livestock use fields revealed the intimate association of these species to sites with high availability of food resources. In addition, both picazuro pigeons and spot-winged pigeons Patagioenas maculosa were associated with woodlots, which provide suitable roosting sites. Our results show that in temperate agroecosystems, the relationships between field characteristics and seed-eating bird abundances vary with season.

关键词： field surroundings field type granivorous birds stubbles temperate agroecosystems woodlots.

Investigation of proper modeling of very dense granular flows in the recirculation system of CFBs

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Particuology 2012年第6期10卷 699-709页

作者： Aristeidis Nikolopoulos Nikos Nikolopoulos Nikos Varveris Sotirios Karellas Panagiotis Grammelis emmanuel Kakaras Laboratory of Steam Boilers and Thermal Plants Thermal Engineering SectorSchool of Mechanical EngineeringNTUAAthensGreece Centre for Research and Technology Hellas Institute for Solid Fuels Technology and ApplicationsAthens Gr-15310Greece

The aim of this paper is the development of new models and] or the improvement of existing numerical models, used for simulating granular flow in CFB （circulating fluidized bed） recirculation systems. Most recent models follow the TFM （two-fluid model） methodology, but they cannot effectively simulate the inter-particle friction forces in the recirculation system, because the respective stress tensor does not incorporate compressibility of flow due to change of effective particle density. As a consequence, the induced normal and shear stresses are not modeled appropriately during the flow of the granular phase in the CFB recirculation system. The failure of conventional models, such as that of yon MisesJCoulomb, is mainly caused by false approximation of the yield criterion which is not applicable to the CFB recirculation system. The present work adopts an alternative yield function, used for the first time in TFM Eulerian modeling. The proposed model is based on the Pitman-Schaeffer-Gray-Stiles yield criterion. Both the temporal deformation of the solid granular phase and the repose angle that the granular phase forms are more accurately simulated by this model. The numerical results of the proposed model agree well with experimental data, implying that frictional forces are efficiently simulated by the new model.

关键词： Euler-EulerCFBRepose angleFull-loop simulationGranular viscosityYield criterion

Petrogenesis of the Mayo-Darley tin formations,anorogenic complex of the Cameroon Line:implication for tin deposit

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Acta Geochimica 2023年第4期42卷 704-725页

作者： Ndema Mbongué Jean Lavenir Ndongfong Edson Fuh emmanuel Eseya Mengu Junior Department of Geology Faculty of SciencesUniversity of BueaP.O.Box 63BueaCameroon Department of Earth Sciences Faculty of SciencesUniversity of Yaounde IP.O.Box 812YaoundéCameroon

The Mayo-Darley massif is an anorogenic complex of the Cameroon Line that has a mantle ***-bearing rocks were analyzed by ICP-AES and INAA analytical *** purpose of this work was to provide new geochemical data for the Mayo-Darley tin formation and to understand its petrogenesis and the origin of tin *** Mayo-Darley tin deposit is made up of tin-granite,and tin-greisen,greisenification was developed on the borders of quartz *** rocks belong to the alkaline series and were classified into acid(SiO2-=61.6%–73.8%;65.4%–98%respectively)and basic(42.9%–47%SiO_(2))*** showed enrichment in HSFE,LILE,Ga/Al and chondrite normalized REE patterns indicating LREE enrichment relative to HREE with a negative Eu anomaly,only sample SB8 of tin-granite showed Eu/Eu*=*** display metaluminous,peralkaline,peraluminous,ferroan,high-K calc-alkaline to shoshonitic,alkalic to calcic affinity,and crystallized at800°*** chemistry of this deposit reflects the primary composition of granite,quartz monzonite,gabbro,and foid *** complex experienced multi-stage sub-solidus hydrothermal fluid reactions and shows variable alteration of feldspars alkali *** rocks are classified as A1-type granite,overlap with the OIB field,and were derived from a within-plate setting,similar to mantle non plumederived *** origin of tin mineralization in MayoDarley has a complex evolution,tin mineralization was derived from hydrothermal and hydrogenous metal-rich deposits and shows Sn–Hf–Zr and Sn–Tl–Nb *** new data confirm the complexity of the Mayo-Darley tin complex and elucidate the origin of tin mineralization.

关键词： Mayo-Darley Massif Cameroon Line Tingranite Tin-bearing greisen A1-type granite Sn–Hf–Zr Sn–Tl–Nb

Consumers'willingness to pay for ethical consumption initiatives on e-commerce platforms

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Journal of Integrative Agriculture 2021年第4期20卷 1012-1020页

作者： WANG Er-peng AN Ning GENG Xian-hui Zhifeng GAO emmanuel KIPROP School of Economics and Management Nanjing Tech UniversityNanjing 211816P.R.China College of Economics and Management Nanjing Agricultural UniversityNanjing 210095P.R.China Food and Resource Economics Department University of FloridaGainesvilleFL 32611-0240USA

Despite China's fast-growing e-commerce and its great achievement in promoting poverty alleviation through consumption,little is known about Chinese consumers'online ethical *** the payment card elicitation method,this paper designs a within-subject survey and a between-subject survey to investigate Chinese consumers'quality perception and preference for apples from poverty-stricken *** results show that before"information shock",emphasizing that taste and safety attributes of apples from poverty-stricken areas are the same as the conventional ones,Chinese consumers on average are willing to pay a 31%premium for apples from poverty-stricken ***"information shock",both the within-subject and between-subject designs show a minimal drop of the premium,implying that the ethical attribute is the main motivation for buying apples from poverty-stricken *** regression results show that quality perception of private attributes has significant effect on consumers'willingness to pay(WTP)for apples from poverty-stricken areas,and trust in government supervision of e-commerce plays an essential role in motivating online ethical consumption.

关键词： ethical consumption apples from poverty-stricken areas WTP interval regression