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Effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats: What we know so far?

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 91-92页

作者： antonios athanasiou eleftherios spartalis mairead hennessy michael spartalis demetrios moris christos damaskos emmanouil pikoulis department of upper gastrointestinal surgery university hospitals birmingham nhs foundation trustBirmingham UK laboratory of experimental surgery and surgical research university of athens medical schoolAg. Thoma 15B Athens 11527 Greece department of surgery wexford general hospitalIreland department of surgery duke universityDurham NC USA first surgery department laikon general hospital national and kapodistrian university of athensGreece

To the editor:We read with great interest the article entitled "Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats" by Ulmer et al.[1].The aim o... 详细信息

关键词： Effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats What we know so far

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Evolution of medical education in ancient Greece

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Chinese Medical Journal 2008年第21期121卷 2202-2206页

作者： emmanouil pikoulis Pavlos Msaouel Efthimios D Avgerinos Sofia Anagnostopoulou Christos Tsigris Medical School of the National Kapodistrian University of Athens Athens Greece

The study of ancient Greece is essential for the proper understanding of the evolution of modern Western medicine. An important innovation of classical Greek medicine was the development of a body of medical theory as... 详细信息

关键词： medical education ancient Greece history of medicine Hippocrates

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Angiomyolipoma arising in the gluteal region

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Chinese Medical Journal 2007年第14期120卷 1284-1286页

作者： emmanouil pikoulis Constantine Bramis Othon Michail George Liapis Evangelos Felekouras Vassiliki Kyriakou John Griniatsos First Department of Surgery Laikon Hospital University of Athens Medical SchoolAthens 115-27Greece Department of Pathology Laikon Hospital University of Athens Medical SchoolAthens 115-27Greece

Angiomyolipoma （AML） is a tumour of uncertain .histogenesis originally believed to be a hamartomatous lesion, but recently recognized as a usually benign clonal mesenchymal neoplasm. Along with lymphagiomyomatosis （LAM）, clear cell ＂sugar＂ turnout （CCST） and clear cell myelomelanocytic tumour （CCMMT）, AML was classified in the so called perivascular epithelioid cell （PEComa） neoplasm family.

关键词： angiomyolipoma buttocks

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Hepatocellular carcinoma in patients co-infected with hepatitis C virus and human immunodeficiency virus

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World Journal of Hepatology 2013年第6期5卷 323-327页

作者： Dimitrios Dimitroulis Serena Valsami Eleftherios Spartalis Emmanuel pikoulis Gregory Kouraklis Second Department of Propedeutic Surgery Athens University Medical School "Laiko" Hospital Blood Transfusion Department Athens University Medical School Areteion Hospital

Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) share a common route of transmission so that about one third of HIV infected individuals show HCV coinfection. Highly active antiretroviral therapy has offered a longer and better life to infected patients. While has removed AIDS-related diseases from the list of most common causes of death their place has been taken by complications of HCV infection, such as cirrhosis, end stage liver disease and hepatocellular carcinoma (HCC). HIV/HCV co-infection requires complex management, especially when HCC is present. Co-infected patients with HCC undergo the same therapeutic protocol as their mono-infected counterparts, but special issues such as interaction between regimens, withdrawal of therapy and choice of immunosuppressive agents, demand a careful approach by specialists. All these issues are analyzed in this minireview.

关键词： Hepatocellular carcinoma Hepatitis C virus, Human immunodeficiency virus Co-infection

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Circadian variation in expression of G_1 phase cyclins D_1 and E and cyclin-dependent kinase inhibitors p16 and p21 in human bowel mucosa

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World Journal of Gastroenterology 2006年第13期12卷 2109-2114页

作者： John Griniatsos Othon P Michail Stamatios Theocharis Antonios Arvelakis Ioannis Papaconstantinou Evangelos Felekouras Emmanouel pikoulis Ioannis Karavokyros Chris Bakoyiannis George Marinos John Bramis Panayiotis O Michail 1st Department of Surgery Medical School University of AthensGreece Department of Forensic Medicine and Toxicology Medical School University of AthensGreece

AIM： To evaluate whether the cellular proliferation rate in the large bowel epithelial cells is characterized by circadian rhythm. METHODS： Between January 2003 and December 2004, twenty patients who were diagnosed as suffering from primary, resectable, non-metastatic adenocarcinoma of the lower rectum, infiltrating the sphincter mechanism, underwent abdominoperineal resection, total mesorectal excision and permanent left iliac colostomy. In formalinfixed and paraffin-embedded biopsy specimens obtained from the colostomy mucosa every six hours （00：00, 06：00, 12：00, 18：00 and 24：00）, we studied the expression of G1 phase cyclins （D1 and E） as well as the expression of the G1 phase cyclin-dependent kinase （CDK） inhibitors p16 and p21 as indicators of cell cycle progres- sion in colonic epithelial cells using immunohistochemical methods. RESULTS： The expression of both cyclins showed a similar circadian fashion obtaining their lowest and highest values at 00：00 and 18：00, respectively （P〈 0.001）. A circadian rhythm in the expression of CDK inhibitor proteins p16 and p21 was also observed, with the lowest levels obtained at 12：00 and 18：00 （P〈0.001）, respectively. When the complexes cyclins D1-p21 and E-p21 were examined, the expression of the cyclins was adversely correlated to the p21 expression throughout the day. When the complexes the cyclins D1-p16 and E-p16 were examined, high levels of p16 expression were correlated to low levels of cyclin expression at 00：00, 06：00 and 24：00. Meanwhile, the highest expression levels of both cyclins were correlated to high levels of p16 expression at 18：00. CONCLUSION： Colonic epithelial cells seem to enter the G1 phase of the cell cycle during afternoon （between 12：00 and 18：00） with the highest rates obtained at 18：00. From a clinical point of view, the present results suggest that G1-phase specific anticancer therapies in afternoon might maximize their anti-tumor effect while minimizing toxicity.

关键词： G1 phase proteins CDK inhibitors Cell proliferation Circadian rhythm

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