检索结果-南通市图书馆

Review of primary sclerosing cholangitis with increased IgG4 levels

World Journal of Gastroenterology 2020年第23期26卷 3126-3144页

作者： Charis D Manganis Roger W Chapman emma l culver Translational Gastroenterology Unit and Oxford NIHR Biomedical Research Centre John Radcliffe HospitalOxford OX39DUUnited Kingdom

Primary sclerosing cholangitis(PSC) is a chronic progressive liver disease. Subtypes of PSC have been described, most recently PSC with elevated serum and/or tissue IgG4 subclass. We aim to summarise the clinical phenotype,disease associations, differential diagnosis, response to therapy and pathogenic mechanisms underlying PSC-high IgG4 subtype. We reviewed Pub Med,MEDlINE and Embase with the search terms "primary sclerosing cholangitis","IgG4", and "IgG4-related sclerosing cholangitis(IgG4-SC)". Elevated serum IgG4 are found in up-to one-quarter, and abundant IgG4-plasma cell infiltrates in the liver and bile ducts are found in up-to one-fifth of PSC patients. This group have a distinct clinical phenotype, with some studies reporting a more aggressive course of liver and associated inflammatory bowel disease, compared to PSCnormal IgG4 and the disease mimic IgG4-SC. Distinguishing PSC-high IgG4 from IgG4-SC remains challenging, requiring careful assessment of clinical features,organ involvement and tissue morphology. Calculation of serum IgG4:IgG1 ratios and use of a novel IgG4:IgG RNA ratio have been reported to have excellent specificity to distinguish IgG4-SC and PSC-high IgG4 but require validation in larger cohorts. A role for corticosteroid therapy in PSC-high IgG4 remains unanswered, with concerns of increased toxicity and lack of outcome data. The immunological drivers underlying prominent IgG4 antibodies in PSC are incompletely defined. An association with PSC-high IgG4 and HlA class-II haplotypes(B*07, DRB1*15), T-helper2 and T-regulatory cytokines(Il4, Il10,Il13) and chemokines(CCl1, CCR8) have been described. PSC-high IgG4 have a distinct clinical phenotype and need careful discrimination from IgG4-SC,although response to immunosuppressive treatments and long-term outcome remains unresolved. The presence of IgG4 likely represents chronic activation to persistent antigenic exposure in genetically predisposed individuals.

关键词： Primary sclerosing cholangitis IgG4 IgG4-related disease IgG4-related sclerosing cholangitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evolving role of magnetic resonance techniques in primary sclerosing cholangitis

引用

World Journal of Gastroenterology 2019年第6期25卷 644-658页

作者： emmanuel A Selvaraj emma l culver Helen Bungay Adam Bailey Roger W Chapman Michael Pavlides Oxford Centre for Clinical Magnetic Resonance Research Division of Cardiovascular Medicine Radcliffe Department of Medicine University of Oxford John Radcliffe Hospital Translational Gastroenterology Unit Nuffield Department of Medicine University of OxfordJohn Radcliffe Hospital Oxford NIHR Biomedical Research Centre Oxford University Hospitals NHS Foundation Trust and the University of Oxford Department of Radiology John Radcliffe Hospital

Development of non-invasive methods to risk-stratify patients and predict clinical endpoints have been identified as one of the key research priorities in primary sclerosing cholangitis(PSC). In addition to serum and histological biomarkers, there has been much recent interest in developing imaging biomarkers that can predict disease course and clinical outcomes in *** resonance imaging/magnetic resonance cholangiopancreatography(MRI/MRCP) continue to play a central role in the diagnosis and follow-up of PSC patients. Magnetic resonance(MR) techniques have undergone significant advancement over the last three decades both in MR data acquisition and interpretation. The progression from a qualitative to quantitative approach in MR acquisition techniques and data interpretation, offers the opportunity for the development of objective and reproducible imaging biomarkers that can potentially be incorporated as an additional endpoint in clinical trials. This review article will discuss how the role of MR techniques have evolved over the last three decades from emerging as an alternative diagnostic tool to endoscopic retrograde cholangiopancreatography, to being instrumental in the ongoing search for imaging biomarker of disease stage, progression and prognosis in PSC.

关键词： Primary sclerosing cholangitis Magnetic resonance imaging Magnetic resonance cholangiopancreatography Magnetic resonance elastography Diffusion magnetic resonance imaging Endoscopic retrograde cholangiopancreatography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exercise training improves long-term memory in obese mice

引用

life Metabolism 2024年第1期3卷 37-50页

作者： Oliver K.Fuller Casey l.Egan Tina l.Robinson Nimna Perera Heidy K.latchman lauren V.Terry emma D.Mclennan Carolina Chavez emma l.Burrows John W.Scott Robyn M.Murphy Henriette van Praag Martin Whitham Mark A.Febbraio Monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneVictoria3052Australia la Trobe Institute for Molecular Science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoria3052Australia Department of Biomedical Sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of life and Environmental Sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked to a range of pathologies,including *** contrast,regular physical activity is associated with the prevention or reduced progression of ***,physical activity can improve memory and spatial cognition,reduce age-related cognitive decline,and preserve brain volume,but the mechanisms are not fully ***,we investigated whether any detrimental effects of high-fat diet(HFD)-induced obesity on cognition,motor behavior,adult hippocampal neurogenesis,and brain-derived neurotrophic factor(BDNF)could be mitigated by voluntary exercise training in male C57Bl/6 ***-induced impairment of motor function was not reversed by ***,voluntary wheel running improved long-term memory and increased hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive decline in obesity.

关键词： obesity exercise cognition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Methane cracking in molten tin for hydrogen and carbon production—a comparison with homogeneous gas phase process

引用

Frontiers of Chemical Science and Engineering 2024年第7期18卷 155-166页

作者： emmanuel Busillo Benedetta de Caprariis Maria Paola Bracciale Vittoria Cosentino Martina Damizia Gaetano Iaquaniello emma Palo Paolo De Filippis Chemical Engineering Department Sapienza University of RomeRome 00184Italy NextChem S.p.A. Rome 00156Italy

Methane cracking is considered a bridge technology between gray and green hydrogen production *** this work an experimental study of methane cracking in molten tin is *** tests were conducted in a quartz reactor(i.d.=1.5 cm,l=20 cm)with capillary injection,varying temperature(950–1070°C),inlet methane flow rate(30–60 ml·min^(-1))and tin height(0–20 cm).The influence of the residence time in the tin and in the headspace on methane conversion and on carbon morphology was *** conversions obtained in tin and in the empty reactor were measured and compared with results of detailed kinetic simulations(CRECK).Furthermore,an expression of a global kinetic constant for methane conversion in tin was also *** highest conversion(65%at Q0=30 ml·min^(-1) and t=1070°C)is obtained for homogeneous gas phase reaction due to the long residence time(70 s),the presence of tin leads to a sharp decrease of residence time(1 s),obtaining a conversion of 35%at 1070°C,thus meaning that tin owns a role in the *** characterization(scanning electron microscopy,Raman)reported a change in carbon toward sheet-like structures and an increase of the carbon structural order in the presence of molten tin media.

关键词： methane cracking molten media H2 production carbon morphology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of a complex couplet care intervention in a neonatal intensive care unit:A mixed methods study protocol

引用

Pediatric Investigation 2024年第2期8卷 139-148页

作者： Michella Bjerregaard Anna Axelin emma louise Malchau Carlsen Hans Okkels Birk Ingrid Poulsen Patrick Palisz Thomas Kallemose Anne Brødsgaard Department of Paediatric and Adolescent Medicine Copenhagen University Hospital Amager HvidovreHvidovreDenmark Department of Public Health Faculty of HealthResearch Unit for Nursing and HealthcareUniversity of AarhusAarhusDenmark Department of Nursing Science University of TurkuTurkuFinland Department of Clinical Medicine Faculty of Health and Medical ScienceUniversity of CopenhagenCopenhagenDenmark Department of Public Health Section of Health Service ResearchUniversity of CopenhagenCopenhagenDenmark Department of People and Technology Roskilde UniversityRoskildeDenmark Department of Clinical Research Copenhagen University Hospital Amager HvidovreHvidovreDenmark Department of Gynaecology and Obstetrics Copenhagen University Hospital Amager HvidovreHvidovreDenmark

Background:Families with an infant in need of intensive care most often experience a harmful separation after *** is due to a division of medical specialties into neonatal care and maternal ***,a couplet care intervention is implemented for mother-infant dyads in a neonatal intensive care *** study protocol provides a comprehensive evaluation of the *** aim is to evaluate the effect and implementation of a complex couplet care intervention to promote zero separation between mother and ***:The couplet care intervention is a family-centered model of care,where treatment-requiring mother-infant dyads will be admitted together and receive couplet care by neonatal *** study adheres to the framework of the Medical Research Council and will use a mixed methods embedded design comprising a quasi-experimental trial and a qualitative process ***,a health economic evaluation will be conducted to assess the cost-effectiveness of this complex couplet care ***:Separation of mother-infant dyads after birth has an adverse impact on family health and *** study protocol evaluates a complex couplet care *** this study,a first step is taken to help bridge the gap between current practices and a new care model to prevent the separation of mothers and their infants.

关键词： Complex interventions Couplet care Family-centered care Neonatology Zero separation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synaptopathy in CHMP2B frontotemporal dementia highlights the synaptic vesicle cycle as a therapeutic target

引用

Neural Regeneration Research 2023年第2期18卷 315-316页

作者： Miranda Robbins emma l.Clayton MRC laboratory of Molecular Biology Department of Zoology University of CambridgeCambridgeUK UK Dementia Research Institute at King’s College london Department of Basic and Clinical Neuroscience Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonMaurice Wohl Clinical Neuroscience InstituteLondonUK

Amyotrophic lateral sclerosis(AlS)and frontotemporal dementia(FTD)are both devastating neurodegenerative *** affecting different regions of the nervous system(FTD affecting primarily the frontal and temporal lobes,whilst AlS presents with motor neuron loss),there is significant overlap between these conditions in terms of genetics,pathology,and disease mechanisms,and they are therefore often grouped as a spectrum of symptoms under the heading FTD/AlS(Abramzon et al.,2020).Significantly,there is currently no cure for AlS or ***,recent mechanistic insight points to a novel pathway to target for potential therapeutic intervention.

关键词： therapeutic pathology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On a Generalized Centralizer Ring of a Finite Group Which Det ermines the Group

引用

Algebra Colloquium 2019年第1期26卷 31-50页

作者： emma l. Rode Department of Mathematics Southern Utah University Cedar City UT 84720 USA

The k-characters are class functions on subsets of G^k called the k-classes of G. For a finite group G, the k-class sums form a basis for a subring of CG^k, which we call the k-S-ring of G、and we think of these rings as generalized centralizer rings. We show that for a finite group G the 3-S-ring determines G. More specifically, the group characters and set products of certain 3-classes of G, which we call “uniform 3-classes", determine G.

关键词： S-ring fc-class centralizer ring

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Confusion over Cold Fusion: A Possible Explanation

引用

Journal of Applied Mathematics and Physics 2022年第12期10卷 3524-3529页

作者： Pirooz Mohazzabi emma l. Schultz-Stachnik Department of Mathematics and Physics University of Wisconsin-Parkside Kenosha USA

The famous 1989 “cold fusion” experiment of Fleischmann and Pons is revisited and the results are discussed. It is shown that these results, which were attributed to nuclear fusion near or at room temperature but were never validated in any other environment, can be explained by presence of radon gas in the laboratory where the experiments were performed.

关键词： Cold Fusion Fleischmann and Pons Experiment Radon Gas

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of l-arginine,guanidinoacetic acid and l-citrulline supplementation in reduced-protein diets on bone morphology and mineralization of laying hens

引用

Animal Nutrition 2023年第3期14卷 225-234页

作者： Hiep Thi Dao Amy F.Moss emma J.Bradbury Robert A.Swick School of Environmental and Rural Science Faculty of ScienceAgricultureBusiness and LawUniversity of New EnglandArmidaleNew South Wales2351Australia Faculty of Animal Science Vietnam National University of AgricultureTrau Quy TownGia Lam DistrictHanoi100000Vietnam Baiada Poultry Pty limited Pendle HillNew South Wales2145Australia

The alterations in feed ingredients and the nutrient matrix to produce reduced-protein diets may affect bone morphology and mineralization in laying *** study was implemented to determine the effects of l-arginine(Arg),guanidinoacetic acid(GAA),and l-citrulline(Cit)supplementation to Argdeficient reduced-protein diets on bone morphology,strength,and mineralization status of laying *** housed Hy-line Brown laying hens were evenly distributed to five dietary treatments with 25 replicates per treatment from 20 to 40 wk of *** consisted of a standard protein diet(17%crude protein,SP),a reduced-protein diet deficient in Arg(13%crude protein,RP),and RP supplemented with Arg(0.35%Arg,RP-Arg),GAA(0.46%GAA equivalent to 0.35%Arg,RP-GAA),or Cit(0.35%Cit equivalent to 0.35%Arg,RP-Cit)to reach the Arg level of SP *** fed the SP diet had similar bone weight,ash,length,width,Seedor index,breaking strength,and serum mineral concentration,but higher toe B level(Plso excreted more K and B compared to those fed the RP diet(Plower Cu digestibility(P=0.01)and higher B retention(Plative femur weight and length(Plline supplementation also increased relative tibia and femur ash,and Zn digestibility(Plementation of GAA to the RP diet decreased serum Ca,P,and Mg levels,decreased tibia Fe and Mg levels and toe Mg level,but increased Al,Fe,Zn,and Mn digestibility(Playing hens to adapt to low mineral intake by increasing mineral ***,bone morphology and breaking strength,and serum mineral level in laying hens were not influenced by dietary CP *** Arg,GAA,or Cit supplementation were effective in improving bone morphology and

关键词： Ash Breaking strength Femur low protein Minerals Digestibility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis

引用

World Journal of Diabetes 2022年第3期13卷 260-271页

作者： Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann emma l Redman David R Webb emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant Diabetes Research Centre University of LeicesterLeicester General HospitalLeicester LE54PWUnited Kingdom Department of Cardiovascular Sciences Glenfield HospitalUniversity of LeicesterLeicester LE39QPUnited Kingdom The Hanning Sleep laboratory University Hospitals of Leicester NHS TrustUniversity of LeicesterLeicester LE54PWUnited Kingdom National Institute for Health Research Leicester Biomedical Research CentreLeicester LE54PWUnited Kingdom leicester Diabetes Centre University Hospitals of Leicester NHS TrustLeicester LE54PWUnited Kingdom National Institute for Health Research Applied Research Collaboration East MidlandsLeicester LE54PWUnited Kingdom Department of Diabetes University Hospitals of Derby and Burton NHS Foundation TrustDerby DE223NEUnited Kingdom

BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger *** To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with *** A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 *** and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood *** and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk *** A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in *** diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older *** results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other *** age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and *** The diagnosis of T2D earlier in life is associated with a worse cardi

关键词： Type 2 diabetes mellitus Early-onset adult type 2 diabetes Age of onset Cardiovascular risk Young adults Glycaemic control Obesity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：