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Biosecurity risk mapping and gap analysis in South East Asia

Journal of Biosafety and Biosecurity 2020年第1期2卷 36-43页

作者： emily valentin castriciones Viji Vijayan On-Site Technical Assistance to the European Union-CBRN Centres of Excellence Regional Secretariat for South-East Asia(EU-CBRN CoE Project 62) Business and Strategies in Europe S.A.Woluwe GateBoulevard de la Woluwe 21150 BrusselsBelgium Department of Safety Health Emergency ManagementResearch Integrity and ComplianceDuke-NUS Medical School8 College RoadSingapore 169857Singapore

Introduction:In today’s globalized world where travel is commonplace,a threat in one region can easily spread throughout the whole *** is,therefore,essential for multi-disciplinary risk assessment,risk mitigation,and collaborative strategies to take place among various stakeholders to mitigate *** strategic plan to deal with biosecurity,therefore,needs to be a complete loop,top to bottom and bottom to *** paper describes the results of Project 62,which involved mapping and biosecurity risk assessment in South East *** and methods:The mapping and biosecurity risk assessment activities for the participating partner countries was carried out in two *** first phase involved risk assessment by six partnercountry bio-experts for their own countries and the second phase involved conducting a joint Strengths,Weaknesses,Opportunities,and Threats(SWOT)analysis and risk assessment for the South East Asian region as whole,together with international bio-experts at a *** and discussion:The following key recommendations of the project show that biosecurity needs to be addressed through stakeholder engagement at multiple levels starting from the top echelons of the government to the worker who needs to recognize and understand the threats they might face:*** analysis of existing information from BWC ISU Article 10,IHR capacities,JEE,UN Security Council Resolution 1540 Action Plan,EU CBRN NAP,and other relevant sources to develop a common understanding of the definition of biosecurity for all stakeholders in the *** of programs for awareness building in biosecurity,not limiting them to laboratory biosecurity but using an all-inclusive approach to include border biosecurity,pandemic response,*** of a country-specific list of high-risk biological *** standardized biosecurity training,including responsible conduct in biosecurity *** for one-health and security interface

关键词： Biosecurity Biosafety Biorisk CBRN Risk mapping Risk assessment Gap analysis South East Asia

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Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease

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Bone Research 2021年第3期9卷 385-395页

作者： Guillaume Courbon Connor Francis Claire Gerber Samantha Neuburg Xueyan Wang emily Lynch Tamara Isakova Jodie LBabitt Myles Wolf Aline Martin valentin David Division of Nephrology and Hypertension Department of Medicineand Center for Translational Metabolism and HealthInstitute for Public Health and MedicineNorthwestern University Feinberg School of MedicineChicagoILUSA Nephrology Division Program in Membrane BiologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA Division of Nephrology Department of Medicineand Duke Clinical Research InstituteDuke University School of MedicineDurhamNCUSA

Bone-produced fibroblast growth factor 23(FGF23)increases in response to inflammation and iron deficiency and contributes to cardiovascular mortality in chronic kidney disease(CKD).Neutrophil gelatinase-associated lipocalin(NGAL or lipocalin 2;LCN2 the murine homolog)is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD *** investigated bone FGF23 regulation by circulating *** 23 weeks,Col4a3KO mice showed impaired kidney function,increased levels of kidney and serum LCN2,increased bone and serum FGF23,anemia,and left ventricular hypertrophy(LVH).Deletion of Lcn2 in CKD mice did not improve kidney function or anemia but prevented the development of LVH and improved survival in association with marked reductions in serum ***2 deletion specifically prevented FGF23 elevations in response to inflammation,but not iron deficiency or phosphate,and administration of LCN2 increased serum FGF23 in healthy and CKD mice by stimulating Fgf23 transcription via activation of cAMP-mediated signaling in bone *** results show that kidney-produced LCN2 is an important mediator of increased FGF23 production by bone in response to inflammation and in ***2 inhibition might represent a potential therapeutic approach to lower FGF23 and improve outcomes in CKD.

关键词： FGF23 kidney inflammation

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