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Chinese Journal of Chemistry 2015年第8期33卷 909-916页

作者： Zhongjie Xu Guozheng Shi Jianyu Yuan emily Glenn Hai-Qiao Wang Wanli Ma Institute of Functional Nano & soft Materials (FUNsoM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University Suzhou Jiangsu 215123 China University of Waterloo 200 University Avenue West Waterloo Ontario N2L3G1 Canada

Two new D-A type polymers PBDSe-DPP and PBDSe-ID were synthesized to explore new ideal semiconduct- ing polymers, by conjugating acceptor unit diketopyrrolopyrrole/isoindigo to a donor unit benzo[l,2-b：4,5-b＇]di- selenophene, which is designed by substituting the sulfur atom with a selenium atom in the benzo[1,2-b：4,5-b＇]- dithiophene. The thermal, optical, electrochemical, photoelectric and photovoltaie properties of the two polymers were studied systematically. Relatively high open circuit voltage （0.7 and 0.75 V） and fill factor （〉65%） were demonstrated for both polymers. Huge increase （by 64% and 120%） of the short circuit current density was achieved for both polymer based devices by using additive compared to the corresponding reference without addi- tive, resulting in decent power conversion efficiency of 3.7% and 2.5% respectively with only simple optimizing consideration. We believe this class of BDSe polymer possesses a good potential to be alternatives of active material for photovoltaic applications.

关键词： semiconducting polymer benzo[1,2-b:4,5-b']diselenophene synthesis characterization photovoltaics

An examination of the population dynamics of syngnathid fishes within Tampa Bay,Florida,USA

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Current Zoology 2010年第1期56卷 118-133页

作者： Heather D.MAsoNJONES emily ROSE Lori Benson McRAE Danielle L.DIXsoN Biology Department University of Tampa Biology Department Texas A & M University School of Marine and Tropical Biology James Cook University

Seagrass ecosystems worldwide have been declining, leading to a decrease in associated fish populations, especially those with low mobility such as syngnathids （pipefish and seahorses）. This two-year pilot study investigated seasonal patterns in density, growth, site fidelity, and population dynamics of Tampa Bay （FL） syngnathid fishes at a site adjacent to two marinas under construction. Using a modified mark-recapture technique, fish were collected periodically from three closely located sites that varied in seagrass species （Thalassia spp., Syringodium spp., and mixed-grass sites） and their distance from open water, but had consistent physical/chemical environmental characteristics. Fish were marked, photographed for body size and gender measurements, and released the same day at the capture site. Of the 5695 individuals surveyed, 49 individuals were recaptured, indicating a large, flexible population. Population density peaks were observed in July of both years, with low densities in late winter and late summer. Spatially, syngnathid densities were highest closest to the mouth of the bay and lowest near the shoreline. Seven species of syngnathid fishes were observed, and species-specific patterns of seagrass use emerged during the study. However, only two species, Syngnathus scovelli and Hippoeampus zosterae, were observed at high frequencies. For these two species, body size decreased across the study period, but while S. scovelli＇s population density decreased, H. zosterae＇s increased. Across six of the seven species, population size declined over the course of this preliminary study; however, seasonal shifts were impossible to distinguish from potential anthropogenic effects of construction [Current Zoology 56 （1）： 118-133, 2010].

关键词： Syngnathids Habitat-use Seahorse Pipefish Population density Mark-recapture

Perception of Potential Health Risk of Climate Change and Utilization of Fans and Air Conditioners in a Representative Population of Hong Kong

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International Journal of Disaster Risk Science 2020年第1期11卷 105-118页

作者： Yang Gao emily Y.Y.Chan Holly C.Y.Lam Aiwei Wang Department of Sport and Physical Education Hong Kong Baptist UniversityHong KongChina Collaborating Centre for Oxford University and CUHK for Disaster and Medical Humanitarian Response The Jockey Club School of Public Health and Primary CareThe Chinese University of Hong KongHong KongChina

Climate change, especially as reflected in heat waves, is a rising threat worldwide. Appropriate use of cooling devices can protect people from health impacts during a heat wave. A population-based telephone survey was conducted in a representative sample of residents in Hong Kong to investigate ownership and use of domestic cooling devices, identify correlates, and examine their associations with risk perception of potential health impact of climate change. More than 90% of the 1002 respondents owned and used cooling devices at home. The majority(57.7%) perceived the potential health risk of climate change at a high level. However, risk perception had no relationship with ownership and utilization of cooling devices. Old people(≥ 65 years), the low-educated, those with low income, and those with chronic diseases were more likely not to use air conditioners when feeling *** findings suggest that there are no signs showing people have taken more protective actions although half of respondents recognized climate change as a threat. Familial economic condition may be a major determinant in ownership and use of air conditioners at home. Old people and those with chronic diseases are at high risk of adverse exposure to climate change and therefore should be equipped with appropriate measures to use cooling devices.

关键词： Climate change Domestic cooling device Heat wave health impact Hong Kong Risk perception

Drug Repurposing for the Treatment of Mycobacterium abscessus Infections

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感染微生物与疾病(英文) 2023年第3期5卷 101-110页

作者： emily J.Baker Antonia Molloy Jonathan A.G.Cox School of Life and Health Sciences Aston UniversityAston TriangleBirminghamUK.

With the ever-increasing burden of antimicrobial resistance,the demand to introduce countermeasures becomes increasingly *** urgency of this need is intensified by the void in antibiotic discovery,with the identification of novel compounds declining with *** increasing concern is Mycobacterium abscessus,which displays high levels of intrinsic resistance that lead to poor success rates,even after lengthy drug *** tackling these issues is now focused on the repurposing of preexisting drugs for antimycobacterial use,facilitating the discovery of antimicrobial compounds amidst a crisis where novel antibiotics are *** of this includes the use of combination treatments,whereby coadministration of synergistic compounds can reduce dose requirements and slow the progression of antimicrobial resistance in the long *** this review,we will introduce the current therapeutic options for *** and provide insight into why treatment is so *** will also compile the current updates within drug repurposing for this pathogen,including the use of unconventional agents such as antimalarial drugs,the repositioning of antitubercu-losis candidates and the repurposing of preexisting antibiotics,including the application of combination *** addition,the in vitro drug screening platforms used in their discovery will be appraised,with the view of highlighting potential future perspectives that may help increase physiological *** review provides a timely appraisal of the future of *** treatment.

关键词： drug repurposing Mycobacterium abscessus antimycobacterial drug discovery antimicrobials

Efficient Gene Targeting in Maize Using Inducible CRISPR-Cas9 and Marker-free Donor Template

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作者： emily Jane Fox.

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Molecular Plant 2020年第8期13卷 1219-1227页

作者： Pierluigi Barone emily Wu Brian Lenderts Ajith Anand William Gordon-Kamm Sergei Svitashev Sandeep Kumar Corteva AgriscienceTM JohnstonIA 50131USA

CRISPR-Cas9 is a powerful tool for generating targeted mutations and genomic ***,precise gene insertion or sequence replacement remains a major hurdle before application of CRISPR-Cas9 technology is fully realized in plant ***,we report high-frequency,selectable marker-free intra-genomic gene targeting(GT)in *** shock-inducible Cas9 was used for generating targeted double-strand breaks and simultaneous mobilization of the donor template from pre-integratad *** construct was designed such that release of the donor template and subsequent DNA repair activated expression of the selectable marker gene within the donor *** approach generated up to 4.7%targeted insertion of the donor sequence into the target locus in TO plants,with up to 86%detected donor template release and 99%mutation rate being observed at the donor loci and the genomic target site,*** previous in planta or intra-genomic homologous recombination reports in which the original chimeric GT plants required extensive progeny screening in the next generation to identify non-chimeric GT individuals,our method provides non-chimeric heritable GT in one generation.

关键词： donor template insertion

Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta

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Bone Research 2015年第1期3卷 40-45页

作者： Douglas J DiGirolamo Vandana Singhal Xiaoli Chang Se-Jin Lee emily L Germain-Lee Department of Orthopaedic Surgery Johns Hopkins University School of Medicine Bone & Osteogenesis Imperfecta Department Kennedy Krieger Institute Department of Molecular Biology and Genetics Johns Hopkins University School of Medicine Department of Pediatrics Johns Hopkins University School of Medicine

Osteogenesis imperfecta（OI） comprises a group of heritable connective tissue disorders generally defined by recurrent fractures, low bone mass, short stature and skeletal fragility. Beyond the skeletal complications of OI,many patients also report intolerance to physical activity, fatigue and muscle weakness. Indeed, recent studies have demonstrated that skeletal muscle is also negatively affected by OI, both directly and indirectly. Given the well-established interdependence of bone and skeletal muscle in both physiology and pathophysiology and the observations of skeletal muscle pathology in patients with OI, we investigated the therapeutic potential of simultaneous anabolic targeting of both bone and skeletal muscle using a soluble activin receptor 2B（ACVR2B） in a mouse model of type Ⅲ OI（oim）. Treatment of 12-week-old oim mice with ACVR2 B for 4 weeks resulted in significant increases in both bone and muscle that were similar to those observed in healthy,wild-type littermates. This proof of concept study provides encouraging evidence for a holistic approach to treating the deleterious consequences of OI in the musculoskeletal system.

关键词： bone Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta

Health Emergency and Disaster Risk Management (Health-EDRM) in Remote Ethnic Minority Areas of Rural China:The Case of a Flood-Prone Village in Sichuan

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International Journal of Disaster Risk Science 2017年第2期8卷 156-163页

作者： emily Ying Yang Chan Chunlan Guo Poyi Lee Sida Liu Carman Ka Man Mark Collaborating Centre for Oxford University and CUHK for Disaster and Medical Humanitarian Response (CCOUC) The Jockey Club School of Public Health and Primary CareThe Chinese University of Hong Kong Nuffield Department of Medicine University of Oxford FXB Centre of Health and Human Rights Harvard University

Remote,rural ethnic-minority communities face greater disaster-related public health risks due to their lack of resources and limited access to health *** Ethnic Minority Health Project(EMHP) was initiated in 2009 to work with remote,disaster-prone ethnic-minority villages that live in extreme *** of the project's aims is to develop and evaluate bottom-up health risk reduction efforts in emergency and disaster risk management(HealthEDRM).This article shares project updates and describes field intervention results from the Yi ethnic community of Hongyan village in China's Sichuan Province,an area that experiences recurrent *** was found that 64% of the village respondents had never considered any form of disaster preparation,even with the recurrent flood *** intervention participants showed sustained knowledge retention and were nine times more likely to know the correct composition of oral rehydration solution(ORS) after the *** also retained the improved knowledge on ORS and disaster preparedness kit ownership12 months after the intervention.

关键词： Disaster preparedness kit Disaster risk reduction Ethnic minority Health emergency and disaster risk management (Health-EDRM) Oral rehydration solution Recurrent floods Rural China

Impacts and challenges of United States medical students during the COVID-19 pandemic

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World Journal of Clinical Cases 2020年第15期8卷 3136-3141页

作者： Stacey Rolak Alexis M Keefe emily L Davidson Prabesh Aryal Sandesh Parajuli Department of Medicine University of Wisconsin School of Medicine and Public HealthMadisonWI 53705United States College of Medicine Nepalese Army Institute of Health SciencesKathmandu 44600Nepal Division of Nephrology Department of Internal MedicineUniversity of Wisconsin School of Medicine and Public HealthMadisonWI 53705United States

The delivery of medical student education has changed rapidly during the coronavirus disease 2019(COVID-19)*** in their pre-clinical years have transitioned to online courses and *** in their clinical years are not permitted on clinical rotations,and face uncertainties in career exploration and the residency application *** students in all stages of training are volunteering and helping their *** future presence of COVID-19 throughout the United States is unknown,and medical students are eager to return to their *** paper outlines current challenges in medical student education and the various responses that have been *** also discuss possible future directions for students through involvement in telemedicine,outpatient clinic visits,and non-respiratory inpatient care tasks as adequate personal protective equipment,COVID-19 testing,and resources become more widely available.

关键词： COVID-19 Education Medical students Telemedicine Healthcare delivery Schools