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Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats

Acta Pharmaceutica Sinica B 2014年第5期4卷 358-367页

作者： Aline Augusti Boligon Robson Borba de Freitas Thiele Faccim de Brum emily pansera waczuk Cláudia Vargas Klimaczewski Daiana Silva deÁvila Margareth Linde Athayde Liliane de Freitas Bauermann Department of Industrial Pharmacy Center of Health SciencesFederal University of Santa MariaSanta Maria 97105-900RSBrazil Department of Physiology and Pharmacology Center of Health SciencesFederal University of Santa MariaSanta Maria 97105-900RSBrazil Department of Biochemistry Federal University of PampaUruguaiana 97500-970RSBrazil

Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric *** buxifolia,commonly known as coronilha,has attracted the interest of the scientific community due to its pharmacological properties and its potential therapeutic *** this study,the preventive effects of the crude extract of Scutia buxifolia(ceSb)against gastric ulcer induced by 70%ethanol were evaluated in male Wistar *** addition,the composition of ceSb was clarified by high-performance liquid chromato-graphy(HPLC).*** extract(100,200 and 400 mg/kg body weight)attenuated oxidative and histopathological features induced by ***,all evaluated doses of ceSb caused significant(P<0.001 and P<0.0001)and dose-dependent increase in sulfhydryl groups(NPSH)levels,catalase(CAT)and superoxide dismutase(SOD)***,the administration of ceSb reversed the increase in lipid peroxidation produced by *** protective effect of the extract could be attributed to antioxidant compounds present in the ceSb,such as flavonoids and phenolic acids,which were quantified by ***,an antioxidant effect of the extract leads to a protection on gastric *** results indicate that *** could have a beneficial role against ethanol toxicity by preventing oxidative stress and gastric tissue injury.

关键词： Scutia buxifolia Antioxidant Gastric ulcer HPLC

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African eggplant(Solanum anguivi Lam.)fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca^(2+)-induced mitochondrial swelling

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Asian Pacific Journal of Tropical Biomedicine 2013年第10期3卷 757-766页

作者： Olusola Olalekan Elekofehinti Jean Paul Kamdem Aline Augusti Bolingon Margareth Linde Athayde Seeger Rodrigo Lopes emily pansera waczuk Ige Joseph Kade Isaac Gbadura Adanlawo Joao Batista Teixeira Rocha Department of Biochemistry Adekunle Ajasin UniversityAkungbaOndo StateNigeria Postgraduate Programme in Biochemical Toxicology Department of ChemistryCCNE.Federal University of Santa Maria.Campus CamobiSanta MariaRS.97105-900Brazil Postgraduate Programme in Pharmaceutical Sciences Federal University of Santa MariaCampus CamohiSanta MariaRS97105-900.Brazil Toxicologia de Produtos Naturais e Sinteticos.Universidade Federal do Pampa CEP 97500-970 UruguaianaRSBrazil Department of Biochemistry Federal University of TechnologyAkureOndo StateNigeria Department of Biochemistry University of Ado EkitiEkiti State.Nigeria

Objective:To evaluate the antioxidant and radical scavenging activities of Solanum anguivi fruit(SAG)and its possible effect on mitochondrial permeability transition pore as well as mitochondrial membrane potential(△Ψ_m)isolated from rat ***:Antioxidant activity of SAG was assayed by using 2,2-diphenyl-1-picrylhydrazyl(DPPH),reducing power,iron chelation and ability to inhibit lipid peroxidation in both liver and brain homogenate of ***,the effect of SAG on mitochondrial membrane potential and mitochondrial swelling were *** and quantification of bioactive polyphenolics was done by ***:SAG exhibited potent and concentration dependent free radical-scavenging activity(IC_(50)/DPPH=275.03±7.8μg/mL).Reductive and iron chelation abilities also increase with increase in SAG *** also inhibited peroxidation of cerebral and hepatic lipids subjected to iron oxidative *** protected against Ca^(2+)(110μmol/L)-induced mitochondrial swelling and maintained the△Ψ_*** analysis revealed the presence of gallic acid[(17.54±0.04)mg/g],chlorogenic acid(21.90±0.02 mg/g),caffeic acid(16.64±0.01 mg/g).rutin[(14.71±0.03)mg/g]and quercetin[(7.39±0.05)mg/g].Conclusions:These effects could be attributed to the bioactive polyphenolic compounds present in the *** results suggest that SAG extract is a potential source of natural antioxidants that may be used not only in pharmaceutical and food industry but also in the treatment of diseases associated with oxidative stress.

关键词： Solanum anguivi fruit Antioxidant activity Oxidative stress Mitochondrial swelling HPLC Polyphenolic compounds MPTP

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