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Stable femtosecond X-rays with tunable polarization from a laser-driven accelerator

Light(Science & Applications) 2017年第1期6卷 410-416页

作者： Andreas Döpp Benoit Mahieu Agustin Lifschitz Cedric Thaury Antoine Doche emilien guillaume Gabriele Grittani Olle Lundh Martin Hansson Julien Gautier Michaela Kozlova Jean Philippe Goddet Pascal Rousseau Amar Tafzi Victor Malka Antoine Rousse Sebastien Corde Kim Ta Phuoc Laboratoire d’Optique Appliquée ENSTACNRS UMR7639Ecole PolytechniqueChemin de la Hunière91761 PalaiseauFrance Present address:Ludwig-Maximilians-Universität München Fakultät für PhysikAm Coulombwall 1Garching 85748Germany ELI Beamlines Project Institute of Physics of the ASCRNa Slovance 218221 Prague 8Czech Republic Department of Physics Lund UniversityPO Box 11822100 LundSweden Department of Physics and Complex Systems Weizmann Institute of Science76100 RehovotIsrael

Technology based on high-peak-power lasers has the potential to provide compact and intense radiation sources for a wide range of innovative *** particular,electrons that are accelerated in the wakefield of an intense laser pulse oscillate around the propagation axis and emit *** betatron source,which essentially reproduces the principle of a synchrotron at the millimeter scale,provides bright radiation with femtosecond duration and high spatial ***,despite its unique features,the usability of the betatron source has been constrained by its poor control and *** this article,we demonstrate the reliable production of X-ray beams with tunable *** ionization-induced injection in a gas mixture,the orbits of the relativistic electrons emitting the radiation are reproducible and *** observe that both the signal and beam profile fluctuations are significantly reduced and that the beam pointing varies by less than a tenth of the beam *** polarization ratio reaches 80%,and the polarization axis can easily be *** anticipate a broad impact of the source,as its unprecedented performance opens the way for new applications.

关键词： laser-plasma interaction laser-wakefield acceleration synchrotron light sources

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2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling

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World Journal of Gastroenterology 2014年第48期20卷 18207-18215页

作者： emilien Loeuillard Julien Bertrand Anni Herranen Chloé Melchior Charlène Guérin Mo?se Co?ffier Moutaz Aziz Pierre Déchelotte guillaume Savoye Rachel Marion-Letellier INSERM UnitUMR1073 Rouen University and Rouen University HospitalRouen Cedex 76183 France Institute for Research and Innovation in Biomedicine University of Rouen Rouen Cedex 76183 France Department of Gastroenterology Rouen University Hospital Rouen Cedex 76183 France Nutrition Unit Rouen University Hospital Rouen Cedex 76183 France Department of Pathology Rouen UniversityHospital Rouen Cedex 76183 France

AIM:To investigate whether targeting proteasome might reverse intestinal fibrosis in ***:Chronic colitis was induced in rats by repeated administration of increasing dose of2,4,6-trinitrobenzene sulfonic acid(TNBS,15,30,45,60,60,60 mg)by rectal injection for 6 wk(from day0 to day 35),while control rats received the ***+bortezomib(BTZ)rats received intraperitoneal injections of BTZ twice weekly(from day 37 to day44)at a dose of 25 mg/kg,whereas the control and TNBS groups received the same amount of the *** scoring of inflammation and fibrosis was *** production of transforming growth factor(TGF)-βwas measured by *** fibrosisrelated proteins such as phospho-p38,phosphoSMAD2/3,Akt and peroxisome proliferator activated receptorγ(PPARγ)were studied by western *** of the tight junction proteins,occludin and claudin-1,were assessed by Western *** proteasome activities(chymotrypsin-like and trypsinlike activities)were ***:TNBS-treated rats had a higher colon weight/length ratio compared to control rats(P0.05).In contrast,bortezomib had no effect on other studied parameters such as fibrosis score,TGF-βsignaling,or tight junction expression(P>0.05 for all).CONCLU

关键词： Bortezomib Colitis Fibrosis Proteasome

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