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The Role of Institutional Investors in the Evolutionary Dynamics of Agro-food Enterprises

Chinese Business Review 2015年第2期14卷 61-71页

作者： Vincenzo Formisano Maria Fedele emanuela Antonucci University of Cassino and Southern Lazio Cassino Italy

The research topic is the one of public finance company whose core business is focused to support investment projects to overcome enterprises technological and structural gap. The research question is： If and how a public finance company is able to create and favor value creation processes sustainability for agro-food enterprises, highlighting the positive emerging externalities for different categories of stakeholders. They have results with particular evidences allow comparisons between the private investments and the support of institutional public investors. In such perspective, the mode of disbursement of soft loans and investment operations made by a public financing company will be examined. The methodological approach used, following a deductive-inductive perspective, is based on the ease study. Such technique able to formulate theories about a little known phenomena in their context, allows the study of recent events on which the researcher has little control. To this, a qualitative analysis on both primary and secondary data adds. From data analysis, it resulted that the Institute of Agribusiness Development （ISA） initiatives facilitated, just for example, the technological innovation of production department and consequent production capacity, the acquisition of production assets for row material processing and optimization of internal logistics, through an innovative automated warehouse. As a result, the case study finds sustainability at multiple levels reached by the activities promoted by ISA and the subsequent co-creation of value for stakeholders involved, small agro-food businesses innovation, and/or internationalization processes. As long as practical implications are concerned, such highlight the importance and the need for public and private institutions in their effort to continue to invest in projects to support the economy of the country. The originality of the paper lies in the proposed interpretation of more integrative paradigms （viable sy

关键词： public finance company shared value creation sustainability agro-food context investment projects

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Validating cone-beam computed tomography for peri-implant bone morphometric analysis

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Bone Research 2014年第2期2卷 103-109页

作者： Yan Huang Jeroen Van Dessel Maarten Depypere Mostafa EzEldeen Alexandru Andrei Iliescu emanuela Dos Santos Ivo Lambrichts Xin Liang Reinhilde Jacobs OMFS IMPATH Research Group Department of Imaging & Pathology Faculty of Medicine University of Leuven and Oral & Maxillofacial SurgeryUniversity Hospitals Leuven Leuven Belgium State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University ESAT/PSI Medical Image Computing KU Leuven Leuven Belgium Faculty of Dentistry UMF Craiova Romania School of Dentistry Pontifical Catholic University of Paraná Curitiba Brazil Biomedical Research Institute Hasselt University Diepenbeek Belgium School of Stomatology Dalian Medical University Dalian China

Cone-beam computed tomography （CBCT） has been recently used to analyse trabecular bone structure around dental implants. To validate the use of CBCT for three-dimensional （3D） peri-implant trabecular bone morphometry by comparing it to two-dimensional （2D） histology, 36 alveolar bone samples （with implants n=27 vs. without implants n=9） from six mongrel dogs, were scanned ex vivo using a high-resolution （80 ~m） CBCT. After scanning, all samples were decalcified and then sectioned into thin histological sections （-6 jim） to obtain high contrast 2D images. By using CTAn imaging software, bone morphometric parameters including trabecular number （Tb.N）, thickness （***）, separation （***） and bone volume fraction （BV/TV） were examined on both CBCT and corresponding histological images. Higher *** and ***, lower BV/TV and Tb.N were found on CBCT images （P〈0.001）. Both measurements on the peri-implant trabecular bone structure showed moderate to high correlation （r=0.65-0.85）. The Bland-Altman plots showed strongest agreement for *** followed by ***, Tb.N and BV/TV, regardless of the presence of implants. The current findings support the assumption that peri-implant trabecular bone structures based on high-resolution CBCT measurements are representative for the underlying histological bone characteristics, indicating a potential clinical diagnostic use of CBCT-based peri-implant bone morphometric characterisation.

关键词： bone CBCT

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Semen analysis in chronic bacterial prostatitis： diagnostic and therapeutic implications

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Asian Journal of Andrology 2009年第4期11卷 461-477页

作者： Vittorio Magri Florian M. E. Wagenlehner Emanuele Montanari emanuela Marras Viviana Orlandi Antonella Restelli Erminio Torresani Kurt G. Naber Gianpaolo Perletti Urology and Sonography Primary Care Clinic Hospital：＂Istituti Clinici di Perfezionamento＂ Milano 20100 Italy Department of Urology and Pediatric Urology Justus-Liebig-University Giessen 35390 Germany Third Urological Clinic San Paolo Hospital University of Milan Milan 20142 Italy Laboratory of Toxicology and Pharmacology Department of Structural and Functional Biology University of Insubria Busto A. 21052 Italy Laboratory of Molecular and Environmental Microbiology Department of Structural and Functional Biology University of lnsubria Varese 21100 Italy Microbiology Unit Hospital：＂Osp. Maggiore Policlinico Mangiagalli Regina Elena＂ Milano 20122 Italy Technical University Munich Munich 80333 Germany

The significance and diagnostic value of semen analysis in chronic bacterial prostatitis has been extensively debated and remains controversial. To investigate the diagnostic relevance of semen culture in the bacteriological workup of prostatitis patients, we retrospectively analyzed a clinical database of 696 symptomatic patients. All patients were routinely subjected to a four-glass test, followed by semen culture and analysis. This allowed to dissect from the database three different diagnostic scenarios, and to compare the ＇two-glass＇ pre-/post- massage test and the standard ＇four-glass＇ test with a ＇five-glass＇ test （four-glass plus post-VB3 semen culture）. The ＇five-glass＇ test showed 3.6- or 6.5-fold increases in relative sensitivity and lesser reductions （-13.2% or -14.7%） in relative specificity for traditional uropathogens （TUs） compared with the four-glass or two-glass test, respectively. The area under the ROC curve and Jouden＇s index were increased, whereas positive and negative likelihood ratios were lower than comparators, indicating that the ＇five-glass＇ assay may be superior in confirming the negative outcome of both standard tests. The five-, four-, and two-glass tests detected TUs （Enterobacteriaceae, Enterococci, etc.） in 120, 33, and 20 patients and unusual pathogens （Streptococci, other Gram-positive species, Mycoplasmata, and others） in 130, 56, and 45 patients, respectively. When patients were subjected to pharmacological treatment, including a combination of a fluoroquinolone and a macrolide, no differences in eradication rates were observed between groups diagnosed with different tests, irrespective of pathogen category. Eradication was associated with long-term sign/symptom remission; no significant intergroup differences in sign/symptom scores were observed throughout a 24-month off-therapy follow-up period. In conclusion, our data support the usefulness of semen analysis in the diagnostic workup ofprostatitis patients when this test is u

关键词： alfuzosin azithromycin chronic bacterial prostatitis chronic pelvic pain syndrome ciprofloxacin Meares and Stamey test National Institutes of Health Chronic Prostatitis Symptom Index prostatitis semen analysis seminal fluid Serenoa repens

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Performance Analysis of a Woodchip Downdraft Gasifier： Numerical Prediction and Experimental Validation

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Journal of Energy and Power Engineering 2015年第4期9卷 336-347页

作者： emanuela Manzino Daniela Olampi Ferruccio Pittaluga Department of Mechanical Energy Management and Transportation Engineering The University of Genova Savona 17100 Italy

The study deals with a multi-faceted theoretical approach, symbolic, analytical and numerical, based on the chemical equilibrium assumption, addressed at predicting the performance trends of downdrafi wood-gasification processes so to assess the optimal ranges of input parameters, in particular the equivalence ratios, suitable to achieving the highest cold gas efficiencies whilst keeping the more the possible tar-free the produced bio-syngas. The time-steady, zero-dimensional model has been developed within MATLAB （the computing language and interactive environment from Matrix Laboratory） and solved by enforcing the constraints posed by the equilibrium constants in relation to two reactions, gas-water shift and methanation. Particular care is devoted toward verifying the real attainment of the equilibrium condition, as attested by an actual presence of products from the equilibrium reactions together with a zero difference AE between the energy flows entering and exiting the system, an issue often overlooked. With respect to other similar theoretical approaches, the numerical model, assisted by the symbolic counterpart for better interpretation and intrinsic validation of results, shows a distinct advantage in predicting rather accurately the syngas composition for varying gasification temperatures, as attested by cross comparisons with experimental data directly taken on an instrumented, dedicated, small-scale downdraft gasifier operational at DIME/SCL （the Savona Combustion Laboratory of DIME, the Dept. of Mechanical, Energy, Management and Transportation Engineering of Genova University）. The behavior of cold gas efficiency clearly points out that, from an energy conversion point of view, the optimal gasification temperatures turn out comprised between 900 ℃ and 1,000 ℃： this range is indeed characterized by the highest concentrations in the energy-rich syngas components CO and H2. For higher temperatures, as induced by higher air-to-fuel ratios, the progressive

关键词： Downdraft gasifier woodchip gasification equilibrium chemistry MATLAB simulation.

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Michela Benaglia&emanuela Colombo/盒子里的披头士

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摄影之友 2023年第7期 76-85页

作者：健一 Michela Benaglia(图) emanuela Colombo(图) 不详

在西班牙凉菜汤中加入蟋蟀或用蜜蜂蛾制作炸玉米饼的想法可能会让我们大多数人感到局促不安。但面对未来日益严重的食物短缺,昆虫可能很快就会成为厨房的主食。两位来自意大利的摄影师用镜头探讨了昆虫和食品在未来的联系。

关键词：面对未来摄影师西班牙

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Physical and psychological condition of senior people in a residential care facility. The effects of an aerobic training

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Health 2010年第7期2卷 773-780页

作者： emanuela Rabaglietti Liubicich Monica Emma Ciairano Silvia 不详

The present study is aimed at investigating the changes between pre-test and post-test, after having introduced an aerobic programme of physical activity (one session, each of 45’ per week for 15 weeks, over a span of roughly four months, delivered by specially trained instructor), in the psychological situation (perception of general health, feelings of geriatric depression) and physical condition (activities of daily living, physical performance in terms of balance and gait, weight, and body mass index–BMI) of a group of senior citizens slightly compromised at Mini Mental State Examination (MMSE: median 23) and living in a residential care facility in northern Italy. The 36-Item Short Form Health Survey Questionnaire (SF-36), the Geriatric Depression Scale (GDS), the Italian short version of Barthel's Index of Activities of Daily Living (BADL), the Tinetti Assessment Tool were administered to 18 old men and women (median age 85.50 years). The findings (we used non- parametric statistical techniques) showed that: 1) general health perception, feelings of depression, and activities of daily were stable;2) general physical performance, and particularly the balance, increased between pre-test and post-test, while weight, BMI and waist circumference decreased. These results underline the importance, especially in the case of women, of participating at an aerobic training delivered by experienced instructors for the physical condition of senior citizens, also when they are slightly cognitively compromised.

关键词： Senior People Training Physical and Psychological Condition

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Carbon and nitrogen mineralization in soil of leguminous trees in a degraded pasture in northern Rio de Janeiro, Brazil

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Journal of Forestry Research 2016年第1期27卷 91-99页

作者： Danielle A. D. Nunes emanuela F. Gama-Rodrigues Patricia A. B. Barreto[ Antonio C. Gama-Rodrigue Paulo H. M. Monroe Chemistry School Rio de Janeiro Federal UniversityRio de Janeiro RJ 21941-909 Brazil Soil Laboratory North Fluminense State UniversityCampos dos Goytacazes RJ 28013-602 Brazil Department of Soil and Agricultural Engineering State University of Southwest Bahia Vitoda da ConquistaBA 45031-300 Brazil

Use of legume trees can improve soil quality in degraded pastures. The aim of this study was to charac- terize C and N mineralization kinetics and estimate the potentially mineralizable C and N in soil under Mimosa caesalpiniifolia Benth. and Acacia auriculiformis A. Cunn. ex Benth. secondary forest and pasture in red-yellow latosols in southeast Brazil. We conducted a laboratory aerobic incubation experiment using a completely ran- domized design of four replicates and four types of plant cover using a modified version of the Stanford and Smith technique （1972） to study C and N mineralization potential. Potentially mineralizable N （No） ranged from 135 to 170 mg kg-1. The predominant form of mineral N for all types of plant cover was N-NO3-. M. caesalpiniifolia was the only species that had a positive influence on N min- eralization. Neither of the legumes influenced C mineral- ization in pasture or secondary forest. The model of N mineralization corresponded to a sigmoidal curve while C mineralization corresponded to an exponential curve, revealing that the N and C mineralization processes were distinct. N mineralized by M. caesalpiniifolia （216 kg ofN ha-1） was adequate to meet the N requirement for a livestock-forest system.

关键词： Carbon dioxide Forest soil Mineralized N Organic matter Soil microorganisms

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Loss of HER2 in breast cancer: biological mechanisms and technical pitfalls

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Cancer Drug Resistance 2022年第4期5卷 971-980页

作者： Stefania Morganti Mariia Ivanova emanuela Ferraro Liliana Ascione Grazia Vivanet Giuseppina Bonizzi Giuseppe Curigliano Nicola Fusco Carmen Criscitiello Division of Early Drug Development for Innovative Therapies IEOEuropean Institute of Oncology IRCCSMilan 20144Italy Department of Oncology and Haemato-Oncology University of MilanoMilan 20122Italy Breast Oncology Center Dana-Farber Cancer InstituteBostonMA 02215USAHarvard Medical SchoolBostonMA 02215USA Biobank for Translational and Digital Medicine Unit IEOEuropean Institute of Oncology IRCCSMilan 20144Italy Division of Pathology IEOEuropean Institute of Oncology IRCCSMilan 20144Italy Breast Medicine Service Department of MedicineMemorial Sloan Kettering Cancer CenterNew YorkNY 10065USA.

Loss of HER2 in previously HER2-positive breast tumors is not rare, occurring in up to 50% of breast cancers;however, clinical research and practice underestimate this issue. Many studies have reported the loss of HER2 afterneoadjuvant therapy and at metastatic relapse and identified clinicopathological variables more frequentlyassociated with this event. Nevertheless, the biological mechanisms underlying HER2 loss are still poorlyunderstood. HER2 downregulation, intratumoral heterogeneity, clonal selection, and true subtype switch have beensuggested as potential causes of HER2 loss, but translational studies specifically investigating the biology behindHER2 loss are virtually absent. On the other side, technical pitfalls may justify HER2 loss in some of these *** best treatment strategy for patients with HER2 loss is currently unknown. Considering the prevalence of thisphenomenon and its apparent correlation with worse outcomes, we believe that correlative studies specificallyaddressing HER2 loss are warranted.

关键词： HER2 loss breast cancer subtype switch tumor heterogeneity clonal selection HER2 downregulation technical pitfalls

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Opportunities and challenges of implementing Pharmacogenomics in cancer drug development

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Cancer Drug Resistance 2019年第1期2卷 43-52页

作者： Paolo Tarantino Dario Trapani Stefania Morganti emanuela Ferraro Giulia Viale Paolo D’Amico Bruno Achutti Duso Giuseppe Curigliano Division of Early Drug Development for Innovative Therapies IEOEuropean Institute of Oncology IRCCSMilan 20141Italy Department of Oncology and Haematology(DIPO) University of MilanMilan 20122Italy

Cancer drug development is a time and resources consuming *** 90%of drugs entering clinical trials fail due to lack of efficacy and/or safety issues,more often after conspicuous research and economic *** of the discarded drugs might be beneficial only in a subgroup of the study patients,and some adverse events might be prevented by identifying those patients more vulnerable to *** implementation of pharmacogenomic biomarkers allows the categorization of patients,to predict efficacy and toxicity and to optimize the drug development *** seventy FDA approved drugs currently present one or more genetic biomarker to keep in consideration,and with the progress of Precision Medicine tailoring therapies on individuals’genomic landscape promises to become a new standard of cancer *** the current article we review the role of pharmacogenomics in cancer drug development,underlying the advantages and challenges of their implementation.

关键词： Pharmacogenomics cancer drug development precision medicine clinical trials

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Pattern of triptans use: a retrospective prescription study in Calabria, Italy

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Neural Regeneration Research 2020年第7期15卷 1340-1343页

作者： Damiana Scuteri Annagrazia Adornetto Laura Rombolà Maria Diana Naturale Adele emanuela De Francesco Stefania Esposito Mariacristina Zito Luigi Antonio Morrone Giacinto Bagetta Paolo Tonin Maria Tiziana Corasaniti Preclinical and Translational Pharmacology Department of PharmacyHealth Science and NutritionUniversity of CalabriaCosenzaItaly School of Hospital Pharmacy University"Magna Graecia"of CatanzaroCatanzaroItaly Pharmacy Unit "Mater Domini"University HospitalCatanzaroItaly Regional Center for Serious Brain Injuries S.Anna InstituteCatanzaroItaly Department of Health Sciences University"Magna Graecia"of CatanzaroCatanzaroItaly

Triptans are 5-hydroxytryptamine 1 B/1 D receptor agonists used in moderate to severe migraine attacks as first line when non-specific,symptomatic,nonsteroidal anti-inflammatory drugs are not *** gain insight in the treatment of migraine in the regional context,this retrospective(from January to August of the years 2017 and 2018)study aimed at monitoring the use of triptans approved by the regional health authority in *** data demonstrate that the overall treatment of migraine with triptans in the different provinces of Calabria falls in the average regional prescription/***,Crotone showed a trend to an increased amount of defined daily dose/1000 inhabitants per *** present analysis might stand for homogeneity of treatment of migraineurs in Calabria and highlights the need for better understanding the apparent differences in the local pattern of almotriptan use to improve the appropriateness.

关键词： 5-HT 1B/1D receptor agonists almotriptan Calabria DDD/1000 inhabitants per day migraine pharmacoepidemiology pharmacology of migraine prescriptions treatment triptans

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