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Hepatic and gastrointestinal disturbances in Egyptian patients infected with coronavirus disease 2019: A multicentre cohort study

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World Journal of Gastroenterology 2021年第40期27卷 6951-6966页

作者： Hend Ibrahim Shousha Shimaa Afify Rabab Maher Noha Asem eman Fouad Ehab F Mostafa Mohammed A Medhat Amr Abdalazeem Hazem Elmorsy Miriam M Aziz Rateba S Mohammed mohamed Ibrahem Hassan Elgarem Dalia Omran mohamed Hassany Bassem Elsayed Ahmed Y Abdelaziz mohamed El Kassas Endemic Medicine Faculty of MedicineCairo UniversityCairo 11562Egypt Gastroenterology Department National Hepatology&Tropical Medicine Research InstituteCairo 11563Egypt Hepatology Department Students HospitalCairo UniversityGiza 12566Egypt The Public Health Department Faculty of MedicineCairo UniversityCairo 11562Egypt Egyptian Ministry of Health and PopulationCairo 11567Egypt Department of Tropical Medicine and Gastroenterology Faculty of MedicineAssiut UniversityAssiut 15655Egypt Endemic Medicine Department Faculty of MedicineHelwan UniversityCairo 13544Egypt Internal Medicine 15 Mayo Smart HospitalMinistry of Health and PopulationCairo 13488Egypt Pediatrics Department Faculty of MedicineCairo UniversityCairo 11562Egypt Occupational and Environmental Medicine Department Faculty of MedicineCairo UniversityCairo 11562Egypt Clinical Biochemistry Department Faculty of medicineCairo UniversityCairo 11562Egypt Endemic Medicine Department Faculty of MedicineCairo UniversityCairo 11562Egypt Urology Department Cairo UniversityCairo 11562Egypt

BACKGROUND Various liver and gastrointestinal involvements occur in patients with coronavirus disease 2019(COVID-19)at variable *** studies report mild liver function disturbances correlated with COVID-19 severity,though liver failure is *** To study liver and gastrointestinal dysfunctions in Egyptian patients with COVID-19 and their relation to disease outcomes METHODS This multicentre cohort study was conducted on 547 Egyptian patients from April 15,2020 to July 29,*** polymerase chain reaction-confirmed COVID-19 cases were included from four quarantine hospitals affiliated to the Egyptian ministry of *** information,laboratory characteristics,treatments,fibrosis-4(FIB-4)index,COVID-19 severity,and outcomes were recorded and compared according to the degree of liver enzyme elevation and the presence of gastrointestinal ***-ups were conducted until discharge or *** analyses were performed to determine the independent factors affecting *** This study included 547 patients,of whom 53(9.68%)died during hospitalization and 1 was discharged upon his ***’mean age was 45.04±17.61 years,and 21.98%had severe or critical *** aminotransferase(ALT)and aspartate aminotransferase(AST)were available for 430 and 428 patients,*** total,26%and 32%of patients had elevated ALT and AST,*** liver injury with ALT or AST elevation exceeding 3-fold was recorded in 21(4.91%)and 16(3.73%)patients,*** gender,smoking,hypertension,chronic hepatitis C,and lung involvement were associated with elevated AST or *** was elevated in 50%of patients over ***-4 was significantly higher in patients admitted to the intensive care unit(ICU),those with more severe COVID-19,and *** independent variables affecting outcome were supplementary vitamin C intake(1 g daily capsules)[odds ratio(OR):0.05,95%confidence interval(CI

关键词： COVID-19 Egypt Liver injury Gastrointestinal symptoms Fibrosis-4 Liver enzymes

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Regression of hepatic fibrosis after pharmacological therapy for nonalcoholic steatohepatitis

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第6期15卷 18-27页

作者： mohamed Abdel-Samiee Essam Salah Ibrahim mohamed Kohla eman Abdelsameea Mohsen Salama Department of Hepatology and Gastroenterology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt Department of Medicine RCSI Medical University of BahrainAdliya 15503Bahrain

The global incidence of nonalcoholic fatty liver disease(NAFLD)is escalating *** covers a range of liver conditions from simple steatosis to the more severe form known as nonalcoholic steatohepatitis,which involves chronic liver inflammation and the transformation of hepatic stellate cells into myofibroblasts that generate excess extracellular matrix,leading to *** ballooning is a key catalyst for fibrosis progression,potentially advancing to cirrhosis and its decompensated *** is a critical prognostic factor for outcomes in patients with NAFLD;therefore,those with substantial fibrosis require timely *** liver biopsy is the most reliable method for fibrosis detection,it is associated with certain risks and limitations,particularly in routine ***,various noninvasive diagnostic techniques have been *** review examines the increasing prevalence of NAFLD,evaluates the noninvasive diagnostic techniques for fibrosis,and assesses their efficacy in staging the *** addition,it critically appraises current and emerging antifibrotic therapies,focusing on their mechanisms,efficacy,and potential in reversing *** review underscores the urgent need for effective therapeutic strategies,given the dire consequences of advanced fibrosis.

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Myofibroblasts Fibrosis Antifibrotic pharmacotherapy Nonalcoholic fatty liver disease treatment strategies Emerging treatments for nonalcoholic steatohepatitis

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Study on the Mediterranean coastal seaweed Ulva linza exposed to natural and stressed environmental conditions

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Journal of Coastal Life Medicine 2015年第10期 766-775页

作者： Ayman Abd Elmoneim El-Gamal eman mohamed Fakhry Dahlia mohamed El-Maghraby Department of Marine Geology Coastal ResearchInstituteNational Water Research Center15El-Pharanna StreetEl-Shallalat21514 AlexandriaEgypt Department of Botany and Microbiology Faculty of ScienceAlexandria University21511 AlexandriaEgypt

Objective:To study Ulva linza(***)as macro-alga exposed to different levels of ionizing radiation from the natural background of ***:Samples of *** were collected from two different habitats at the two terminals of the rocky shore of Abu Qir Bay,Alexandria,*** western terminal at Abu Qir represented an area of normal background radiation while the eastern terminal at Rosetta represented an area of relatively high background *** between the algae grown in areas of relatively high and normal background radiation was investigated by using different ***,the ambient water quality was measured and the concentrations of natural radionuclides(^(238)U,^(232)Th and^(40)K)bio-accumulated in the tested macro-alga were ***:The algae naturally exposed to radionuclides(^(238)U series,^(232)Th series and^(40)K)were *** dose rates in *** inhabiting in Rosetta and Abu Qir were calculated as 70.12 and 42.67 nGy/h,*** analysis of algal samples demonstrated that total pigment contents were 2.21 and 2.19 mg/g on a fresh weight basis for *** inhabiting in Rosetta and Abu Qir,*** acid compositions showed comparable profiles for both algal samples with saturated fatty acids as major *** results of protein profiles confirmed slight differential expression in protein ***-related randomly amplified polymorphic DNA provided evidence that both samples were strongly *** using transmission electron microscopy,no obvious ultra structural changes in the examined cells were ***:These experimental results demonstrate that radiation doses are not high enough to cause damage or manifest any significant variation in Ulva tissues.

关键词： Ulva linza Radionuclides Protein profile Random amplified polymorphic DNA Electron microscopy

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Correlations between serum kidney injury molecule-1,cystatin C and immunosuppressants:A cross-sectional study of renal transplant patients in Bahrain

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Journal of Biomedical Research 2024年第3期38卷 269-277页

作者： Kannan Sridharan Shamik Shah Mona Al Hammad Fatima Ali Mohammed Sindhan Veeramuthu Mona Abdulla Taher Mustafa mohamed Hammad Lamees Jawad eman Farid Department of Pharmacology and Therapeutics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Department of Nephrology Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Internal Medicine College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Salmaniya Medical Complex ManamaKingdom of Bahrain Department of Laboratory Medicine Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Microbiology Immunologyand Infectious DiseasesCollege of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain

Renal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for *** creatinine is the standard for monitoring kidney function;however,cystatin C(Cys C)and kidney injury molecule-1(KIM-1)have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney ***,we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil,tacrolimus,sirolimus,everolimus,or cyclosporine to evaluate kidney *** used both the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)2021 equation,which is based on creatinine and combined creatinine with Cys C,and the CKD-EPI 2012 equation,which is based on Cys C alone,to estimate glomerular filtration rate(GFR).Then,we assessed the association between serum KIM-1 and GFR<90 mL per minute per 1.73 *** observed significantly higher serum Cys C levels in patients with the elevated serum creatinine,compared with those with normal serum *** estimated GFRs based on creatinine were significantly higher than those based on the other equations,while a significant positive correlation was observed among all *** KIM-1 levels were negatively correlated with the estimated GFRs by the CKD-EPI Cys C and the combined creatinine with Cys C equations.A serum KIM-1 level above 0.71 ng/mL is likely to indicate GFR<90 mL per minute per 1.73 *** observed a significant correlation between serum creatinine and Cys C in our renal transplant ***,serum KIM-1 may be used to monitor renal function when using potentially nephrotoxic drugs in renal transplants.

关键词： KIM-1 cystatin C mycophenolate mofetil tacrolimus everolimus sirolimus cyclosporine

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Catalyst Free Synthesis of Pyridine-2,6-bis(2-bromo-propane-1,3-dione) and Pyrdine-2,6-bis(<i>N</i>-arylthiazoline-2-thiones)

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Green and Sustainable Chemistry 2015年第1期5卷 39-45页

作者： Korany A. Ali mohamed A. Elsayed eman Ali Ragab Applied Organic Chemistry Department National Research Centre Dokki-Giza Egypt Department of Chemistry Faculty of Science Cairo University Giza Egypt

We have described herein a catalyst-free preparation method of pyridine-2,6-bis(N-alkylthiazoline-2-thiones) (4a-i) by the reaction of primary amines, CS2, and pyridine-2,6-bis(2-bromo-1,3- dicarbonyl) derivatives (2a-c) in water. Also, we have described a catalyst free, green chemistry protocols to monobromination of pyridine-2,6-bis(2-bromo-1,3-dicarbonyl) derivatives with high yield, using NBS as a brominating agent, that led to eco-friendly isolation and purification proce-dures. Furthermore, we have studied the reactivity of pyridine-2,6-bis(2-bromo-1-methyl-pro- pane-1,3-dione) (2a) towards thiourea to afford 2,6-bis(5-benzoyl-2-aminothiazol-4-yl)pyridine (9).

关键词： N-Alkylthiazoline-2-Thiones Catalyst-Free Reactions Monobromination 2 6-Disubstituted Pyridine

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Exploring the anti-inflammatory bioactive metabolites of some marine algae through integration of metabolomics,network pharmacology and molecular docking analyses

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Food Bioscience 2022年第6期50卷 861-874页

作者： Dina S.Ghallab eman Shawky Doaa A.Ghareeb Shaymaa A.Abdulmalek Soad M.Mohy El-Din mohamed M.Mohyeldin Reham S.Ibrahim Department of Pharmacognosy Faculty of PharmacyAlexandria UniversityEgypt Center of Excellency for Preclinical Study (CE-PCS) Pharmaceutical and Fermentation Industries Development CentreCity of Scientific Research and Technological ApplicationsSRTA-CityNew Borg El-Arab CityAlexandriaEgypt Bio-screening and Preclinical Trial Lab Biochemistry DepartmentFaculty of ScienceAlexandria UniversityAlexandriaEgypt Biochemistry Department Faculty of ScienceAlexandria UniversityAlexandriaEgypt Botany and Microbiology Department Faculty of ScienceAlexandria UniversityAlexandria21511Egypt

Marine algae are well-acknowledged as a prime store of largely unexplored extraordinary chemical entities potentially ameliorating against inflammation however,the efficacy mechanism remains *** study offers an integrated strategy of several bioinformatics and computational tools as well as bio-guided fractionation,and multi-step experimental validations integrated with metabolomics to systematically provide a shortcut of potentially active anti-inflammatory biomarkers of ***,multi-level network model of“multi-components-multi-targets-multiple pathways”was ***,an in vitro anti-inflammatory testing was estimated via monitoring release of pro-inflammatory ***-guided fractionation of *** integrated with UPLC-MS analysis of the most promising enriched fractions in terms of anti-inflammatory efficacy were *** docking studies on the top enriched targets were ultimately ***-level network analysis illuminated that the intricate pharmacological mechanisms underlying inflammation mitigation was the knockout of the crucial targets of TLR2,AKT1 and PRKCA and further regulation of principal pathways as PI3K-Akt signaling pathway,arachidonic acid(AA)metabolism and Toll-like receptor signaling *** vitro testing,*** exhibited the greatest ***-MS analysis of Spirulina active fractions showed linolenic acid,hydroxy linolenic acid,eicosapentaenoic acid,catechin and carnosic acid were efficacy constituents for mitigating *** docking showed that eicosapentaenoic,hydroxy linolenic acid and carnosic acid displayed favorable molecular binding capacity to TLR2,AKT1 and *** rationally developed workflow offered the convincing evidence marine algae armed with an arsenal of weapons to regain the harmony disturbed in inflammatory disorders by multi-targeted synergistic functions.

关键词： Bioinformatics Seaweeds Network pharmacology Molecular docking Metabolomics

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Colorectal cancer in Arab world:A systematic review

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1791-1798页

作者： Nahed A Makhlouf Muhammad Abdel-Gawad Aya M Mahros Sameh A Lashen Mariam Zaghloul Ahmed Eliwa eman E Elshemy Zainab Ali-Eldin Doaa Abdeltawab Fathiya El-Raey Dalia Omran Marwa Khalaf Nancy Fanous Ahmed Shawkat Abdelmohsen Ahmed Abu-Elfatth mohamed Abdelghani Mahmoud Farouk mohamed Abdelaziz mohamed Alboraie Department of Tropical Medicine and Gastroenterology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Department of Hepatology Gastroenterologyand Infectious DiseasesAl-Azhar UniversityAssiut 71631Egypt Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafrelsheikh 33656Egypt Department of Internal Medicine Alexandria UniversityAlexandria 21521Egypt Department of Internal Medicine Al-Azhar UniversityCairo 11884Egypt Department of Hepatogastroenterology and Infectious Diseases Al-Azhar UniversityCairo 11651Egypt Department of Internal Medicine Ain Shams UniversityCairo 11646Egypt Department of Hepatogastroenterology and Infectious diseases Faculty of MedicineAl-Azhar UniversityDamietta 34511CairoEgypt Department of Endemic Medicine Cairo UniversityCairo 12613Egypt Department of Tropical Medicine and Gastroenterology Assiut Liver CenterAssiut 71511Egypt Department of Gastroenterology Hepatology and EndoscopyPolice Authority HospitalCairo 12654Egypt Department of Clinical Oncology and Nuclear Medicine Al-Azhar UniversityCairo 11824Egypt

BACKGROUND The incidence of colorectal cancer(CRC)is increasing among young individuals in the Arab world as well as in other regions of the *** To explore the incidence and prevalence of CRC in the Arab *** The PubMed,Scopus,Web of Science,EBSCO and Wiley databases were searched to retrieve relevant articles irrespective of the language or the publication *** search terms were("colon OR rectum OR sigmoid OR rectal OR colonic OR colorectal")AND("cancer OR malignancy OR malignant OR neoplasm")AND("Jordan"OR"United Arab Emirates"OR"Bahrain"OR"Tunisia"OR"Algeria"OR"Djibouti"OR"Saudi Arabia"OR"Sudan"OR"Syria"OR"Somalia"OR"Iraq"OR"Oman"OR"Palestine"OR"Qatar"OR"Comoros"OR"Kuwait"OR"Lebanon"OR"Libya"OR"Egypt"OR"Morocco"OR"Mauritania"OR"Yemen").Reviews,metaanalyses,and articles containing nonoriginal data were *** articles were screened,and relevant data were *** statistics were used for data *** Nine studies were *** of the studies provided information regarding the prevalence of *** prevalence of CRC was 0.72% in Saudi Arabia and 0.78% in the United Arab Emirate,while in Egypt,it ranged from 0.4% to 14%.Four studies showed information regarding the *** annual incidence rate of CRC in Qatar was 7.5/100000/*** Egypt,the crude incidence rate(CIR)in males was 3.1 for colon cancer and 1 for rectal cancer,while in females,it was 2.3 for colon cancer and 0.8 for rectal *** age-standardized rate for CRC incidence in 2003 was 36.90 for males,26.50 for females,and 30.49 for both sexes in Saudi *** 2016,the CIRs in Saudi Arabia were 3.6 and 2.1 in females for colon cancer and rectal cancer,respectively,while in males,it was 3.3 and 2.8 for colon cancer and rectal cancer,*** study in Egypt revealed that 25% of CRC cases occurred among individuals younger than 40 years *** There is a considerable prevalence of CRC in some Arab *** studies are n

关键词： Colorectal cancer Incidence Prevalence Arab world

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Study of the Central Heavy-Ion Collision with Emulsion at 4.5 A GeV/c

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Journal of Modern Physics 2011年第7期2卷 669-674页

作者： Alblomy Abd El-Daiem mohamed abdo Khalifa Atef Abdel-hafiez 不详

We have investigated the main experimental characteristics(multiplicity correlation ,angular distributions and the analysis of emission of the shower particles produced at target fragments in central collisions of 28Si+AgBr at 4.5AGeV/c has shown a formation of hadronic and baryonic clusters. Events of central collisions are defined, here, as those having no projectile charged fragments, even a singly charged one, emitted within 30 of the beam direction.

关键词： Multiplicity Correlation Multiplicity Distributions Hadronic Clusters Baryonic Clusters

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Dapagliflozin as an oral antihyperglycemic agent in the management of diabetes mellitus in patients with liver cirrhosis

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World Journal of Experimental Medicine 2024年第4期14卷 147-158页

作者： Zeinab Seif El-Din Mohammed Afify Essam Zayed Dalia Elsabaawy El Sayed Tharwa Ahmed Elsharawy eman Abdelsameea mohamed Akl Rady Department of Hepatology and Gastroenterology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt Department of Clinical Pharmacy Pharmacy CollegeMenoufia UniversityShebin El-Kom 32511Egypt Department of Clinical Pathology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt

BACKGROUND The use of dapagliflozin in patients with cirrhosis has been relatively restricted due to concerns regarding its overall safety and pharmacological profile in this *** To determine the safety and effectiveness of dapagliflozin in the co-management of diabetes mellitus and cirrhosis with or without *** The patients studied were divided into two groups:100 patients in the control group received insulin,while 200 patients received *** patients were classified as Child A,B,or C based on the Child–Pugh *** A or B and Child C were administered doses of 10 mg and 5 mg of dapagliflozin,*** The rate of increased diuretics dose was markedly elevated in the group that received insulin compared to the group that received *** addition,dapagliflozin treatment substantially reduced weight,body mass index,and fasting blood glucose compared to the insulin group during ***,there were no significant differences in hemoglobin A1c,liver function,or laboratory investigations between both groups during the follow-up *** incidence of hypoglycemia,hepatic encephalopathy,variceal bleeding,and urinary tract infection was significantly higher in the insulin group compared to the dapagliflozin *** contrast,the dapagliflozin group experienced significantly higher rates of frequent urination and *** addition,the insulin group exhibited a marked worsening of ascites compared to the dapagliflozin *** Dapagliflozin demonstrated safety and efficacy in the treatment of diabetic patients who have cirrhosis with or without *** resulted in an improvement of ascites,as well as a decrease in diuretic dose and Child–Pugh score.

关键词： Dapagliflozin Cirrhosis Diabetes mellitus Hemoglobin Liver diseases

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Cordial Labeling of Corona Product of Path Graph and Second Power of Fan Graph

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Open Journal of Discrete Mathematics 2021年第2期11卷 31-42页

作者： Ashraf Ibrahim Hefnawy Elrokh Shokry Ibrahim mohamed Nada eman mohamed El-Sayed El-Shafey Department of Math Faculty of Science Menoufia University Shebeen El-Kom Egypt Department of Math Faculty of Science El-Azhar University Cairo Egypt

A graph is said to be cordial if it has 0 - 1 labeling which satisfies particular conditions. In this paper, we construct the corona between paths and second power of fan graphs and explain the necessary and sufficie... 详细信息

关键词： Corona Second Power of Fan Cordial Graph

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