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Launching a paradigm for first and redo-surgery in primary congenital glaucoma: institutional experience

International Journal of Ophthalmology(English edition) 2019年第2期12卷 226-234页

作者： Tharwat H.mokbel eman m.El Hefney Sherein m.Hagras Amani E.Badawi manal A.Kasem Ahmed A.Al Nagdy Sherief E.El Khouly Walid m.Gaafar mansoura Ophthalmic Center Faculty of Medicine Mansoura University

AIm: To evaluate the outcome of the initial and the redo-surgeries for primary congenital glaucoma(PCG) correlated to its degree of severity. mETHODS: A retrospective study involved patients with PCG presented between 2010 and 2018. medical records were reviewed to assess the degree of the preoperative severity according to the intraocular pressure(IOP), corneal diameter and corneal edema. Success and failure rates were calculated for both first and redo-surgeries at 6 and 12 mo respectively then correlated to the severity of the cases. RESULTS: Complete records were retrieved for 272 eyes(153 patients) with PCG: 43 eyes were mild, 136 moderate and 93 severe. Combined trabeculotomy and trabeculectomy(CTT) had the highest success rate in moderate(96.4%) and severe cases(59.3%) while trabeculotomy had the highest success rate in mild cases(96.3%). medical records of 88 eyes(63 patients) with recurrent PCG were analyzed, most with severe presentation(59 eyes). Ahmed glaucoma valve(AGV) was used in 67(76%) eyes and augmented trabeculectomy in 21(24%) eyes. At 12 mo, there was no statistically significant difference between both surgeries in total success rate(P=0.256). For mild cases, success rate was 100% for both surgeries. Severe cases had higher success rates following AGV(87%) than augmented trabeculectomy(20%). Preoperative severity of the disease was an independent factor affecting the failure rate in secondary trabeculectomy but not in AGV. Patients younger than 24 mo had higher probabilities of failure following both redo-surgeries with hazard ratio =1.325 and 0.37 for augmented trabeculectomy and AGV respectively. CONCLUSION: Preoperative assessment of the severity of eyes with PCG helps in the selecting the optimal primary and secondary surgery. For first surgery, trabeculotomy is more effective in mild cases whereas; CTT and augmented subscleral trabeculectomy(SST) are appropriate for moderate and severe cases. AGV proved to be superior to augmented SST in

关键词： Ahmed glaucoma valve augmented trabeculectomy Egypt primary congenital glaucoma

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Fractional Order Generalized Thermoelastic Infinite medium with Cylindrical Cavity Subjected to Harmonically Varying Heat

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Engineering（科研） 2011年第1期3卷 32-37页

作者： Hamdy m. Youssef eman A. Al-Lehaibi Faculty of Engineering Umm Al-Qura University

In this work, a mathematical model of an elastic material with cylindrical cavity will be constructed. The governing equations will be taken into the context of the fractional order generalized thermoelasticity theory (Youssef 2010). Laplace transform and direct approach will be used to obtain the solution when the boundary of the cavity is exposed to harmonically heat with constant angular frequency of thermal vibration. The inverse of Laplace transforms will be computed numerically using a method based on Fourier expansion techniques. Some comparisons have been shown in figures to present the effect of the fractional order parameter and the angular frequency of thermal vibration on all the studied felids.

关键词： Thermoelasticity Generalized Thermoelasticity Fractional Order Cylindrical Cavity Harmonically Heat

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multisystem inflammatory syndrome in pediatric COVID-19 patients:a meta-analysis

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World Journal of Pediatrics 2021年第2期17卷 141-151页

作者： eman A.Toraih mohammad H.Hussein Rami m.Elshazli Adam Kline Ruhul munshi Nasrin Sultana Sharven Taghavi mary Killackey Juan Duchesne manal S.Fawzy Emad Kandil Department of Surgery Tulane UniversitySchool of MedicineNew OrleansLAUSA Genetics Unit Department of Histology and Cell BiologyFaculty of MedicineSuez Canal UniversityIsmailiaEgypt Department of Biochemistry and molecular Genetics Faculty of Physical TherapyHorus University-EgyptNew Damietta 34517Egypt Tulane University School of MedicineNew OrleansLAUSA Division of Endocrine and Oncologic Surgery Department of SurgerySchool of MedicineTulane UniversityNew OrleansLA 70112USA Department of medicine Larkin Community HospitalFlorida.MiamiUSA Trauma/Acute Care and Critical Care Department of SurgeryTulane UniversitySchool of MedicineNew OrleansLAUSA Department of medical Biochemistry and molecular Biology Faculty of MedicineSuez Canal UniversityIsmailiaEgypt Department of Biochemistry College of MedicineNorthern Border UniversityArarKingdom of Saudi Arabia

Background We aimed to systematically review the clinical and laboratory features of patients with the multisystem inflam-matory syndrome in pediatrics diagnosed during the COVID-19 *** sources A literature search in Web of Science,Pubmed,Scopus,and Science Direct was made up to June 29,*** Analysis of 15 articles(318 COVID-19 patients)revealed that although many patients presented with the typical multisystem inflammatory syndrome in pediatrics,Kawasaki-like features as fever(82.4%),polymorphous maculopapular exanthema(63.7%),oral mucosal changes(58.1%),conjunctival injections(56.0%),edematous extremities(40.7%),and cervical lymphadenopathy(28.5%),atypical gastrointestinal(79.4%)and neurocognitive symptoms(31.8%)were also *** had elevated serum lactic acid dehydrogenase,D-dimer,C-reactive protein,procalcitonin,interleukin-6,troponin I levels,and *** 77.0%developed hypotension,and 68.1%went into shock,while 41.1%had acute kidney *** care was needed in 73.7%of cases;13.2%were intubated,and 37.9%required mechanical *** immunoglobulins and steroids were given in 87.7%and 56.9%of the patients,respectively,and anticoagulants were utilized in 67.0%.Pediatric patients were discharged after a hospital stay of 6.77 days on average(95%CI 4.93-8.6).Conclusions Recognizing the typical and atypical presentation of the multisystem inflammatory syndrome in pediatric COVID-19 patients has important implications in identifying children at *** cardiac and renal decompensation and early interventions in patients with multisystem inflammatory syndrome is critical to prevent further morbidity.

关键词： COVID-19 Kawasaki-like syndrome multisystem inflammatory syndrome in pediatrics SARS-CoV-2

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HBV vaccine efficacy and detection and genotyping of vaccineé asymptomatic breakthrough HBV infection in Egypt

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World Journal of Hepatology 2011年第6期3卷 147-156页

作者： eman AE Abushady magda mA Gameel John D Klena Salwa F Ahmed Kouka SE Abdel-wahab Sanya m Fahmy microbiology department Faculty of Medicine Nourthern Border UniversityArar 1321Saudi Arabia microbiology department Faculty of MedicineAL-Azhar UniversityCairo R695-11651Egypt molecular Epidemiology unit Clinical Trials ProgramNAMRU-3Cairo 11157Egypt Pediatric department Faculty of MedicineAL-Azhar UniversityCairo R695-11651Egypt

AIm:To evaluate the impact of mass vaccination against the hepatitis B virus (HBV) in Egypt,and to search for vaccinee asymptomatic breakthrough HBV infection and its ***:Seven hundred serum samples from vaccinated children and adults (aged 2-47 years) were used for quantitative and qualitative detection of HBsAb by *** hundred and sixty serum samples representing undetectable or low or high HBsAb were screened for markers of active HBV infection (HBsAg,HBcAb (IgG) and HBeAb by ELISA,plus HBsAg by AxSYm) and HBV-DNA genotyping by nested multiplex PCR and by DNA ***:It was found that 65% of children aged 2-4 years,and 20.5% aged 4-13 years,as well as 45% adults were good responders to HBV vaccination mounting protective level *** responders were 28%,59.5% and 34%,and non-responders were 7%,20% and 21% respectively,in the three studied *** of asymptomatic HBV infections were HBsAg detected by ELISA in 2.5% vs 11.39% by *** markers were HBcAb (IgG) in 1.38%,HBeAb in 0.83%,and HBV-DNA in 7.8%.All had HBV genotype E ***:It is concluded that HBV vaccine is efficient in controlling HBV infection among children and *** vaccine breakthrough infection was by HBV genotype E.A booster dose of vaccine is recommended,probably four years after initial vaccination.

关键词： HBV vaccine evaluation Egyptain children Adults Genotype E vaccine escape HBV

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Anti-inflammatory and antioxidant potential capacities of AD-mSCs and Bm-mSCs in suppressing pancreaticβ-cells auto-immunity and apoptosis in rats with T1Dm induced model

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BIOCELL 2022年第3期46卷 745-757页

作者： SHADY G.EL-SAWAH FAYEZ ALTHOBAITI HANAN m.RASHWAN ADIL ALDHAHRANI mARWA A.ABDEL-DAYEm eman FAYAD REHAB m.AmEN EL SHAImAA SHABANA EHAB I.EL-HALLOUS Zoology Department Faculty of ScienceArish UniversityNorth SinaiEgypt Biotechnology Department Faculty of ScienceTaif UniversityTaifSaudi Arabia Clinical Laboratory Science Department Turabah University CollegeTaif UniversityTaifSaudi Arabia Department of Pharmacology and Biochemistry Faculty of PharmacyHorus University-EgyptNew DamiettaEgypt Biology Department College of ScienceUniversity of BishaBishaSaudi Arabia Fellow of Biochemistry Genetic UnitChildren HospitalFaculty of MedicineMansoura UniversityDakahlia GovernorateEgypt Biology Department Faculty of ScienceTaif UniversityTaifSaudi Arabia

Since Type 1 diabetes(T1Dm)occurs whenβ-cells mass is reduced to less than 20%of the normal level due to autoimmune destruction of cells resulting in the inability to secrete insulin,preservation or replenishment of the functionalβ-cells mass has become a major therapeutic focus for this diabetic type ***,this 4-week work plan was designed to determine which mesenchymal stem cells(mSCs)type is more appropriate to alleviate pancreatic hazards resulting from diabetes induction;via tracking a comparative study between mSCs derived from adipose tissue(AD-mSCs)and from bone marrow(Bm-mSCs)in management of T1Dm considering their immunomodulatory,anti-apoptotic and antioxidative *** were divided randomly into 4 groups;control,STZdiabetic(D),D+AD-mSCs,and D+Bm-mSCs *** stem cells types in this study were ***,both oxidative stress and antioxidant markers were evaluated using colorimetric analysis,while inflammatory,immune and apoptotic markers were assessed through flow cytometric *** showed that diabetic rats treated with either AD-mSCs or Bm-mSCs exhibited marked pancreatic antioxidant and anti-inflammatory activities that were able to initiate pancreatic immunomodulation and reducingβ-cells apoptotic death,thus,help to restore their normal insulin secretion and hypoglycemic ***,AD-mSCs injection was shown to be superior as a pancreatic regenerative tool in overcoming diabetes;owing to their marked antioxidant,anti-inflammatory,immunomodulatory,and anti-apoptotic characteristics over Bm-mSCs treatment.

关键词： Antioxidants Apoptosis Diabetes Inflammation Stem cells

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minimizing the Loss Probability in m/m/2/1 Queueing System with Ordered Entry

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American Journal of Operations Research 2018年第1期8卷 33-41页

作者： eman Ahmed Kamel Department of mathematic Faculty of Science EL-Minia University EL-Minia City Egypt

This study analyzed the m/m/2/1 queueing model with queue of length one (waiting room of capacity just one), heterogeneous servers and ordered entry using the method of semi-markov process. The customers who arrive in the system enter the free server;if the two servers are free, the customers enter the first server. If the two servers are busy, just one customer can wait at the waiting room. If the two servers are busy and the waiting room has a customer, the following customers will leave the system without receiving any service. Such a customer is called LOST COSTOmER. The probability of lost customers in the queueing system under examination was computed. Furthermore, by using inequality obtained from Jensen’s inequality, it was shown that the loss probability was minimum when inter-arrival times fit deterministic distribution [1] [2].

关键词： Loss Probability Heterogeneous Servers Semi-markov Process Laplace-Stieltjes Transform

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Investigation of the antioxidant defensive role of both AD-mSCs and Bm-mSCs in modulating the alteration in the oxidative stress status in various STZ-diabetic rats’tissues

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BIOCELL 2021年第6期45卷 1561-1568页

作者： SHADY G.EL-SAWAH FAYEZ ALTHOBAITI ADIL ALDHAHRANI eman FAYAD mARWA A.ABDEL-DAYEm REHAB m.AmEN EL SHAImAA SHABANA EHAB I.EL-HALLOUS HANAN m.RASHWAN Zoology Department Faculty of ScienceArish UniversityNorth SinaiEgypt Biotechnology Department Faculty of ScienceTaif UniversityTaif21944Saudi Arabia Clinical Laboratory Science Department Turabah University CollegeTaif UniversityTaif21995Saudi Arabia Department of Pharmacology and Biochemistry Faculty of PharmacyHorus University-EgyptNew Damietta34518Egypt Biology Department College of ScienceUniversity of BishaBisha61922Saudi Arabia Fellow of Biochemistry Genetic UnitChildren HospitalFaculty of MedicineMansoura UniversityMansouraEgypt Biology Department Faculty of ScienceTaif UniversityTaifSaudi Arabia

Diabetes mellitus(Dm)could negatively affect patients’health via inducing a lot of serious functional hazards in many tissues’cells at molecular ***,many scientists had proposed stem cell therapy being an appropriate alternative treatment protocol for numerous health threatening issues including ***,the current study was designed to investigate the antioxidant potentiality of two mSCs types in alleviating tissues’oxidative stress dramatic elevation resulting as a consequence of Type 1 Dm *** our 4 weeks study,animals were divided into four groups:control group,STZ-diabetic group(D),D+AD-mSCs group and D+Bm-mSCs *** reported that diabetic rats treated with either AD-mSCs or Bm-mSCs exhibited a marvelous body tissues(Pancreas,Liver and Kidney)enhancing capabilities in attenuating the oxidative stress status;as evidenced by XO,ROS,and mDA levels down-regulation;with a general concomitant elevation in the antioxidants’content;evidenced by many enzymatic and non-enzymatic antioxidants up-regulation;relative to the diabetic untreated ***,comparing both treatments with each other and to control group,most of the measured parameters were reverted back to near normal levels after AD-mSCs injection;which clearly point out their stunning health benefits and superiority as anti-diabetic agent in overcoming different tissues’complications;owing to their marked cytoprotective and regenerative potentialities.

关键词： Antioxidants Diabetes mesenchymal stem cells Oxidative stress

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Enhancement of mTC Performance in LTE Networks by maximizing Random Access Procedure Throughput

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Journal of Electrical Engineering 2018年第1期6卷 40-45页

作者： Ibraheem m. Fayed eman S. El-Din Network Planning Department National Telecommunication Institute Cairo 11768 Egypt

A fundamental requirement for any cellular system is the possibility for the device to request a connection setup, commonly referred to as random access procedure. In LTE （long term evolution） networks, the distribution of a limited number of radio resources among H2H （Human-to-Human） users and increasing number of mTC （machine-Type-Communication） devices in m2m （machine-to-machine） communications is one of the main problems. An analytical model is conducted to compute the throughput for message 1 and message 2. This is done using a markov chain model for the four messages signaling flow with buffering for message 4. This model is used in LTE 3GPP （Third-Generation Partnership Project） random access. The network performance will be enhanced by determining a dedicated arrival rate corresponding to maximum throughput of message 2 that will assist the network planner to optimize the network performance. In this paper, a deduced arrival rate less than 3.333 requests/ms will maximize network throughput.

关键词： mTC (machine type communication) m2m LTE network random access procedure.

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Simultaneous integrated boost ImRT in pediatric:evaluation for two commercial treatment planning systems

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The Chinese-German Journal of Clinical Oncology 2013年第1期12卷 6-14页

作者： Ehab m.Attalla Ismail Eldesoky eman Eldebawy Radiotherapy&Nuclear medicine Department National Cancer Institute Cairo University Children Cancer Hospital

Objective： The aim of the work was to compare the dosimetric results that were obtained by using two treatment planning systems （TPS） Siemens KonRad version 2.2.23, Elekta XiO version 4.4 to perform a simultaneous integrated boost （SIB） for head and neck and central nervous system （CNS） cases in paediatric patients. methods： The CT scan data for five paediatric patients, with head and neck and CNS tumors, were transferred into both of the TPSs. Clinical step-and-shoot intensity-modulated radiotherapy （ImRT） treatment plans were designed using 6 mV photon beam for delivery on a Siemens Oncor Accelerator with multileaf collimator mLC （82 leaf）. Plans were optimized to achieve the same clinical objectives using the same beam energy, number and direction of beams. The analysis was based on isodose distributions, the dose volume histogram （DVH） for planning target volume （PTV） and the relevant organs at risk （OARs） as well as volume receiving 2 Gy and 5 Gy, also total number of segments, mU/segment, and the number of mU/cGy had been investigated. Treatment delivery time and conformation number were two other parameters in this study. Results： The segmentation using KonRad was more efficient, resulting in fewer segments （reduction between 13.2% and 48.3%）, fewer m Us （reduction between 10.7% and 33%） and that reflected on treatment delivery times to be shorter by up to 8 rain or 46%. In most of the cases KonRad had the highest volume receiving in excess of 2 and 5 Gy, and XiO showed the lowest. Also KonRad achieved slightly better conformality （0.76 ± 0.054） than XiO （0.73 ± 0.05） while XiO presented a higher modulation factor value （3.3 mU/cGy） than KonRad （2.4 mU/cGy）. Conclusion： The KonRad treatment planning system was found to be superior to the XiO treatment planning system. This is true for the possible increase of radiation-induced secondary malignancies as well as for the local control.

关键词： intensity-modulated radiotherapy (ImRT) KonRad simultaneous integrated boost (SIB) XiO

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FSH/LH Ratio as a Predictor of the IVF Outcome in Young Women

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Open Journal of Obstetrics and Gynecology 2018年第10期8卷 817-825页

作者： eman Shaeer Ahmed m. maged Dina Shaheen Hala Gomaa Obstetrics and Gynaecology Department Kasr Aini Hospital Cairo University Giza Egypt Centre of Fertility and Andrology Care (CFAC) Cairo Egypt Internal medicine Department Kasr Aini Hospital Cairo University Giza Egypt New Life Fertility Center Mississauga Canada

In Vitro Fertilization (IVF) is the treatment for many causes of infertility. many studies were done to investigate different factors that can affect the success rate. This study was conducted to evaluate if cycle day 3 (CD3) follicle-stimulating hormone (FSH)/luteinizing hormone (LH) ratio can be a predictor for the IVF outcome in young sub-fertile females ≤ 35 years with normal baseline FSH. This is a retrospective case control study conducted at the Centre of Fertility and Andrology Care (CFAC) in Egypt where 235 sub-fertile women underwent IVF. Patients were grouped based on CD3 FSH/LH ratio. Group A consisted of ≤35-year-old women with FSH/LH ratio ≤35-year-old women with FSH/LH ratio ≥ 2. The primary outcomes include the fertilization rate, implantation rate and the clinical pregnancy rate. The secondary outcomes include duration and the total dose of gonadotrophin used. We found that, there was no significant difference in the total dose of gonadotropin used during the IVF cycle. Also, there was no significant difference in the number of retrieved and fertilized oocytes and the number of good embryos. Clinical pregnancy rate was the same in both groups. In conclusion, in patients younger than 35 years, CD3 FSH/LH ratio is not a predictor for IVF outcome.

关键词： FSH/LH Ratio Ovarian Reserve IVF Pregnancy Rate

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