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Role of endoscopic ultrasound and cyst fluid tumor markers in diagnosis of pancreatic cystic lesions

World Journal of Gastrointestinal Endoscopy 2022年第6期14卷 402-415页

作者： Hussein Hassan Okasha Abeer Abdellatef Shaimaa Elkholy mohamad-Sherif mogawer Ayman Yosry magdy Elserafy eman medhat Hanaa Khalaf magdy Fouad Tamer Elbaz Ahmed Ramadan mervat E Behiry Kerolis Y William Ghada Habib mona Kaddah Haitham Abdel-Hamid Amr Abou-Elmagd Ahmed Galal Wael A Abbas Ahmed Youssef Altonbary mahmoud El-Ansary Aml E Abdou Hani Haggag Tarek Ali Abdellah mohamed A Elfeki Heba Ahmed Faheem Hani m Khattab mervat El-Ansary Safia Beshir mohamed El-Nady Department of Internal medicine and Hepatogastroenterology Kasr Al-Aini HospitalsCairo UniversityKasr Al-Aini HospitalsCairo UniversityCairo 11451Egypt Department of Endemic Diseases Cairo UniversityCairo 11451Egypt Department of Tropical medicine and Gastroenterology Minia UniversityMinia 61511Egypt Department of Internal medicine Kasr Al-Aini HospitalsCairo UniversityCairo 11562Egypt Department of Gastroenterology Armed forces College of MedicineCairo 11451Egypt Endoscopy and Internal medicine Consultant at Dr/Ahmed Galal Endoscopy Center Alexandria 35516Egypt Department of Internal medicine Faculty of MedicineAssuit UniversityAssuit 71111Egypt Department of Gastroenterology and Hepatology Mansoura UniversityMansoura 35511Egypt Department of Gastroenterology and Hepatology Theodor Bilharz Research InstituteCairo 11451Egypt Department of microbiology and Immunology Faculty of Medicine for girls Al-Azhar UniversityCairo 11451Egypt Department of Internal medicine Faculty of MedicineAin shams UniversityCairo 11451Egypt Department of Internal medicine Bani-suef UniversityBani-suefBani-suef 62511Egypt Department of Pathology Faculty of MedicineCairo UniversityCairo 11451Egypt Department of Clinical Pathology Faculty of MedicineCairo UniversityCairo 11451Egypt Department of Environmental medicine&Clinical Pathology National Research CentreCairo 11451Egypt

BACKGROUND Pancreatic cystic lesions(PCLs) are common in clinical practice. The accurate classification and diagnosis of these lesions are crucial to avoid unnecessary treatment of benign lesions and missed opportunities for early treatment of potentially malignant *** To evaluate the role of cyst fluid analysis of different tumor markers such as cancer antigens [e.g., cancer antigen(CA)19-9, CA72-4], carcinoembryonic antigen(CEA), serine protease inhibitor Kazal-type 1(SPINK1), interleukin 1 beta(IL1-β), vascular endothelial growth factor A(VEGF-A), and prostaglandin E2(PGE2)], amylase, and mucin stain in diagnosing pancreatic cysts and differentiating malignant from benign *** This study included 76 patients diagnosed with PCLs using different imaging modalities. All patients underwent endoscopic ultrasound(EUS) and EUS-fine needle aspiration(EUS-FNA) for characterization and sampling of different *** The mean age of studied patients was 47.4 ± 11.4 years, with a slight female predominance(59.2%). mucin stain showed high statistical significance in predicting malignancy with a sensitivity of 87.1% and specificity of 95.56%. It also showed a positive predictive value and negative predictive value of 93.1% and 91.49%, respectively(P mucin stain, cyst fluid glucose, SPINK1, amylase, and CEA levels had high statistical significance(P malignancy in PCLs showed a statistically significant positive correlation with mural nodules, lymph nodes, cyst diameter, mucin stain, and cyst fluid CEA. meanwhile, logistic multivariable regression analysis proved that mural nodules, mucin stain, and SPINK1 were independent predictors of malignancy in cystic pancreatic *** EUS examination of cyst morphology with cytopathological analysis and cyst fluid ana

关键词： Pancreatic cystic neoplasm mucinous cystic neoplasm Intraductal papillary mucinous neoplasm mucin stain Amylase

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Anticancer effect of Psidium guajava(Guava) leaf extracts against colorectal cancer through inhibition of angiogenesis

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Asian Pacific Journal of Tropical Biomedicine 2020年第7期10卷 293-307页

作者： Bronwyn Lok Doblin Sandai Hussein m.Baharetha mansoureh Nazari V muhammad Asif Chu Shan Tan AmS Abdul majid eman Laboratory Discipline of PharmacologySchool of Pharmaceutical SciencesUniversiti Sains MalaysiaPenangMalaysia Infectomics Cluster Advance Medical and Dental InstituteUniversiti Sains MalaysiaPenangMalaysia Department of Pharmacy College of Medicine and Health SciencesHadhramout UniversityHadhramoutYemen Department of Pharmacology Faculty of Pharmaceutical SciencesGovernment College University FaisalabadFaisalabadPakistan Discipline of Pharmacology School of Pharmaceutical SciencesUniversiti Sains MalaysiaPenangMalaysia ACRF Department of Cancer Biology and Therapeutics John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia

Objective:To evaluate the anti-angiogenic and anticancer activities of Psidium guajava leaf extracts against angiogenesis-dependent colorectal ***:Three extracts were produced using distilled water,ethanol,and n-hexane as *** extracts were physically characterised through gas chromatography–mass spectrometry,ultraviolet–visible spectroscopy,and Fourier transform infrared *** antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl,total phenolic content,and total flavonoid content *** assess their anti-angiogenic activity,cell viability and rat aortic ring assays were conducted,while cell migration,tube formation,colony formation,and VEGF ELISA assays were conducted to elucidate their effects on different aspects of *** docking was used to assess the antiangiogenic potential of some possible compounds in the *** spheroid assay was used to assess the extracts’potential as a treatment for colorectal ***:The ethanol extract showed the best antioxidant *** distilled water and ethanol extracts exhibited more inhibitory activity against ***926 cell viability and aortic ring microvessel *** addition,the ethanol extract performed significantly better than the distilled water extract against cell migration and colony formation,and VEGF expression of the cells was suppressed by the ethanol *** the distilled water and ethanol extracts showed significant inhibitory effect on ***926 tube formation and tumour spheroids consisting of ***926 and HCT116 *** ethanol extract containedβ-caryophyllene andβ-elemene by phytochemical analysis and subsequent docking studies,which may contribute to its anti-angiogenic ***:The ethanol extract of Psidium guajava has potential in the treatment of colorectal cancer through the inhibition of angiogenesis.

关键词： Angiogenesis Antioxidant Colorectal cancer Psidium guajava VEGF

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Anti-tumour activity and toxicological studies of combination treatment of Orthosiphon stamineus and gemcitabine on pancreatic xenograft model

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World Journal of Gastroenterology 2022年第32期28卷 4620-4634页

作者： Ashwaq Hamid Salem Yehya Ayappa V Subramaniam muhammad Asif Gurjeet Kaur Amin m S Abdul majid Chern Ein Oon Institute for Research in molecular medicine Universiti Sains MalaysiaPenang 11800Malaysia Cancer Research Eman BiodiscoveriesKedah 08000Malaysia Department of Pharmacology Faculty of PharmacyThe Islamia University of BahawalpurPunjab 63100Pakistan Department of Cancer Biology and Therapeutics The John Curtin School of Medical ResearchAustralia 2601Australia

BACKGROUND Pancreatic cancer is the most aggressive cancer *** is the first line chemo-drug used for pancreatic cancer but exerts a broad spectrum of organ toxicities and adverse effects in *** To evaluate the anti-tumour activity and toxicological effects of Orthosiphon stamineus extract formulation(ID:C5EOSEW5050ESA trademarked as Nuvastatic^(Tm)),and gemcitabine combination on pancreatic xenograft *** mice were randomly divided into six groups of 6 mice each(n=6)and given different treatments for 28 *** study design consisted of a 2 x 3 factorial treatment structure,with gemcitabine(yes/no)by oral(at 1200 and 400 mg/kg per day).Human pancreatic cancer cells were injected subcutaneously into the flanks of athymic nude mice.C5EOSEW5050ESA(200 or 400 mg/kg per day)was administered orally,while gemcitabine(10 mg/kg per 3 d)was given intraperitoneally either alone or in combination *** analyses of vital organs,tumour tissues,and incidence of lethality were *** of tumour necrosis and proliferation were determined by haematoxylin-eosin staining and immunohistochemistry for Ki-67,*** No signs of toxicity or damage to vital organs were observed in all treatment groups compared to the untreated group.C5EOSEW5050ESA at 200 mg/kg and gemcitabine combination had no additive antitumor effects compared to a single ***,a comparably greater response in a reduction in tumour growth,Ki-67 protein expression,and necrosis was demonstrated by 400 mg/kg of C5EOSEW5050ESA and gemcitabine combination than that of the individual *** These results highlighted the synergistic activity of C5EOSEW5050ESA with gemcitabine to reduce pancreatic tumour growth in mice compared to a single ***,this study provides valuable insights into using C5EOSEW5050ESA as a complementary treatment with gemcitabine for pancreatic cancer.

关键词： Pancreatic cancer Orthosiphon stamineus C5EOSEW5050ESA Gemcitabine Complementary medicine

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海南岛全新世碳酸盐沉积及成岩作用

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矿物岩石 1995年第1期15卷 50-57页

作者： m.Lassen W.Schneider 耿爱琴刘效曾 Institut 成都理工学院成都610059

三亚湾珊瑚礁可以分为5个微相:生物骨架岩、生物屑、礁岩屑、珊瑚碎块、强烈改造的生物屑.成岩作用包括同生沉积作用、胶结、藻缠结、细粒物充填、机械和化学侵蚀.排浦更新世白云岩与掘穴生物的钻孔有关,粉至中晶结构为混合水成因.峨曼... 详细信息

三亚湾珊瑚礁可以分为5个微相:生物骨架岩、生物屑、礁岩屑、珊瑚碎块、强烈改造的生物屑.成岩作用包括同生沉积作用、胶结、藻缠结、细粒物充填、机械和化学侵蚀.排浦更新世白云岩与掘穴生物的钻孔有关,粉至中晶结构为混合水成因.峨曼更新世灰岩为分质灰岩、角砾状灰岩、豆状灰岩.生物屑经重结晶,X(mgCO_3)小于2%,贫铁.三亚湾潮间带海滩岩胶结物为文石和高镁方解石,见悬挂式胶结和渗滤砂.

关键词：全新世碳酸盐沉积成岩作用海滩岩珊瑚礁

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The Palestinian Terrestrial Vertebrate Fauna Preserved at the Biology Exhibitions of the Universities of the Gaza Strip

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Research in Ecology 2020年第4期2卷 9-21页

作者： Abdel Fattah N Abd Rabou Nour J musallam eman J musallam Kamal E Elkahlout Kamal J Elnabris Tarek A El-Bashiti Ismail I Abdel Aziz Reham m Ishneiwra Eqbal S Radwan Hana S Saada Ashraf A Shafei Nedal A Fayyad Saleh N mwafy Huda E Abu Amra Ramy A Abu Alajeen mohammed F Abu Owda Randa N Alfarra Haifaa A Hassouna Reem A Hassouna mohammed R Al-Agha mohammed A Abd Rabou Department of Biology and Biotechnology Islamic University of GazaGaza StripPalestine Department of English Islamic University of GazaGaza StripPalestine Department of Biology Al-Azhar UniversityGaza StripPalestine Department of Biology Al-Aqsa UniversityGaza StripPalestine Department of Geography Al-Aqsa UniversityGaza StripPalestine Department of Curricula and Teaching methods Islamic University of GazaGaza StripPalestine Department of Curricula and Teaching methods Ministry of EducationGaza StripPalestine Department of Pharmaceutical Sciences University of PalestineGaza StripPalestine Department of Environment and Earth Sciences Islamic University of GazaGaza StripPalestine Department of Information Technology University College of Applied SciencesGaza StripPalestine

The Gaza Strip(365 km^(2))of Palestine(27,000 km^(2))is home to a wealth of terrestrial vertebrate *** of these faunistic species find their ways to preservation at the local ***,the current study comes to document the Palestinian terrestrial vertebrate fauna acquired by the biology exhibitions(BEs)of Al-Azhar University,Islamic University of Gaza and Al-Aqsa University that are located at the Gaza City of the Gaza *** amphibians,reptiles,birds and mammals preserved at BEs of the universities in question were surveyed and scientifically classified during a three-month period extending from January to march,*** study showed that all BEs of local universities are underdeveloped,lacking attention and suffer from specimen scarcity and good *** BE at Al-Azhar University is the best in the arrangement and preservation of bird specimens.A total number of 200 specimens belonging to 54 terrestrial vertebrate fauna species,39 families and 17 orders was recorded at *** constituted 40.7%of the total species recorded,followed by birds(38.9%),mammals(14.8%)and amphibians(5.6%).The Islamic University of Gaza was considered the best in terms of the number of preserved species(39.8%),followed by Al-Azhar University(36.3%)and Al-Aqsa University(23.9%).The Common Toad(Bufo viridis)was the most preserved among the amphibian species *** was the biggest reptilian order,comprising 20 species(8 lizards and 12 snakes),with the Syrian Black Snake(Coluber jugularis asianus)was the *** Palestine Viper(Vipera palaestinae)is endemic to Palestine and most venomous and dangerous to human *** Great White Pelican(Pelecanus onocrotalus)was the largest Palestinian bird preserved at BE of Al-Azhar *** Egyptian mongoose(Herpestes ichneumon)and the Common Badger(meles meles)were the biggest mammalian specimens preserved,while the Palestine mole-rat(Spalax leucodon ehrenbergi)was the only Palestine endemic spe

关键词： Terrestrial vertebrate fauna Preservation Biology exhibitions Gaza universities Gaza Strip Palestine

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沉降颗粒物和底泥中污染物水平的生物学和化学测定方法——瑞典一条河流系统在多氯联苯污染的湖泊被清淤之前、之中和之后

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人类环境杂志 1998年第5期27卷 402-409页

作者： magnusEngwall CarinaNf DagBroman BjrnBrunstrm 张国梁乌普萨拉大学斯德哥尔摩大学

一项基于在培养的鸡胚肝中诱导乙氧基异吩噁唑酮-O-脱乙基酶(EROD)的灵敏测定方法,与化学分析一起被用来确定埃姆河(eman)颗粒物中的污染物类二噁(口英)的水平。在多氧联苯(PCB)污染的湖泊——Jarnsjon湖进行清淤之前、之中和之后,在该... 详细信息

一项基于在培养的鸡胚肝中诱导乙氧基异吩噁唑酮-O-脱乙基酶(EROD)的灵敏测定方法,与化学分析一起被用来确定埃姆河(eman)颗粒物中的污染物类二噁(口英)的水平。在多氧联苯(PCB)污染的湖泊——Jarnsjon湖进行清淤之前、之中和之后,在该河流系统采集的底泥和沉降颗粒物(SPm)提取物被分成含有:①一元芳香族/脂肪族 ;②二元芳香族(如 PCBs、多氯联苯二噁(口英)和二苯并呋喃);③多元芳香族化合物(如多环芳香烃类)的3个级分。采自Jarnsjon湖的样品含有最高PCB浓度,并且Jarnsjon湖样品中的二元芳香族浸提物显示出最高的EROD诱导二元芳香族化合物的活性。在Jarnsjon湖清淤之后采集的底泥中,二元芳香族组的类二噁(口英)活性大约只有清淤前底泥中活性的1%,这表明,就湖泊中PCB污染底泥的清除而言治理是成功的。在Jarnsjon湖下游立即采集的沉降颗粒物中,二元芳香族类二噁(口英)化合物的水平在清淤期间升高,清淤之后降低。可是,清淤后浓度比Jarnsjon湖上游湖泊沉降颗粒物中的要高,表明在清淤后的几年中,二元芳香族类二噁(口英)化合物的水平升高现象仍存在于Jarnsjon湖下游水系统中。

关键词：湖泊沉降颗粒物底泥污染物水平生物学化学测定多氯联苯瑞典

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