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Virologica Sinica 2021年第4期36卷 565-576页

作者： eman Teer Danzil E.Joseph Richard H.Glashoff m.Faadiel Essop Centre for Cardio-metabolic Research in Africa(CARmA) Department of Physiological SciencesStellenbosch UniversityStellenbosch 7600South Africa Division of medical microbiology&Immunology Department of PathologyStellenbosch University and NHLSCape Town 7505South Africa

Although monocytes and macrophages are key mediators of the innate immune system,the focus has largely been on the role of the adaptive immune system in the context of human immunodeficiency virus(HIV)*** more attention and research work regarding the innate immune system-especially the role of monocytes and macrophages during early HIV-1 infection-is *** monocytes and tissue macrophages are both susceptible targets of HIV-1 infection,and the early host response can determine whether the nature of the infection becomes pathogenic or *** example,monocytes and macrophages can contribute to the HIV reservoir and viral persistence,and influence the initiation/extension of immune activation and chronic *** the expansion of monocyte subsets(classical,intermediate and non-classical)provide an increased understanding of the crucial role they play in terms of chronic inflammation and also by increasing the risk of coagulation during HIV-1 *** review discusses the role of monocytes and macrophages during HIV-1 pathogenesis,starting from the early response to late dysregulation that occurs as a result of persistent immune activation and chronic *** changes are also linked to downstream targets such as increased coagulation and the onset of cardiovascular diseases.

关键词： monocytes Human immunodeficiency virus(HIV) Persistent immune activation Coagulation Cardiovascular diseases(CVD)

Teleaudiology practice in COVID-19 pandemic in Egypt and Saudi Arabia

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Journal of Otology 2022年第2期17卷 78-83页

作者： Reem elbeltagy eman H.Waly Huny m.Bakry Audiovestibular medicine Otorhinolaryngology DepartmentFaculty of MedicineZagazig UniversityEgypt Health Communication Sciences Department.College of Health and Rehabilitation Sciences Princess Nourah bint Abdulrahman UniversitySaudi Arabia Community Environmental and Occupational Medicine DepartmentFaculty of MedicineZagazig UniversityEgypt

Objective:To evaluate the audiologists’attitudes and practice towards teleaudiology,as well as to assess the audiological services provided in Egypt and Saudi Arabia during the COVID-19 ***:A cross sectional study was conducted among 112 audiologists who were recruited through convenience *** logistic regression was used to test the association between practice of tele audiology as a dependent variable and some independent ***:25.4%of the studied sample were practicing tele ***’age and attitude toward telemedicine were the independent predictors of tele audiology practice at p value≤***:The tele audiology practice is ***,raising the knowledge of audiologist about the great value of practicing tele audiology is very important,infrastructure,equipment,and technology especially telecommunication should be improved and facilitated for both audiologist and patients.

关键词： COVID-19 Telemedicine Audiology Egypt Saudi Arabia

Exendin-4 inhibits the survival and invasiveness of two colorectal cancer cell lines via suppressing GS3Kβ/β-catenin/NF-κB axis through activating SIRT1

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BIOCelL 2021年第5期45卷 1337-1353页

作者： ATTALLA F.el-KOTT AYmAN E.el-KENAWY eman R.elBEALY ALI S.ALSHEHRI HEBA S.KHALIFA mASHAel mOHAmmED BIN-mEFERIJ EHAB E.mASSOUD AmIRA m.ALRAmLAWY Biology Department College of ScienceKing Khalid UniversityAbha61413Saudi Arabia Zoology Department College of ScienceDamanhour UniversityDamanhour22511Egypt Pathology Department College of MedicineTaif UniversityTaif11099Saudi Arabia Biology Department College of Science for GirlsKing Khalid UniversityAbha61413Saudi Arabia Biology Department College of SciencePrincess Nourah Bint Abdulrahman UniversityRiyadh84428Saudi Arabia Biology Department Faculty of Science and ArtsDahran AljnoubKing Khalid UniversityAbha61413Saudi Arabia Research Center for Advanced materials Science King Khalid UniversityAbha61413Saudi Arabia Agriculture Research Centre SoilWater and Environment Research InstituteGiza12619Egypt mansoura Research Centre for Cord Stem Cell(mARC-CSC) Stem Cells BankChildren’s HospitalMansoura UniversityMansoura35516Egypt

This study examined if the anti-tumorigenesis effect of Exendin-4 in HT29 and HCT116 colorectal cancer(CRC)involves modulation of SIRT1 and Akt/GSR3K/β-catenin/NF-κB ***29 and HCT116 cells were treated either with increasing levels of Exendin-4(0.0-200μm)or with Exendin-4(at its IC50)in the presence or absence of EX-527(10μm/a selective SIRT1 inhibitor)or Exendin-4(9-39)amide(E(9-39)A)(1μm/an Exendin-4 antagonist).In a dose-dependent manner,Exendin-4 inhibited cell survival,but enhanced levels of lactate dehydrogenase(LDH)and single-stranded DNA(ssDNA)in both HT29 and *** both cell lines and at it has an IC50(45μm for HT29 and 35μm for HCT1165),Exendin-4 also significantly reduced cell survival,migration,and invasion of both cell types,with no effect on the expression GLP-1 receptors(GLPRs)nor of the activity of *** these doses,Exendin-4 also increased the expression of SIRT1 but reduced the acetylation of NF-κB and the expression of Bax and cleaved caspase-3 and in both cell ***,protein levels of p-GS3Kβ(Ser9),total and acetylatedβ-catenin,and Anix2 were significantly decreased,but levels of p-GS3Kβ(Ser9)and p-β-catenin(Ser33/37/Thr41)were significantly increased in both HT29 and HCT116-exendin-4 treated *** the effects exerted by Exendin-4 were completely prevented by Ex527 or E(9-39)*** conclusion,Exendin-4 suppresses the tumorigenesis of HT29 and HCT116 CRC cell activation of GS3Kβ-induced inhibition ofβ-catenin and NF-κβin a SIRT1-dependent mechanism.

关键词： Colorectal cancer Exendin-4 SIRT1 GS3Kβ β-catenin NF-κB

WEIGHTED PSEUDO ALmOST-PERIODIC SOLUTIONS OF SHUNTING INHIBITORY CelLULAR NEURAL NETWORKS WITH mIXED DelAYS

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Acta mathematica Scientia 2016年第6期36卷 1662-1682页

作者： mohammed salah m'HAmDI Chaouki AOUITI Abderrahmane TOUATI Adel m. ALImI Vaclav SNASel Department of mathematics University of Carthage Faculty of Sciences of Bizerta BP W 7021 Zarzouna Bizerta Tunisia REGIm-lab: Research Groups on Intelligent machines University of Sfax National Engineering School of Sfax (ENIS) BP 1173 Sfax 3038 Tunisia VSB Technical University of Ostrava Czech Republic

In this paper, we prove the existence and the global exponential stability of the unique weighted pseudo almost-periodic solution of shunting inhibitory cellular neural networks with mixed time-varying delays comprising different discrete and distributed time delays. Some sufficient conditions are given for the existence and the global exponential stability of the weighted pseudo almost-periodic solution by employing fixed point theorem and differential inequality techniques. The results of this paper complement the previously known ones. Finally, an illustrative example is given to demonstrate the effectiveness of our results.

关键词： weighted pseudo almost-periodic solution shunting inhibitory cellular neuralnetworks mixed delays global exponential stability

Enhancement of mTC Performance in LTE Networks by maximizing Random Access Procedure Throughput

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Journal of electrical Engineering 2018年第1期6卷 40-45页

作者： Ibraheem m. Fayed eman S. el-Din Network Planning Department National Telecommunication Institute Cairo 11768 Egypt

A fundamental requirement for any cellular system is the possibility for the device to request a connection setup, commonly referred to as random access procedure. In LTE （long term evolution） networks, the distribution of a limited number of radio resources among H2H （Human-to-Human） users and increasing number of mTC （machine-Type-Communication） devices in m2m （machine-to-machine） communications is one of the main problems. An analytical model is conducted to compute the throughput for message 1 and message 2. This is done using a markov chain model for the four messages signaling flow with buffering for message 4. This model is used in LTE 3GPP （Third-Generation Partnership Project） random access. The network performance will be enhanced by determining a dedicated arrival rate corresponding to maximum throughput of message 2 that will assist the network planner to optimize the network performance. In this paper, a deduced arrival rate less than 3.333 requests/ms will maximize network throughput.

关键词： mTC (machine type communication) m2m LTE network random access procedure.

Antioxidant, hepatoprotective and nephroprotective activities of Gazania rigens against carbon tetrachloride-induced hepatotoxicity and nephrotoxicity in rats

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Traditional medicine Research 2022年第5期7卷 29-39页

作者： Alshymaa Abdel-Rhman Gomaa mamdouh Nabil Samy eman Zekry Attia mina Ezzat Attya michael Atef Fawzy Samar Yehia Desoukey mohamed salah Kamel Department of Pharmacognosy Faculty of PharmacyMinia UniversityMinia 61519Egypt Department of Pathology Faculty of MedicineMinia UniversityMinia 61519Egypt Department of Biochemistry Faculty of PharmacyMinia UniversityMinia 61519Egypt

Objective:The current study investigated the efficacy of total ethanolic extract and various fractions of Gazania rigens to protect against carbon tetrachloride-induced liver and kidney damage in rats and evaluated their antioxidant ***:The antioxidant activity of the total extract and fractions(petroleum ether,ethyl acetate,and aqueous)of Gazania rigens was examined using 2,2’-diphenyl-1-picrylhydrazyl radical scavenging and phosphomolybdate assays,and their total phenolic and flavonoid contents were *** hepatoprotective and nephroprotective potentials were studied at a dose of 300 mg/kg for six consecutive days followed by induction of hepatorenal injury using carbon tetrachloride single dose(1.5 mL/kg,1:1 v/v in olive oil,intraperitoneal)the next ***:The results revealed the potent hepato and nephroprotective effects of ethyl acetate and aqueous fractions by significantly(Pm levels of alanine aminotransferase,aspartate aminotransferase,total bilirubin,creatinine,urea,triglycerides,cholesterol,and lactate dehydrogenase,along with elevated serum albumin *** improvement of hepatic and renal antioxidant capacities and catalase activities,together with the prominent reduction of hepatic and renal malondialdehyde contents,were confirmed by histopathological ***:The potent hepatoprotective and nephroprotective effects of the total extract and different fractions of Gazania rigens may be attributed to the presence of highly phenolic and flavonoid compounds along with their complementary antioxidant scavenging properties.

关键词： Asteraceae Gazania rigens antioxidant hepatoprotective nephroprotective

The impact of an educational intervention in caregiving outcomes in Jordanian caregivers of patients receiving hemodialysis: A single group pre-and-post test

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International Journal of Nursing Sciences 2018年第2期5卷 144-150页

作者： eman Khamis Alnazly Nursing Deartment Al-Ahliyya Amman UniversityJordan

Objectives:Chronic renal failure affects the physiological,psychological,functional ability,and independent status of the patient,which might result in a burden to the family members caring for *** objective of the study was to identify caregivers'level of burden and establish the impact of educational intervention programs on caregiving ***:This was a one-group pre-test post-test study conducted between April and August 2017 on family caregivers of hemodialysis patients.A convenient sample of 169 caregivers was used.A sociodemographic questionnaire,the OBCS,and BCOS were utilized for data collection,which occurred at baseline and two weeks *** collected data were analyzed using SPSS where t-test determined the impact of the ***:Caregivers were found to be moderately burdened(m=2.73,SD=0.23)and their lives had changed for the worst as a result of caregiving(m=3.17,SD=5.89).There were significant differences in caregiving outcome scores before and after the intervention(Pmodialysis adds extra responsibilities to the caregivers'schedule thus leaving them substantially *** caregivers on the required care eased their burden and improved caregiving *** are made that healthcare professionals should assess caregiver burden,and address their physical and mental health *** should also be regularly educated on the regular caregiving tasks to ease their burden.

关键词： Burden Caregiver Hemodialysis Informative materials Self-perceived burden

Positive Definite Solutions for the System of Nonlinear matrix Equations X+ A*Y-nA= I, Y+ B*X-mB= I

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Applied mathematics 2014年第13期5卷 1977-1987页

作者： salah m. el-Sayed Asmaa m. Al-Dubiban Department of Scientific Computing Faculty of Computers and Informatics Benha University Benha Egypt Faculty of Science and Arts Qassim University Qassim KSA

In this paper, some properties of the positive definite solutions for the nonlinear system of matrix equations X + A*Y-nA = I, Y + B*X-mB = I are derived. As a matter of fact, an effective iterative method to obtain the positive definite solutions of the system is established. These solutions are based on the convergence of monotone sequences of positive definite matrices. moreover, the necessary and sufficient conditions for the existence of the positive definite solutions are obtained. Finally, some numerical results are given.

关键词： System of Nonlinear matrix Equations Iterative methods monotonic Sequence Positive Definite matrices

氨三乙酸、缬氨酸、亮氨酸的三元过渡金属配合物:合成和生物学应用(英文)

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无机化学学报 2013年第9期29卷 1969-1978页

作者： mostafa m H Khalil Eglal R Souaya eman H Ismail eman Rabie Chemistry Department Faculty of ScienceAin Shams University11566AbbassiaCairoEgypt.埃及 Chemistry Department Faculty of ScienceTaibah UniversityAl-Madina Al-MunawarahB.O:344.Kingdom of Saudi Arabia沙特阿拉伯王国

以氨三乙酸HNTA2-为主要配体,缬氨酸(valine)或亮氨酸(leucine)为次要配体在微酸性介质中合成了Ni(Ⅱ),Cu(Ⅱ),and Zn(Ⅱ)的三元配合物。用元素分析、热分析、FTIR,UV-Vis分光光度法,磁性测量和质谱法表征了合成的三元配合物。结果表明... 详细信息

以氨三乙酸HNTA2-为主要配体,缬氨酸(valine)或亮氨酸(leucine)为次要配体在微酸性介质中合成了Ni(Ⅱ),Cu(Ⅱ),and Zn(Ⅱ)的三元配合物。用元素分析、热分析、FTIR,UV-Vis分光光度法,磁性测量和质谱法表征了合成的三元配合物。结果表明,三元配合物可在金属(m):氨三乙酸(HNTA)∶缬氨酸(valine)或亮氨酸(leucine)=1∶1∶1时制得,其分子结构为[m(HNTA)(valine)(H2O)2].1.5H2O and[m(HNTA)(leucine)(H2O)2].1.5H2O(其中m=Ni(Ⅱ)or Cu(Ⅱ))和H2[Zn(NTA)(valine)(H2O)]H2O。标题三元过渡金属配合物为八面体对称构型。同时研究了该三元配合物对大肠杆菌,金黄色葡萄球菌,白色念珠菌,黄曲霉菌(菌株从开罗大学理学院微分析中心获得)的抗菌活性。根据推荐的知名方法用标准的抗菌和抗真菌剂进行体外测试(in vitro)以评估我们的新制备的配合物对细菌和真菌物种的生长抑制活性。

关键词：缬氨酸亮氨酸三元配合物生物学应用

Thyme oil inclusion levels in a rabbit ration: Evaluation of productive performance, carcass criteria and meat quality under hot environmental conditions

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Animal Nutrition 2018年第4期4卷 410-416页

作者： Ahmed A.A.Abdel-Wareth eman m.m.Taha Karl-Heinz Südekum Jayant Lohakare Department of Animal and Poultry Production Faculty of Agriculture South Valley University Department of Food Science and Technology Faculty of Agriculture South Valley University Institute of Animal Science University of Bonn Department of Agriculture-Animal Science University of Arkansas at Pine Bluff

The aim of this study was to determine the impact of thyme essential oil supplementation in rabbit rations on performance, carcass criteria, and meat quality under hot environmental conditions. A total of 75, 4-week-old Californian male rabbits were assigned to 5 dietary treatments until 12 weeks of *** rabbits were reared in an open house system(38C average ambient temperature and 26% to 35%relative humidity). Treatments were as follows: unsupplemented standard ration, negative control(CON); standard ration supplemented with 1.50 g/kg olive oil as carrier, positive control(POS);POS t 50 mg/kg thyme oil(TO1); POS t 100 mg/kg thyme oil(TO2); and POS t 150 mg/kg thyme oil(TO3). Dietary thyme oil up to 150 mg/kg improved(P mance in comparison to CON. The highest average daily gain and most efficient feed conversion ratio(linear,P me oil improved(P meat was greater(P mpared with CON. Differences were also recorded in oxymyoglobin and metmyoglobin contents in rabbit meat among treatments. In conclusion, thyme oil of a specified composition and to be added to a rabbit ration up to 100 mg/kg using 1.50 g/kg olive oil as a carrier can be used as an efficient feed additive for improving productive performance of rabbits under hot environmental conditions.

关键词： Antioxidant Essential oil meat characteristics Nutrition Production