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Correlations between serum kidney injury molecule-1,cystatin C and immunosuppressants:A cross-sectional study of renal transplant patients in Bahrain

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Journal of Biomedical Research 2024年第3期38卷 269-277页

作者： Kannan Sridharan Shamik Shah Mona Al Hammad Fatima Ali Mohammed Sindhan Veeramuthu Mona Abdulla Taher Mustafa Mohamed Hammad Lamees Jawad eman farid Department of Pharmacology and Therapeutics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Department of Nephrology Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Internal Medicine College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Salmaniya Medical Complex ManamaKingdom of Bahrain Department of Laboratory Medicine Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Microbiology Immunologyand Infectious DiseasesCollege of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain

Renal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for *** creatinine is the standard for monitoring kidney function;however,cystatin C(Cys C)and kidney injury molecule-1(KIM-1)have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney ***,we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil,tacrolimus,sirolimus,everolimus,or cyclosporine to evaluate kidney *** used both the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)2021 equation,which is based on creatinine and combined creatinine with Cys C,and the CKD-EPI 2012 equation,which is based on Cys C alone,to estimate glomerular filtration rate(GFR).Then,we assessed the association between serum KIM-1 and GFR<90 mL per minute per 1.73 *** observed significantly higher serum Cys C levels in patients with the elevated serum creatinine,compared with those with normal serum *** estimated GFRs based on creatinine were significantly higher than those based on the other equations,while a significant positive correlation was observed among all *** KIM-1 levels were negatively correlated with the estimated GFRs by the CKD-EPI Cys C and the combined creatinine with Cys C equations.A serum KIM-1 level above 0.71 ng/mL is likely to indicate GFR<90 mL per minute per 1.73 *** observed a significant correlation between serum creatinine and Cys C in our renal transplant ***,serum KIM-1 may be used to monitor renal function when using potentially nephrotoxic drugs in renal transplants.

关键词： KIM-1 cystatin C mycophenolate mofetil tacrolimus everolimus sirolimus cyclosporine

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Comparison on Efficacy and Safety of Three Inpatient Insulin Regimens for Management of Non-Critical Patients with Type 2 Diabetes

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Pharmacology & Pharmacy 2013年第7期4卷 556-565页

作者： eman Said Samar farid Nirmeen Sabry May Fawzi Department of Clinical Pharmacy Faculty of Pharmacy Cairo University Cairo Egypt Departments of Internal Medicine Facultyof Internal Medicine Faculty of Medicine Cairo University Cairo Egypt.

Background: Hyperglycemia in hospitalized patients is associated with poor clinical outcomes. Scheduled Subcutaneous Insulin therapy has been recommended for better glycemic control. Aims: To compare efficacy and safety of traditional sliding scale insulin (SSI) versus modified 70/30 insulin versus basal plus supplemental scale (SS) insulin regimens for glycemic control of inpatients with diabetes. Methods: In a prospective trial, 62 patients with diabetes were randomized to receive either hospital SSI (N = 22), or twice daily 70/30 insulin plus supplemental lunchtime insulin for BG ≥ 150 mg/dL (N = 21) or once every night glargine plus prandial glulisine for BG ≥ 150 mg/dL (N = 19). 70/30 insulin and glargine were started respectively at 0.4 and 0.2 U/kg/day for BG ≤ 200 mg/dL or 0.5 and 0.3 U/kg/day for BG above 200 mg/dL. Results: Starting at BG level of 204 ± 68, 200 ± 50 and 241 ± 94 mg/dL in SSI, 70/30 insulin and glargine/glulisine groups respectively, (F(2,35.47) = 1.467, p = 0.244, Welch test), mean daily BG after first day of hospitalization was statistically significant (F(2,35.58) = 7.043, p = 0.003, Welch test) lower in 70/30 insulin group (171 ± 38 mg/dL) compared to (218 ± 71 mg/dL) in SSI group (p = 0.026) and (225 ± 65 mg/dL) in glargine/glulisine group (p = 0.01). Conclusions: With poorly educated nursing staff, basal plus SS insulin failed to provide adequate glycemic control. However, tailored 70/30 insulin regimen resulted in statistically significant glycemic control compared to traditional SSI.

关键词： Type 2 DM Sliding Scale Insulin 70/30 Insulin Basal Insulin Supplemental Insulin

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Seasonal Effect on Biomarkers of Exposure to Petroleum Hydrocarbons in the Coasts of North Western Suez Gulf,Egypt

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Journal of Environmental & Earth Sciences 2019年第1期1卷 38-48页

作者： Omayma E.Ahmed Mustafa M.Emara Nazik A.farid1 Enas A.El-Sabagh eman M.Kamal Egyptian Petroleum Research Institute Egypt Chemistry Department Faculty of Science(boys)Al-Azhar UniversityEgypt Faculty of Science(girls)Al-Azhar University CairoEgypt

Petroleum hydrocarbons of surface water were collected from eight loca-tions of from the coasts of north western Suez Gulf,*** extracted petroleum hydrocarbons were determined by gas chromatography-flame ionization detector and quantified by integrating the areas of both the resolved and unresolved *** results confirm that the con-centration is relatively higher than the recommended in the regulations of the Egyptian low of Environment of No.4/1994 of petroleum *** various *** dissolved petroleum hydrocarbons ranged from 5.639 to 74.8 and 1.868 to 65.698 mg/ml for summer and winter sea-sons,*** indicates that chronic oil pollution,in addition to hydrocarbon concentrations,the diagnostic indices used shows that the hydrocarbons in the area were comes from biogenic,petrogenic and anthropogenic ***-IR spectrometric analysis confirms die petro-genic nature of pollutants.

关键词： Egypt Oil hydrocarbon Physicochemical Diagnostic Gas chromatography Suez canal

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Embedded Coded Relay System for Molecular Communications

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Computers, Materials & Continua 2022年第8期72卷 2729-2748页

作者： eman S.Attia Ashraf A.M.Khalaf Fathi E.Abd El-Samie Saied M.Abd El-atty Konstantinos A.Lizos Osama Alfarraj farid Shawki Imran Khan Ki-Il Kim Department of Electrical Engineering Faculty of EngineeringMinia UniversityMiniaEgypt Department of Electronics and Electrical Communications Faculty of Electronic EngineeringMenoufia UniversityMenoufiaEgypt Department of Informatics Faculty of Mathematics and Natural SciencesUniversity of Oslo(UiO)Norway Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Department of Electrical Engineering University of Engineering&TechnologyPeshawar814Pakistan Department of Computer Science and Engineering Chungnam National UniversityDaejeon34134Korea

With the emergence of the COVID-19 pandemic,the World Health Organization(WHO)has urged scientists and industrialists to exploremodern information and communication technology(ICT)as a means to reduce or even eliminate *** World Health Organization recently reported that the virus may infect the organism through any organ in the living body,such as the respiratory,the immunity,the nervous,the digestive,or the cardiovascular *** the abovementioned goal,we envision an implanted nanosystem embedded in the intra living-body *** main function of the nanosystem is either to perform diagnosis and mitigation of infectious diseases or to implement a targeted drug delivery system(i.e.,delivery of the therapeutic drug to the diseased tissue or targeted cell).The communication among the nanomachines is accomplished via communication-based molecular *** control/interconnection of the nanosystem is accomplished through the utilization of Internet of bio-nano things(IoBNT).The proposed nanosystem is designed to employ a coded relay nanomachine disciplined by the decode and forward(DF)principle to ensure reliable drug delivery to the targeted ***,both the sensitivity of the drug dose and the phenomenon of drug molecules loss before delivery to the target cell site in long-distance due to the molecules diffusion process are taken into *** this paper,a coded relay NM with conventional coding techniques such as RS and Turbo codes is selected to achieve minimum bit error rate(BER)performance and high signal-to-noise ratio(SNR),while the detection process is based on maximum likelihood(ML)probability and minimum error probability(MEP).The performance analysis of the proposed scheme is evaluated in terms of channel capacity and bit error rate by varying system parameters such as relay position,number of released molecules,relay and receiver *** results are validated through simulation and demonstrate that the proposed scheme can

关键词： Molecular communication nanonetwork internet of bio-nano things coded relay scheme coding

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