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Virologica Sinica 2021年第4期36卷 565-576页

作者： eman Teer Danzil E.Joseph Richard H.Glashoff M.Faadiel Essop Centre for Cardio-metabolic Research in Africa(CARMA) Department of Physiological SciencesStellenbosch UniversityStellenbosch 7600South Africa Division of Medical Microbiology&Immunology Department of PathologyStellenbosch University and NHLSCape Town 7505South Africa

Although monocytes and macrophages are key mediators of the innate immune system,the focus has largely been on the role of the adaptive immune system in the context of human immunodeficiency virus(HIV)*** more attention and research work regarding the innate immune system-especially the role of monocytes and macrophages during early HIV-1 infection-is *** monocytes and tissue macrophages are both susceptible targets of HIV-1 infection,and the early host response can determine whether the nature of the infection becomes pathogenic or *** example,monocytes and macrophages can contribute to the HIV reservoir and viral persistence,and influence the initiation/extension of immune activation and chronic *** the expansion of monocyte subsets(classical,intermediate and non-classical)provide an increased understanding of the crucial role they play in terms of chronic inflammation and also by increasing the risk of coagulation during HIV-1 *** review discusses the role of monocytes and macrophages during HIV-1 pathogenesis,starting from the early response to late dysregulation that occurs as a result of persistent immune activation and chronic *** changes are also linked to downstream targets such as increased coagulation and the onset of cardiovascular diseases.

关键词： Monocytes Human immunodeficiency virus(HIV) Persistent immune activation Coagulation Cardiovascular diseases(CVD)

氨三乙酸、缬氨酸、亮氨酸的三元过渡金属配合物:合成和生物学应用(英文)

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无机化学学报 2013年第9期29卷 1969-1978页

作者： Mostafa M H Khalil Eglal R Souaya eman H Ismail eman Rabie Chemistry Department Faculty of ScienceAin Shams University11566AbbassiaCairoEgypt.埃及 Chemistry Department Faculty of ScienceTaibah UniversityAl-Madina Al-MunawarahB.O:344.Kingdom of Saudi Arabia沙特阿拉伯王国

以氨三乙酸HNTA2-为主要配体,缬氨酸(valine)或亮氨酸(leucine)为次要配体在微酸性介质中合成了Ni(Ⅱ),Cu(Ⅱ),and Zn(Ⅱ)的三元配合物。用元素分析、热分析、FTIR,UV-Vis分光光度法,磁性测量和质谱法表征了合成的三元配合物。结果表明... 详细信息

以氨三乙酸HNTA2-为主要配体,缬氨酸(valine)或亮氨酸(leucine)为次要配体在微酸性介质中合成了Ni(Ⅱ),Cu(Ⅱ),and Zn(Ⅱ)的三元配合物。用元素分析、热分析、FTIR,UV-Vis分光光度法,磁性测量和质谱法表征了合成的三元配合物。结果表明,三元配合物可在金属(M):氨三乙酸(HNTA)∶缬氨酸(valine)或亮氨酸(leucine)=1∶1∶1时制得,其分子结构为[M(HNTA)(valine)(H2O)2].1.5H2O and[M(HNTA)(leucine)(H2O)2].1.5H2O(其中M=Ni(Ⅱ)or Cu(Ⅱ))和H2[Zn(NTA)(valine)(H2O)]H2O。标题三元过渡金属配合物为八面体对称构型。同时研究了该三元配合物对大肠杆菌,金黄色葡萄球菌,白色念珠菌,黄曲霉菌(菌株从开罗大学理学院微分析中心获得)的抗菌活性。根据推荐的知名方法用标准的抗菌和抗真菌剂进行体外测试(in vitro)以评估我们的新制备的配合物对细菌和真菌物种的生长抑制活性。

关键词：缬氨酸亮氨酸三元配合物生物学应用

Susceptibility patterns and virulence genotypes of Helicobacter pylori affecting eradication therapy outcomes among Egyptian patients with gastroduodenal diseases

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World Journal of Gastroenterology 2023年第19期29卷 2950-2960页

作者： Ahmed Morad Asaad Gasser El-Azab eman Abdelsameea Osama Elbahr Ahmed Kamal Mohamed Abdel-Samiee Ahmed Abdelfattah Heba Abdallah Doha Maher Ahmed El-Refaie Samar Ebrahim Ghanem Shamshul Ansari Samah Mohammed Awad Department of Microbiology College of MedicineZagazig UniversityZagazig 44519Egypt Department of Hepatology and Gastroenterology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt Department of Clinical Pathology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt Department of Pathology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt Department of Clinical Biochemistry and Molecular Diagnostics National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt Department of Health Sciences Higher Colleges of TechnologyAbu Dhabi Women's CollegeAbu Dhabi 25026United Arab Emirates Department of Clinical Microbiology and Immunology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt

BACKGROUND Helicobacter pylori(***)is a significant human pathogen that is responsible for a variety of illnesses,including mucosa-associated lymphoid tissue lymphoma,gastric cancer,peptic ulcers,and *** To investigate the frequency of *** infection and its resistance patterns among Egyptian patients and to determine the influence of *** virulence genetic determinants on the eradication success of 14-d triple therapy *** *** infections were investigated in 72 patients with gastroduodenal complications suggestive of *** *** cagA and vacA genotypes of cultured strains were studied using polymerase chain *** patients underwent 14 d of triple-therapy *** treatment response was examined using histology and a rapid urease test 6 wk after therapy *** The intention-to-treat eradication rate was 59.2%(95%CI:48.2%-70.3%).Rates of *** resistance to clarithromycin,amoxicillin,and metronidazole were 52.8%,81.9%,and 100%,*** eradication of *** was more significantly associated with vacA s1-positive strains[adjusted odds ratio(aOR)=0.507,95%CI:0.175-0.822].A significant association was found between failed eradication rate and *** strains resistant to clarithromycin(aOR=0.204,95%CI:-0.005 to 0.412)and amoxicillin(aOR=0.223,95%CI:0.026-0.537).CONCLUSION This study’s low *** eradication rate following 14-d triple therapy is concerning and *** pan-resistance to metronidazole followed by the high resistance to ciprofloxacin,amoxicillin,and clarithromycin in this research is challenging and of great concern.

关键词： Helicobacter pylori Eradication therapy Virulence Clarithromycin resistance cagA gene vacA gene

Purslane protects against the reproductive toxicity of carbamazepine treatment in pilocarpine-induced epilepsy model

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Asian Pacific Journal of Tropical Biomedicine 2017年第4期7卷 339-346页

作者： Widad Makhdour Al-Bishri eman Salah Abdel-Reheim Amr Reda Zaki Biochemistry Department Faculty of ScienceAl Faisaliah CampusKing Abdulaziz University Department of Zoology Faculty of ScienceBeni-Suef University Department of Forensic Medicine and Clinical Toxicology Faculty of MedicineBeni-Suef University

Objective: To investigate the protective effect of purslane with carbamazepine ***: Male albino rats were modulated by pilocarpine to be *** the normal and epileptic rats were treated with carbamazepine, purslane or carbamazepine plus purslane, with separate non-treated control groups for both normal and epileptic ***: The data from the current study showed amelioration in amino acids and electrolytes in the epileptic rats treated with purslane and carbamazepine, with this amelioration occurring without decreasing the fertility hormones(testosterone,dehydroepiandrosterone, luteinizing hormone and follicle stimulating hormone).Purslane treatments also prevented the increase in *** decreased epileptic hyperexcitability with purslane was evidenced by decreased glial fibrillary acidic protein and lipid ***: Natural products like purslane could be used with the highly repetitive drugs like carbamazepine to reduce or prevent its side-effects.

关键词： Pilocarpine Purslane Carbamazepine Epilepsy Fertility hormones

The potency of N,N′-diphenyl-1,4-phenylenediamine and adiposederived stem cell co-administration in alleviating hepatorenal dysfunction complications associated with type 1 diabetes mellitus in rats

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BIOCELL 2023年第8期47卷 1885-1895页

作者： HANY M.ABD EL-LATEEF SAFA H.QAHL eman FAYAD SARAH A.ALTALHI IBRAHIM JAFRI EL SHAIMAA SHABANA MARWA K.DARWISH REHAB MAHER SAAD SHAABAN SHADY G.EL-SAWAH Department of Chemistry College of ScienceKing Faisal UniversityAl-AhsaSaudi Arabia Chemistry Department Faculty of ScienceSohag UniversitySohagEgypt Department of Biology College of ScienceUniversity of JeddahJeddahSaudi Arabia Department of Biotechnology College of ScienceTaif UniversityTaifSaudi Arabia Fellow of Biochemistry Genetic UnitChildren HospitalFaculty of MedicineMansoura UniversityMansouraEgypt Chemistry Department(Biochemistry Branch) Faculty of ScienceSuez UniversitySuezEgypt Department of Clinical Laboratories Sciences College of Applied Medical SciencesShaqra UniversityRiyadhSaudi Arabia Biology Department Faculty of ScienceMansoura UniversityMansouraEgypt Department of Chemistry Organic Chemistry DivisionCollege of ScienceMansoura UniversityMansouraEgypt Zoology Department Faculty of ScienceArish UniversityNorth SinaiEgypt

Background:The increasing occurrence of diabetes mellitus(DM)noted worldwide has considerably elicited concern in the recent *** is associated with elevated vascular complications,morbidity,mortality,and poor quality of *** this context,mesenchymal stem cells(MSCs)have shown significant therapeutic potentialities in managing and curing type 1 DM owing to their self-renewable,immunosuppressive,and differentiation *** investigated the potential action of N,N′-diphenyl-1,4-phenylenediamine(DPPD),a well-known synthetic antioxidant to enhance the therapeutic ability of the adipose-derived stem cells(AD-MSCs)in alleviating kidney and liver complications in diabetic ***:Over the four weeks of experiments,albino male rats(n=36)were split into six test groups:control,DPPD(250 mg/kg,i.p.),STZ-diabetic(D),D+DPPD,D+AD-MSCs(1×10^(6)cell/rat,i.v.),and D+AD-MSCs+DPPD treated ***:Significant declines in the renal and hepatic oxidative stress markers(MDA,ROS,and AGEs)were observed coupled with a significant elevation in many antioxidant marker levels(GSH,SOD,CAT,GPx,HO-1,and TAC)in the diabetic rats treated with either DPPD or AD-MSCs or their co-administered injection compared to the diabetic untreated *** was suggested to be the leading cause of amelioration of the kidney functions(as measured by urea,uric acid,and creatine levels)and liver functions(as evidenced by the levels of AST,ALT,ALP,bilirubin,total proteins,albumin,and globulins).Conclusion:DPPD and AD-MSCs co-administration showed superior results in terms of the enhancement of the relative hepato-renal function,indicating the beneficial role of DPPD supplementation in increasing the therapeutic potential of AD-MSCs.

关键词： Antioxidants Diabetic nephropathy DPPD Oxidative stress Stem cells

Prevalence of Depression in Elderly People Living With HIV:A Systematic Review and Meta-analysis

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Infectious Microbes & Diseases 2023年第4期5卷 167-171页

作者： Gasmelseed Y.Ahmed Chandni Saha eman M.Almusalami Ali A.Rabaan Saad Alhumaid Abdelraheem A.Ali AbdAllah A.Basheer Yousra Babikir Ziyad Fahad Aljofan Abbas Al Mutair Columbia University Hospital New YorkNew YorkUSA Research Center Almoosa Specialist HospitalAlhasaSaudi Arabia Molecular Diagnostic Laboratory Johns Hopkins Aramco HealthcareAlhasaSaudi Arabia Ministry of Health AlhasaSaudi Arabia Faculty of Medicine and Health Sciences Managil University for Sciences and TechnologyAl ManagilSudan Montclair University MontclairNew JerseyUSA College of Medicine King Saud UniversityRiyadhSaudi Arabia School of Nursing University of WollongongWollongongNew South WalesAustralia Medical Surgical Nursing Department Princess Nourah Bint Abdulrhamn UniversityRiyadhSaudi Arabia Nursing Department AlmoosaCollege of Health SciencesAl-MubarrazSaudi Arabia Nursing Department Prince Sultan Military CollegeDhahranSaudi Arabia

We conducted a systematic review andmeta-analysis to determine the prevalence of depression among elderly people living with *** searched electronic databases and included 12 observational studies that reported on depression among people who were 50 years of age or older and had *** studies were mostly hospital-based and fromWestern and African *** included a total of 5868 older peoplewith HIV,ofwhom 1667 had *** prevalence of depression was 28%with heterogeneity of 95.2%.Prevalence ranged from 14.5%in the Netherlands to 42.4%in South *** therewas asymmetry in the funnel plot,the Egger’s test showed no significant publication *** meta-analysis found a high burden of depression among older people with *** health services addressing psychosocial needs and interventions to prevent and treat depression are needed,especially in community *** providers and policymakers should address the prevalence of depression in such communities.

关键词： AIDS aging with HIV depression psychosocial needs

Outcome of non surgical hepatic decompression procedures in Egyptian patients with Budd-Chiari

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世界胃肠病学杂志：英文版 2011年第7期17卷 906-913页

作者： Ahmed Eldorry eman Barakat Heba Abdella Sara Abdelhakam Mohamed Shaker Amr Hamed Mohammad Sakr Department of Radiodi-agnosis and Interventional Radiology Faculty of Medicine AinShams University Department of Tropical Medicine Faculty of Medicine Ain Shams University

AIM: To evaluate outcome of patients with Budd-Chiari syndrome after balloon angioplasty ± stenting or transjugular intrahepatic portosystemic shunt (TIPS). METHODS: Twenty five patients with Budd-Chiari syndrome admitted to Ain Shams University Hospitals, Tropical Medicine Department were included. Twelve patients (48%) with short segment occlusion were candidates for angioplasty; with stenting in ten cases and without stenting in two. Thirteen patients (52%) had Transjugular Intrahepatic Portosystemic Shunt. Patients were followed up for 12-32 mo. RESULTS: Patency rate in patients who underwent angioplasty ± stenting was 83.3% at one year and at end of follow up. The need of revision was 41.6% with one year survival of 100%, dropped to 91.6% at end of follow up. In patients who had Transjugular Intrahepatic Portosystemic Shunt, patency rate was 92.3% at one year, dropped to 84.6% at end of follow up. The need of revision was 38.4% with one year and end of follow up survival of 100%. Patients with patent shunts showed marked improvement compared to those with occluded shunts. CONCLUSION: Morbidity and mortality following angioplasty ± stenting and TIPS are low with satisfactory outcome. Proper patient selection and management of shunt dysfunction are crucial in improvement.

关键词：患者血管成形术肝程序减压埃及手术 TIPS

Determination of Voriconazole in Human Plasma by Liquid Chromatography Tandem Mass Spectrometry: Application in Therapeutic Drug Monitoring

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American Journal of Analytical Chemistry 2023年第9期14卷 378-389页

作者： Waleed Alhussaini Ezzeldeen Ghanem Magd Alsahly Amani Kurdi eman Alharbi Imadul Islam Majed Aljeraisy Department of Pharmaceutical Analysis King Abdullah International Medical Research Center King Saud bin Abdulaziz University for Health Sciences Ministry of the National Guard—Health Affairs Riyadh Saudi Arabia Research Office King Abdullah International Medical Research Center King Saud bin Abdulaziz University for Health Sciences Ministry of the National Guard—Health Affairs Riyadh Saudi Arabia

A sensitive, accurate and robust Liquid Chromatography Tandem Mass Spectrometry method has been developed and validated to measure voriconazole trough levels in human plasma. The plasma samples were mixed with fluconazole as an Internal Standard and directed to protein precipitation and drug extraction. An aliquot of 1 μl was injected into the chromatographic system and separated by the Acquity BEH C18 column at a flow rate of 0.30 ml/min in a gradient mobile phase consisting of acetonitrile, Ultrapure water (UPW), methanol and formic acid. Voriconazole was detected by a Triple Quadrupole Detector (TQD) operating on Multiple Reaction Monitoring (MRM) and a positive ion mode Electrospray ionization (ESI) Q1 mass: 350.1 m/z, Q3 mass: 281.1 m/z. Method linearity of the calibration curve (0.10 - 8.00 μg/ml) indicated a correlation coefficient r ≥ 0.99. The intra and inter-assay accuracy was within 85% - 115% and the intra and inter-assay precision was ≤5.76%. Voriconazole recovery percentage was between 97.69 - 119.62%. The method was successively applied in routine voriconazole TDM.

关键词： Voriconazole Human Plasma Liquid Chromatography Tandem Mass Spectrometry Therapeutic Drug Monitoring

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感悟中国--来华留学生学习生活散记

孔子学院（中阿文对照版） 2022年第2期 64-69页

作者： eman Hammad(翻译) 不详

在现代中国,做什么都很便利我在中国生活四年半了,时刻都能感知到周边的巨大变化,时刻都能体会到生活的丰实和便利。初到大学时,学校统一安排宿舍,轻松解决了住宿问题。真是经济实惠啊!在成都,越米越多的地铁线路被修建,而且公交网络也... 详细信息

在现代中国,做什么都很便利我在中国生活四年半了,时刻都能感知到周边的巨大变化,时刻都能体会到生活的丰实和便利。初到大学时,学校统一安排宿舍,轻松解决了住宿问题。真是经济实惠啊!在成都,越米越多的地铁线路被修建,而且公交网络也相对发达。百度地图和高德地图等应用软件,让我们在陌生的城市也能迅速找到自己的方向和目的地。

关键词：百度地图应用软件地铁线路四年公交网络高德地图学生学习生活目的地

Characteristics and outcome of newborn admitted with acute bilirubin encephalopathy to a tertiary neonatal intensive care unit

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World Journal of Pediatrics 2019年第1期15卷 42-48页

作者： Nahed Fahmy Helal eman Abdel Ghany Abdel Ghany Walaa Alsharany Abuelhamd Amna Yehea Ahmed Alradem Department of Pediatrics Faculty of MedicineCairo UniversityCairoEgypt Ministry of Health CairoEgypt

Background Acute bilirubin encephalopathy (ABE) still represents a significant cause of morbidity and mortality throughout the world,especially in developing *** aimed to determine the prevalence of ABE based on the Johnson bilirubininduced neurologic dysfunction (BIND) score and to describe the discharge *** We prospectively studied all newborns ≥ 35 weeks with ABE by evaluating signs of mental sensorium,muscle tone,and cry patterns over 1 *** 12% (81 out of 674) of the newborns admitted for neonatal hyperbilirubinemia had a BIND score > *** admission age was 6 ± 4.1 days;total serum bilirubin (TSB) was 31.2± 10 mg/dL (range 17.5-75.2).Of these newborns,40.7% and 21% had evidence of haemolysis and sepsis,*** mortality was 9.9%;58% of the newborns showed signs of mild-to-moderate BIND at discharge,while 32.1% survived with an apparently normal *** BIND score was significantly correlated with admission TSB (r=0.476,P < 0.001).Similarly,BIND score at discharge was correlated with admission TSB (r=0.442,P < 0.001) and admission BIND score (r =0.888,P < 0.001).The regression model showed that admission TSB (P < 0.001) and maternal illiteracy (P =0.034) were predictors of the BIND score at admission,while admission BIND score was the best indicator of the discharge score (P < 0.001).Conclusions ABE is still a major problem in our *** TSB and maternal illiteracy are good predictors of bilirubin encephalopathy at admission and discharge.

关键词： Bilirubin-induced neurologic dysfunction Bilirubin encephalopathy Kernicterus Neonatal hyperbilirubinemia